CN108904972A - A kind of embedded nerve electrode based on carbon nano tube line - Google Patents

A kind of embedded nerve electrode based on carbon nano tube line Download PDF

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Publication number
CN108904972A
CN108904972A CN201810771411.9A CN201810771411A CN108904972A CN 108904972 A CN108904972 A CN 108904972A CN 201810771411 A CN201810771411 A CN 201810771411A CN 108904972 A CN108904972 A CN 108904972A
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electrode
nerve
nerve electrode
embedded
embedded nerve
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隋晓红
朱丰源
王逸林
朱璟然
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Shanghai Jiaotong University
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Shanghai Jiaotong University
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    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
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    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6877—Nerve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0529—Electrodes for brain stimulation
    • A61N1/0531—Brain cortex electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0548—Oral electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces

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Abstract

The invention discloses a kind of embedded nerve electrodes based on carbon nano tube line, it is related to medical instruments field, including expose portion and insulated part, the expose portion and the insulated part derive from same root carbon nanotube line electrode, the carbon nanotube line electrode of the expose portion directly exposes, and the carbon nanotube line electrode of the insulated part is wrapped up by insulating layer；The expose portion carries out electro photoluminescence for the record of electroneurographic signal or to nerve fiber.The nerve electrode size of the disclosure of the invention is small, has flexible structure and closely with neuronal contacts, and this set can reduce the mechanical damage caused by nerve fiber, be advantageously implemented et al. Ke steady in a long-term.The carbon nano-tube material that nerve electrode uses has the advantages that charge injectability is high, it can either realize that the electroneurographic signal of high s/n ratio records using the nerve electrode of small-size carbon nanotube line, it can be realized local nerve electro photoluminescence again, improve the spatial selectivity of nerve electrode electro photoluminescence.

Description

A kind of embedded nerve electrode based on carbon nano tube line
Technical field
The present invention relates to medical instruments field more particularly to a kind of embedded nerve electrodes based on carbon nano tube line.
Background technique
As the physical channel of biological nervous system and artificial electron's equipment, the performance of embedded nerve electrode is directly determined The acquisition of biological neural electric signal and the long-term reliability of nerve electric stimulation.The design consideration of nerve electrode mainly includes The mechanics and electrochemical stability and the repeatability of manufacture craft etc. of the biocompatibility of material and biological safety, electrode.
Traditional embedded nerve electrode for periphery and central nervous tissue mostly uses polymer, platinum, iridium or silicon Material, although the function of electrode may be implemented, it can be difficult to accomplishing high-biocompatibility, flexibility (i.e. low mechanical damage Property), the unification of high s/n ratio and high charge injectability.Wherein, the flexibility of electrode is a huge problem, and flexibility is greatly Influence the relative motion between electrode and nerve fibre, flexible higher, the relative motion between electrode and nerve fibre of electrode It is fewer, caused by mechanical damage it is smaller, be conducive to nerve fiber regeneration and improve nerve signal signal-to-noise ratio.Electrode is thinner, Bending modulus is smaller then flexible better；However electrode thickness is influenced by material electrochemical properties itself and engineering properties, it is general Logical material is meticulous is easily broken off and can improve impedance, is unfavorable for electrode and implements electro photoluminescence.Therefore, develop have both it is superior it is flexible, The novel electrode of electrochemical properties and biocompatibility is the key that realize electroneurographic signal record or stimulation steady in a long-term.
Through the literature search of existing technologies, Cutrone et al. is in Journal of Neural Engineering " the A three-dimensional self-opening delivered on (neural engineering periodical, 12 (2015) 016016) Intraneural peripheral interface (SELINE) " (the peripheral nerve interface of three-dimensional self-retaining), this article propose A kind of nerve electrode being fixed in peripheral nerve beam based on polyimide material.Specifically mentality of designing is：Pass through width For 150 μm of structure, the electrod-array that width is 360 μm is fixed in peripheral nerve beam in body.The substrate of the electrod-array Material is polyimides, and gold is used as electrode material.Its deficiency is：Organism is during free movement, due to polyamides Asia The flexibility of amido bottom material is insufficient, therefore will lead to the mechanical damage for the nerve fibre that the electrod-array can directly cause in nerve tract Wound cannot achieve permanently effective electroneurographic signal record or stimulation.Simultaneously as gold is injected as the charge of electrode material Ability is poor, when being used as stimulating electrode, is easy to happen electrochemical corrosion, can not be used as stimulating electrode for a long time.
