CN115429282B - Composite microneedle structure and nerve microelectrode - Google Patents
Composite microneedle structure and nerve microelectrode Download PDFInfo
- Publication number
- CN115429282B CN115429282B CN202210880707.0A CN202210880707A CN115429282B CN 115429282 B CN115429282 B CN 115429282B CN 202210880707 A CN202210880707 A CN 202210880707A CN 115429282 B CN115429282 B CN 115429282B
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- needle
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- soft
- composite microneedle
- clamping groove
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- 239000002131 composite material Substances 0.000 title claims abstract description 31
- 210000005036 nerve Anatomy 0.000 title abstract description 14
- 210000000944 nerve tissue Anatomy 0.000 claims abstract description 33
- 238000002513 implantation Methods 0.000 claims description 11
- 230000001537 neural effect Effects 0.000 claims 1
- 230000007547 defect Effects 0.000 abstract description 4
- 210000001519 tissue Anatomy 0.000 abstract description 3
- 239000000463 material Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 239000004642 Polyimide Substances 0.000 description 2
- 210000004204 blood vessel Anatomy 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000036982 action potential Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000008094 contradictory effect Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
- A61B5/293—Invasive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/262—Needle electrodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
- A61B5/25—Bioelectric electrodes therefor
- A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
- A61B5/294—Bioelectric electrodes therefor specially adapted for particular uses for nerve conduction study [NCS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
Abstract
The invention discloses a composite micro-needle structure and a nerve micro-electrode, wherein the composite micro-needle structure is used for implanting the micro-electrode of nerve tissue, the composite micro-needle structure comprises a hard needle and a soft needle, the front end of the hard needle is provided with a clamping groove structure, and the front end of the soft needle is provided with a clamping strip structure; the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into tissues, and then the hard needle is pulled out. The technical scheme provided by the invention can bring the soft needle into the nerve tissue through the hard needle, and then pull out the hard needle, so that the defect of adopting a single hard needle or soft needle can be avoided, the soft needle and the hard needle can be well fixed, the soft needle is prevented from being warped to a certain extent, the hard needle is convenient to pull out, and the damage to the tissue can be ensured to be smaller.
Description
Technical Field
The invention relates to the field of brain-computer interface nerve microelectrodes in biomedical engineering technology, in particular to a composite microneedle structure and a nerve microelectrode.
Background
Currently, most invasive microneedle structures are single type electrodes, such as a michigan electrode, a utah electrode, and a polyimide electrode with a soft needle structure.
For a hard needle (a rigid needle), the hard needle cannot be adaptively deformed along with the expansion and contraction of a blood vessel during implantation, and certain damage can be caused to nerve tissues; the soft needle structure is easy to deform during implantation, and the implantation is assisted by external equipment, but the problems of complex structure, low efficiency and the like exist.
Disclosure of Invention
The invention mainly aims to provide a compound micro-needle structure, which aims to bring a soft needle into nerve tissues through a hard needle and then pull out the hard needle, so that the defect of adopting a single hard needle or a soft needle can be avoided, the soft needle and the hard needle can be well fixed, the soft needle is prevented from being warped to a certain extent, the hard needle is convenient to pull out, and the damage to the nerve tissues can be ensured to be smaller.
To achieve the above object, the present invention provides a composite microneedle structure for a microelectrode for implanting into nerve tissue, the composite microneedle structure comprising:
the front end of the hard needle is provided with a clamping groove structure; and
the front end of the soft needle is provided with a clamping strip structure;
the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into the nerve tissue, and then the hard needle is pulled out.
Optionally, the hard needle and the soft needle are both of a structure with a narrow front end and a wide rear end.
Optionally, the front end upper surface of hard needle sets up protruding chamber, protruding chamber upper end opening, protruding chamber's two inside walls are close to diapire department and all are equipped with the recess to form the draw-in groove structure.
Optionally, the front end of the hard needle is provided as a tip for accessing nerve tissue.
Optionally, a stopper is disposed at the rear end of the clamping groove structure, and two ends of the extending direction of the stopper are flush with two outer side walls of the convex cavity to form a closed structure.
