WO2024021325A1

WO2024021325A1 - Composite microneedle structure and preparation method therefor

Info

Publication number: WO2024021325A1
Application number: PCT/CN2022/126572
Authority: WO
Inventors: 黄立; 黄晟; 童贝
Original assignee: 武汉衷华脑机融合科技发展有限公司
Priority date: 2022-07-25
Filing date: 2022-10-21
Publication date: 2024-02-01
Also published as: CN115251931A; CN115251931B

Abstract

A composite microneedle structure of a hard needle and a soft needle and a preparation method therefor. A structure (3) similar to a petal is patterned at the tail part of the soft needle (2), a bolt structure (4) is grown on the surface of the hard needle (1), and the bolt structure (4) can pass through the petal structure (3), so that the hard needle (1) and the soft needle (2) can be fixed, and no displacement between the hard needle (1) and the soft needle (2) can be ensured. After the hard needle (1) drives the soft needle (2) to be implanted into a tissue together, the hard needle (1) is pulled downward, and the petal structure (3) on the soft needle (2) is bent and deformed to a certain extent until the bolt structure (4) completely withdraws. The hard needle (1) is then continuously pulled backward, and the soft needle (2) remains in the body, achieving the implant of the microneedle.

Description

A composite microneedle structure and its preparation method

Technical field

The invention relates to the field of brain-computer interface of biomedical engineering technology, and specifically relates to a microneedle structure composed of hard needles and soft needles and a preparation method thereof.

Background technique

At present, most invasive microneedle structures are single-type electrodes, such as Michigan electrodes and Utah electrodes with hard needle structures, and silicon nitride electrodes with soft needle structures.

Hard needles (rigid needles) cannot adapt to the expansion and contraction of blood vessels during implantation, and may cause certain damage to the tissue; while soft needle structures are prone to deformation during implantation and require the use of external equipment to assist implantation. , but there are problems such as complex structure and low efficiency. The above two single types of needles cannot meet the current clinical needs.

Therefore, there is currently a need for a solution to solve the problems in the existing technology.

Contents of the invention

The present invention provides a microneedle structure composed of hard needles and soft needles, which can at least solve some of the problems existing in the prior art.

In order to solve the above technical problems, according to one aspect of the present invention, the present invention provides the following technical solutions:

A composite microneedle structure includes hard needles and soft needles. A first connection part is arranged on the soft needle, and a second connection part is arranged on the hard needle. The first connection part and the third connection part are arranged on the hard needle. The two connecting parts are matched and connected to realize the combination of the hard needle and the soft needle.

As a preferred solution of the composite microneedle structure of the present invention, it is preferable to configure the first connecting portion at the tail end of the soft needle to facilitate the combination of hard needles and soft needles.

As a preferred solution of the composite microneedle structure of the present invention, the first connection part is preferably a patterned petal structure at the tail end of the soft needle.

As a preferred solution of the composite microneedle structure of the present invention, the second connection part is preferably a plug structure arranged at a corresponding position of the hard needle to cooperate with the petal structure.

As a preferred solution of the composite microneedle structure of the present invention, the plug structure arranged at the corresponding position of the hard needle and matched with the petal structure is realized by growing.

As a preferred embodiment of the composite microneedle structure of the present invention, the number of the petal structures is at least one or more.

As a preferred solution of the composite microneedle structure of the present invention, the number of the plug structures is at least one or more.

A method for preparing the above composite microneedle structure, including the following steps:

S1. Configure the first connection part on the soft needle;

S2. Arrange the second connecting part that cooperates with the first connecting part at the corresponding position of the hard needle,

S3. Fit and connect the first connecting part and the second connecting part to obtain a composite microneedle structure.

A neural microelectrode, including the above composite microneedle structure or the composite microneedle structure prepared by the above preparation method of the composite microneedle structure.

The application of the above-mentioned composite microneedle structure during tissue implantation can well fix the hard needles and soft needles, prevent them from moving between them, and make the hard needles more convenient to pull out.

The beneficial effects of the present invention are as follows:

The invention provides a composite microneedle structure of hard needles and soft needles and a preparation method thereof. A petal-like structure is patterned at the tail of the soft needle, and a plug structure is grown on the surface of the hard needle. The plug structure will pass through the petal structure. This plays the role of fixing the hard needle and the soft needle, and ensures that there will be no displacement between the hard needle and the soft needle; when the hard needle drives the soft needle to implant into the tissue, by pulling the hard needle downward, the soft needle The petal structure will bend and deform to a certain extent until the pin structure is completely withdrawn, and then continue to pull out the hard needle backwards, leaving the soft needle in the body to achieve microneedle implantation.

Description of drawings

In order to explain the embodiments of the present invention or the technical solutions in the prior art more clearly, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on the structures shown in these drawings without exerting creative efforts.

Figure 1 is a schematic structural diagram of the composite microneedle of the present invention;

Figure 2 is a schematic diagram of the petal structure of the composite microneedle structure of the present invention;

Figure 3 is a schematic cross-sectional view of the connection part of the composite microneedle structure of the present invention;

Explanation of reference numbers:

1-hard needle, 2-soft needle, 3-petal structure, 4-pin structure.

