CN115281682A - Composite microneedle structure and preparation method thereof - Google Patents
Composite microneedle structure and preparation method thereof Download PDFInfo
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- CN115281682A CN115281682A CN202210878796.5A CN202210878796A CN115281682A CN 115281682 A CN115281682 A CN 115281682A CN 202210878796 A CN202210878796 A CN 202210878796A CN 115281682 A CN115281682 A CN 115281682A
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- 239000002131 composite material Substances 0.000 title claims description 44
- 238000002360 preparation method Methods 0.000 title abstract description 11
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 6
- 229910052710 silicon Inorganic materials 0.000 claims description 6
- 239000010703 silicon Substances 0.000 claims description 6
- 230000001537 neural effect Effects 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 3
- 150000004767 nitrides Chemical class 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 229910052581 Si3N4 Inorganic materials 0.000 description 12
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 12
- 238000002513 implantation Methods 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 238000006073 displacement reaction Methods 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
- A61B5/268—Bioelectric electrodes therefor characterised by the electrode materials containing conductive polymers, e.g. PEDOT:PSS polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/685—Microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
- A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention belongs to the field of biomedical engineering technology brain-computer interfaces, and particularly provides a microneedle structure compounded by a hard needle and a soft needle and a preparation method thereof.
Description
Technical Field
The invention relates to the field of biomedical engineering technology brain-computer interfaces, in particular to a microneedle structure compounded by a hard needle and a soft needle and a preparation method thereof.
Background
At present, most invasive micro-needle structures are single-type electrodes, such as a michigan electrode and a utah electrode in a hard needle structure and a silicon nitride electrode in a soft needle structure.
When a hard needle (rigid needle) is implanted, the hard needle cannot deform adaptively along with the expansion and contraction of blood vessels, and certain damage may be caused to tissue; the soft needle structure is easy to deform when implanted, and needs to be implanted by means of external equipment, but has the problems of complex structure, low efficiency and the like, and the two single types of needle bodies cannot meet the current clinical requirements.
Thus, there is a need for a solution to the problems of the prior art.
Disclosure of Invention
The invention provides a microneedle structure combining a hard needle and a soft needle, which can at least solve part of problems in the prior art.
To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:
a composite micro-needle structure comprises a hard needle and a soft needle, wherein a fixing structure is configured on the hard needle to surround three sides of the soft needle, so that the hard needle and the soft needle are combined.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the fixing structure is a drawer type fixing structure.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: and arranging a fixed structure on the hard needle in a growing mode.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: a certain gap is reserved between the fixing structure of the hard needle and the soft needle.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the hard needle is a silicon-based electrode.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the soft needle material comprises polymer and nitride, and the thickness of the soft needle is less than 10 microns.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the fixing structure comprises a first fixing part and at least two second fixing parts, and the at least two second fixing parts are arranged on two sides of the first fixing part.
To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:
the preparation method of the composite microneedle structure comprises the following steps:
s1, configuring a fixing structure on the hard needle;
and S2, surrounding three surfaces of the soft needle by using the fixing structure to obtain the composite micro-needle structure.
The preferable scheme of the preparation method of the composite microneedle structure is as follows: the fixing structure is a drawer type fixing structure.
A neural microelectrode comprises the composite microneedle structure or the composite microneedle structure prepared by the preparation method of the composite microneedle structure.
When the composite microneedle structure is applied to tissue implantation, the hard needle and the soft needle can be well fixed, and the hard needle can be more conveniently pulled out while the hard needle and the soft needle are prevented from moving.
The invention has the following beneficial effects:
the invention provides a hard needle and soft needle composite microneedle structure and a preparation method thereof, wherein a drawer type fixing structure is directly grown on a hard needle without any graphical processing on the tail part of the soft needle, three sides of the soft needle are surrounded, but a certain gap is left between the hard needle and the soft needle, so that the effect of fixing the hard needle and the soft needle is achieved, the hard needle and the soft needle can be prevented from displacement, when the hard needle drives the soft needle to be implanted into tissues together, the hard needle can be easily pulled out by directly pulling the hard needle backwards, and meanwhile, the soft needle is kept in the body, so that the implantation of the microneedle is realized.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
Fig. 1 is a schematic view of a composite microneedle structure according to the present invention;
FIG. 2 is a schematic view of a fastening structure of the composite microneedle structure of the present invention;
fig. 3 is a schematic cross-sectional view of a fixing portion of a composite microneedle structure according to the present invention;
the reference numbers indicate:
1-hard needle, 2-soft needle, 3-fixed structure.