Optionally, the lower surface of the front end of the soft needle is provided with a T-shaped bulge so as to form a clamping strip structure.
Alternatively, both the lower surface of the hard needle and the upper surface of the soft needle are provided as smooth planes.
Optionally, the front end of the soft needle is provided with a tip, the side wall of the front section of the soft needle, which is close to the tip, is provided with a barb, and the tip of the barb is inclined backwards.
Optionally, the clamping groove structure is an elongated cylinder, the clamping strip structure is a hollow annular tube, and the inner diameter of the hollow annular tube is equal to the diameter of the elongated cylinder.
The invention also provides a nerve microelectrode, which comprises the compound microneedle structure, wherein the compound microneedle structure comprises the following components: the front end of the hard needle is provided with a clamping groove structure; the front end of the soft needle is provided with a clamping strip structure; the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into the nerve tissue, and then the hard needle is pulled out.
According to the technical scheme, the clamping groove structure is arranged at the front end of the hard needle, the clamping strip structure is arranged at the front end of the soft needle, and the clamping groove structure and the clamping strip structure can be mutually matched to realize clamping, so that the soft needle can be brought into nerve tissues through the hard needle and then pulled out, the defect of adopting a single hard needle or soft needle can be avoided, the soft needle and the hard needle can be well fixed, the soft needle is prevented from being warped to a certain extent, and the important thing is that the hard needle is conveniently pulled out, and meanwhile, the damage to the nerve tissues can be ensured to be small.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are required in the embodiments or the description of the prior art will be briefly described, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the structures shown in these drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic perspective view of an embodiment of a composite microneedle structure according to the present invention;
FIG. 2 is an enlarged schematic view of the front end of the needle of FIG. 1 including a hard needle and a soft needle;
FIG. 3 is an enlarged schematic view of the hard needle slot structure of FIG. 1;
FIG. 4 is an enlarged schematic view of the hard needle forward end of FIG. 1;
FIG. 5 is a perspective view of the soft needle of FIG. 1 from a perspective;
FIG. 6 is an enlarged schematic view of the forward end of the soft needle of FIG. 5;
fig. 7 is a schematic cross-sectional view of the composite microneedle structure of fig. 1.
Description of the embodiments of the invention the reference numerals:
| reference numerals | Name of the name | Reference numerals | Name of the name |
| 100 | Composite microneedle structure | 13 | Stop block |
| 1 | Hard needle | 2 | Soft needle |
| 11 | Clamping groove structure | 21 | Clamping strip structure |
| 12 | Convex cavity | 22 | Protrusions |
| 122 | Groove |
The achievement of the objects, functional features and advantages of the present invention will be further described with reference to the accompanying drawings, in conjunction with the embodiments.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
It should be noted that, if directional indications (such as up, down, left, right, front, and rear … …) are included in the embodiments of the present invention, the directional indications are merely used to explain the relative positional relationship, movement conditions, etc. between the components in a specific posture (as shown in the drawings), and if the specific posture is changed, the directional indications are correspondingly changed.
In addition, if there is a description of "first", "second", etc. in the embodiments of the present invention, the description of "first", "second", etc. is for descriptive purposes only and is not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defining "a first" or "a second" may explicitly or implicitly include at least one such feature. In addition, the meaning of "and/or" as it appears throughout includes three parallel schemes, for example "A and/or B", including the A scheme, or the B scheme, or the scheme where A and B are satisfied simultaneously. In addition, the technical solutions of the embodiments may be combined with each other, but it is necessary to base that the technical solutions can be realized by those skilled in the art, and when the technical solutions are contradictory or cannot be realized, the combination of the technical solutions should be considered to be absent and not within the scope of protection claimed in the present invention.
The invasive nerve microelectrode is used as a sensing device, is one of nerve electric activity sensing means with highest resolution at present, and can record action potential of a nerve system even a single neuron on the premise of not damaging the nerve system as much as possible. Currently, most invasive microneedle structures are single type electrodes, such as a michigan electrode, a utah electrode, and a polyimide electrode with a soft needle structure. For a hard needle (a rigid needle), the hard needle cannot be adaptively deformed along with the expansion and contraction of a blood vessel during implantation, and certain damage can be caused to nerve tissues; the soft needle structure is easy to deform during implantation, and the implantation is assisted by external equipment, but the problems of complex structure, low efficiency and the like exist.