Summary of the invention
In view of the above drawbacks of the prior art, the technical problem to be solved by the present invention is to existing nerve electrodes to be difficult to There are high-biocompatibility, low mechanical damage, high s/n ratio and high charge injectability simultaneously, cannot achieve permanently effective pair Bioelectrical signals are acquired the problem of with output.
In view of the above drawbacks of the prior art, the present invention provides a kind of embedded nerve based on carbon nano tube line Pole, including expose portion 1 and insulated part 2, the expose portion 1 derive from same root carbon nanotube with the insulated part 2 Line electrode, the carbon nanotube line electrode of the expose portion 1 directly expose, the carbon nanotube line electrode quilt of the insulated part 2 Insulating layer package；The expose portion 1 carries out electro photoluminescence for the record of electroneurographic signal or to nerve.
Further, the material of the nerve electrode is carbon nano tube line, and the diameter of the carbon nano tube line is 100nm- 100μm。
Further, the carbon nano tube line is drawn by the single-root carbon nano-tube that a plurality of diameter is 0.1nm-10nm.
Further, the carbon nano tube line electrode length range of the expose portion 1 is 1 μm of -1mm.
Further, the insulating layer material of the insulated part 2 is c-type Parylene (Parylene-C) or medical Silica gel (Silicone).
Further, the thickness of insulating layer of the insulated part 2 is 1 μm -5 μm.
Further, the nerve scaffold carrier of the embedded nerve electrode is the cuspidated rigid solid structure of tool, such as Tungsten wire, stainless steel wire.
Further, the recording mode of the embedded nerve electrode is that differential type records or non-differential type records, institute It states differential type record and refers to the differential record for realizing the electroneurographic signal in two channels by two adjacent carbon nanotube line electrodes, The ambient noise interference for eliminating common mode, improves signal-to-noise ratio.
Further, the embedded nerve electrode is single-channel electrodes or multi-channel electrode.
Further, the stimulation mode of the embedded nerve electrode be monopole electro photoluminescence or bipolar electro photoluminescence, it is described Monopole electro photoluminescence refers to that recycling electrode (return electrode) size is greater than stimulating electrode size, and apart from stimulation electricity Pole is more than 1 centimetre of stimulation mode, and the recycling electrode and stimulating electrode form a circuit；The bipolar electro photoluminescence refers to The stimulation mode that two distances are used in conjunction in tens microns to several millimeters of stimulating electrode.
Further, the embedded nerve electrode can be used in periphery or central nervous system tissue.
Further, the implantation of the embedded nerve electrode refers to that the expose portion 1 is completely disposed at peripheral nerve In beam or inside central nervous tissue.
Compared with prior art, the present invention has the advantages that：
1, the material that nerve electrode provided by the invention uses is carbon nano tube line, and carbon nano tube line has superior soft Property, i.e., composite bending modulus is very low；Under minimum diameter, the flexible of carbon nano tube line will be significantly larger than the metals such as platinum, iridium, realize mind Through fitting closely between electrode and nerve fiber, it is implanted into after the nerve electrode and is not easy to cause nerve fiber in body use for a long time Mechanical damage.
2, the carbon nanotube wire material that nerve electrode provided by the invention uses has superior tensile strength, in carbon nanometer In pipeline diameter and the comparable situation of nerve fibre, such as at 10 μm, do not pulled apart by bio-tissue internal force.
3, the chemical property for the carbon nanotube wire material that nerve electrode provided by the invention uses is good, has very high electricity Lotus injectability can realize that effective charge transmits using small-size carbon nanotube line electrode, to improve electro photoluminescence Spatial selectivity, and guarantee the persistence and validity of electro photoluminescence.
