CN115153565B - Composite microneedle structure - Google Patents
Composite microneedle structure Download PDFInfo
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- CN115153565B CN115153565B CN202210672922.1A CN202210672922A CN115153565B CN 115153565 B CN115153565 B CN 115153565B CN 202210672922 A CN202210672922 A CN 202210672922A CN 115153565 B CN115153565 B CN 115153565B
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- 239000002131 composite material Substances 0.000 title claims description 20
- 238000000034 method Methods 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims description 7
- 210000005036 nerve Anatomy 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 229910052581 Si3N4 Inorganic materials 0.000 claims description 3
- 229910021420 polycrystalline silicon Inorganic materials 0.000 claims description 3
- 229920005591 polysilicon Polymers 0.000 claims description 3
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910010271 silicon carbide Inorganic materials 0.000 claims description 3
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 claims description 3
- 239000002210 silicon-based material Substances 0.000 claims description 3
- 239000007943 implant Substances 0.000 abstract description 6
- 238000002513 implantation Methods 0.000 abstract description 6
- 210000004204 blood vessel Anatomy 0.000 abstract description 5
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 230000003044 adaptive effect Effects 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 description 19
- 241001465754 Metazoa Species 0.000 description 5
- 239000011521 glass Substances 0.000 description 5
- 230000008602 contraction Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 210000004872 soft tissue Anatomy 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 229910000566 Platinum-iridium alloy Inorganic materials 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 238000013528 artificial neural network Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- HWLDNSXPUQTBOD-UHFFFAOYSA-N platinum-iridium alloy Chemical class [Ir].[Pt] HWLDNSXPUQTBOD-UHFFFAOYSA-N 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000008054 signal transmission Effects 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- UONOETXJSWQNOL-UHFFFAOYSA-N tungsten carbide Chemical compound [W+]#[C-] UONOETXJSWQNOL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/262—Needle electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/263—Bioelectric electrodes therefor characterised by the electrode materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention provides a compound micro-needle structure which comprises a hard needle and a soft needle, wherein the soft needle is arranged on the upper surface of the hard needle, at least one soft needle fixing piece is arranged on the upper surface of the hard needle at intervals along the length direction of the hard needle, and the soft needle fixing piece is used for fixing the edge of the soft needle on the hard needle. This compound microneedle structure drives soft needle and implants the tissue together through hard needle, simultaneously through setting up soft needle mounting along the whole length within range of hard needle, effectively avoid soft needle to take place warp deformation in the middle of the soft needle of implantation tissue in-process to after the microneedle implants the tissue, hard needle can extract, and soft needle can stretch out and draw back along with the blood vessel and carry out adaptive deformation, has solved among the prior art rigid microneedle and has easily led to the fact implantation damage, and soft microneedle is inconvenient for the operator to implant the problem in the tissue with the microneedle body.
Description
Technical Field
The invention belongs to the technical field of microelectrodes, and particularly relates to a composite microneedle structure.
Background
Microelectrodes refer to electrodes having dimensions on the order of micrometers or nanometers (i.e., <100 micrometers) in at least one dimension of the electrode. Has been widely used in analytical chemistry, medical research and other fields. The physiological functions of human and animals are directly or indirectly regulated by the neural network in brain, and the microelectrode is required to collect stronger electric signals for recording the change of the discharge frequency of single neuron, and long-time observation and research are carried out. Among them, microelectrodes implantable in the Central Nervous System (CNS) for long periods of time have a wide range of applications.
The common microelectrode is composed of two types of metal and glass, the metal microelectrode is a high-strength metal fine needle, the part except the tip is insulated by paint or glass, the metal electrode wire is formed by electrolytic corrosion of stainless steel, platinum iridium alloy or tungsten carbide wire in an acidic solution, and various finished products are available, so that the microelectrode has the defect that the geometric shape and the insulation state of the microelectrode are difficult to keep consistent. The glass microelectrode is formed by drawing a hard capillary tube according to the requirement of a user, and when the glass microelectrode is used for measuring the resting potential and the action potential in cells, the tip end of the glass microelectrode is required to be smaller than 0.5 micron; for measuring the potential of inactive sites in the extracellular active region, the tip may be 1-5 microns.
The microneedles of the two microelectrodes are rigid microneedles, and cannot be adaptively deformed along with the expansion and contraction of blood vessels during implantation, so that the microneedles are easy to damage human tissues or animal tissues. If the micro-needle of the micro-electrode is made of flexible materials, the micro-needle is easy to deform in the process of implanting the micro-needle into tissues, so that an operator cannot conveniently implant the micro-needle body into the tissues.
