CN115251931A - Composite microneedle structure and preparation method thereof - Google Patents
Composite microneedle structure and preparation method thereof Download PDFInfo
- Publication number
- CN115251931A CN115251931A CN202210880695.1A CN202210880695A CN115251931A CN 115251931 A CN115251931 A CN 115251931A CN 202210880695 A CN202210880695 A CN 202210880695A CN 115251931 A CN115251931 A CN 115251931A
- Authority
- CN
- China
- Prior art keywords
- needle
- hard
- soft
- petal
- composite microneedle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002131 composite material Substances 0.000 title claims description 43
- 238000002360 preparation method Methods 0.000 title abstract description 11
- 238000002513 implantation Methods 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 5
- 230000001537 neural effect Effects 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 3
- 230000000694 effects Effects 0.000 abstract description 3
- 238000005516 engineering process Methods 0.000 abstract description 3
- 229910052581 Si3N4 Inorganic materials 0.000 description 10
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 10
- 210000001519 tissue Anatomy 0.000 description 9
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- 238000005452 bending Methods 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 229910052741 iridium Inorganic materials 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- 238000004377 microelectronic Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 210000000944 nerve tissue Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 238000000059 patterning Methods 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/251—Means for maintaining electrode contact with the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention belongs to the field of biomedical engineering technology brain-computer interfaces, and particularly provides a micro-needle structure compounded by a hard needle and a soft needle and a preparation method thereof, wherein a petal-like structure is patterned at the tail part of the soft needle, and a plug pin structure grows on the surface of the hard needle and penetrates through the petal structure, so that the effect of fixing the hard needle and the soft needle is achieved, and the hard needle and the soft needle can be ensured not to be displaced; after the hard needle drives the soft needle to be implanted into tissues together, the petal structure on the soft needle can be bent and deformed to a certain degree by pulling the hard needle downwards until the bolt structure is completely withdrawn, then the hard needle is continuously pulled out backwards, the soft needle is kept in the body, and the implantation of the microneedle is realized.
Description
Technical Field
The invention relates to the field of biomedical engineering technology brain-computer interfaces, in particular to a microneedle structure compounded by a hard needle and a soft needle and a preparation method thereof.
Background
At present, most invasive micro-needle structures are single-type electrodes, such as a michigan electrode and a utah electrode in a hard needle structure and a silicon nitride electrode in a soft needle structure.
When a hard needle (rigid needle) is implanted, the hard needle cannot deform adaptively along with the expansion and contraction of blood vessels, and certain damage may be caused to tissue; the soft needle structure is easy to deform when being implanted, and needs to be implanted by means of external equipment, but has the problems of complex structure, low efficiency and the like, and the two single types of needle bodies cannot meet the current clinical requirements.
Thus, there is a need for a solution to the problems of the prior art.
Disclosure of Invention
The invention provides a microneedle structure combining a hard needle and a soft needle, which can at least solve part of problems in the prior art.
To solve the above technical problem, according to an aspect of the present invention, the present invention provides the following technical solutions:
the utility model provides a compound micropin structure, includes hard needle and soft needle dispose first connecting portion on the soft needle dispose the second connecting portion on the hard needle, first connecting portion with the cooperation of second connecting portion is connected, realizes the hard needle with the compound of soft needle.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the first connecting part is preferably arranged at the tail part of the soft needle so as to facilitate the compounding of the hard needle and the soft needle.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the first connecting part is preferably a petal structure patterned at the tail of the soft needle.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the second connecting part is preferably a plug pin structure matched with the petal structure and arranged at the corresponding position of the hard needle.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the plug pin structure matched with the petal structure and arranged at the corresponding position of the hard needle is realized in a growing mode.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the number of the petal structures is at least one or more.
As a preferable embodiment of the composite microneedle structure according to the present invention, wherein: the number of the bolt structures is at least one or more.
In order to solve the above technical problems, according to one aspect of the present invention, the present invention provides the following technical solutions:
the preparation method of the composite microneedle structure comprises the following steps:
s1, configuring a first connecting part on the soft needle;
s2, configuring a second connecting part matched with the first connecting part at the corresponding position of the hard needle,
and S3, connecting the first connecting part and the second connecting part in a matching manner to obtain the composite microneedle structure.
A neural microelectrode comprises the composite microneedle structure or the composite microneedle structure prepared by the preparation method of the composite microneedle structure.
