CN1152674C - 氟代醚组合物和抑制路易斯酸存在下其降解的方法 - Google Patents
氟代醚组合物和抑制路易斯酸存在下其降解的方法 Download PDFInfo
- Publication number
- CN1152674C CN1152674C CNB98802053XA CN98802053A CN1152674C CN 1152674 C CN1152674 C CN 1152674C CN B98802053X A CNB98802053X A CN B98802053XA CN 98802053 A CN98802053 A CN 98802053A CN 1152674 C CN1152674 C CN 1152674C
- Authority
- CN
- China
- Prior art keywords
- sevoflurane
- water
- lewis acid
- degraded
- container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Catalysts (AREA)
- Steroid Compounds (AREA)
Abstract
Description
1 | 2 | 3 | |
A | 50mg Al2O320ppm水 | 50mg Al2O3100ppm水 | 50mg Al2O3260ppm水 |
B | 20mg Al2O320ppm水 | 20mg Al2O3100ppm水 | 20mg Al2O3260ppm水 |
C | 10mg Al2O320ppm水 | 10mg Al2O3100ppm水 | 10mg Al2O3260ppm水 |
样品 | 计算的总湿度(ppm) | pH | HFIP(ppm) | 除HFIP外的总降解物(ppm) |
对照,瓶 | 6.0 | 6 | 57 | |
对照,安瓿1,RT | 3.0 | 7 | 50 | |
对照,安瓿2,RT | 4.0 | 6 | 51 | |
A装置(振荡过夜) | ||||
1 | 109 | 0 | 1.525 | 201614 |
2 | 206 | 0 | 2.456 | 105518 |
3 | 303 | 0 | 4.027 | 127134 |
4 | 595 | 5.0 | 7 | 82 |
5 | 951 | 5.0 | 12 | 84 |
B装置(不振荡) | ||||
1 | 109 | 0 | 1.936 | 195364 |
2 | 206 | 0 | 3.390 | 170869 |
3 | 303 | 0 | 5.269 | 101845 |
4 | 595 | 6.0 | 21 | 107 |
5 | 951 | 6.0 | 10 | 63 |
样品 | 总湿度 | pH | HFIP(ppm) | 总降解物(ppm) |
示踪水,60℃,144小时 | ||||
1 | 109 | 0 | 850 | 474796 |
2 | 206 | 3.5 | 78 | 4865 |
3-1 | 303 | 3.5 | 1316 | 6868 |
3-2 | 303 | 5.0 | 8 | 60 |
4 | 595 | 5.5 | 7 | 66 |
5-1 | 951 | 5.5 | 4 | 52 |
5-2 | 951 | 5.5 | 5 | 60 |
示踪水,40℃,200小时 | ||||
6-1 | 不加水 | 0 | 232 | 102435 |
6-2 | 不加水 | 2.5 | 24 | 68 |
7 | 109 | 3.0 | 40 | 77 |
8 | 206 | 5.0 | 7 | 59 |
9 | 303 | 5.0 | 6 | 59 |
10 | 595 | 6.0 | 6 | 60 |
11 | 951 | 6.0 | 5 | 60 |
降解产物(ppm) | |||
瓶号 | HFIP | P2 | 总量 |
1 | 124 | <10 | 185 |
2 | 84 | <10 | 123 |
3 | 77 | <10 | 137 |
4 | 56 | <10 | 89 |
5 | 144 | <10 | 190 |
6 | 63 | <10 | 96 |
7 | 58 | <10 | 95 |
8 | 60 | <10 | 102 |
9 | 51 | <10 | 106 |
10 | 65 | <10 | 140 |
降解产物(ppm) | |||
瓶号 | HFIP | P2 | 总量 |
1 | 1026 | 7938 | 14243 |
2 | 912 | 3013 | 6428 |
3 | 1160 | 4662 | 10474 |
4 | 908 | 3117 | 7381 |
5 | 907 | 6687 | 11774 |
6 | 1128 | 5448 | 11313 |
7 | 1152 | 2371 | 6695 |
8 | 1199 | 2925 | 7386 |
9 | 1560 | 4183 | 10325 |
10 | 1455 | 2255 | 6667 |
降解产物(ppm) | ||||||
HFIP | P2 | 总降解物 | ||||
时间 | 0小时 | 18小时 | 0小时 | 18小时 | 0小时 | 18小时 |
对照组(20ppm水) | ||||||
2 | <10 | 777 | <10 | 2291 | <50 | 5995 |
3 | <10 | 790 | <10 | 2714 | <50 | 6552 |
5 | 11 | 688 | <10 | 2446 | <50 | 5485 |
7 | <10 | 894 | <10 | 1171 | <50 | 4124 |
8 | <10 | 824 | <10 | 1950 | <50 | 5139 |
研究组(400ppm水) | ||||||
1 | 12 | 605 | <10 | <10 | <50 | 669 |
4 | <10 | 84 | <10 | <10 | <50 | 98 |
6 | <10 | 331 | <10 | <10 | <50 | 357 |
9 | <10 | 294 | <10 | <10 | <50 | 315 |
10 | 10 | 528 | <10 | <10 | <50 | 577 |
降解产物(ppm) | ||||||
HFIP | P2 | 总降解物 | ||||
时间 | 36小时 | 178小时 | 36小时 | 178小时 | 36小时 | 178小时 |
研究组(400ppm水) | ||||||
1 | <10 | 16 | <10 | <10 | <50 | <50 |
4 | <10 | <10 | <10 | <10 | <50 | <50 |
6 | <10 | 28 | <10 | <10 | <50 | <50 |
9 | <10 | 15 | <10 | <10 | <50 | <50 |
10 | <10 | 19 | <10 | <10 | <50 | <50 |
Claims (4)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/789,679 | 1997-01-27 | ||