Disclosure of Invention
The invention aims to provide a composite microneedle structure which can at least solve part of defects in the prior art.
In order to achieve the above purpose, the invention adopts the following technical scheme:
the utility model provides a compound microneedle structure, includes hard needle and soft needle, soft needle is arranged in hard needle upper surface, hard needle upper surface is equipped with at least one soft needle mounting along its length direction interval, soft needle mounting will soft needle edge is fixed in on the hard needle.
Further, the hard needle is made of a silicon material.
Furthermore, the soft needle is made of silicon nitride, polysilicon and silicon carbide materials.
Further, the soft needle fixing piece is an inverted L-shaped hook, the bottom of the inverted L-shaped hook is fixed on the upper surface of the hard needle, a certain gap is reserved between the horizontal section of the inverted L-shaped hook and the upper surface of the hard needle, barbs are horizontally and outwards extended from the edges of two sides of the soft needle, and at least partial superposition exists between the inverted L-shaped hook and the projection of the barbs of the soft needle on the surface of the hard needle.
Further, the barb and the soft needle are integrally formed.
Further, the plurality of inverted L-shaped hooks are arranged on the upper surface of the hard needle, the inverted L-shaped hooks are arranged at equal intervals along the length direction of the hard needle, and the openings of the inverted L-shaped hooks face the same direction; the barbs at the edges of the two sides of the soft needle are multiple and are arranged in one-to-one correspondence with the inverted L-shaped hooks on the upper surface of the hard needle.
Further, the opening of each inverted L-shaped hook faces the tip of the hard needle.
Further, the inverted L-shaped hooks on two sides of the hard needle are symmetrically arranged about the axis of the hard needle.
Further, the soft needle is provided with at least one body electrode point for acquiring nerve signals.
Furthermore, the composite microneedle structure further comprises an integrated circuit chip, wherein the integrated circuit chip is bonded with the tail part of the soft needle to form electric connection, and the integrated circuit chip receives, analyzes and processes the nerve signals collected by the body electrode point.
Compared with the prior art, the invention has the beneficial effects that:
according to the composite microneedle structure provided by the invention, the soft needles are driven by the hard needles to be implanted into tissues together, meanwhile, the soft needle fixing parts are arranged along the whole length range of the hard needles, so that buckling deformation of the soft needles in the middle of the soft needles in the process of implantation into the tissues is effectively avoided, the hard needles can be pulled out after the microneedles are implanted into the tissues, the soft needles can be adaptively deformed along with the expansion and contraction of blood vessels, and the problem that the rigid microneedles are easy to cause implantation damage in the prior art, and the soft microneedles are inconvenient for operators to implant the microneedles into the tissues is solved.
The present invention will be described in further detail with reference to the accompanying drawings.
Drawings
FIG. 1 is a schematic illustration of the structure of a composite microneedle of the present invention;
FIG. 2 is an enlarged view of section I of FIG. 1;
FIG. 3 is a schematic cross-sectional view of a composite microneedle structure of the present invention.
Reference numerals illustrate: 1. a hard needle; 2. a soft needle; 3. an inverted L-shaped hook; 4. and (3) barbs.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like indicate orientations or positional relationships based on the orientation or positional relationships shown in the drawings, merely to facilitate describing the present invention and simplify the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention.
In the description of the present invention, it should be noted that, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or by an abutting connection or integrally connected; the specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
The terms "first," "second," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first", "a second" may include one or more such features, either explicitly or implicitly; in the description of the present invention, unless otherwise indicated, the meaning of "a plurality", "a number" or "a plurality" is two or more.
As shown in fig. 1, 2 and 3, the present embodiment provides a composite microneedle structure, which includes a hard needle 1 and a soft needle 2, the soft needle 2 is disposed on the upper surface of the hard needle 1, a plurality of soft needle fixing members are disposed on the upper surface of the hard needle 1 along the length direction of the hard needle 1 at intervals, and the soft needle fixing members fix the edge of the soft needle 2 on the hard needle 1. Wherein the hard needle 1 has a certain rigidity, and can be implanted into soft tissues of human or animals, for example, the hard needle 1 can be made of silicon materials; the soft needle 2 needs to have certain flexibility, for example, the soft needle 2 can be made of materials such as silicon nitride, polysilicon, silicon carbide and the like.