The application of the composite microneedle structure in tissue implantation can well fix the hard needle and the soft needle, prevent the hard needle and the soft needle from moving, and simultaneously enable the hard needle to be more conveniently pulled out.
The invention has the following beneficial effects:
the invention provides a hard needle and soft needle composite microneedle structure and a preparation method thereof.A petal-like structure is patterned at the tail part of a soft needle, a plug pin structure grows on the surface of the hard needle and can penetrate through the petal structure, so that the hard needle and the soft needle are fixed, and the hard needle and the soft needle can not be displaced; after the hard needle drives the soft needle to be implanted into tissues together, the petal structure on the soft needle can be bent and deformed to a certain degree by pulling the hard needle downwards until the bolt structure is completely withdrawn, then the hard needle is continuously pulled out backwards, the soft needle is kept in the body, and the implantation of the microneedle is realized.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the structures shown in the drawings without creative efforts.
Fig. 1 is a schematic view of a composite microneedle structure according to the present invention;
FIG. 2 is a schematic view of a petal configuration of the composite microneedle arrangement of the present invention;
fig. 3 is a schematic cross-sectional view of a connection portion of a composite microneedle structure according to the present invention;
the reference numbers indicate:
1-hard needle, 2-soft needle, 3-petal structure and 4-bolt structure.
The implementation, functional features and advantages of the objects of the present invention will be further explained with reference to the accompanying drawings.
Detailed Description
The following will clearly and completely describe the technical solutions in the embodiments, and obviously, the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and back … …) are involved in the embodiment of the present invention, the directional indications are only used to explain the relative position relationship between the components, the motion situation, and the like in a specific posture (as shown in the drawing), and if the specific posture is changed, the directional indications are changed accordingly.
In addition, if there is a description relating to "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying relative importance or to implicitly indicate the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the feature. In addition, technical solutions between various embodiments may be combined with each other, but must be realized by a person skilled in the art, and when the technical solutions are contradictory or cannot be realized, such a combination should not be considered to exist, and is not within the protection scope of the present invention.
The invasive neural microelectrode is one of the nerve electrical activity sensing means with the highest resolution at present as a sensing device, and can record action potential of a nervous system or even a single neuron on the premise of not damaging the nervous system as much as possible. At present, most invasive micro-needle structures are single-type electrodes, such as a michigan electrode and a utah electrode in a hard needle structure and a silicon nitride electrode in a soft needle structure. When the hard needle (rigid needle) is implanted, the hard needle cannot be adaptively deformed along with the expansion and contraction of blood vessels, and certain damage may be caused to nerve tissues; the soft needle structure is easy to deform during implantation, and needs to be implanted by means of external equipment, but has the problems of complex structure, low efficiency and the like.
The invention provides a hard needle and soft needle composite microneedle structure and a preparation method thereof. The tail part of the soft needle is patterned to form a structure similar to a petal, the surface of the hard needle is provided with a bolt structure, and the bolt structure can penetrate through the petal structure, so that the effect of fixing the hard needle and the soft needle is achieved, and the hard needle and the soft needle can be guaranteed not to displace.
The invention provides the following technical scheme:
a composite micro-needle structure and a preparation method thereof comprise a hard needle 1 and a soft needle 2, wherein a petal structure 3 is patterned at the tail part of the soft needle 2, a plug pin structure 4 grows on the hard needle 1, and the petal structure 3 is matched and connected with the plug pin structure 4 to realize the composite of the hard needle 1 and the soft needle 2.
After the hard needle 1 drives the soft needle 2 to be implanted into tissues together, the petal structure 3 on the soft needle 2 can be bent and deformed to a certain degree by pulling the hard needle 1 downwards until the bolt structure 4 is completely withdrawn, then the hard needle 1 is continuously pulled out backwards, the soft needle 2 is kept in the body, and the implantation of the micro-needle is realized.
The number of the petal structures and the number of the bolt structures matched with the petal structures can be set according to needs as long as stable connection of the petal structures and the bolt structures can be realized, the number of the petal structures and the number of the bolt structures matched with the petal structures are both N, N is a positive integer larger than or equal to 1, and can be 1, 2, 3, 4, 5, 6, 7 and … ….
A neural microelectrode comprises the composite microneedle structure or the composite microneedle structure prepared by the preparation method of the composite microneedle structure.
When the compound microneedle structure is applied to tissue implantation, the hard needle 1 and the soft needle 2 can be well fixed, and the hard needle 1 can be more conveniently pulled out while the movement between the hard needle and the soft needle is prevented.