In view of the foregoing, the present invention provides a composite microneedle structure 100, which is convenient and safe for implantation of microelectrodes by the composite microneedle structure 100. Referring to fig. 1 to 7, an embodiment of a composite microneedle structure 100 according to the present invention is shown.
It should be noted that, in the following embodiments, the up-down direction related to the composite microneedle structure 100 corresponds to the vertical direction, that is, the gravity direction; the forward-backward direction and the left-right direction of the composite microneedle structure 100 correspond to the forward-backward direction and the left-right direction of the user, respectively.
Referring to fig. 1, the present invention provides a composite microneedle structure 100, where the composite microneedle structure 100 includes a hard needle 1 and a soft needle 2, a clamping groove structure 11 is disposed at the front end of the hard needle 1, and a clamping bar structure 21 is disposed at the front end of the soft needle 2; the clamping bar structure 21 can be clamped into the clamping groove structure 11, so that the hard needle 1 brings the soft needle 2 into the nerve tissue, and then the hard needle 1 is pulled out.
According to the technical scheme, the front end of the hard needle 1 is provided with the clamping groove structure 11, the front end of the soft needle 2 is provided with the clamping strip structure 21, the clamping strip structure 21 can be matched with the clamping groove structure 11 to be clamped, when the hard needle 1 enters into the nerve tissue of a human body, the clamping strip clamped with the clamping groove of the hard needle 1 drives the soft needle 2 to enter into the nerve tissue together, and then the hard needle 1 is pulled out, so that the defect of adopting a single hard needle 1 or the soft needle 2 can be avoided, the soft needle 2 and the hard needle 1 can be well fixed, the soft needle 2 is prevented from being warped to a certain extent, and importantly, the hard needle 1 is conveniently pulled out, and meanwhile, the damage to the nerve tissue can be ensured to be small.
In the technical scheme of the invention, the hard needle 1 is a michigan electrode, in this embodiment, the material of the clamping groove is not limited, and under different application requirements, the clamping groove and the clamping strip are made of materials or silicon materials with good biocompatibility and biodegradability, although other materials harmless to human nerves are also feasible. The hard needle 1 and the clamping groove structure 11 are fixedly connected or integrally formed, the hard needle 1 and the clamping groove structure 11 and the soft needle 2 and the clamping strip structure 21 are fixedly connected or integrally formed, and when the clamping groove structure 11 and the clamping strip structure 21 are clamped together, the hard needle 1 and the soft needle 2 move together in nerve tissues.
In order to make the composite microneedle conveniently implanted into the nerve tissue of the human body and maintain the structural performance of the microelectrode, please refer to fig. 1, in this embodiment, the hard needle 1 is a michigan electrode, and the michigan electrode is a three-dimensional electrode array formed by assembling a plurality of silicon needles with a plurality of recording channels, and the surface is made into a process surface layer to form a cuboid-like structure, and in this embodiment, a section of slender implantation section is arranged at the front end of the cuboid-like structure, so that the front end of the hard needle 1 is narrow and the rear end is wide. This design allows for more convenient penetration of the hard needle 1 into the nerve tissue of the human body. The soft needle 2 is made of SiN material, has flexibility, is inconvenient to penetrate into nerve tissues, has good prospect in terms of biocompatibility, and has the same shape as the hard needle 1, and is smaller than the hard needle 1, so that the soft needle 2 can be conveniently clamped on the hard needle 1 without falling off.
Further, in an embodiment, referring to fig. 7, in order to make the locking between the hard needle 1 and the soft needle 2 firm, the hard needle cannot fall off during implantation, a protruding cavity 12 is provided on the upper surface of the front end of the hard needle 1, the upper end of the protruding cavity 12 is opened, and grooves 122 are provided on two inner side walls of the protruding cavity 12 near the bottom wall to form a locking portion of the slot structure 11, so that the locking strip is locked into the protruding cavity 12 to achieve locking. The engaging portion of the slot structure 11 may be provided in a sectional manner, or may be provided in an integral manner without being segmented.