4, by the present invention in that realizing the differential record of electroneurographic signal with two channel carbon nano tube line electricity, biology is reduced The influence of ambient noise caused by body and motion process, to further increase the signal-to-noise ratio of record nerve signal.
5, the implantation carrier of carbon nano tube line nerve electrode of the present invention is that have cuspidated rigid solid structure, such as tungsten wire, The damage caused by nerve fiber in implantation process can be significantly reduced.
It is described further below with reference to technical effect of the attached drawing to design of the invention, specific structure and generation, with It is fully understood from the purpose of the present invention, feature and effect.
Detailed description of the invention
Fig. 1 show a kind of schematic diagram of preferred embodiment of the invention in peripheral nerve beam；
Fig. 2 show a kind of preferred embodiment of the invention used in the schematic diagram of cortex and deep brain position；
Wherein, 1- expose portion, 2- insulated part, 3- nerve cord, 4- nerve tract, the blood vessel in 5- nerve cord, 6- brain Cortex, 7- Basal ganglia, 8- cerebellum, 9- central sulcus, 10- oblongata.
Specific embodiment
Below in conjunction with attached drawing to a kind of preferred reality of the embedded nerve electrode based on carbon nano tube line of the present invention It applies example to be described in detail, but the present invention is not limited in the embodiment.In order to make the public have thorough understanding to the present invention, Concrete details is described in detail in following present invention preferred embodiment.
Embodiment 1
As shown in Figure 1, two embedded nerve electrodes based on carbon nano tube line are implanted to the same of peripheral nerve dry 3 In peripheral nerve beam 4, for recording the peripheral nerve fiber electric signal under motion state and carrying out part to periphery nerve tract 4 Electro photoluminescence.Wherein, the embedded nerve electrode based on carbon nano tube line includes expose portion 1 and insulated part 2, expose portion 1 derives from same root carbon nanotube line electrode with insulated part 2, and the carbon nanotube line electrode of expose portion 1 directly exposes, insulation The carbon nanotube line electrode of part 2 is wrapped up by insulating layer；Expose portion 1 is used for the record of electric signal or pierces to nerve Swash.
Embedded nerve electrode material is carbon nano tube line, and the diameter of carbon nano tube line is 10 μm.The carbon nano tube line by The single-root carbon nano-tube of a plurality of 0.1nm-10nm is drawn.The carbon nano tube line electrode length range of expose portion 1 is 1 μm- 500μm.The insulating layer material of insulated part 2 is c-type Parylene (Parylene-C) or medical silica-gel (Silicone). The thickness of insulating layer of insulated part 2 is 1 μm -5 μm.
The recording mode of embedded nerve electrode is differential type record, and differential type record refers to be received by two adjacent carbon Mitron line electrode realizes the differential record of the electroneurographic signal in two channels, eliminates the ambient noise interference of common mode, improves signal-to-noise ratio.
For embedded nerve electrode using multi-channel electrode, the stimulation mode of nerve electrode is two close stimulation electricity Bipolar electro photoluminescence between pole, bipolar electro photoluminescence refer to the stimulation mode that two close stimulating electrodes are used in conjunction with.
The implant site of embedded nerve electrode include but is not limited to ulnar nerve, nervus radialis, median nerve, sciatic nerve and Its branch；The carrier of nerve electrode is tungsten wire in the present embodiment, and electrode implantation process is：Carrier carries embedded nerve electrode and wears Saturating perineurium, is pierced into inside nerve fiber；Carrier is withdrawn from, embedded nerve electrode is stayed in inside nerve tract, neuroelectricity The implantation of pole refers to that expose portion 1 is completely disposed in peripheral nerve beam 4 or inside central nervous tissue, since carrier is tool Nerve cord 3 is damaged in cuspidated rigid solid structure, the implantation of nerve electrode caused by the blood vessel 5 in nerve tract 4 or nerve cord Hurt smaller.
