CN115243691A - Irak4抑制剂治疗ali/ards中的应用 - Google Patents

Irak4抑制剂治疗ali/ards中的应用 Download PDF

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CN115243691A
CN115243691A CN202180018110.9A CN202180018110A CN115243691A CN 115243691 A CN115243691 A CN 115243691A CN 202180018110 A CN202180018110 A CN 202180018110A CN 115243691 A CN115243691 A CN 115243691A
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acute
lung injury
medicament
respiratory distress
distress syndrome
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冯焱
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Shanghai Lingtai Biomedical Technology Co ltd
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Shanghai Lingtai Biomedical Technology Co ltd
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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Abstract

IRAK4小分子抑制剂在制备治疗或预防急性肺损伤或急性呼吸窘迫综合症及其相关病症的药物的应用。通过实验证明，所述IRAK4小分子抑制剂能够明显的减少炎症因子的产生，阻止嗜酸性粒细胞、中性粒细胞和淋巴细胞的浸润，对LPS诱导的急性肺损伤或急性呼吸窘迫综合症显示出良好的预防和治疗作用，有望成为新一代的治疗急性肺损伤和急性呼吸窘迫综合症的药物。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202180018110.9A 2020-04-20 2021-04-16 Irak4抑制剂治疗ali/ards中的应用 Pending CN115243691A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020103286487 2020-04-20
CN202010328648.7A CN113521079A (zh) 2020-04-20 2020-04-20 Irak4抑制剂在治疗ali/ards中的应用
PCT/CN2021/087924 WO2021213287A1 (zh) 2020-04-20 2021-04-16 Irak4抑制剂治疗ali/ards中的应用

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CN115243691A true CN115243691A (zh) 2022-10-25

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CN202010328648.7A Pending CN113521079A (zh) 2020-04-20 2020-04-20 Irak4抑制剂在治疗ali/ards中的应用
CN202180018110.9A Pending CN115243691A (zh) 2020-04-20 2021-04-16 Irak4抑制剂治疗ali/ards中的应用

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024094190A1 (zh) * 2022-11-04 2024-05-10 上海领泰生物医药科技有限公司 Irak4降解剂及其用途

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3219329A1 (en) * 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
CN107406416A (zh) * 2014-11-26 2017-11-28 拜耳医药股份有限公司 新型取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN107872977A (zh) * 2015-04-30 2018-04-03 拜耳制药股份公司 Irak4抑制剂与btk抑制剂的组合产品
CN109071491A (zh) * 2016-04-29 2018-12-21 拜耳医药股份有限公司 吲唑的合成
CN109152771A (zh) * 2016-06-01 2019-01-04 拜耳医药股份有限公司 2-取代的吲唑用于治疗和预防自身免疫疾病的用途
CN109219603A (zh) * 2016-06-01 2019-01-15 拜耳动物保健有限责任公司 用于治疗和预防动物的过敏性和/或炎症性疾病的取代吲唑

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406416A (zh) * 2014-11-26 2017-11-28 拜耳医药股份有限公司 新型取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN107872977A (zh) * 2015-04-30 2018-04-03 拜耳制药股份公司 Irak4抑制剂与btk抑制剂的组合产品
EP3219329A1 (en) * 2016-03-17 2017-09-20 Bayer Pharma Aktiengesellschaft Combinations of copanlisib
CN109071491A (zh) * 2016-04-29 2018-12-21 拜耳医药股份有限公司 吲唑的合成
CN109152771A (zh) * 2016-06-01 2019-01-04 拜耳医药股份有限公司 2-取代的吲唑用于治疗和预防自身免疫疾病的用途
CN109219603A (zh) * 2016-06-01 2019-01-15 拜耳动物保健有限责任公司 用于治疗和预防动物的过敏性和/或炎症性疾病的取代吲唑

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WO2021213287A1 (zh) 2021-10-28
CN113521079A (zh) 2021-10-22

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