In this embodiment, since the hard needle 1 has a certain rigidity, the soft needle 2 is spread on the upper surface of the hard needle 1, so that the hard needle 1 can drive the soft needle to be implanted into the soft tissue of a human body or an animal together, when the soft needle 2 is implanted into the tissue, the hard needle 1 is pulled out again, the hard needle 1 is separated from the soft needle 2, the soft needle 2 is left in the implanted tissue, the soft needle 2 has a certain flexibility, and can be adaptively deformed along with the expansion and contraction of a blood vessel in the implanted tissue, thereby avoiding the problem that the soft tissue of the human body or the animal is damaged by the traditional rigid micro. The soft needle 2 is required to be fixed with the hard needle 1, and the soft needle 2 is fixed on the hard needle 1 by arranging a soft needle fixing part on the upper surface of the hard needle 1 in the embodiment, meanwhile, the installation position of the soft needle fixing part is specifically designed at the two side edges of the soft needle within the whole length range of the hard needle 1, so that the distribution of electrode leads on the soft needle 2 is not influenced, and the effect of preventing the middle of the soft needle 2 from warping possibly occurs.
The soft needle fixing part in this embodiment not only can fix the soft needle 2 when the micro needle is implanted into the tissue, so that the hard needle 1 can drive the soft needle 2 to be implanted into the tissue together, but also can conveniently separate the soft needle 2 from the hard needle 1 when the hard needle 1 is pulled out, so that the optional optimized embodiment provides a specific structure of the soft needle fixing part, as shown in fig. 1 and fig. 2, the soft needle fixing part is an inverted-L-shaped hook 3, the bottom of the inverted-L-shaped hook 3 is fixed on the upper surface of the hard needle 1, a certain gap is reserved between the horizontal section of the inverted-L-shaped hook 3 and the upper surface of the hard needle 1, barbs 4 are horizontally and outwardly extended from two side edges of the soft needle 2, and the projections of the inverted-L-shaped hook 3 and the barbs 4 on the soft needle 2 on the surface of the hard needle 1 are at least partially overlapped. When the soft needle 2 is fixed, the barbs 4 at the two side edges of the soft needle 2 are pressed into the inverted L-shaped hooks 3, so that the soft needle 2 and the hard needle 1 are connected into a whole, and the purpose that the hard needle 1 drives the soft needle 2 to be implanted into tissues together is realized; the fixed part of the inverted L-shaped hook 3 is the barb 4, and the barb 4 is formed by extending the edge of the soft needle 2 outwards horizontally, so that the fixed structure of the soft needle 2 and the hard needle 1 does not influence the distribution of electrode leads on the soft needle 2; when the soft needle 2 is implanted into the tissue and then the hard needle 1 is pulled out, as the barb 4 of the soft needle 2 is simply pressed and detachably connected with the inverted L-shaped hook 3 on the hard needle 1, the barb 4 can be separated from the inverted L-shaped hook 3 only by applying a certain acting force to the barb, so that the separation of the soft needle 2 and the hard needle 1 can be realized, and the pulling-out process of the hard needle 1 is completed. Preferably, the barbs 4 and the soft needle 2 are designed as an integral structure.
Further optimizing the above embodiment, the plurality of inverted L-shaped hooks 3 on the upper surface of the hard needle 1 are arranged at equal intervals along the length direction of the hard needle 1, correspondingly, the plurality of barbs 4 on the two side edges of the soft needle 2 are arranged in one-to-one correspondence with the inverted L-shaped hooks 3 on the upper surface of the hard needle 1, so that the soft needle 2 on the hard needle 1 can be fixed within the whole length range of the hard needle 1, thereby playing a role in preventing the middle of the soft needle 2 from possibly warping; meanwhile, the openings of the inverted L-shaped hooks 3 are designed to face the same direction, and all the openings face the needle tip direction of the hard needle 1, so that when the hard needle 1 is pulled out, the barbs 4 can be separated from the corresponding inverted L-shaped hooks 3 only by pulling out the hard needle 1 horizontally and backwards for a certain distance, the fixation between the soft needle 2 and the hard needle 1 is released, then the hard needle 1 is pulled downwards for a certain distance, the hard needle 1 and the soft needle 2 are separated, the hard needle 1 can be withdrawn, a unhooking related structure is not required to be specially designed, and the operation is convenient.
For the distribution form of the soft needle fixing parts on two sides of the soft needle 2, optionally, the inverted L-shaped hooks 3 on two sides of the soft needle 2 may be sequentially staggered along the length direction of the hard needle 1, or may be oppositely arranged, and in this embodiment, the inverted L-shaped hooks 3 on two sides of the hard needle 1 are preferably symmetrically arranged about the axis of the hard needle 1.
In addition, the composite microneedle structure in the above embodiment further includes an integrated circuit chip, and at least one body electrode point is provided on the soft needle 2, and the body electrode point is used for collecting nerve signals; the integrated circuit chip is bonded with the tail part of the soft needle 2 to form electric connection, and receives, analyzes and processes the nerve signals collected by the body electrode point. In the traditional microelectrode structure, the integrated circuit chip is connected with the micro needle by the lead, so that information acquired by the micro needle is transmitted to the integrated circuit chip through the electric wire, the signal transmission speed of the integrated circuit chip is low, the efficiency is low, the integrated circuit chip is connected with the soft needle 2 in a bonding mode in the embodiment, the information transmission path is reduced, and the information transmission efficiency is improved.
In summary, the composite microneedle structure provided by the invention drives the soft needle to be implanted into the tissue together through the hard needle, and meanwhile, the soft needle fixing piece is arranged along the whole length range of the hard needle, so that buckling deformation of the soft needle in the middle of the soft needle in the process of implanting the soft needle into the tissue is effectively avoided, the hard needle can be pulled out after the microneedle is implanted into the tissue, the soft needle can be adaptively deformed along with the expansion and contraction of a blood vessel, and the problem that the rigid microneedle is easy to cause implantation damage in the prior art, and the soft microneedle is inconvenient for an operator to implant the microneedle body into the tissue is solved.
The foregoing examples are merely illustrative of the present invention and are not intended to limit the scope of the present invention, and all designs that are the same or similar to the present invention are within the scope of the present invention.
Claims (9)
1. A composite microneedle structure, characterized by: the soft needle comprises a hard needle and a soft needle, wherein the soft needle is arranged on the upper surface of the hard needle, at least one soft needle fixing piece is arranged on the upper surface of the hard needle at intervals along the length direction of the hard needle, and the soft needle fixing piece is used for fixing the edge of the soft needle on the hard needle;
the soft needle fixing piece is an inverted L-shaped hook, the bottom of the inverted L-shaped hook is fixed on the upper surface of the hard needle, a gap is reserved between the horizontal section of the inverted L-shaped hook and the upper surface of the hard needle, barbs are horizontally and outwards arranged on the edges of two sides of the soft needle in an extending mode, and the projections of the inverted L-shaped hook and the barbs of the soft needle on the surface of the hard needle are at least partially overlapped.
2. The composite microneedle structure of claim 1, wherein: the hard needle is made of silicon material.
3. The composite microneedle structure of claim 1, wherein: the soft needle is made of silicon nitride, polysilicon and silicon carbide materials.
4. The composite microneedle structure of claim 1, wherein: the barb and the soft needle are integrally formed.
5. The composite microneedle structure of claim 1, wherein: the plurality of inverted L-shaped hooks are arranged on the upper surface of the hard needle at equal intervals along the length direction of the hard needle, and the openings of the inverted L-shaped hooks face the same direction; the barbs at the edges of the two sides of the soft needle are multiple and are arranged in one-to-one correspondence with the inverted L-shaped hooks on the upper surface of the hard needle.
6. The composite microneedle structure of claim 5, wherein: the opening of each inverted L-shaped hook faces the tip of the hard needle.
7. The composite microneedle structure of claim 5, wherein: the inverted L-shaped hooks on two sides of the hard needle are symmetrically arranged about the axis of the hard needle.
8. The composite microneedle structure of any one of claims 1-7, wherein: the soft needle is provided with at least one body electrode point for acquiring nerve signals.
9. The composite microneedle structure of claim 8, wherein: the integrated circuit chip is bonded with the tail of the soft needle to form electric connection, and the integrated circuit chip receives, analyzes and processes the nerve signals collected by the body electrode point.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210672922.1A CN115153565B (en) | 2022-06-15 | 2022-06-15 | Composite microneedle structure |
| PCT/CN2022/127284 WO2023240874A1 (en) | 2022-06-15 | 2022-10-25 | Composite microneedle structure |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210672922.1A CN115153565B (en) | 2022-06-15 | 2022-06-15 | Composite microneedle structure |
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| Publication Number | Publication Date |
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| CN115153565A CN115153565A (en) | 2022-10-11 |
| CN115153565B true CN115153565B (en) | 2024-03-12 |
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| CN202210672922.1A Active CN115153565B (en) | 2022-06-15 | 2022-06-15 | Composite microneedle structure |
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| WO (1) | WO2023240874A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115153565B (en) * | 2022-06-15 | 2024-03-12 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure |
| CN115281682B (en) * | 2022-07-25 | 2024-06-14 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and preparation method thereof |
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| WO2023240874A1 (en) | 2023-12-21 |
| CN115153565A (en) | 2022-10-11 |
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