Example 1
As shown in fig. 1-2, a composite microneedle structure comprises a hard needle 1 and a soft needle 2, wherein 4 petal structures 3 are patterned at the tail of the soft needle 2, 4 plug pin structures 4 grow at corresponding positions on the hard needle 1, and the petal structures 3 are connected with the plug pin structures 4 in a matching manner, so that the hard needle 1 and the soft needle 2 are combined.
After hard needle 1 drives soft needle 2 and together implants the tissue, through pulling hard needle 1 downwards, petal structure 3 on the soft needle 2 can take place certain degree bending deformation, withdraws from completely until bolt structure 4, then continues to extract hard needle 1 backward, remains soft needle 2 and stays internally, realizes the implantation of micropin.
Example 2
A preparation method of a composite microneedle structure comprises the following steps:
s1, patterning a petal structure 3 at the tail part of the soft needle 2;
s2, arranging a bolt structure 4 matched with the petal structure 3 at the corresponding position of the hard needle 1;
and S3, connecting the petal structures 3 with the bolt structures 4 in a matching manner to obtain the composite microneedle structure.
After hard needle 1 drives soft needle 2 and together implants the tissue, through pulling hard needle 1 downwards, petal structure 3 on the soft needle 2 can take place certain degree bending deformation, withdraws from completely until bolt structure 4, then continues to extract hard needle 1 backward, remains soft needle 2 and stays internally, realizes the implantation of micropin.
Example 3
In the embodiment, a composite microneedle structure is prepared by adopting a michigan electrode and a silicon nitride electrode, the michigan electrode belongs to a thin film electrode, and is similar to the integrated circuit manufacturing, and a micro-electronic manufacturing technology is adopted, and conductive metal is sprayed and plated on a thin sheet taking silicon or ceramic material as a substrate according to a designed electrode circuit; or etching to remove the unnecessary part on the whole printed board covered with the conductive metal layer to leave the required electrode circuit, wherein the conductive metal can be nickel, stainless steel, tungsten, gold or molybdenum; except for the recording point, the other conducting lines connecting the recording point and the output end are covered with an insulating layer, the common insulating material is silicon nitride, and the surface of the recording point is plated with iridium or gold in order to enhance the conductivity and biocompatibility. The recording dots of the michigan electrode are generally arranged in a linear array of recording dots on a recording rod at regular intervals, and are therefore referred to as a linear electrode array. As shown in fig. 1-2, a composite microneedle structure comprises a hard needle 1 and a soft needle 2, wherein the hard needle 1 is a michigan electrode, the soft needle 2 is a silicon nitride electrode, 4 petal structures 3 are patterned at the tail of the silicon nitride electrode, a plug pin structure 4 grows on the michigan electrode, and the petal structures 3 and the plug pin structure 4 are connected in a matching manner to realize the combination of the michigan electrode and the silicon nitride electrode.
After the michigan electrode drives the silicon nitride electrode to be implanted into tissues together, the petal structure 3 on the silicon nitride electrode can be bent and deformed to a certain degree by pulling the michigan electrode downwards until the bolt structure 4 is completely withdrawn, then the michigan electrode is continuously pulled out backwards, the silicon nitride electrode is kept to be left in the body, and the implantation of the micro-needle is realized.
Regarding the circuit requirements of the micro-needle matched with the micro-needle, it can be known by combining with the chinese patent application CN 114271835A that the micro-needle with the readout circuit comprises at least one micro-needle body and the readout circuit, the micro-needle body is located on the readout circuit, the readout circuit is formed on a silicon substrate, the micro-needle body and components of the readout circuit are respectively located on the front and back sides of the silicon substrate, and a first contact of the micro-needle body is electrically connected with a second contact of the readout circuit to realize the rapid reading of the neural data. In the case of the circuit, it is only necessary to consider that the contact for electrical connection is arranged without interfering with the hole structure, such as an evasive design, or the hole structure arrangement and the circuit contact arrangement are all sufficiently implemented by those skilled in the art.
As shown in figure 3, the invention provides a hard needle 1 and soft needle 2 composite micro-needle structure, a petal structure 3 is patterned at the tail part of a soft needle 2, a plug pin structure 4 is grown on the surface of the hard needle 1, and the plug pin structure 4 can penetrate through the petal structure 3, so that the hard needle 1 and the soft needle 2 can be fixed, and the hard needle 1 and the soft needle 2 can not be displaced. After the hard needle 1 drives the soft needle 2 to be implanted into tissues together, the petal structure 3 on the soft needle 2 can be bent and deformed to a certain degree by pulling the hard needle 1 downwards until the bolt structure 4 is completely withdrawn, then the hard needle 1 is continuously pulled out backwards, the soft needle 2 is kept in the body, and the soft needle 2 is implanted.