The implementation, functional features and advantages of the present invention will be further described with reference to the accompanying drawings.
Detailed Description
The following will clearly and completely describe the technical solutions in the embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, back, 8230; etc.) are involved in the embodiment of the present invention, the directional indications are only used for explaining the relative positional relationship between the components, the motion situation, etc. in a specific posture (as shown in the figure), and if the specific posture is changed, the directional indications are correspondingly changed.
In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In addition, technical solutions between the embodiments may be combined with each other, but must be based on the realization of the technical solutions by a person skilled in the art, and when the technical solutions are contradictory to each other or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
The invasive neural microelectrode is one of the nerve electrical activity sensing means with the highest resolution at present as a sensing device, and can record action potential of a nervous system or even a single neuron on the premise of not damaging the nervous system as much as possible. At present, most invasive micro-needle structures are single-type electrodes, such as a michigan electrode and a utah electrode in a hard needle structure and a silicon nitride electrode in a soft needle structure. When the hard needle (rigid needle) is implanted, the hard needle cannot be adaptively deformed along with the expansion and contraction of blood vessels, and certain damage may be caused to nerve tissues; the soft needle structure is easy to deform during implantation, and needs to be implanted by means of external equipment, but has the problems of complex structure, low efficiency and the like.
The invention provides a hard needle and soft needle composite microneedle structure, when a hard needle drives a soft needle to be implanted into tissues together, the hard needle is directly pulled backwards, so that the hard needle can be easily pulled out, and meanwhile, the soft needle is kept in a body, so that the implantation of the microneedle is realized; the drawer type fixing structure directly grows on the hard needle without performing any graphical processing on the tail part of the soft needle, surrounds three sides of the soft needle, but can leave a certain gap with the soft needle, so that the effect of fixing the hard needle and the soft needle is achieved, and the hard needle and the soft needle can not be displaced.
The invention provides the following technical scheme:
a composite micro-needle structure and a preparation method thereof comprise a hard needle 1 and a soft needle 2, wherein a fixing structure 3 is configured on the hard needle 1 to surround three sides of the soft needle 2, so that the composite of the hard needle 1 and the soft needle 2 is realized. The fixing structure 3 is a drawer-type fixing structure. And arranging a fixing structure on the hard needle is realized in a growing mode.
A certain gap is reserved between the fixing structure of the hard needle 1 and the soft needle 2, when the hard needle drives the soft needle to be implanted into tissues together, the hard needle is directly pulled backwards, the hard needle can be easily pulled out, meanwhile, the soft needle is kept in the body, and the implantation of the micro needle is realized. Wherein, the hard needle is a silicon-based electrode, the soft needle material comprises polymer and nitride, and the thickness of the soft needle is less than 10 microns.
A neural microelectrode comprises the compound microneedle structure or the compound microneedle structure prepared by the preparation method of the compound microneedle structure.
When the compound microneedle structure is applied to tissue implantation, the hard needle 1 and the soft needle 2 can be well fixed, and the hard needle 1 can be more conveniently pulled out while the movement between the hard needle 1 and the soft needle is prevented.
Example 1
As shown in fig. 1-2, a composite microneedle structure includes a hard needle 1 and a soft needle 2, a drawer-type fixing structure 3 grows on the hard needle 1, surrounds three sides of the soft needle 2, plays a role in fixing the hard needle 1 and the soft needle 2, and can ensure that the hard needle 1 and the soft needle 2 do not displace relative to each other, thereby realizing the composite of the hard needle 1 and the soft needle 2.
