CN115279770A - 用于治疗与sting活性有关的疾病的化合物和组合物 - Google Patents

用于治疗与sting活性有关的疾病的化合物和组合物 Download PDF

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Publication number
CN115279770A
CN115279770A CN202080097812.6A CN202080097812A CN115279770A CN 115279770 A CN115279770 A CN 115279770A CN 202080097812 A CN202080097812 A CN 202080097812A CN 115279770 A CN115279770 A CN 115279770A
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China
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independently selected
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optionally substituted
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ring
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CN202080097812.6A
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English (en)
Chinese (zh)
Inventor
W·R·劳世
H·M·塞德尔
S·范卡彻曼
J·卡茨
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Novartis Pharma AG
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Afumdeyou Co ltd
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Application filed by Afumdeyou Co ltd filed Critical Afumdeyou Co ltd
Publication of CN115279770A publication Critical patent/CN115279770A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CN202080097812.6A 2019-12-31 2020-12-30 用于治疗与sting活性有关的疾病的化合物和组合物 Pending CN115279770A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962955853P 2019-12-31 2019-12-31
US62/955,853 2019-12-31
US202063090547P 2020-10-12 2020-10-12
US63/090,547 2020-12-10
PCT/US2020/067463 WO2021138419A1 (en) 2019-12-31 2020-12-30 Compounds and compositions for treating conditions associated with sting activity

Publications (1)

Publication Number Publication Date
CN115279770A true CN115279770A (zh) 2022-11-01

Family

ID=74550729

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080097812.6A Pending CN115279770A (zh) 2019-12-31 2020-12-30 用于治疗与sting活性有关的疾病的化合物和组合物

Country Status (8)

Country Link
US (1) US20230115274A1 (https=)
EP (1) EP4085061A1 (https=)
JP (1) JP2023509421A (https=)
CN (1) CN115279770A (https=)
PY (1) PY2089151A (https=)
TW (1) TW202136255A (https=)
UY (1) UY39005A (https=)
WO (1) WO2021138419A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116023321A (zh) * 2022-12-30 2023-04-28 中国药科大学 Sting抑制剂前药及其医药用途
WO2024125629A1 (zh) * 2022-12-16 2024-06-20 中国药科大学 脲类化合物及其作为sting抑制剂的医药用途

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112823036B (zh) 2018-07-03 2024-11-08 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物
EP4267129A1 (en) 2020-12-22 2023-11-01 IFM Due, Inc. Methods of treating cancer
EP4267128A1 (en) 2020-12-22 2023-11-01 IFM Due, Inc. Methods of treating cancer
WO2022140397A1 (en) 2020-12-22 2022-06-30 Ifm Due, Inc. Methods of treating cancer
US20240060982A1 (en) 2020-12-22 2024-02-22 Ifm Due, Inc. Methods of treating cancer
JP2024502470A (ja) * 2021-01-08 2024-01-19 アイエフエム デュー インコーポレイテッド Ｓｔｉｎｇ活性に関連する状態を治療するための化合物および組成物
TW202235073A (zh) 2021-01-08 2022-09-16 美商Ｉｆｍ Ｄｕｅ有限公司 用於治療與sting活性相關的病狀之化合物及組合物
UY39892A (es) 2021-08-10 2023-03-31 Novartis Pharma Ag Compuestos y composiciones para tratar afecciones asociadas con la actividad de STING
WO2024032597A1 (zh) * 2022-08-11 2024-02-15 杭州中美华东制药有限公司 具有sting抑制作用的酰胺类化合物及其药物组合物和用途
WO2024064358A1 (en) 2022-09-23 2024-03-28 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
AU2023368953A1 (en) * 2022-10-28 2025-03-27 Boehringer Ingelheim International Gmbh Heterocyclic compounds as sting antagonists
WO2025228902A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Heterocyclic acids as sting antagonists and the use thereof as medicament
WO2025228899A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Further heterocyclic compounds as sting antagonists and the use thereof as medicament
WO2025228900A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Arylamide substituted indazoles and the use thereof as medicament
US20250333398A1 (en) 2024-04-30 2025-10-30 Boehringer Ingelheim International Gmbh Monoaryl and hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament
WO2025228895A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Hetaryl substituted indazoles and benzimidazoles as sting antagonists and the use thereof as medicament
WO2025228889A1 (en) 2024-04-30 2025-11-06 Boehringer Ingelheim International Gmbh Monoarylic heterocyclic compounds as sting antagonists and the use thereof as medicament

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019201939A1 (en) * 2018-04-16 2019-10-24 Ecole Polytechnique Federale De Lausanne (Epfl) Sting inhibitors
WO2020010092A1 (en) * 2018-07-03 2020-01-09 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
WO2006083005A1 (ja) * 2005-02-03 2006-08-10 Takeda Pharmaceutical Company Limited 縮合ピリミジン誘導体およびその用途
WO2012062462A1 (en) * 2010-11-10 2012-05-18 Grünenthal GmbH Substituted heteroaromatic carboxamide and urea derivatives as vanilloid receptor ligands
WO2012075380A1 (en) 2010-12-03 2012-06-07 The Trustees Of The University Of Pennsylvania Tip60 inhibitors
FR2970967B1 (fr) * 2011-01-27 2013-02-15 Pf Medicament Derives de type azaindazole ou diazaindazole comme medicament
CN109394752A (zh) 2013-10-21 2019-03-01 德雷克塞尔大学 治疗慢性乙型肝炎病毒感染的sting激动剂的用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019201939A1 (en) * 2018-04-16 2019-10-24 Ecole Polytechnique Federale De Lausanne (Epfl) Sting inhibitors
WO2020010092A1 (en) * 2018-07-03 2020-01-09 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
CN112823036A (zh) * 2018-07-03 2021-05-18 艾福姆德尤股份有限公司 用于治疗与sting活性有关的疾病的化合物和组合物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
R. B. 西尔弗曼: "《有机药物化学》", vol. 2008, 31 January 2008, 化学工业出版社, pages: 19 - 20 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024125629A1 (zh) * 2022-12-16 2024-06-20 中国药科大学 脲类化合物及其作为sting抑制剂的医药用途
CN116023321A (zh) * 2022-12-30 2023-04-28 中国药科大学 Sting抑制剂前药及其医药用途
WO2024141128A3 (zh) * 2022-12-30 2024-08-22 中国药科大学 Sting抑制剂前药及其医药用途
CN116023321B (zh) * 2022-12-30 2024-11-29 中国药科大学 Sting抑制剂前药及其医药用途

Also Published As

Publication number Publication date
TW202136255A (zh) 2021-10-01
UY39005A (es) 2021-07-30
JP2023509421A (ja) 2023-03-08
EP4085061A1 (en) 2022-11-09
US20230115274A1 (en) 2023-04-13
WO2021138419A1 (en) 2021-07-08
PY2089151A (es) 2022-05-11

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Effective date of registration: 20250205

Address after: Basel, SUI

Applicant after: NOVARTIS PHARMA AG

Country or region after: Switzerland

Address before: U.S.A.

Applicant before: Afumdeyou Co.,Ltd.

Country or region before: U.S.A.

TA01 Transfer of patent application right