Embodiment 2
As shown in Fig. 2, two adjacent carbon nanotube line electrodes are implanted to cortex respectively, electricity is carried out to the nerve of brain The differential record of signal or the nerve electric stimulation of part；For recording the neural electrical activity of motor cortex, or realization to body sense Feel that cortex, visual cortex carry out electro photoluminescence, realizes somatesthesia or visual feedback.Wherein, based on the implantation of carbon nano tube line Formula nerve electrode includes expose portion 1 and insulated part 2, and expose portion 1 and insulated part 2 derive from same root carbon nano tube line Electrode, the carbon nanotube line electrode of expose portion 1 directly expose, and the carbon nanotube line electrode of insulated part 2 is wrapped up by insulating layer； Expose portion 1 carries out electro photoluminescence for the record of electroneurographic signal or to nerve.
The material of embedded nerve electrode is carbon nano tube line, and the diameter of carbon nano tube line is 10 μm.The carbon nano tube line It is drawn by the single-root carbon nano-tube that a plurality of diameter is 0.1nm-5nm.The carbon nano tube line electrode length range of expose portion 1 It is 1 μm -5 μm.The insulating layer material of insulated part 2 is c-type Parylene (Parylene-C) or medical silica-gel (Silicone) polymer of good biocompatibilities such as.The thickness of insulating layer of insulated part 2 is 2 μm -4 μm.
The recording mode of embedded nerve electrode is differential type record, and differential type record refers to be received by two adjacent carbon Mitron line electrode realizes the differential record of the electroneurographic signal in two channels, eliminates the ambient noise interference of common mode, improves signal-to-noise ratio.
For embedded nerve electrode using multi-channel electrode, the stimulation mode of nerve electrode is two close stimulation electricity Bipolar electro photoluminescence between pole, bipolar electro photoluminescence refer to the stimulation mode that two close stimulating electrodes are used in conjunction with.
The implant site of embedded nerve electrode includes but is not limited to cerebral cortex 6, the load of nerve electrode in the present embodiment Tool is tungsten wire, and electrode implantation process is：Carrier carries embedded nerve electrode and penetrates perineurium, is pierced into cerebral nerve tissue It is internal；Carrier is withdrawn from, embedded nerve electrode is stayed in inside cerebral nerve, the implantation of nerve electrode refers to expose portion 1 It is completely disposed inside brain cortex neural, such as cerebral cortex 6, since carrier is the cuspidated rigid solid structure of tool, neuroelectricity The implantation of pole damages smaller caused by brain neuroblastoma or cerebral vessels.
Embodiment 3
As shown in Fig. 2, two adjacent carbon nanotube line electrodes are implanted to brain deep layer respectively, for carrying out the mind of deep brain Through electric signal record or electrical stimulation regulation.Wherein, the embedded nerve electrode based on carbon nano tube line includes expose portion 1 With insulated part 2, expose portion 1 and insulated part 2 derive from same root carbon nanotube line electrode, the carbon nanometer of expose portion 1 Pipeline electrode directly exposes, and the carbon nanotube line electrode of insulated part 2 is wrapped up by insulating layer；Expose portion 1 is used for neural telecommunications Number record or to nerve carry out electro photoluminescence.
The material of embedded nerve electrode is carbon nano tube line, and the diameter of carbon nano tube line is 10 μm.The carbon nano tube line It is drawn by the single-root carbon nano-tube that a plurality of diameter is 5nm-10nm.The carbon nano tube line electrode length range of expose portion 1 It is 1 μm -500 μm.The insulating layer material of insulated part 2 is c-type Parylene (Parylene-C) or medical silica-gel (Silicone).The thickness of insulating layer of insulated part 2 is 3 μm -5 μm.
The recording mode of embedded nerve electrode is non-differential type record.
Embedded nerve electrode is monopole electro photoluminescence, monopole using single-channel electrodes, the stimulation mode of nerve electrode Electro photoluminescence refers to being recycling electrode (return electrode) size greater than stimulating electrode size, and apart from stimulating electrode Stimulation mode more than 1 centimetre, and recycle one circuit of electrode and stimulating electrode formation.