In an alternative embodiment, the fixing structure includes a first fixing portion and at least two second fixing portions, the at least two second fixing portions are disposed on two sides of the first fixing portion, the first fixing portion and the second fixing portion are both distributed on the hard needle by growing, a gap exists between the first fixing portion and the second fixing portion relative to the hard needle, and the second fixing portion is distributed below the first fixing portion, which may be understood as that the second fixing portion is closer to a needle point of the hard needle. The first fixing part is perpendicular to the axis of the hard needle, and the second fixing part is parallel to the axis of the hard needle, so that a structure surrounded on three sides is formed, and the soft needle can be accommodated conveniently. In a preferred embodiment, a gap between the first fixing portion and the hard needle is equal to a thickness of the soft needle (slightly larger than the thickness of the soft needle), a gap between the second fixing portion and the hard needle is equal to a thickness of the soft needle (slightly larger than the thickness of the soft needle), and a width of the accommodating cavity formed by the second fixing portion is equal to a width of the soft needle (slightly larger than the width of the soft needle).
In other embodiments, more second fixing portions may be further disposed on the hard needle, which may be determined according to actual situations, for example, 3, 4 or more second fixing portions may be disposed on the hard needle, wherein a portion of the second fixing portions is disposed on one side of the first fixing portion, and another portion of the second fixing portions is disposed on the other side of the first fixing portion.
A certain gap is reserved between the fixing structure of the hard needle 1 and the soft needle 2, the hard needle 1 drives the soft needle 2 to be implanted into tissues together, the hard needle 1 is directly pulled backwards, the hard needle 1 can be easily pulled out, and meanwhile, the soft needle 2 is reserved in the body, so that the implantation of the micro needle is realized.
Example 2
A preparation method of a composite microneedle structure comprises the following steps:
s1, growing a drawer type fixing structure 3 on the hard needle 1;
s2, surrounding three surfaces of the soft needle 2 by using the drawer type fixing structure 3, playing a role in fixing the hard needle 1 and the soft needle 2, and ensuring that the hard needle 1 and the soft needle 2 cannot be displaced to obtain the composite microneedle structure.
A certain gap is reserved between the fixing structure of the hard needle 1 and the soft needle 2, the hard needle 1 drives the soft needle 2 to be implanted into tissues together, the hard needle 1 is directly pulled backwards, the hard needle 1 can be easily pulled out, and meanwhile, the soft needle 2 is reserved in the body, so that the implantation of the micro needle is realized.
Example 3
In the embodiment, a composite microneedle structure is prepared by adopting a michigan electrode and a silicon nitride electrode, the michigan electrode belongs to a thin film electrode, and is similar to the integrated circuit manufacturing, and a micro-electronic manufacturing technology is adopted, and conductive metal is sprayed and plated on a thin sheet taking silicon or ceramic material as a substrate according to a designed electrode circuit; or etching to remove the unnecessary part on the whole printed board covered with the conductive metal layer, and leaving the required electrode circuit, wherein the conductive metal can be nickel, stainless steel, tungsten, gold or molybdenum; except for the recording point, the other conducting lines connecting the recording point and the output end are covered with an insulating layer, the common insulating material is silicon nitride, and the surface of the recording point is plated with iridium or gold in order to enhance the conductivity and biocompatibility. The recording dots of the michigan electrode are generally arranged in a linear array of recording dots on a recording rod at regular intervals, and are therefore referred to as a linear electrode array. As shown in fig. 1-2, a composite microneedle structure includes a hard needle 1 and a soft needle 2, the hard needle 1 is a michigan electrode, the soft needle 2 is a silicon nitride electrode, a drawer-type fixing structure 3 grows on the michigan electrode, surrounds three sides of the silicon nitride electrode, and plays a role in fixing the michigan electrode and the silicon nitride electrode, and can ensure that the michigan electrode and the silicon nitride electrode do not displace, thereby realizing the combination of the michigan electrode and the silicon nitride electrode.
A certain gap is reserved between the fixing structure of the michigan electrode and the silicon nitride electrode, the michigan electrode drives the silicon nitride electrode to be implanted into tissues together, and then the michigan electrode is pulled backwards directly, so that the michigan electrode can be pulled out easily, and meanwhile, the silicon nitride electrode is kept in vivo, and the implantation of the microneedle is realized.
