CN115212274A - Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof - Google Patents
Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof Download PDFInfo
- Publication number
- CN115212274A CN115212274A CN202210731994.9A CN202210731994A CN115212274A CN 115212274 A CN115212274 A CN 115212274A CN 202210731994 A CN202210731994 A CN 202210731994A CN 115212274 A CN115212274 A CN 115212274A
- Authority
- CN
- China
- Prior art keywords
- radix
- chinese medicine
- traditional chinese
- chronic colitis
- root
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 55
- 230000001684 chronic effect Effects 0.000 title claims abstract description 34
- 206010009887 colitis Diseases 0.000 title claims abstract description 33
- 238000000855 fermentation Methods 0.000 title claims abstract description 28
- 230000004151 fermentation Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 210000000582 semen Anatomy 0.000 claims abstract description 10
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims abstract description 7
- 241000756943 Codonopsis Species 0.000 claims abstract description 6
- 241000726221 Gemma Species 0.000 claims abstract description 6
- 239000009636 Huang Qi Substances 0.000 claims abstract description 6
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 6
- 240000008669 Hedera helix Species 0.000 claims abstract description 5
- 239000009806 pulsatillae Substances 0.000 claims abstract description 5
- 235000013399 edible fruits Nutrition 0.000 claims description 12
- 244000077995 Coix lacryma jobi Species 0.000 claims description 9
- 235000010580 Psophocarpus tetragonolobus Nutrition 0.000 claims description 9
- 241000206469 Pulsatilla Species 0.000 claims description 9
- 241000046198 Triteleia hyacinthina Species 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 235000013372 meat Nutrition 0.000 claims description 9
- 244000307697 Agrimonia eupatoria Species 0.000 claims description 8
- 241000132012 Atractylodes Species 0.000 claims description 8
- 241000007126 Codonopsis pilosula Species 0.000 claims description 8
- 240000005717 Dioscorea alata Species 0.000 claims description 8
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 8
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 8
- 235000017443 Hedysarum boreale Nutrition 0.000 claims description 8
- 235000007858 Hedysarum occidentale Nutrition 0.000 claims description 8
- 230000002457 bidirectional effect Effects 0.000 claims description 8
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 claims description 8
- 239000001963 growth medium Substances 0.000 claims description 8
- 241001523681 Dendrobium Species 0.000 claims description 7
- 244000170916 Paeonia officinalis Species 0.000 claims description 7
- 235000006484 Paeonia officinalis Nutrition 0.000 claims description 7
- 241001180876 Saposhnikovia Species 0.000 claims description 7
- 235000000125 common agrimony Nutrition 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 241000675108 Citrus tangerina Species 0.000 claims description 6
- 244000197580 Poria cocos Species 0.000 claims description 6
- 235000008599 Poria cocos Nutrition 0.000 claims description 6
- 244000046146 Pueraria lobata Species 0.000 claims description 6
- 235000010575 Pueraria lobata Nutrition 0.000 claims description 6
- 239000000725 suspension Substances 0.000 claims description 6
- 229940107666 astragalus root Drugs 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 241000045403 Astragalus propinquus Species 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 3
- 235000006533 astragalus Nutrition 0.000 claims description 3
- 239000008103 glucose Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000008223 sterile water Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 22
- 229940079593 drug Drugs 0.000 abstract description 7
- 241000196324 Embryophyta Species 0.000 abstract description 6
- 238000010521 absorption reaction Methods 0.000 abstract description 4
- 244000005700 microbiome Species 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract description 4
- 238000009472 formulation Methods 0.000 abstract description 2
- 231100000419 toxicity Toxicity 0.000 abstract description 2
- 230000001988 toxicity Effects 0.000 abstract description 2
- 230000001737 promoting effect Effects 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 9
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 210000002784 stomach Anatomy 0.000 description 6
- 206010012735 Diarrhoea Diseases 0.000 description 5
- 208000004880 Polyuria Diseases 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000035619 diuresis Effects 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- 206010030113 Oedema Diseases 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 210000005260 human cell Anatomy 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000010563 solid-state fermentation Methods 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 235000016993 Agrimonia Nutrition 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 208000004262 Food Hypersensitivity Diseases 0.000 description 1
- 206010016946 Food allergy Diseases 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 244000116484 Inula helenium Species 0.000 description 1
- 235000002598 Inula helenium Nutrition 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- 235000001188 Peltandra virginica Nutrition 0.000 description 1
- 206010051986 Pneumatosis Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000020932 food allergy Nutrition 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 210000003097 mucus Anatomy 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 210000000664 rectum Anatomy 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000001599 sigmoid colon Anatomy 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 210000004876 tela submucosa Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/285—Aucklandia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8994—Coix (Job's tears)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
A biologically fermented Chinese medicinal formulation for treating chronic colitis is prepared from radix Puerariae Preparata, radix Saposhnikoviae Preparata, atractylodis rhizoma, fructus Caricae, pericarpium Citri Tangerinae Preparata, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali; a preparation method of a biological fermentation traditional Chinese medicine prescription for treating chronic colitis comprises four steps. The invention adopts a plurality of traditional Chinese medicine formula proportions effective in treating chronic colitis, and the finished product of the formula prepared by a fermentation process decomposes the micro toxicity in natural plant medicines by microorganisms, and the effective components in the medicines are circulated into components with smaller molecular weight and easier absorption by organism cells, thereby effectively improving the medicine effect and playing a powerful support for curing chronic colitis. Based on the above, the invention has good application prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine formulas and preparation methods, in particular to a biological fermentation traditional Chinese medicine formula for treating chronic colitis and a preparation method.