The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structural changes made by using the content of the present specification or other related technical fields within the spirit of the present invention are included in the scope of the present invention.
Claims (10)
1. The utility model provides a compound microneedle structure, its characterized in that includes hard needle and soft needle dispose first connecting portion on the soft needle dispose the second connecting portion on the hard needle, first connecting portion with the cooperation of second connecting portion is connected, realizes the hard needle with the compound of soft needle.
2. A composite microneedle arrangement according to claim 1, wherein said first connection is provided at the tail of said soft needle to facilitate the combination of the hard and soft needles.
3. A composite microneedle arrangement according to claim 1 or 2, wherein said first connecting portion is a petal pattern patterned at the tail of the soft needle.
4. A composite microneedle structure according to claim 1 or 2, wherein said second connecting portion is a pin structure fitted to the petal structure and disposed at a corresponding position of the hard needle.
5. A composite microneedle structure according to claim 1 or 2, wherein the plug structures arranged at the corresponding positions of the hard needles to cooperate with the petal structures are realized by means of growth.
6. A composite microneedle structure according to claim 1 or 2, wherein the number of petal structures and the number of pin structures are the same, and are at least one or more.
7. A method for producing a composite microneedle structure, characterized by comprising the steps of:
s1, configuring a first connecting part on the soft needle;
s2, configuring a second connecting part matched with the first connecting part at the corresponding position of the hard needle,
and S3, connecting the first connecting part and the second connecting part in a matching manner to obtain the composite microneedle structure.
8. The method of claim 7, wherein the step of preparing a composite microneedle structure comprises: the first connecting part is of a petal structure, and the second connecting part is of a bolt structure.
9. A neural microelectrode comprising the composite microneedle structure according to any one of claims 1 to 6 or the composite microneedle structure prepared by the method for preparing the composite microneedle structure according to any one of claims 7 to 8.
10. Use of a composite microneedle structure according to any one of claims 1 to 6 or prepared by a method of preparing a composite microneedle structure according to any one of claims 7 to 8 for tissue implantation.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210880695.1A CN115251931A (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and preparation method thereof |
| PCT/CN2022/126572 WO2024021325A1 (en) | 2022-07-25 | 2022-10-21 | Composite microneedle structure and preparation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210880695.1A CN115251931A (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115251931A true CN115251931A (en) | 2022-11-01 |
Family
ID=83770077
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210880695.1A Pending CN115251931A (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and preparation method thereof |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115251931A (en) |
| WO (1) | WO2024021325A1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115281682A (en) * | 2022-07-25 | 2022-11-04 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and preparation method thereof |
| CN115500832A (en) * | 2022-08-24 | 2022-12-23 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101884530A (en) * | 2010-07-14 | 2010-11-17 | 中国科学院半导体研究所 | Flexible probe electrode used for recording electric signal of neural activity and implanting tool thereof |
| US20100331935A1 (en) * | 2009-05-01 | 2010-12-30 | Phillipe Tabada | Rigid Spine Reinforced Polymer Microelectrode Array Probe and Method of Fabrication |
| US20130211485A1 (en) * | 2012-02-13 | 2013-08-15 | Agency For Science, Technology And Research | Probe Device and a Method of Fabricating the Same |
| US20200261025A1 (en) * | 2017-09-08 | 2020-08-20 | Board Of Regents, The University Of Texas System | System and method for making and implanting high-density electrode arrays |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8224417B2 (en) * | 2007-10-17 | 2012-07-17 | Neuronexus Technologies, Inc. | Guide tube for an implantable device system |
| WO2022005386A1 (en) * | 2020-07-03 | 2022-01-06 | Neuronano Ab | Microelectrode for insertion into soft tissue |