Referring to fig. 3 and 4, in a further embodiment, the front end of the hard needle 1 is configured to be similar to a tapered tip, and the front end of the hard needle 1 gradually and slowly decreases in a horizontal direction to form a tip, so that the resistance of the slot structure 11 is reduced when entering into nerve tissue, thereby facilitating the entry of the hard needle 1, and the hard needle 1 and the soft needle 2 are clamped by the slot structure 11 and the clamping strip structure 21, so that the soft needle 2 is also driven to enter conveniently.
Further, in an embodiment, referring to fig. 3, a stopper 13 is disposed at a rear end of the slot structure 11, two ends of the stopper 13 in an extending direction are flush with two outer sidewalls of the protruding cavity 12, a shape of the stopper 13 is not limited, the embodiment is preferably a cuboid shape, a height of the stopper 13 in an up-down direction is the same as a height of the protruding cavity 12, and left and right ends of the stopper 13 are in sealing connection with the left and right outer sidewalls of the protruding cavity 12, so that the stopper 13 and the protruding cavity 12 form a closed structure. The stop 13 prevents the clip structure 21 from sliding out of the slot structure 11 when the clip is clipped into the cavity 12, and prevents the soft needle 2 from sliding out of the tissue.
In order to make the locking bar structure 21 of the soft needle 2 match with the locking groove structure 11 of the hard needle 1 and firmly locked, in this embodiment, referring to fig. 7, the size of the locking bar structure 21 matches with the shape of the locking groove structure 11, and the front end lower surface of the soft needle 2 is provided with an inverted "T" shaped protrusion 22 along the front-back direction, i.e. a strip-shaped protrusion 22 is formed on the front end lower surface of the soft needle 2, the lower end section of the protrusion 22 is widened, the cross section is similar to the inverted "T", and the length of the protrusion 22 in the left-right direction is the same as the depth of the recess 122, so that the protrusion 22 exactly locks into the recess 122 to realize locking, and the soft needle 2 is prevented from sliding out of the hard needle 1 during movement. The card strip structure 21 may be a bar-shaped bump protruding from the surface of the soft needle 2.
Further, in an embodiment, referring to fig. 1, the lower surface of the hard needle 1 and the upper surface of the soft needle 2 are both provided with smooth planes, and a smooth coating may be coated on the lower surface of the hard needle 1 and the upper surface of the soft needle 2, so that the hard needle 1 reduces resistance when driving the soft needle 2 to invade the nerve tissue, and simultaneously reduces damage to the nerve tissue.
Further, in an embodiment, referring to fig. 5 and 6, the front end of the soft needle 2 is provided with a tip, the design is matched with the tip of the front end of the hard needle 1, so that the shape is adapted during the clamping without increasing the resistance to the implantation, the side wall of the front section of the soft needle 2, which is close to the tip, is provided with barbs, the tips of the barbs incline backwards, the design is favorable for the soft needle 2 to enter into the nerve tissue under the driving of the hard needle 1, and after the hard needle 1 is pulled out, the soft needle 2 can be stabilized in the nerve tissue without swinging randomly.
In order to make the hard needle 1 and the soft needle 2 clamped more firmly, and facilitate the composite microneedle to be easily implanted into the nerve tissue, further, in this embodiment, the dimension of the clamping strip structure 21 is matched with the dimension of the clamping groove structure 11, specifically, the length of the clamping strip structure 21 in the front-back direction is slightly shorter than the clamping groove structure 11, so that when the hard needle 1 is implanted into the nerve tissue, the soft needle 2 can be driven to enter the nerve tissue without the soft needle 2 being clamped outside; the width of the clamping strip structure 21 in the left-right direction is slightly smaller than that of the clamping groove structure 11, so that the protrusions 22 of the clamping strip structure 21 can be clamped into the protruding cavities 12 of the clamping grooves; the thickness of the clamping strip structure 21 in the up-down direction is basically equal to that of the clamping groove structure 11 in the up-down direction, or is slightly smaller than that of the clamping strip structure, so that the clamping strip structure 21 can be tightly clamped with the clamping groove structure 11, and the clamping strip structure cannot fall off when being implanted into nerve tissues.