The realization of the purpose, functional features and advantages of the present invention will be further described with reference to the embodiments and the accompanying drawings.

Detailed ways

The technical solutions in the embodiments will be clearly and completely described below. Obviously, the described embodiments are only some of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts fall within the scope of protection of the present invention.

It should be noted that if the embodiments of the present invention involve directional indications (such as up, down, left, right, front, back...), then the directional indications are only used to explain the position of a certain posture (as shown in the drawings). The relative positional relationship, movement conditions, etc. between the components under the display). If the specific posture changes, the directional indication will also change accordingly.

In addition, if there are descriptions involving “first”, “second”, etc. in the embodiments of the present invention, the descriptions of “first”, “second”, etc. are only for descriptive purposes and shall not be understood as indications or implications. Its relative importance or implicit indication of the number of technical features indicated. Therefore, features defined as "first" and "second" may explicitly or implicitly include at least one of these features. In addition, the technical solutions in various embodiments can be combined with each other, but it must be based on the realization by those of ordinary skill in the art. When the combination of technical solutions is contradictory or cannot be realized, it should be considered that such a combination of technical solutions does not exist. , nor within the protection scope required by the present invention.

As a kind of sensing device, invasive neural microelectrodes are currently one of the highest resolution means of sensing neural electrical activity. They can record the action potentials of the nervous system or even single neurons without damaging the nervous system as much as possible. At present, most invasive microneedle structures are single-type electrodes, such as Michigan electrodes and Utah electrodes with hard needle structures, and silicon nitride electrodes with soft needle structures. Hard needles (rigid needles) cannot adapt to the expansion and contraction of blood vessels during implantation, and may cause certain damage to neural tissue; while soft needle structures are prone to deformation during implantation, requiring the use of external equipment to assist implantation. However, there are problems such as complex structure and low efficiency.

The invention provides a composite microneedle structure of hard needles and soft needles and a preparation method thereof. When the hard needle drives the soft needle to be implanted into the tissue together, by pulling the hard needle downward, the petal structure on the soft needle will bend to a certain extent. Deform until the pin structure is completely withdrawn, and then continue to pull out the hard needle backwards, leaving the soft needle in the body to achieve microneedle implantation. A petal-like structure is patterned at the tail of the soft needle, and a latch structure is grown on the surface of the hard needle. The latch structure will pass through the petal structure, thereby fixing the hard needle and the soft needle, and ensuring that the hard needle and the soft needle are There will be no displacement between them.

The present invention provides the following technical solutions:

A composite microneedle structure and its preparation method, including a hard needle 1 and a soft needle 2. A petal structure 3 is patterned at the tail of the soft needle 2. A plug structure 4 is grown on the hard needle 1. The petals The structure 3 and the plug structure 4 are cooperatively connected to realize the combination of the hard needle 1 and the soft needle 2 .

When the hard needle 1 drives the soft needle 2 to implant into the tissue together, by pulling the hard needle 1 downward, the petal structure 3 on the soft needle 2 will bend and deform to a certain extent until the latch structure 4 is completely withdrawn, and then continues to be pulled out backwards Hard needle 1 and soft needle 2 remain in the body to achieve microneedle implantation.

The number of the petal structures and the number of the latch structures matching them can be set as needed, as long as a stable connection between the petal structures and the latch structures can be achieved. The number of the petal structures and the number of the latch structures matching them are both N. , N is a positive integer ≥ 1, for example, it can be 1, 2, 3, 4, 5, 6, 7, ....

When the above-mentioned composite microneedle structure is used for tissue implantation, it can well fix the hard needle 1 and the soft needle 2, prevent movement between them, and make the hard needle 1 more convenient to pull out.

Example 1

As shown in Figure 1-2, a composite microneedle structure includes hard needles 1 and soft needles 2. Four petal structures 3 are patterned at the tail of the soft needle 2, and grow at corresponding positions on the hard needle 1. There are four latch structures 4, and the petal structure 3 and the latch structure 4 are cooperatively connected to realize the combination of the hard needle 1 and the soft needle 2.

After the hard needle 1 drives the soft needle 2 to implant into the tissue together, by pulling the hard needle 1 downward, the petal structure 3 on the soft needle 2 will bend and deform to a certain extent until the latch structure 4 is completely withdrawn, and then continue to pull out the hard needle backward. Needle 1, keep soft needle 2 in the body to achieve microneedle implantation.

Example 2

A method for preparing a composite microneedle structure, including the following steps:

S1. Pattern the petal structure 3 at the tail of the soft needle 2;

S2. Arrange the latch structure 4 that cooperates with the petal structure 3 at the corresponding position of the hard needle 1;

S3. Fit and connect the petal structure 3 and the plug structure 4 to obtain a composite microneedle structure.