US08/789,679 US5990176A (en) | 1997-01-27 | 1997-01-27 | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100368062A Division CN1321958C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1244797A CN1244797A (zh) | 2000-02-16 |
CN1152674C true CN1152674C (zh) | 2004-06-09 |
Family
ID=25148366
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB98802053XA Expired - Lifetime CN1152674C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
CNB2004100368062A Expired - Lifetime CN1321958C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
CNA2006101016375A Pending CN1899271A (zh) | 1997-01-27 | 1998-01-23 | 储存七氟烷的方法以及防止七氟烷被路易斯酸降解的方法 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100368062A Expired - Lifetime CN1321958C (zh) | 1997-01-27 | 1998-01-23 | 氟代醚组合物和抑制路易斯酸存在下其降解的方法 |
CNA2006101016375A Pending CN1899271A (zh) | 1997-01-27 | 1998-01-23 | 储存七氟烷的方法以及防止七氟烷被路易斯酸降解的方法 |
Country Status (28)
Country | Link |
---|---|
US (6) | US5990176A (zh) |
EP (2) | EP1114641B1 (zh) |
JP (5) | JP3183520B2 (zh) |
KR (1) | KR100368672B1 (zh) |
CN (3) | CN1152674C (zh) |
AR (2) | AR011090A1 (zh) |
AT (2) | ATE201987T1 (zh) |
AU (1) | AU726733B2 (zh) |
BG (2) | BG109751A (zh) |
BR (1) | BR9806996A (zh) |
CA (2) | CA2278133C (zh) |
CO (1) | CO4920220A1 (zh) |
CZ (1) | CZ297092B6 (zh) |
DE (2) | DE69800928T2 (zh) |
DK (2) | DK0967975T3 (zh) |
ES (2) | ES2256104T3 (zh) |
GR (1) | GR3036190T3 (zh) |
HK (1) | HK1074434A1 (zh) |
HU (1) | HUP0002101A3 (zh) |
IL (1) | IL130150A (zh) |
NO (1) | NO993606L (zh) |
NZ (1) | NZ335994A (zh) |
PL (1) | PL334477A1 (zh) |
PT (2) | PT1114641E (zh) |
SK (1) | SK284243B6 (zh) |
TR (1) | TR199901579T2 (zh) |
WO (1) | WO1998032430A1 (zh) |
ZA (1) | ZA98418B (zh) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5990176A (en) * | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
US6162443A (en) | 1998-01-09 | 2000-12-19 | Abbott Laboratories | Container for an inhalation anesthetic |
US20030200963A1 (en) * | 1998-01-09 | 2003-10-30 | Flament-Garcia Mary Jane | Container for an inhalation anesthetic |
US6074668A (en) * | 1998-01-09 | 2000-06-13 | Abbott Laboratories | Container for an inhalation anesthetic |
AU759641B2 (en) * | 1998-08-19 | 2003-04-17 | Skyepharma Canada Inc. | Injectable aqueous dispersions of propofol |
EP1439677B9 (en) | 1999-01-08 | 2007-11-07 | Sony Deutschland GmbH | Synchronisation symbol structure for an OFDM system |
TW523409B (en) * | 2000-09-15 | 2003-03-11 | Baxter Int | Container for inhalation anesthetic |
BR0303489A (pt) * | 2003-09-10 | 2005-07-05 | Cristalia Prod Quimicos Farm | Composição farmacêutica estabilizada de composto flúor-éter e método para inibir a degradação de composto flúor-éter. uso de agente estabilizante para inibir a degradação de composto flúor éter |
DE602004007149T2 (de) * | 2003-09-10 | 2008-02-28 | Cristália Produtos Químicos Farmacêuticos Ltda. | Stabile pharmazeutische zusammensetzung einer fluorether-verbindung für die anästhesie, verfahren zur stabilisierung einer fluorether-verbindung, verwendung eines stabilisierungsmittels zum ausschluss des abbaus einer fluorether-verbindung |
WO2006113636A2 (en) * | 2005-04-18 | 2006-10-26 | Minrad Inc. | Preparation of sevoflurane with negligible water content |
