CN1152254A - 治疗食品组合物和降低血糖波动的方法 - Google Patents
治疗食品组合物和降低血糖波动的方法 Download PDFInfo
- Publication number
- CN1152254A CN1152254A CN95193996A CN95193996A CN1152254A CN 1152254 A CN1152254 A CN 1152254A CN 95193996 A CN95193996 A CN 95193996A CN 95193996 A CN95193996 A CN 95193996A CN 1152254 A CN1152254 A CN 1152254A
- Authority
- CN
- China
- Prior art keywords
- methods according
- carbohydrate
- fat
- protein
- cornstarch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 54
- 239000008280 blood Substances 0.000 title claims abstract description 26
- 210000004369 blood Anatomy 0.000 title claims abstract description 26
- 235000013305 food Nutrition 0.000 title claims abstract description 22
- 235000000346 sugar Nutrition 0.000 title claims abstract description 15
- 238000000034 method Methods 0.000 title claims description 30
- 230000001225 therapeutic effect Effects 0.000 title abstract description 4
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 44
- 235000014633 carbohydrates Nutrition 0.000 claims abstract description 44
- 208000013016 Hypoglycemia Diseases 0.000 claims abstract description 27
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 24
- 229920002261 Corn starch Polymers 0.000 claims abstract description 23
- 239000008120 corn starch Substances 0.000 claims abstract description 23
- 229940099112 cornstarch Drugs 0.000 claims abstract description 23
- 235000018102 proteins Nutrition 0.000 claims abstract description 21
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 21
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 21
- 235000011888 snacks Nutrition 0.000 claims abstract description 17
- 235000019197 fats Nutrition 0.000 claims description 18
- 238000010521 absorption reaction Methods 0.000 claims description 8
- 235000017060 Arachis glabrata Nutrition 0.000 claims description 6
- 244000105624 Arachis hypogaea Species 0.000 claims description 6
- 235000010777 Arachis hypogaea Nutrition 0.000 claims description 6
- 235000018262 Arachis monticola Nutrition 0.000 claims description 6
- 235000020232 peanut Nutrition 0.000 claims description 6
- 235000014571 nuts Nutrition 0.000 claims description 5
- 235000013336 milk Nutrition 0.000 claims description 4
- 239000008267 milk Substances 0.000 claims description 4
- 210000004080 milk Anatomy 0.000 claims description 4
- 235000021081 unsaturated fats Nutrition 0.000 claims description 4
- 108010073771 Soybean Proteins Proteins 0.000 claims description 3
- LPQOADBMXVRBNX-UHFFFAOYSA-N ac1ldcw0 Chemical compound Cl.C1CN(C)CCN1C1=C(F)C=C2C(=O)C(C(O)=O)=CN3CCSC1=C32 LPQOADBMXVRBNX-UHFFFAOYSA-N 0.000 claims description 3
- 235000015243 ice cream Nutrition 0.000 claims description 3
- 235000012771 pancakes Nutrition 0.000 claims description 3
- 235000011962 puddings Nutrition 0.000 claims description 3
- 235000019710 soybean protein Nutrition 0.000 claims description 3
- 102000004407 Lactalbumin Human genes 0.000 claims description 2
- 108090000942 Lactalbumin Proteins 0.000 claims description 2
- 230000007062 hydrolysis Effects 0.000 claims description 2
- 238000006460 hydrolysis reaction Methods 0.000 claims description 2
- 238000004080 punching Methods 0.000 claims 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 230000002218 hypoglycaemic effect Effects 0.000 abstract description 21