Example 3

In this embodiment, a Michigan electrode and a silicon nitride electrode are used to prepare a composite microneedle structure. The Michigan electrode is a thin-film electrode, similar to integrated circuit manufacturing. Microelectronics manufacturing technology is used to fabricate a composite microneedle structure on a silicon or ceramic material-based sheet according to the design. For good electrode lines, spray conductive metal; or on the printed board covered with a conductive metal layer, etching to remove unnecessary parts, leaving the required electrode lines. The conductive metal can be nickel, stainless steel, tungsten, gold Or molybdenum; except for the recording point, the remaining conductive lines connecting the recording point and the output end are covered with an insulating layer. The commonly used insulating material is silicon nitride. In order to enhance the conductivity and biocompatibility, the surface of the recording point is plated with iridium or gold. . The arrangement of Michigan electrode recording points is generally a series of recording points arranged linearly at equal intervals on a recording rod, so it is called a linear electrode array. As shown in Figure 1-2, a composite microneedle structure includes a hard needle 1 and a soft needle 2. The hard needle 1 is a Michigan electrode, and the soft needle 2 is a silicon nitride electrode. In the nitride Four petal structures 3 are patterned on the tail of the silicon electrode, and a plug structure 4 is grown on the Michigan electrode. The petal structure 3 and the plug structure 4 are cooperatively connected to realize the Michigan electrode and the nitridation Silicon electrode composite.

After the Michigan electrode drives the silicon nitride electrode to be implanted into the tissue, by pulling the Michigan electrode downward, the petal structure 3 on the silicon nitride electrode will bend and deform to a certain extent until the pin structure 4 is completely withdrawn, and then continue to pull back. The Michigan electrode is removed and the silicon nitride electrode is retained in the body to achieve microneedle implantation.

Regarding the circuit requirements for the use of microneedles, combined with the Chinese patent application CN 114271835A, it can be seen that a microneedle with a readout circuit includes at least one microneedle body and a readout circuit. The microneedle body is located on the readout circuit. The readout circuit is Formed on the silicon base, the components of the microneedle body and the readout circuit are located on the front and back sides of the silicon base respectively. The first contact point of the microneedle body is electrically connected to the second contact point of the readout circuit to realize neural data processing. Read quickly. In the case where the above circuit exists, it is only necessary to consider that the electrically connected contacts do not interfere with the hole structure, such as avoidance design, or the above hole structure settings and circuit contact settings are all within the capabilities of those skilled in the art. Implementation.

As shown in Figure 3, the present invention provides a composite microneedle structure of hard needles 1 and soft needles 2. A petal structure 3 is patterned at the tail of the soft needle 2, and a plug structure 4 is grown on the surface of the hard needle 1. The plug structure 4 will pass through the petal structure 3, thereby fixing the hard needle 1 and the soft needle 2, and ensuring that the hard needle 1 and the soft needle 2 will not be displaced. When the hard needle 1 drives the soft needle 2 to implant into the tissue together, by pulling the hard needle 1 downward, the petal structure 3 on the soft needle 2 will bend and deform to a certain extent until the latch structure 4 is completely withdrawn, and then continues to be pulled out backwards The hard needle 1 is retained and the soft needle 2 remains in the body to realize the implantation of the soft needle 2.

The above are only preferred embodiments of the present invention, and do not limit the patent scope of the present invention. Under the inventive concept of the present invention, equivalent structural transformations made by using the contents of the description of the present invention, or directly/indirectly applied in other related The technical fields are all included in the patent protection scope of the present invention.

Claims

A composite microneedle structure, characterized in that it includes hard needles and soft needles, a first connection part is arranged on the soft needle, a second connection part is arranged on the hard needle, and the first connection part It is matched with the second connecting part to realize the combination of the hard needle and the soft needle.
A composite microneedle structure according to claim 1, characterized in that the first connection part is arranged at the tail of the soft needle to facilitate the combination of hard needles and soft needles.
A composite microneedle structure according to claim 1 or 2, characterized in that the first connection part is a patterned petal structure at the tail end of the soft needle.
A composite microneedle structure according to claim 1 or 2, characterized in that the second connecting part is a plug structure arranged at a corresponding position of the hard needle to cooperate with the petal structure.
A composite microneedle structure according to claim 1 or 2, characterized in that the latch structure arranged at the corresponding position of the hard needle and matched with the petal structure is realized by growing.
A composite microneedle structure according to claim 1 or 2, characterized in that the number of petal structures and the number of plug structures are the same, at least one or more.
A method for preparing a composite microneedle structure, which is used to prepare the composite microneedle structure according to any one of claims 1 to 6, including the following steps:

S1. Configure the first connection part on the soft needle;

S2. Arrange the second connecting part that cooperates with the first connecting part at the corresponding position of the hard needle,

S3. Fit and connect the first connecting part and the second connecting part to obtain a composite microneedle structure.
The method for preparing a composite microneedle structure according to claim 7, wherein the first connection part is a petal structure, and the second connection part is a pin structure.
A neural microelectrode, characterized in that the neural microelectrode includes the composite microneedle structure described in any one of claims 1-6 or the composite microneedle structure described in any one of claims 7-8. The composite microneedle structure prepared by the preparation method.
Application of the composite microneedle structure according to any one of claims 1 to 6 or the composite microneedle structure prepared by the preparation method of the composite microneedle structure according to any one of claims 7 to 8 in tissue implantation .