WO2009049460A1 (fr) * | 2007-10-15 | 2009-04-23 | Jiangsu Hengrui Medicine Co., Ltd. | Nouveau matériau conditionné de sévoflurane |
WO2009094459A1 (en) * | 2008-01-22 | 2009-07-30 | The Board Of Regents Of The University Of Texas System | Volatile anesthetic compositions comprising extractive solvents for regional anesthesia and/or pain relief |
US20090275785A1 (en) | 2008-05-01 | 2009-11-05 | Barry Jones | Distillation Method For The Purification Of Sevoflurane And The Maintenance Of Certain Equipment That May Be Used In The Distillation Process |
US8563115B2 (en) * | 2008-08-12 | 2013-10-22 | Xerox Corporation | Protective coatings for solid inkjet applications |
US8092822B2 (en) * | 2008-09-29 | 2012-01-10 | Abbott Cardiovascular Systems Inc. | Coatings including dexamethasone derivatives and analogs and olimus drugs |
US8283643B2 (en) * | 2008-11-24 | 2012-10-09 | Cymer, Inc. | Systems and methods for drive laser beam delivery in an EUV light source |
US8191992B2 (en) * | 2008-12-15 | 2012-06-05 | Xerox Corporation | Protective coatings for solid inkjet applications |
US9278048B2 (en) * | 2009-05-06 | 2016-03-08 | Baxter International, Inc. | Pharmaceutical product and method of use |
US9102604B1 (en) | 2010-02-15 | 2015-08-11 | Baxter International Inc. | Methods for cleaning distilling columns |
CN105193774B (zh) * | 2015-09-21 | 2018-01-16 | 山东新时代药业有限公司 | 一种七氟烷吸入剂 |
CN105106182B (zh) * | 2015-09-21 | 2017-12-29 | 山东新时代药业有限公司 | 七氟烷吸入剂 |
BE1024432B1 (fr) | 2016-11-02 | 2018-02-19 | Central Glass Company, Limited | Procédé pour le lavage de récipient de stockage de sévoflurane et procédé pour le stockage de sévoflurane |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2992276A (en) * | 1959-05-20 | 1961-07-11 | Du Pont | Process for preparing polyfluoro alkyl compounds |
US3527813A (en) * | 1966-10-03 | 1970-09-08 | Air Reduction | 1,1,2 - trifluoro - 2 - chloroethyl difluoromethyl ether and its method of preparation |
US3689571A (en) * | 1970-07-31 | 1972-09-05 | Baxter Laboratories Inc | Fluorinated ether |
GB1499818A (en) * | 1974-12-06 | 1978-02-01 | Ici Ltd | Anaesthetic composition |
US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
US4469898A (en) * | 1979-12-26 | 1984-09-04 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
JP2786108B2 (ja) * | 1994-03-31 | 1998-08-13 | セントラル硝子株式会社 | フルオロメチル−1,1,1,3,3,3−ヘキサフルオロイソプロピルエーテルの精製方法 |
IT1270239B (it) * | 1994-06-17 | 1997-04-29 | Zambon Spa | Composizione farmaceutica solida contenente acido (s)-2-(4- isobutilfenil) propionico come principio attivo |
US5990176A (en) | 1997-01-27 | 1999-11-23 | Abbott Laboratories | Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid |
-
1997
- 1997-01-27 US US08/789,679 patent/US5990176A/en not_active Expired - Lifetime
-
1998
- 1998-01-19 ZA ZA98418A patent/ZA98418B/xx unknown
- 1998-01-23 NZ NZ335994A patent/NZ335994A/xx not_active IP Right Cessation
- 1998-01-23 JP JP53216898A patent/JP3183520B2/ja not_active Expired - Lifetime
- 1998-01-23 HU HU0002101A patent/HUP0002101A3/hu unknown
- 1998-01-23 BR BR9806996-9A patent/BR9806996A/pt active IP Right Grant