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 16
- 102000004877 Insulin Human genes 0.000 abstract description 8
- 108090001061 Insulin Proteins 0.000 abstract description 8
- 229940125396 insulin Drugs 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 2
- 235000021309 simple sugar Nutrition 0.000 abstract description 2
- 238000002560 therapeutic procedure Methods 0.000 abstract description 2
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 18
- 201000001421 hyperglycemia Diseases 0.000 description 6
- 238000010411 cooking Methods 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 235000008429 bread Nutrition 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 2
- 208000003443 Unconsciousness Diseases 0.000 description 2
- 210000004100 adrenal gland Anatomy 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940096919 glycogen Drugs 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 235000021400 peanut butter Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000002787 reinforcement Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 230000002618 waking effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 229920000945 Amylopectin Polymers 0.000 description 1
- 229920000856 Amylose Polymers 0.000 description 1
- 208000019901 Anxiety disease Diseases 0.000 description 1
- 208000002249 Diabetes Complications Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 102100036264 Glucose-6-phosphatase catalytic subunit 1 Human genes 0.000 description 1
- 101710099339 Glucose-6-phosphatase catalytic subunit 1 Proteins 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010028347 Muscle twitching Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- FRYDSOYOHWGSMD-UHFFFAOYSA-N [C].O Chemical compound [C].O FRYDSOYOHWGSMD-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001800 adrenalinergic effect Effects 0.000 description 1
- 230000003178 anti-diabetic effect Effects 0.000 description 1
- 239000003472 antidiabetic agent Substances 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- 239000008122 artificial sweetener Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N ferric oxide Chemical compound O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 235000011868 grain product Nutrition 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 235000003642 hunger Nutrition 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000006362 insulin response pathway Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000015205 orange juice Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000021085 polyunsaturated fats Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012797 qualification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000006794 tachycardia Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/16—Fatty acid esters
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/14—Organic oxygen compounds
- A21D2/18—Carbohydrates
- A21D2/186—Starches; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A21—BAKING; EDIBLE DOUGHS
- A21D—TREATMENT, e.g. PRESERVATION, OF FLOUR OR DOUGH, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS; PRESERVATION THEREOF
- A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
- A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
- A21D2/24—Organic nitrogen compounds