Regarding the circuit requirements of the micro-needle matched with the micro-needle, it can be known by combining with the chinese patent application CN 114271835A that the micro-needle with the reading circuit comprises at least one micro-needle body and the reading circuit, the micro-needle body is located on the reading circuit, the reading circuit is formed on a silicon substrate, components of the micro-needle body and the reading circuit are respectively located on the front and back sides of the silicon substrate, and a first contact of the micro-needle body is electrically connected with a second contact of the reading circuit to realize the rapid reading of the neural data. In the case of the circuit, it is only necessary to consider that the contact for electrical connection is arranged without interfering with the hole structure, such as an evasive design, or the hole structure arrangement and the circuit contact arrangement are all sufficiently implemented by those skilled in the art.
As shown in fig. 3, the present invention provides a composite microneedle structure comprising a hard needle 1 and a soft needle 2, without any graphical processing on the tail of the soft needle 2, a drawer-type fixing structure 3 is directly grown on the hard needle 1 to surround three sides of the soft needle 2, so as to play a role of fixing the hard needle 1 and the soft needle 2, and ensure that no displacement occurs between the hard needle 1 and the soft needle 2, when the hard needle 1 drives the soft needle 2 to be implanted into a tissue together, the hard needle 1 is directly pulled backwards, so that the hard needle 1 can be easily pulled out, and the soft needle 2 is retained in the body, so as to realize the implantation of the soft needle 2.
The above description is only a preferred embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications and equivalents of the present invention, which are made by the present specification and directly/indirectly applied to other related technical fields within the spirit of the present invention are included in the scope of the present invention.
Claims (10)
1. A composite microneedle structure, characterized by: the needle comprises a hard needle and a soft needle, wherein a fixing structure is arranged on the hard needle to surround three sides of the soft needle, so that the hard needle and the soft needle are compounded.
2. A composite microneedle structure according to claim 1, wherein: the fixing structure is a drawer type fixing structure.
3. A composite microneedle structure according to claim 1 or 2, characterized in that: and arranging a fixed structure on the hard needle in a growing mode.
4. A composite microneedle structure according to claim 1 or 2, characterized in that: a certain gap is reserved between the fixing structure of the hard needle and the soft needle.
5. A composite microneedle structure according to claim 1 or 2, characterized in that: the hard needle is a silicon-based electrode.
6. A composite microneedle structure according to claim 1 or 2, characterized in that: the soft needle material comprises polymer and nitride, and the thickness of the soft needle is less than 10 microns.
7. A composite microneedle structure according to claim 1 or 2, characterized in that: the fixing structure comprises a first fixing part and at least two second fixing parts, and the at least two second fixing parts are arranged on two sides of the first fixing part.
8. A method for preparing a composite microneedle structure, comprising: for preparing a composite microneedle structure according to any one of claims 1 to 6, comprising the steps of:
s1, configuring a fixing structure on the hard needle;
and S2, surrounding three surfaces of the soft needle by using the fixing structure to obtain the composite micro-needle structure.
9. The method of claim 8, wherein the composite microneedle structure comprises: the fixing structure is a drawer type fixing structure.
10. A neural microelectrode comprising the composite microneedle structure according to any one of claims 1 to 6 or the composite microneedle structure prepared by the method for preparing the composite microneedle structure according to any one of claims 7 to 8.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210878796.5A CN115281682B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and preparation method thereof |
| PCT/CN2022/126571 WO2024021324A1 (en) | 2022-07-25 | 2022-10-21 | Composite microneedle structure and preparation method therefor |
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| CN202210878796.5A CN115281682B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and preparation method thereof |
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| CN115281682B CN115281682B (en) | 2024-06-14 |
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- 2022-10-21 WO PCT/CN2022/126571 patent/WO2024021324A1/en unknown
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| CN115281682B (en) | 2024-06-14 |
| WO2024021324A1 (en) | 2024-02-01 |
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