- 1998-01-23 PT PT01107733T patent/PT1114641E/pt unknown
- 1998-01-23 CN CNB98802053XA patent/CN1152674C/zh not_active Expired - Lifetime
- 1998-01-23 CN CNB2004100368062A patent/CN1321958C/zh not_active Expired - Lifetime
- 1998-01-23 CN CNA2006101016375A patent/CN1899271A/zh active Pending
- 1998-01-23 DE DE69800928T patent/DE69800928T2/de not_active Revoked
- 1998-01-23 PT PT98902707T patent/PT967975E/pt unknown
- 1998-01-23 CZ CZ0256199A patent/CZ297092B6/cs not_active IP Right Cessation
- 1998-01-23 DK DK98902707T patent/DK0967975T3/da active
- 1998-01-23 AT AT98902707T patent/ATE201987T1/de not_active IP Right Cessation
- 1998-01-23 ES ES01107733T patent/ES2256104T3/es not_active Expired - Lifetime
- 1998-01-23 EP EP01107733A patent/EP1114641B1/en not_active Expired - Lifetime
- 1998-01-23 IL IL13015098A patent/IL130150A/en not_active IP Right Cessation
- 1998-01-23 SK SK861-99A patent/SK284243B6/sk not_active IP Right Cessation
- 1998-01-23 AU AU59300/98A patent/AU726733B2/en not_active Expired
- 1998-01-23 EP EP98902707A patent/EP0967975B1/en not_active Revoked
- 1998-01-23 DK DK01107733T patent/DK1114641T3/da active
- 1998-01-23 CA CA002278133A patent/CA2278133C/en not_active Expired - Lifetime
- 1998-01-23 AT AT01107733T patent/ATE320798T1/de active
- 1998-01-23 CO CO98003122A patent/CO4920220A1/es unknown
- 1998-01-23 DE DE69833884T patent/DE69833884T2/de not_active Expired - Lifetime
- 1998-01-23 KR KR10-1999-7006724A patent/KR100368672B1/ko not_active IP Right Cessation
- 1998-01-23 WO PCT/US1998/001376 patent/WO1998032430A1/en active Application Filing
- 1998-01-23 ES ES98902707T patent/ES2170474T3/es not_active Expired - Lifetime
- 1998-01-23 TR TR1999/01579T patent/TR199901579T2/xx unknown
- 1998-01-23 PL PL98334477A patent/PL334477A1/xx not_active IP Right Cessation
- 1998-01-23 CA CA002626424A patent/CA2626424A1/en not_active Abandoned
- 1998-01-26 AR ARP980100336A patent/AR011090A1/es active IP Right Grant
-
1999
- 1999-07-23 NO NO19993606A patent/NO993606L/no not_active Application Discontinuation
- 1999-08-10 BG BG109751A patent/BG109751A/bg unknown
- 1999-08-10 BG BG103656A patent/BG65414B1/bg unknown
- 1999-11-23 US US09/447,853 patent/US6288127B1/en not_active Expired - Lifetime
-
2000
- 2000-11-16 JP JP2000349024A patent/JP3664648B2/ja not_active Expired - Lifetime
-
2001
- 2001-07-06 GR GR20010401038T patent/GR3036190T3/el not_active IP Right Cessation
- 2001-08-08 US US09/924,573 patent/US6444859B2/en not_active Expired - Lifetime
-
2002
- 2002-07-03 US US10/190,271 patent/US6677492B2/en not_active Expired - Lifetime
-
2003
- 2003-06-26 US US10/606,821 patent/US20040048932A1/en not_active Abandoned
-
2005
- 2005-04-06 JP JP2005109476A patent/JP2005279283A/ja not_active Ceased
- 2005-06-29 HK HK05105456A patent/HK1074434A1/xx not_active IP Right Cessation
- 2005-12-27 JP JP2005374621A patent/JP2006143742A/ja not_active Ceased
- 2005-12-27 JP JP2005374622A patent/JP2006137769A/ja not_active Ceased
-
2006
- 2006-02-27 US US11/362,954 patent/US20060148906A1/en not_active Abandoned
- 2006-11-16 AR ARP060105042A patent/AR057610A2/es unknown
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