- A21D2/26—Proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L25/00—Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
- A23L25/30—Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
- A23L7/10—Cereal-derived products
- A23L7/117—Flakes or other shapes of ready-to-eat type; Semi-finished or partly-finished products therefor
- A23L7/126—Snacks or the like obtained by binding, shaping or compacting together cereal grains or cereal pieces, e.g. cereal bars
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L9/00—Puddings; Cream substitutes; Preparation or treatment thereof
- A23L9/10—Puddings; Dry powder puddings
- A23L9/12—Ready-to-eat liquid or semi-liquid desserts, e.g. puddings, not to be mixed with liquids, e.g. water, milk
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S426/00—Food or edible material: processes, compositions, and products
- Y10S426/808—Starch base snack product
Abstract
用于治疗糖尿病人降低血糖水平波动并防止低血糖发作的治疗食品组合物,每单位含有约20-50g营养物质,所述营养物质包括缓慢吸收的或消化的复合碳水化合物,优选玉米淀粉;更迅速吸收的碳水化合物;蛋白质,和脂肪,但基本上不含单糖。通过将新食品组合物作为晚上或就寝时间的小吃或在白天施用给接受胰岛素治疗或有可能引起低血糖活性的患者,来治疗糖尿病患者以降低血糖波动并防止低血糖。
Description
与申请有关的背景
本申请是1994年3月15日待审查申请08/213542的接续申请。
本发明涉及糖尿病的治疗方法。更具体地说,本发明涉及防止糖尿病患者血糖水平剧烈波动的治疗方法和组合物。
低血糖主要有两种。迅速的肾上腺释放引起出汗,震颤,心动过速,焦虑和饥饿。中枢神经系统的症状包括头晕,头痛,精神迟钝,意识模糊,行为不正常,抽搐以及丧失意识。低血糖经常发生或严重时,神经系统的症状更突出,而肾上腺期可能识别不出来。随着血浆葡萄糖的迅速降低或大波动(如在胰岛素反应中一样),肾上腺素能的症状就会明显(Harrison’sPrinciples of Internal Medicine,11th Ed.,McGraw-Hill BookCompany,New York,1987,p.1800)。
已经开发了许多方法以达到将糖尿病患者的血液葡萄糖保持在一相对稳定水平的目的,如开环的连续皮下胰岛素泵和多天注射胰岛素。这些强化的胰岛素方案是与家中的葡萄糖检测结合在一起的,许多患者通过每天刺指6-8次来测量其血液葡萄糖水平以确保接近要保持的正常血糖水平。开出这种处方是因为研究已经表明,通过避免过量的高血糖水平,可以改善糖尿病患者的长期排出。但是这种降低高血糖发作的方案还会使患者经历更低的血糖反应(低血糖)。
糖尿病并发症和控制试验的结果表明,强化胰岛素治疗,尽管它会延缓并减少长期视网膜,肾脏和神经病,但会使低血糖增加3-9倍,其中大多数是在夜间发作(L.Y.Dawson,Clinical Diabetes,11:88-96,1993),有时这些低血糖的发氏族严重的,而且会导致丧失意识和抽搐。严重低血糖在夜间更经常发生,而与在白天不同,患者在睡觉。醒来时,糖尿病患者可能会开始感觉到低血糖反应,而且可能会用糖来进行自我治疗以使其血糖恢复到正常范围。在睡着时,患者没有这种意识,因此这时的低血糖就更危险。
需要开发各种方法以便在连续强化治疗糖尿病过程中减少低血糖的发生。已经用玉米淀粉有效地防止与I型糖原贮存有关的低血糖,这种病在肝,肾和肠中有遗传性葡萄糖-6-磷酸酶活性缺失或缺陷,从而导致糖原在这些器官中积累和禁食期间的低血糖。在·摄取未烹调的玉米淀粉后6- 8小时都不会产生低血糖(J.I.Wolfsdorf,etal.,Am.J.Clin.Nutr.,51:1051-7,1990)。但是,用于这种治疗的玉米淀粉的剂量为每kg体重1.75g。该剂量远远高于糖尿病患者可以耐受的剂量。
另一项研究在在糖尿病患者中完成的,在患者住院期间供给玉米淀粉,结果血液中的葡萄糖水平的最低点降低。使儿童禁食,然后用未烹调的玉米淀粉作为标准就寝时间小吃的完全碳水化合物含量(30g的碳水化合物)给他们(M.T..Ververs et al.,Eur.J.Clin.Nutr.,47:268-73,1983)。然而,在该项研究中,玉米淀粉并未能防止低血糖,而且研究人员也未对不同剂量进行评价以确定最大效力。
因此,还需要一种更好的方法来治疗I型和II型糖尿病。具体地说,需要治疗或保持的方法来避免严重的低血糖发作,同时又不会引发高血糖。
通过摄取治疗食品组合物来调节和稳定糖尿病患者中的血液葡萄糖水平,所述组合物含糊缓慢代谢的复合碳水化合物,优选未烹调的玉米淀粉,更迅速代谢的复合碳水化合物,蛋白质和脂肪。所述食品组合物从胃肠道缓慢吸收,然后在糖尿病患者中可保持高达9小时的相对稳定的血糖水平。
优选在就寝时间前将所述水平组合物(可以是小吃形式的)施用给糖尿病患者,而且可基本有效地防止低血糖的夜间发作,同时又不会引起高血糖。
本发明涉及施用给患I型或II型糖尿病患者的治疗水平组合物,以帮助保持适当的血液葡萄糖调节并防止其大的波动,即低血糖和高血糖发作。将治疗组合物作为治疗全过程中的一部分施用,所述全过程包括控制饮食,施用胰岛素和/或在适当情况下的其他药疗法。
新食品组合物含有其必要组分:
a) 从人胃肠道缓慢吸收的复合碳水化合物(下文称为“缓慢吸收的碳水化合物”),即消化缓慢,而且甚至在3-4小时后均不能完全代谢;
b) 从消化道更迅速吸收的复合碳水化合物(下文称为“迅速吸收的碳水化合物”);
c) 蛋白质;和
d) 脂肪。
如本文所用的,术语“复合碳水化合物”指包括淀粉,多聚葡萄糖和其他多糖的大分子碳水化合物。
含前述组分的治疗组合物可以是任何传统“小吃”形式,如,棒,布丁,小饼,薄饼,牛奶和冰激淋等的混合饮料等。模仿糖果或燕麦花卷棒的小吃型棒最便于贮存,运送和施用目的,而用划线,打孔或刻槽于其上生产的时,在适当时很容易用于分开达到施用部分棒的目的。
新食品组合物优选每份或单位,如棒含有约20到约50g的营养物质,包含:
· 约17-24g的总碳水化合物(约5-15g缓慢吸收的碳水化合物和约7-19g迅速吸收的碳水化合物);
· 约5-20g的蛋白质;和
· 约3-7g的脂肪,优选至少三分之一的单不饱和脂肪。
本文所用的术语“营养物质”指碳水化合物,蛋白质和脂肪。
本发明的治疗食品组合物优选每份或单位提供约115-230卡,其中:
· 约50-70%来自缓慢吸收的和迅速吸收的复合碳水化合物;
· 约15-25%来自蛋白质;和
· 约15-25%来自脂肪。
在本发明优选的实施方案中,新食品组合物是棒形式,包含17-24g的总碳水化合物,或在标准糖尿病食谱中,一对一和一半的“面包交换”当量。所述棒含有约5-15g缓慢吸收的未烹调玉米淀粉形式的碳水化合物,所述玉米淀粉通常含有约27%重的直链淀粉和73%重的支链淀粉。优选的实施方案还含有约7-19g迅速吸收的复合碳水化合物,但基本上不含单糖;约5-20g蛋白质;和约3-7g脂肪,至少三分之一是单不饱和脂肪。
在支链食品组合物中的成分可饱和任何足够的纯度和特效性的传统食谱成分,优选它们可提供前述的总卡路里量和分别来自碳水化合物,蛋白质和脂肪的卡路里百分比,其中缓慢吸收的碳水化合物,迅速吸收的碳水化合物,蛋白质和脂肪的相对重量范围按前文的说明。在小吃型棒的优选实施方案中,成分可包括,例如,未烹调玉米淀粉作为缓慢吸收的碳水化合物;多聚葡萄糖,花生,花生衍生物(如花生酱),其他坚果或坚果衍生物作为迅速吸收的碳水化合物源,脂肪和蛋白质;以及其他蛋白质源如大豆蛋白质,乳清蛋白和酪蛋白水解产物。在食品组合物中可以饱和人工甜味剂或糖替代物〔甜菊苷或山梨醇),但不饱和单糖如果糖。还可以使用在小吃或糖果型棒制备中常用的着色剂,水,盐,防腐剂和其他标准成分或添加剂,只要最终棒或其他形式的新食品组合物的总营养物质和卡路里在上述限定的参数范围内。
由于未烹调的玉米淀粉的碳水化合物含量和其代谢率是已知的,而且相当均一,而且它容易配制到各种美味的食品组合物中,所以未烹调的玉米淀粉是本发明优选的缓慢吸收的碳水化合物。
许多糖尿病消费含约30g碳水化合物的就寝时间小吃,通常是面包,谷类制品或牛奶。借助本发明的治疗方法,给患糖尿病的患者施用一到两份或单位的治疗食谱组合物,例如根据本发明制备的一到两棒,来代替或部分代替其正常的晚上或就寝时间前的小吃(与其被要求的面包和蛋白质交换一致)。施用单位的数量,包括单位份数(例如半个棒)取决于患者的年龄,体重和疾病状况(不论患者摄取胰岛素或其他抗糖尿病药物与否)以及通过刺指血液葡萄糖水平或其他血糖治疗平均值确定的患者夜间血糖图。治疗的目的是防止血液葡萄糖水平低于60mg/dl(按低血糖定义的),又不会高于约250mg/dl(按高血糖定义的)。
在较小的儿科患者或夜间几乎不发作低血糖的患者中,可以施用比一单位少的剂量。
在用糖尿病儿童和青少年进行的临床研究中已经发现根据本发明制备的水平组合物,并按本文所述施用,在摄取后8-9小时或更长的时间,能够有效地将血糖水平保持在60mg/dl一250 mg/dl在“正常”范围内。
还可以在白天,用预先测量的新食品组合物剂量治疗施用胰岛素以促进葡萄糖食后吸收的患者,所述新食品组合物将在6-8小时被缓慢地代谢成单糖葡萄糖,这样来代替接受易引起血液葡萄糖水平迅速产生快速下降的峰的简单碳水化合物,如橙汁或其他糖源。在醒着的时间里,患者的葡萄糖利用和要求不同,而且取决于活动的水平和类型,如剧烈练习。因此确切的量和实际剂量的频率将因患者的不同而不同,而且对于每个患者来说,每天与每天也不同。可以用血液葡萄糖试验(通常用刺指以得到血样)来监测每天的葡萄糖水平,也用患者自己与低血糖发作有关的症状的主观经验来监测。因此,在本发明的实践中,以新食品组合物的形式施用了足够的复合碳水化合物以使血液葡萄糖水平保持在平均患者中正常约60mg/dl这个水平上一点。
在医药和具体糖尿病患者管理领域中的专业人员应该理解,本发明的组合物和方法对于传统食谱管理和药物或胰岛素治疗是很有帮助的,而且容易施用和接受的方式以避免血液葡萄糖水平出现过高的峰和谷,特别是由许多糖尿病人经历的低血糖发作。
下面是本发明新组合物和方法的说明性实施例。但这些实施例不是为了提供成分,具体的配方生产方法或剂量方式,这些是仅仅为实施本发明必须使用的。实施例1含玉米淀粉的棒
根据本发明以小吃型香草坚果棒形式制备治疗食谱组合物。棒共重31g,含山梨醇,玉米淀粉,大豆蛋白质分离物,花生酱,水,多聚葡萄糖,花生,乳清蛋白浓缩物,天然香精,卵磷脂和柠檬酸。
在营养学上,棒提供了120卡路里(一个面包的当量),其中约54%来自碳水化合物,23%来自蛋白质,23%来自脂肪。所述棒饱和7g蛋白质,约3g总脂肪;约0.5g饱和脂肪,1g多不饱和脂肪和1g单不饱和脂肪。
所述棒的总碳水化合物含量为17g,其中5g是玉米淀粉(未烹调的),约12g是主要由多聚葡萄糖和花生提供的迅速吸收的碳水化合物。
所述棒含95mg钠和40mg钾。实施例2治疗糖尿病患者
将实施例1中的棒施用给以前经历了夜间低血糖发作的8名糖尿病儿童。每名儿童消费一个棒作为他或她常规夜间小吃的一部分,连续3-5个晚上,在夜间和在醒来后的早晨对每名患者的血液葡萄糖水平测量数次。
如在下文表1所列的数据,只有一名患者在消费了治疗棒后有低血糖,而且在从那个患者取的12个样品中,只有一个血糖读数超出正常,具有定义为血液葡萄糖水平<60mg/dl的低血糖。相反,所与患者在其消费了不含玉米淀粉的常规夜间小吃后,以前都曾经历过中度到严重的夜间低血糖发作。
表1
血液葡萄糖读数(mg/dl)患者1:天 1 2 3 4 50 68 340 188 221 1721 652 103 248 197 161 1693 864 1165 165 203 169 149 1396 1757 2048 236 177 141 115 81患者2:天 1 2 3 40 57 74 61 1651 772 643 86 82 72 784 815 776 96 94 182 1257 988 80 82 172 163患者3:天 1 2 3 4 50 144 51 219 256 1011 2012 146 226 153 106 883 1764 96 101 180 87 935 746 98 131 155 86 857 928 114 211 279 114 142患者4:天 1 2 3 4 50 160 144 88 96 1441 1022 100 95 66 206 22834 97 50 83 265 14656 10578 122 153 72 203 84患者5:天 1 2 3 4 50 53 154 99 117 681 164 122 138 199 852 128 157 148 194 1033 146 158 175 175 864 124 156 122 124 1165 116 157 131 140 1656 102 156 105 139 1757 108 160 107 132 2048 118 167 110 149 285患者6:天 1 2 30 52 129 212123 106 83 188456 97 13278 124 175 179患者7:天 1 2 3 40 134 78 67 242123456 177 115 13278 196 132 169 205患者8:天 1 2 30 320 160 36512 269 327 2643456 282 387 22878 175 322 223
新食品组合物的独特配给,混合了缓慢和迅速吸收的碳水化合物,蛋白质和脂肪,使复合碳水化合物逐渐水解并吸收,使血糖水平稳定达8-9个小时,消除了食后期间糖尿病患者中的低血糖。
因此, 已经表明提供了达到本发明各种目的并很符号实施应用条件的组合物和方法。
象各种可能的实施方案可在上述本发明基础上制备一样,在上述实施方案的基础上可进行各种改变,认为本文描述的所有物质均作了说明性解释,但不是限制意义的。
在下列权利要求中列出了由文字专利要求保护的新的和需要被保护的。
Claims (28)
1 用于治疗糖尿病患者以消除血糖水平的波动并防止低血糖发作的治疗食品组合物,每份或单位含有约20-50g的营养物质,包括:
a) 约5-15g缓慢吸收的复合碳水化合物;
b) 约7-19g迅速吸收的复合碳水化合物;
c) 约5-20g蛋白质;和
d) 约3-7g脂肪。
2 根据权利要求1的组合物,总碳水化合物含量为约17-24g。
3 根据权利要求1的组合物,其中所述缓慢吸收的碳水化合物是玉米淀粉。
4 根据权利要求3的组合物其中所述玉米淀粉是未烹调的。
5 根据权利要求3的组合物,每单位含有约5 g的玉米淀粉。
6 根据权利要求1的组合物,其中至少所述脂肪的三分之一是单不饱和脂肪。
7 用于治疗糖尿病患者以消除血糖水平的波动并防止低血糖发作的治疗食品组合物,所述组合物每份或单位提供约115-230卡路里,其中:
a)约50-70%来自缓慢吸收和迅速吸收的复合碳水化合物;
b)约15-25%来自蛋白质;和
c)约15-20%来自脂肪。
8 根据权利要求1或7的组合物是小吃棒,布丁,饼,薄饼和牛奶和冰激淋等的混合饮料形式。
9 根据权利要求8的组合物是小吃棒形式。
10 根据权利要求9的组合物,其中所述棒用在其上划线,打孔和划槽以便于分成部分单位而生产的。
11 根据权利要求1或7的组合物,基本上没有单糖。
12 根据权利要求1或7的组合物,其中所述迅速吸收的碳水化合物,蛋白质,脂肪由多聚葡萄糖,花生,花生衍生物或其他坚果或坚果衍生物提供。
13 根据权利要求1或7的组合物,其中所述蛋白质有大豆蛋白质,乳清蛋白或酪氨酸水解产物提供。
14 治疗糖尿病患者以消除血糖水平波动并防止低血糖发作的方法,所述方法包括给患者施用每份或单位含约20-50g营养物质的治疗食品组合物,包括:
a) 缓慢吸收的复合碳水化合物;
b) 迅速吸收的复合碳水化合物;
c) 蛋白质;和
d) 脂肪。
15 根据权利要求14的方法,其中所述组合物每单位含有:
a) 约5-15g缓慢吸收的复合碳水化合物;
b) 约7-19g迅速吸收的复合碳水化合物;
c) 约5-20g蛋白质;和
d) 约3-7g脂肪。
16 根据权利要求15的方法,其中所述组合物每单位含约共17-24g的碳水化合物。
17 根据权利要求14的方法,其中所述缓慢吸收的碳水化合物是玉米淀粉。
18 根据权利要求17的方法,其中所述玉米淀粉是未烹调的。
19 根据权利要求17的方法,其中所述组合物每单位含约5g玉米淀粉。
20 根据权利要求14的方法,其中至少三分之一的所述脂肪是单不饱和的。
21 根据权利要求14的方法,其中所述组合物是小吃棒,布丁,饼,薄饼和牛奶和冰激淋等的混合饮料形式。
22 根据权利要求21的方法,其中所述组合物是小吃棒形式。
23 根据权利要求22的方法,其中所述棒用在其上划线,打孔和划槽以便于分成部分单位而生产的。
24 根据权利要求14的方法,其中将约1-2单位的所述组合物施用给患者。
25 根据权利要求14的方法,其中将半单位的所述组合物施用给患者。
26 根据权利要求14的方法,其中将所述组合物作为晚上或就寝时间前的小吃施用给患者。
27 根据权利要求14的方法,其中将所述组合物在白天施用给接受胰岛素治疗或忙于锻练的患者。
28 根据权利要求14的方法,其中所述患者是儿童或青少年。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/418,210 US5605893A (en) | 1994-03-15 | 1995-04-07 | Method of using a therapeutic food composition to diminish blood sugar fluctuations in diabetic patients |
US08/418,210 | 1995-04-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1152254A true CN1152254A (zh) | 1997-06-18 |
Family
ID=23657160
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95193996A Pending CN1152254A (zh) | 1995-04-07 | 1995-08-25 | 治疗食品组合物和降低血糖波动的方法 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5605893A (zh) |
EP (1) | EP0765126B1 (zh) |
JP (1) | JP3589673B2 (zh) |
CN (1) | CN1152254A (zh) |
AR (1) | AR001286A1 (zh) |
AT (1) | ATE216564T1 (zh) |
AU (1) | AU718692B2 (zh) |
BR (1) | BR9507944A (zh) |
CA (1) | CA2191714C (zh) |
DE (1) | DE69526501D1 (zh) |
FI (1) | FI964884A (zh) |
IL (1) | IL115470A (zh) |
NZ (1) | NZ292038A (zh) |
WO (1) | WO1996031129A1 (zh) |
ZA (1) | ZA957800B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100342329C (zh) * | 1999-02-02 | 2007-10-10 | 太阳微系统有限公司 | 零开销异常处理 |
CN104286849A (zh) * | 2014-09-26 | 2015-01-21 | 上海励成营养产品科技股份有限公司 | 一种糖尿病专用型肠内营养多聚合剂 |
CN105941540A (zh) * | 2016-07-14 | 2016-09-21 | 福建万亿店中店电子商务有限责任公司 | 一种低血糖的糖尿病患者适用的面包 |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843921A (en) | 1994-03-15 | 1998-12-01 | Childrens Hospital Of Los Angeles | Therapeutic food composition and method to diminish blood sugar fluctuations |
MY115050A (en) * | 1995-10-16 | 2003-03-31 | Mead Johnson Nutrition Co | Diabetic nutritional product having controlled absorption of carbohydrate |
JP2000509258A (ja) * | 1996-04-12 | 2000-07-25 | ベス・イスラエル・デイーコネス・メデイカル・センター・インコーポレーテツド | 糖尿病用補足バー |
US5866555A (en) * | 1997-03-12 | 1999-02-02 | Beth Israel Deaconess Medical Center | Diabetic supplement bar |
US5902797A (en) * | 1997-11-10 | 1999-05-11 | Beth Israel Deaconess Medical Center | Nutritional supplement for use in the treatment of attention deficit |
US5968896A (en) * | 1998-01-16 | 1999-10-19 | Beth Israel Deaconess Medical Center | Nutritional supplement for preoperative feeding |
US6458378B1 (en) * | 1999-03-16 | 2002-10-01 | The Iams Company | Pet food composition for controlling postprandial glycemic response |
US5932258A (en) * | 1998-04-06 | 1999-08-03 | The Iams Company | Composition and process for improving glucose metabolism in companion animals |
AU4573799A (en) * | 1998-06-19 | 2000-01-05 | Beth Israel Deaconess Medical Center | Dietary supplement for individuals under stress |
US6630159B2 (en) * | 1999-02-23 | 2003-10-07 | The Procter & Gamble Company | Limiting weight gain of cats by feeding carbohydrate source that excludes rice |
US7001618B1 (en) | 1999-07-09 | 2006-02-21 | The Iams Company | Nutritional composition for weight management |
US6238708B1 (en) * | 1999-02-23 | 2001-05-29 | The Iams Company | Composition and process for controlling glucose metabolism in companion animals by dietary starch |
US6534487B1 (en) * | 1999-08-03 | 2003-03-18 | Childrens Hospital Los Angeles | Methods for suppressing appetite and enhancing exercise and recovery |
US6905702B1 (en) * | 1999-11-08 | 2005-06-14 | Children's Hospital Los Angeles | Methods for regulating blood glucose and appetite suppression in type 2 diabetics |
GB2372446A (en) * | 1999-11-08 | 2002-08-28 | Los Angeles Childrens Hospital | Methods for regulating blood glucose and appetite suppression in type 2 diabetics |
DE19954233A1 (de) | 1999-11-11 | 2001-05-31 | Nutricia Nv | Diabetikernahrung |
US6248375B1 (en) * | 2000-03-14 | 2001-06-19 | Abbott Laboratories | Diabetic nutritionals and method of using |
US6316427B1 (en) | 2000-04-04 | 2001-11-13 | Metcon Medicin Ab | Treatment for diabetes |
EP1169923B1 (en) * | 2000-07-07 | 2005-09-21 | Ridley Block Operations, Inc. | Solid nutritional foods and methods of making the same |
DE60121981D1 (de) * | 2000-10-25 | 2006-09-14 | Metcon Medicin Ab | Zusammensetzung zur behandlung von störungen des blutzuckerstoffwechsels und verfahren zu ihrer herstellung |
MY135783A (en) * | 2001-09-07 | 2008-06-30 | Meiji Dairies Corp | Nutritional composition for controlling blood sugar level |
SE526943C2 (sv) * | 2002-08-26 | 2005-11-22 | Indevex Ab | Födoämneskompositionsprodukt |
US20060100171A1 (en) * | 2002-09-09 | 2006-05-11 | Ekhart Peter F | Branched alpha-glucans for weight management |
US20040052915A1 (en) * | 2002-09-13 | 2004-03-18 | Carlson Ting L. | Use of low glycemic index sweeteners in food and beverage compositions |
CA2521620C (en) * | 2003-04-11 | 2012-11-27 | Cargill, Incorporated | Pellet systems for preparing beverages |
ITVI20030105A1 (it) * | 2003-05-26 | 2004-11-27 | Roberto Menardi | Prodotto dietetico particolarmente idoneo per |
US20050202063A1 (en) * | 2003-08-26 | 2005-09-15 | Ebn International Kft | Food product |
US20050058766A1 (en) * | 2003-09-11 | 2005-03-17 | Han Chung Wan | Anti-diabetic diet and method for providing a proportioned ground food |
US20050058759A1 (en) * | 2003-09-15 | 2005-03-17 | Schmidt James Carl | Protein enhanced low carbohydrate snack food |
GB0325942D0 (en) * | 2003-11-06 | 2003-12-10 | Glycologic Ltd | Compositions and uses thereof |
US20050186306A1 (en) * | 2004-02-19 | 2005-08-25 | Susanne Sonneveld | Low carbohydrate cereal-like food product |
CA2559470A1 (en) * | 2004-03-17 | 2005-09-29 | Cargill, Incorporated | Low glycemic sweeteners and products made using the same |
ES2444847T3 (es) * | 2005-02-15 | 2014-02-27 | Cargill, Incorporated | Procedimientos de preparación de jarabes |
AU2006266551B2 (en) * | 2005-07-05 | 2011-12-08 | N.V. Nutricia | A carbohydrate fraction and use thereof for a flat postprandial glucose response |
US10058117B2 (en) * | 2009-11-23 | 2018-08-28 | Randall Scott Hickle | Dietary health food composition, package and method of use |
AR087159A1 (es) | 2011-06-20 | 2014-02-26 | Gen Biscuit | Galletita para desayuno con glucosa de lenta disponibilidad |
US20140212494A1 (en) * | 2011-09-22 | 2014-07-31 | Purdue Research Foundation | Methods of Improving Digestive Health |
US9345727B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component and uses thereof |
US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
US8889633B2 (en) | 2013-03-15 | 2014-11-18 | Mead Johnson Nutrition Company | Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof |
US9352020B2 (en) | 2013-03-15 | 2016-05-31 | Mead Johnson Nutrition Company | Reducing proinflammatory response |
US9345741B2 (en) | 2013-03-15 | 2016-05-24 | Mead Johnson Nutrition Company | Nutritional composition containing a peptide component with adiponectin simulating properties and uses thereof |
US9138455B2 (en) | 2013-03-15 | 2015-09-22 | Mead Johnson Nutrition Company | Activating adiponectin by casein hydrolysate |
AU2016219070B2 (en) | 2015-02-13 | 2020-06-11 | Mars, Incorporated | Pet food feeding system |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3619209A (en) * | 1968-08-21 | 1971-11-09 | Gen Foods Corp | Pudding composition containing lipid ester |
US3969514A (en) * | 1974-07-17 | 1976-07-13 | Swift & Company | Combination food product having discrete phases of nut spread and of a second food spread |
JPS5974976A (ja) * | 1982-10-25 | 1984-04-27 | Yasutake Hichi | 血糖値上昇抑制剤を添加した飲食物 |
US5169662A (en) * | 1989-08-31 | 1992-12-08 | New Generation Foods, Inc. | Dietary product and method for manufacture |
EP0422307A1 (en) * | 1989-10-10 | 1991-04-17 | Merrell Dow Pharmaceuticals Inc. | Novel alpha-glucosidase inhibitors |
JPH0728693B2 (ja) * | 1990-02-20 | 1995-04-05 | 松谷化学工業株式会社 | インシュリン分泌を抑制する食品組成物 |
FR2673812B1 (fr) * | 1991-03-13 | 1994-04-01 | Roussel Uclaf | Nouvelles compositions destinees a etre utilisees en dietetique et en therapeutique et renfermant une combinaison particuliere de glucides et leurs applications. |
US5356879A (en) * | 1992-02-14 | 1994-10-18 | Biospherics, Incorporated | D-tagatose as anti-hyperglycemic agent |
IL112967A0 (en) * | 1994-03-15 | 1995-06-29 | Los Angeles Childrens Hospital | Pharmaceutical compositions comprising a complex carbohydrate to diminish hypoglycemia in patients with diabetes mellitus |
-
1995
- 1995-04-07 US US08/418,210 patent/US5605893A/en not_active Expired - Lifetime
- 1995-08-25 NZ NZ292038A patent/NZ292038A/en not_active IP Right Cessation
- 1995-08-25 JP JP53026696A patent/JP3589673B2/ja not_active Expired - Fee Related
- 1995-08-25 CN CN95193996A patent/CN1152254A/zh active Pending
- 1995-08-25 AU AU33728/95A patent/AU718692B2/en not_active Expired
- 1995-08-25 EP EP95930278A patent/EP0765126B1/en not_active Expired - Lifetime
- 1995-08-25 DE DE69526501T patent/DE69526501D1/de not_active Expired - Lifetime
- 1995-08-25 AT AT95930278T patent/ATE216564T1/de not_active IP Right Cessation
- 1995-08-25 CA CA002191714A patent/CA2191714C/en not_active Expired - Lifetime
- 1995-08-25 WO PCT/US1995/010803 patent/WO1996031129A1/en active IP Right Grant
- 1995-08-25 BR BR9507944A patent/BR9507944A/pt not_active Application Discontinuation
- 1995-09-15 ZA ZA957800A patent/ZA957800B/xx unknown
- 1995-09-29 IL IL11547095A patent/IL115470A/xx not_active IP Right Cessation
-
1996
- 1996-03-14 AR AR33574696A patent/AR001286A1/es unknown
- 1996-12-05 FI FI964884A patent/FI964884A/fi not_active Application Discontinuation
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100342329C (zh) * | 1999-02-02 | 2007-10-10 | 太阳微系统有限公司 | 零开销异常处理 |
CN104286849A (zh) * | 2014-09-26 | 2015-01-21 | 上海励成营养产品科技股份有限公司 | 一种糖尿病专用型肠内营养多聚合剂 |
CN105941540A (zh) * | 2016-07-14 | 2016-09-21 | 福建万亿店中店电子商务有限责任公司 | 一种低血糖的糖尿病患者适用的面包 |
Also Published As
Publication number | Publication date |
---|---|
DE69526501D1 (de) | 2002-05-29 |
MX9606068A (es) | 1998-06-28 |
ZA957800B (en) | 1996-05-06 |
BR9507944A (pt) | 1997-09-02 |
CA2191714C (en) | 2002-04-23 |
FI964884A (fi) | 1997-02-06 |
AR001286A1 (es) | 1997-10-08 |
AU718692B2 (en) | 2000-04-20 |
IL115470A0 (en) | 1995-12-31 |
CA2191714A1 (en) | 1996-10-10 |
JP3589673B2 (ja) | 2004-11-17 |
AU3372895A (en) | 1996-10-23 |
IL115470A (en) | 2000-06-01 |
NZ292038A (en) | 1998-09-24 |
ATE216564T1 (de) | 2002-05-15 |
EP0765126A1 (en) | 1997-04-02 |
JPH11500625A (ja) | 1999-01-19 |
EP0765126B1 (en) | 2002-04-24 |
WO1996031129A1 (en) | 1996-10-10 |
FI964884A0 (fi) | 1996-12-05 |
US5605893A (en) | 1997-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1152254A (zh) | 治疗食品组合物和降低血糖波动的方法 | |
Anderson | Plant fiber and blood pressure | |
US6774111B1 (en) | Carbohydrate system and a method for providing nutrition to a diabetic | |
Jenkins et al. | Starchy foods and fiber: reduced rate of digestion and improved carbohydrate metabolism | |
US5422346A (en) | Instant dried dahlia inulin juice and its method of production and usage | |
EP1202639B1 (en) | Method for suppressing appetite | |
CN1191085A (zh) | 一种无糖冰淇淋及其制备方法 | |
EP2294932B1 (en) | Carbohydrate mixture and the use thereof for preparing a product for oral or enteral nutrition | |
CN1101133C (zh) | 具有降血糖作用的缮食纤维百乐饼干的配方及其生产工艺 | |
WO2001033976A1 (en) | Methods for regulating blood glucose and appetite suppression in type 2 diabetics | |
Venhaus et al. | Self-selected unrefined and refined carbohydrate diets do not affect metabolic control in pump-treated diabetic patients | |
JPH01500030A (ja) | 低カロリ−状態での窒素保持のための成長ホルモンの使用 | |
CN112715961A (zh) | 一种有助于老年糖尿病人增肌的食品组合物 | |
CN1197485C (zh) | 无糖蛋白营养液 | |
CN1969640B (zh) | 酮食液体奶 | |
CN110771762A (zh) | 一种适用于糖尿病人的具有对抗术前术后应激反应的功能性饮料 | |
CN1742628A (zh) | 糖尿病人营养治疗食品膳食纤维素粉产品 | |
CN1256883A (zh) | 降糖南瓜营养面粉 | |
CN117356715A (zh) | 一种低卡益生元糖浆及其制备方法和应用 | |
CN114176180A (zh) | 一种调理血糖平衡的功能性饮料 | |
CN115644426A (zh) | 一种糖尿病康复方法 | |
CN1256897A (zh) | 降糖南瓜枸杞系列果茶 | |
Powers et al. | The fructose story | |
Del Toma et al. | Nutrition and Diabetes Management Unit, Ospedale Forlanini, 00149 | |
Mascioli | Very-Low-Calorie Diets |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C01 | Deemed withdrawal of patent application (patent law 1993) | ||
WD01 | Invention patent application deemed withdrawn after publication |