The implant site of embedded nerve electrode includes but is not limited to Basal ganglia 7, cerebellum 8, central sulcus 9 or oblongata 10； The carrier of nerve electrode is tungsten wire in the present embodiment, and electrode implantation process is：Carrier carries embedded nerve electrode and penetrates nerve Film is pierced into inside nerve fiber；Carrier is withdrawn from, embedded nerve electrode is stayed in inside nerve tract, the implantation of nerve electrode Refer to that expose portion 1 is completely disposed inside brain neuroblastoma, such as Basal ganglia 7, cerebellum 8, central sulcus 9 or oblongata 10, due to carrying Tool is the cuspidated rigid solid structure of tool, the implantation of nerve electrode damaged caused by brain neuroblastoma or cerebral vessels compared with It is small.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea Technical solution, all should be within the scope of protection determined by the claims.

Claims (14)

1. a kind of embedded nerve electrode, which is characterized in that the embedded nerve electrode includes by a plurality of single-root carbon nano-tube Carbon nano tube line made of drawing.
2. embedded nerve electrode as described in claim 1, which is characterized in that the diameter of the single-root carbon nano-tube is 0.1nm-10nm；The diameter of the carbon nano tube line is 100nm-100 μm.
3. embedded nerve electrode as claimed in claim 2, wherein the embedded nerve electrode include expose portion and Insulated part, the expose portion and the insulated part derive from same root carbon nanotube line electrode, the expose portion Carbon nanotube line electrode directly exposes, and the carbon nanotube line electrode of the insulated part is wrapped up by insulating layer；The expose portion Electro photoluminescence is carried out for the record of electroneurographic signal or to nerve.
4. embedded nerve electrode as described in claim 3, which is characterized in that the insulating layer material of the insulated part is C-type Parylene or medical silica-gel.
5. embedded nerve electrode as described in claim 4, which is characterized in that the insulating layer thickness of the insulated part (2) Degree is 1 μm -5 μm.
6. embedded nerve electrode as described in claim 1, which is characterized in that the nerve of the embedded nerve electrode is planted Entering carrier is the cuspidated rigid solid structure of tool.
7. embedded nerve electrode as described in claim 6, which is characterized in that the rigid solid structure is by tungsten wire or not Rust steel wire is made.
8. embedded nerve electrode as described in claim 1, which is characterized in that the record side of the embedded nerve electrode Formula is that differential type records or non-differential type records.
9. embedded nerve electrode as described in claim 1, which is characterized in that the embedded nerve electrode is single channel Electrode or multi-channel electrode array.
10. embedded nerve electrode as described in claim 1, which is characterized in that the stimulation of the embedded nerve electrode Mode is monopole electro photoluminescence or bipolar electro photoluminescence.
11. a kind of method for implantation of embedded nerve electrode, which is characterized in that carrier is carried such as any one of claim 3-10 The embedded nerve electrode penetrates perineurium, is pierced into inside nerve fiber；Carrier is withdrawn from, by the implantable nerve Electrode stays in inside nerve tract.
12. a kind of application of embedded nerve electrode, which is characterized in that will be such as implantation of any of claims 1-10 Formula nerve electrode is used for ulnar nerve, nervus radialis, median nerve, sciatic nerve and its branch.
13. a kind of application of embedded nerve electrode, which is characterized in that will be such as implantation of any of claims 1-10 Formula nerve electrode is used for cerebral cortex.
14. a kind of application of embedded nerve electrode, which is characterized in that will be such as implantation of any of claims 1-10 Formula nerve electrode is used for Basal ganglia, cerebellum, central sulcus or the oblongata of brain deep layer.
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CN111481830A (en) * 2020-04-24 2020-08-04 上海交通大学 Closed-loop electrical nerve stimulation system and method for setting parameters of closed-loop electrical nerve stimulation
CN112617864A (en) * 2020-11-19 2021-04-09 南京医科大学 Self-curling peripheral nerve electrode and preparation method thereof
CN113180885A (en) * 2021-04-01 2021-07-30 重庆市畜牧科学院 Optic nerve interface and its preparing method
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