| CN111990995B (en) * | 2020-09-10 | 2024-06-14 | 中国科学院半导体研究所 | Flexible electrode implantation system |
| CN112386262A (en) * | 2020-11-18 | 2021-02-23 | 中国科学院半导体研究所 | U-shaped flexible electrode implantation system and preparation method thereof |
| CN112999511B (en) * | 2021-03-10 | 2024-03-19 | 中国科学院半导体研究所 | Flexible electrode lead-in device |
| CN114014252B (en) * | 2021-11-02 | 2024-05-31 | 杭州电子科技大学温州研究院有限公司 | High-density low-noise rigid-flexible combined nerve probe and preparation method thereof |
| CN114376580A (en) * | 2022-01-04 | 2022-04-22 | 中国科学院上海微系统与信息技术研究所 | Flexible nerve electrode, preparation method thereof and brain-computer interface |
| CN114788700A (en) * | 2022-02-25 | 2022-07-26 | 武汉衷华脑机融合科技发展有限公司 | Neural interface with auxiliary structure |
| CN115153566A (en) * | 2022-06-16 | 2022-10-11 | 武汉衷华脑机融合科技发展有限公司 | Microelectrode structure and manufacturing method thereof |
| CN115054825A (en) * | 2022-06-17 | 2022-09-16 | 中国科学院脑科学与智能技术卓越创新中心 | Flexible electrode for acupuncture and moxibustion and manufacturing method thereof |
-
2022
- 2022-07-25 CN CN202210880695.1A patent/CN115251931A/en active Pending
- 2022-10-21 WO PCT/CN2022/126572 patent/WO2024021325A1/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100331935A1 (en) * | 2009-05-01 | 2010-12-30 | Phillipe Tabada | Rigid Spine Reinforced Polymer Microelectrode Array Probe and Method of Fabrication |
| CN101884530A (en) * | 2010-07-14 | 2010-11-17 | 中国科学院半导体研究所 | Flexible probe electrode used for recording electric signal of neural activity and implanting tool thereof |
| US20130211485A1 (en) * | 2012-02-13 | 2013-08-15 | Agency For Science, Technology And Research | Probe Device and a Method of Fabricating the Same |
| US20200261025A1 (en) * | 2017-09-08 | 2020-08-20 | Board Of Regents, The University Of Texas System | System and method for making and implanting high-density electrode arrays |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115281682A (en) * | 2022-07-25 | 2022-11-04 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and preparation method thereof |
| CN115281682B (en) * | 2022-07-25 | 2024-06-14 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and preparation method thereof |
| CN115500832A (en) * | 2022-08-24 | 2022-12-23 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure |
| CN115500832B (en) * | 2022-08-24 | 2024-04-02 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2024021325A1 (en) | 2024-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN115251931A (en) | Composite microneedle structure and preparation method thereof | |
| US6624510B1 (en) | Electrode array having a thin, flexible substrate | |
| US7032302B1 (en) | Dry physiological recording device | |
| US7941201B2 (en) | Microprobe array structure and method for manufacturing the same | |
| US7881764B1 (en) | Physiological recording device | |
| US8238995B2 (en) | Self-adhering electrodes and methods of making the same | |
| KR101785287B1 (en) | Microneedle electrode patch and fabrication method of the microneedle electrode patch | |
| CN112244850B (en) | Intracranial deep electrode recording device and preparation method and system thereof | |
| CN114343654A (en) | Flexible microneedle structure | |
| CN113777145A (en) | Method for manufacturing micro-needle biosensor | |
| CN115153566A (en) | Microelectrode structure and manufacturing method thereof | |
| CN113261969B (en) | Brain electrode needle, brain electrode unit and arrayed brain electrode | |
| CN115281682B (en) | Composite microneedle structure and preparation method thereof | |
| US20180353753A1 (en) | Systems and methods for flexible electrode arrays | |
| CN219720705U (en) | Microneedle array electrode | |
| CN201375515Y (en) | Electric potential mapping electrode of | |
| CN209137753U (en) | A kind of intracorporal electrode plate of implantable mouse | |
| CN115500831B (en) | Composite microneedle structure based on integrated circuit chip | |
| CN114469109B (en) | Microneedle brain electrode based on organic metal porous polymer and manufacturing method thereof | |
| CN115227254B (en) | Composite microneedle structure and nerve microelectrode | |
| CN114469108A (en) | Novel microneedle substrate structure | |
| CN115381457A (en) | Flexible substrate brain-computer interface signal acquisition regulation probe array and preparation method thereof | |
| CN109330590B (en) | Epidermal electrode for epidermal signal acquisition and application thereof | |
| CN217793074U (en) | Flexible micro-needle structure | |
| CN115227254A (en) | Composite microneedle structure and nerve microelectrode |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |