CN102499666B - Neural microelectrode with rigid and flexible structures - Google Patents
Neural microelectrode with rigid and flexible structures Download PDFInfo
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- CN102499666B CN102499666B CN 201110314330 CN201110314330A CN102499666B CN 102499666 B CN102499666 B CN 102499666B CN 201110314330 CN201110314330 CN 201110314330 CN 201110314330 A CN201110314330 A CN 201110314330A CN 102499666 B CN102499666 B CN 102499666B
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Abstract
The invention relates to a neural microelectrode with rigid and flexible structures. The microelectrode comprises a rigid structure part and a flexible structure part, wherein the geometric structure of the electrode is improved and a flexible material coating is coated on the surface of the electrode; the flexible structure part can completely replace the rigid structure part or penetrates through the rigid structure part or is attached to the rigid structure; the rigid material is silicon or other ceramic materials; the flexible material is polyimide, benzocyclobutene, SU-8, polydimethyl siloxane and poly-p-xylene; the method for improving the geometric shape of the electrode mainly comprises the step of reducing the sectional area of the electrode; a layer of flexible material coating is deposited on the surface of the electrode; and the flexible coating material is conductive hydrogel, mucoprotein and polyethyleneimine. According to the invention, the flexibility of the improved microelectrode is effectively improved, the injury of jiggle to biological tissues is alleviated, which is beneficial to the long-term in-vivo indwelling of the electrode.
Description
Technical field
What the present invention relates to is a kind of biomedical engineering, particularly a kind of neural multibody system microelectrode.
Background technology
Nervous system is the huge system of the complexity of an opening, is the exploration of the rich challenge of human beings for neural further investigation.The mankind are making great efforts to explore neural secret, the effective means of the neuropathy that seeks treatment always for centuries.Along with people's going deep into Neuroscience Research, derived the such subject of neural engineering, it is the cross discipline of neuroscience, material science, microelectric technique and information science, and is significant at aspects such as the treatment that discloses neural working mechanism and sacred disease and neural rehabilitations.Nerve prosthesis equipment such as the deep brain stimulation device, is used nerve microelectrode as the contact interface of nervous system and external equipment.Deep brain stimulation is a kind of neurosurgical treatment scheme, namely stimulates brain with electronic signal, for many years, it has become an extremely successful Therapeutic Method and has been used for treating some refractory diseases, chronic pain for example, parkinson disease are trembled and myodystonia.
In neural engineering system, the parts of most critical be exactly nerve-electrical interface be microelectrode.Its function main manifestations is two kinds of forms: a kind of is neural activity to be converted to the signal of telecommunication go on record and analyze and research; Another kind is to utilize signal of telecommunication excitation or suppress neural activity with the practical function electricity irritation.
But, the implantation of microelectrode can bring reaction of high order, such as the power that involves of wire, the matrix material heat generating biocompatible of implantation, with the Long Term Contact of meninges, and nervous tissue and the factors such as relative fine motion between implant electrode all may cause the generation of tissue encapsulation phenomenon.The rigidity of electrode is generally larger, the relative nervous tissue of implant electrode hardness is higher, and peripheral nerve has the larger characteristics such as mobility, cause being difficult between electrode and nerve stable fixing, exist fine motion between the two interface, this suture than quality softness is easier to cause mechanical injuries to nerve fiber on every side, but damage is confined in the zone of contiguous microelectrode.The fine motion meeting produces stress concentration, nerve fiber is caused chronic mechanical injuries, showing as nerve fiber attenuates, the nerve fiber rarefaction appears, induce simultaneously the fibrous connective tissue parcel, cause stimulation and the record performance of microelectrode to descend, limited microelectrode and in human peripheral nerve, kept somewhere for a long time.Therefore, the topmost limitation of implanted neural microelectrode is how steadily in the long term nerve to be recorded and stimulate.Improve microelectrode flexible, reduce fine motion, the long-time stability of implanting microelectrode are had very important meaning.
Find by prior art documents Shih-Chang Chuang; Chang-Hsiao Chen; Huan-Chieh Su etc. are at Micro Electro Mechanical Systems (MEMS), 2010 IEEE 23rd International Conference on, vol., no., pp.1003-1006 writes articles " Design and fabrication of flexible neural microprobe for three dimensional assembly " (" design of three-dimensional flexible nervus and manufacturing " the 23rd ieee international conference) on the 24-28 Jan. 2010.Proposed a kind of method of new microelectrode flexible design in this article, namely utilized the polymeric materials such as SU-8 and Parylene to replace silicon and be used as base material.The microelectrode of this method preparation although the low Young's modulus of elasticity characteristic of its polymeric material can improve the microelectrode flexibility, is conducive to the adhesion on microelectrode and biological tissue surface, but because of the too soft Operation that is unfavorable for microelectrode.In addition, this article only considers how to improve the microelectrode flexibility from the material angle, does not propose the improvement project of suitable raising microelectrode flexibility in the microelectrode geometrical aspects.
Summary of the invention
The object of the invention is to overcome the deficiency of existing nerve microelectrode structure, a kind of neural multibody system microelectrode is provided, it is less that this microelectrode has less rigidity, microelectrode is implanted the fine motion that produces, can reduce microelectrode and implant the fine motion that produces, alleviate the damage to neurocyte, improve the reliability of microelectrode, make the microelectrode can in vivo indwelling steady in a long-term.
Technical solution of the present invention is as follows:
A kind of neural multibody system microelectrode is made of shank and bar section, and described bar section is a cuspidated bar of tool, and this bar is provided with electrode site, and its characteristics are:
Described bar section is the structure that flexible structure that the rigid structure made of rigid material and flexible material are made combines, and comprising:
Described bar is that flexible structure consists of, and described electrode site is rigid structure;
Or one section bar that described bar is connected with described shank is flexible structure;
Or be through and wear flexible structure between the rigid structure;
Or described bar is rigid structure, is coated one deck flexible coating material on the rigid structure at described bar.
Or one section bar that described bar section is connected with described shank has less diameter.
Or described bar section has engraved structure.
The flexible material of described flexible structure is polyimides, benzocyclobutene, SU-8, polydimethylsiloxane and Parylene.
In electrode surface deposition one deck flexible material coating, create soft nervous tissue and hard interelectrode mechanical damping layer, the degree of adhesion of intensifier electrode and nervous tissue can effectively stop the fine motion between electrode and tissue;
Described flexible coating material refers to conductive hydrogel, mucin and polymine.
The present invention from how blocking, absorbing the aspects such as fine motion and damping vibration attenuation considers, electrode structure is improved.It is to be noted: such scheme is not independently, and researcher can according to concrete design needs, be considered these schemes synthesis.
Technique effect of the present invention is as follows:
The present invention has simple, practical characteristics, compare with existing nerve electrode, the present invention is the flexibility of intensifier electrode effectively, reduce electrode rigidity, reach good effectiveness in vibration suppression, alleviate the fine motion of tissue-electrode interface to the damage of nervous tissue, make the in vivo indwelling that electrode can be steady in a long-term.
Description of drawings
Fig. 1 and Fig. 2 are the structural representation of the embodiment of the invention.
Among the figure: (1) and a are the electrode schematic diagram of rigid material;
(2) and b be the electrode schematic diagram of flexible material;
(3) and c be the schematic diagram that flexible material is adopted in the junction of electrode shank and bar section;
(4) be the schematic diagram of modified electrode shank and bar section junction geometry;
(5), (6) are for to carry out improved structural representation to the electrode integral geometry;
(7) and d be structural representation in electrode surface deposition flexible material coating.
The specific embodiment
Below in conjunction with drawings and Examples the present invention is elaborated, but protection scope of the present invention should not be limited to following embodiment.
A kind of neural multibody system microelectrode, be made of shank and bar section, described bar section is a cuspidated bar of tool, and this bar is provided with electrode site, its characteristics are that described bar section is the structure that flexible structure that the rigid structure made of rigid material and flexible material are made combines, and comprising:
Described bar is that flexible structure consists of, and described electrode site is rigid structure;
Or one section bar that described bar is connected with described shank is flexible structure;
Or be through and wear flexible structure between the rigid structure;
Or described bar is rigid structure, is coated one deck flexible coating material on the rigid structure at described bar.
Or one section bar that described bar section is connected with described shank has less diameter.
Or described bar section has engraved structure.
The flexible material of described flexible structure is polyimides, benzocyclobutene, SU-8, polydimethylsiloxane and Parylene.
In electrode surface deposition one deck flexible material coating, create soft nervous tissue and hard interelectrode mechanical damping layer, the degree of adhesion of intensifier electrode and nervous tissue can effectively stop the fine motion between electrode and tissue;
Described flexible coating material refers to conductive hydrogel, mucin and polymine.
First kind embodiment
Shown in b, c among (2), (3) and Fig. 2 among Fig. 1, the rigid material with substrate among (2) and the b substitutes with flexible material; (3) key position of electrode and among the c, namely flexible material is adopted in the junction of electrode shank and bar section.The rigid material here is silicon materials, and flexible material is Parylene.Parylene has good biocompatibility and agent of low hygroscopicity, and has good mechanical performance and dielectric property, uses it on the electrode fabrication, can effectively increase the electrode flexibility, alleviate fine motion to the damage of nervous tissue, the intensifier electrode reliability is suitable for long-term implantation.
Equations of The Second Kind embodiment
(4), (5), (6) are depicted as the geometric electrode structure are improved among the figure.(4) reduce in right amount the diameter of the junction of electrode shank and bar section in; (5) in electrode stem section center drilling; (6) in netted hollow out is made by electrode stem section.
The present embodiment can effectively reduce electrode rigidity by reducing electrode stem section sectional area, increases electrode flexible, reaches good effectiveness in vibration suppression, thereby alleviates fine motion to the damage of nervous tissue, and the intensifier electrode reliability is suitable for long-term implantation.
The 3rd class embodiment
Shown in d among (7) and Fig. 2 among Fig. 1, in electrode surface deposition one deck conductive hydrogel coating, as the mechanical damping layer between tissue and the electrode.
The flexible material that the present embodiment adopts is the conductive hydrogel coating, hydrogel is a kind of desirable tissue engineering bracket material, it has good three-dimensional pore space degree and water solublity, it is similar with cerebral tissue that the mechanical performance of hydrogel can be done, dry hydrogel is after implanting, and it is fixing that its swelling properties is conducive in tissue it.It is coated in electrode surface, can effectively increases the electrode flexibility, reach good effectiveness in vibration suppression, alleviate fine motion to the damage of nervous tissue, the intensifier electrode reliability is suitable for long-term implantation.
Claims (3)
1. a neural multibody system microelectrode is made of shank and bar section, and described bar section is a cuspidated bar of tool, and this bar is provided with electrode site, it is characterized in that:
Described bar section is the structure that flexible structure that the rigid structure made of rigid material and flexible material are made combines, and comprising:
One section bar that described bar is connected with described shank is flexible structure;
Or be through and wear flexible structure between the rigid structure;
Or one section bar that described bar section is connected with described shank has less diameter;
Or described bar section has engraved structure.
2. neural multibody system microelectrode as claimed in claim 1 is characterized in that, the flexible material of described flexible structure is polyimides, benzocyclobutene, SU-8, polydimethylsiloxane or Parylene.
3. neural multibody system microelectrode as claimed in claim 1 is characterized in that, described flexible coating material is conductive hydrogel, mucin or polymine.
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| CN 201110314330 CN102499666B (en) | 2011-10-17 | 2011-10-17 | Neural microelectrode with rigid and flexible structures |
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| CN 201110314330 CN102499666B (en) | 2011-10-17 | 2011-10-17 | Neural microelectrode with rigid and flexible structures |
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| CN102499666B true CN102499666B (en) | 2013-04-24 |
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Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102764479B (en) * | 2012-07-13 | 2015-04-15 | 中国科学院深圳先进技术研究院 | Flexible nerve tract electrode and preparation method thereof |
| CN104857630A (en) * | 2015-05-08 | 2015-08-26 | 上海交通大学 | Low-damage implanted nerve electrode |
| CN107158560A (en) * | 2017-04-27 | 2017-09-15 | 清华大学 | It is controllable from deformation nerve microelectrode based on swelling behavior characteristic |
| CN109663208B (en) * | 2019-02-15 | 2022-04-26 | 上海交通大学 | Flexible nerve electrode based on multilayer stacked structure substrate and manufacturing method |
| CN111657937B (en) * | 2020-06-12 | 2023-06-09 | 西北工业大学 | Three-dimensional flexible nerve microelectrode based on self-expanding hydrogel and preparation method |
| CN112999432B (en) * | 2021-03-15 | 2022-05-20 | 上海交通大学 | Preparation method of flexible brain nerve electrode coating and electrode assembled by same |
| CN113855031A (en) * | 2021-09-18 | 2021-12-31 | 浙江清华柔性电子技术研究院 | Flexible microneedle electrode and preparation method thereof |
| CN114014252B (en) * | 2021-11-02 | 2024-05-31 | 杭州电子科技大学温州研究院有限公司 | High-density low-noise rigid-flexible combined nerve probe and preparation method thereof |
| CN115153565B (en) * | 2022-06-15 | 2024-03-12 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure |
| CN115227254B (en) * | 2022-07-25 | 2024-06-25 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and nerve microelectrode |
| CN115813399A (en) * | 2022-12-08 | 2023-03-21 | 天津大学 | Nano material modified nerve electrode and preparation method thereof |
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|---|---|---|---|---|
| EP1062973A1 (en) * | 1999-06-25 | 2000-12-27 | NeuroKinetic ApS | A multifunction electrode for neural tissue stimulation |
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| CN101172184A (en) * | 2007-10-10 | 2008-05-07 | 中国科学院上海微系统与信息技术研究所 | Three-dimensional flexible nervus and preparation method |
| CN101248994A (en) * | 2007-10-10 | 2008-08-27 | 天津大学 | Active neuro micro-electrode |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1062973A1 (en) * | 1999-06-25 | 2000-12-27 | NeuroKinetic ApS | A multifunction electrode for neural tissue stimulation |
| WO2003077988A1 (en) * | 2002-03-14 | 2003-09-25 | Duke University | Miniaturized high-density multichannel electrode array for long-term neuronal recordings |
| CN101172184A (en) * | 2007-10-10 | 2008-05-07 | 中国科学院上海微系统与信息技术研究所 | Three-dimensional flexible nervus and preparation method |
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Non-Patent Citations (1)
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