In this embodiment, the clamping groove structure 11 is an elongated cylinder, the clamping bar structure 21 is a hollow annular tube, the inner diameter of the hollow annular tube is equal to the diameter of the elongated cylinder, the clamping groove structure 11 of the elongated cylinder can be just inserted into the clamping bar structure 21 of the hollow annular tube, meanwhile, a second stop block is arranged at the rear end of the clamping groove structure 11, the shape of the second stop block is not limited, the second stop block can be annular or convex, and the second stop block can prevent the soft needle 2 from sliding out when the soft needle 1 is brought into the nerve tissue.
The invention also provides a nerve microelectrode, which comprises the composite microneedle structure, wherein the composite microneedle structure specifically refers to the embodiment, and because the nerve microelectrode adopts all the technical schemes of all the embodiments, the nerve microelectrode has all the beneficial effects brought by the technical schemes of the embodiments, and the description is omitted herein.
The foregoing description is only of the preferred embodiments of the present invention and is not intended to limit the scope of the invention, and all equivalent structural changes made by the description of the present invention and the accompanying drawings or direct/indirect application in other related technical fields are included in the scope of the invention.
Claims (8)
1. A composite microneedle structure for a microelectrode for implantation into nerve tissue, the composite microneedle structure comprising:
the front end of the hard needle is provided with a clamping groove structure; and
the front end of the soft needle is provided with a clamping strip structure;
the clamping strip structure can be clamped into the clamping groove structure, so that the hard needle brings the soft needle into the nerve tissue, and then the hard needle is pulled out;
the lower surface of the front end of the soft needle is provided with a T-shaped bulge along the front-back direction so as to form a clamping strip structure;
the front end of the soft needle is provided with a tip, the side wall of the front section of the soft needle, which is close to the tip, is provided with barbs, and the tips of the barbs incline backwards.
2. The composite microneedle structure of claim 1, wherein said hard needles and said soft needles are each narrow at the front end and wide at the rear end.
3. The composite microneedle structure of claim 2, wherein a forward end of said rigid needle is configured as a tip for accessing nerve tissue.
4. The composite microneedle structure of claim 1, wherein the upper surface of the front end of the rigid needle is provided with a convex cavity, the upper end of the convex cavity is open, and both inner side walls of the convex cavity are provided with grooves near the bottom wall to form a clamping groove structure.
5. The composite microneedle structure of claim 4, wherein the rear end of the slot structure is provided with a stop, and the left and right ends of the stop are flush with the two outer side walls of the convex cavity.
6. The composite microneedle structure of claim 1, wherein both the lower surface of the hard needles and the upper surface of the soft needles are provided as smooth planar surfaces.
7. The composite microneedle structure of claim 1, wherein said clip strip structure is sized to match a size of said card slot structure.
8. A neural microelectrode comprising the composite microneedle structure of any one of claims 1-7.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210880707.0A CN115429282B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and nerve microelectrode |
| PCT/CN2022/126573 WO2024021326A1 (en) | 2022-07-25 | 2022-10-21 | Composite microneedle structure and neural microelectrode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210880707.0A CN115429282B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and nerve microelectrode |
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| Publication Number | Publication Date |
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| CN115429282A CN115429282A (en) | 2022-12-06 |
| CN115429282B true CN115429282B (en) | 2024-02-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210880707.0A Active CN115429282B (en) | 2022-07-25 | 2022-07-25 | Composite microneedle structure and nerve microelectrode |
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| Country | Link |
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| CN (1) | CN115429282B (en) |
| WO (1) | WO2024021326A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115281682A (en) * | 2022-07-25 | 2022-11-04 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and preparation method thereof |
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| WO2024021326A1 (en) | 2024-02-01 |
| CN115429282A (en) | 2022-12-06 |
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