Background
Chronic colitis is a chronic, recurrent and multiple disease, and inflammatory edema, ulcer and bleeding lesions of intestinal tracts are caused by various pathogenic reasons, and are generally limited to mucous membranes and submucosa, and frequently occur in rectum, sigmoid colon and even whole colon. The disease is characterized by long course of disease, repeated attack in chronic, abdominal pain and diarrhea as main symptoms, mucus and stool and constipation or diarrhea occur alternately, the time is good and good, and the disease is continuous, and can be seen at any age, but the disease is more common in young and strong years of 20 to 30 years old, and in recent years, the patients with serious symptoms are more common in middle-aged and elderly people, and the proportion of male and female is not obviously different. The research suggests that the pathogenic cause is often related to mental factors such as infection, hypoimmunity, heredity, food allergy, defense dysfunction and the like, and the common causes are also related to nonspecific colitis, irritable bowel syndrome, inflammatory bowel disease, antibiotics abuse, intestinal flora imbalance, small intestine malabsorption and the like.
At present, the treatment of chronic colitis generally adopts western medicine mode treatment, and the western medicine mode has the defect of treating both symptoms and root causes, so that patients after treatment often relapse due to the influence of various factors. The traditional Chinese medicine has the advantage of treating the root cause of diseases, but in the treatment of chronic colitis, no traditional Chinese medicine formula can effectively treat the chronic colitis in the currently known technology, so that the provision of the formula for treating the chronic colitis and the preparation method thereof are particularly necessary.
Disclosure of Invention
In order to overcome the defect that no prescription can effectively treat the chronic colitis and treat the primary and secondary symptoms, the invention provides a biological fermentation traditional Chinese medicine prescription for treating the chronic colitis and a preparation method thereof, wherein multiple prescriptions effective for the chronic colitis are mixed, natural plant medicines are used as culture media to carry out bidirectional selective fermentation with different strains, the micro-toxicity in the natural plant medicines is decomposed by microorganisms, and effective components in the medicines are circulated into components with smaller molecular weight and easier absorption through organism cells, so that the medicine effect is effectively improved, and the biological fermentation traditional Chinese medicine prescription for treating the chronic colitis and the preparation method thereof play a powerful support for curing the chronic colitis.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a biological fermentation traditional Chinese medicine formula for treating chronic colitis is characterized in that the adopted traditional Chinese medicine raw materials comprise stewed kudzuvine root, stewed divaricate saposhnikovia root, largehead atractylodes rhizome, stewed fruit, stewed tangerine peel, costustoot, raw white paeony root, honey-fried licorice root, chinese pulsatilla root, hairyvein agrimony, dendrobium, indian buead, coix seed, common yam rhizome, white hyacinth bean, codonopsis pilosula, and raw astragalus root; the raw materials comprise, by weight, 10-30g of roasted radix puerariae, 15-35g of roasted divaricate saposhnikovia root, 10-30g of bighead atractylodes rhizome, 10-30g of roasted meat fruit, 10-25g of roasted dried orange peel, 10-25g of costustoot, 10-25g of raw white paeony root, 10-25g of honey-fried licorice root, 10-25g of Chinese pulsatilla root, 10-25g of hairyvein agrimony, 10-20g of dendrobium, 9-20g of poria cocos, 10-20g of coix seed, 10-20g of common yam rhizome, 10-20g of white hyacinth bean, 8-15g of codonopsis pilosula and 8-15g of raw astragalus membranaceus.
A preparation method of a biological fermentation traditional Chinese medicine prescription for treating chronic colitis is characterized by comprising the following steps: weighing and mixing stewed radix Puerariae, stewed radix Saposhnikoviae, atractylodis rhizoma, stewed meat fruit, stewed pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali, decocting, and making into Chinese medicinal liquid; and B, step B: adding 3 ml of sterile water into the screened bidirectional fermentation strain JCY-01 inclined plane to prepare a strain suspension for later use; and C: b, inoculating the JCY-01 strain suspension in the step B into the traditional Chinese medicine culture medium in the step A and fermenting; step D: and C, sterilizing the traditional Chinese medicine fermentation liquor fermented in the step C at high temperature and high pressure to prepare a finished product of the traditional Chinese medicine fermentation liquor.
Further, in the step A, in the decoction of the traditional Chinese medicine liquid, 3 parts of glucose are added into 100 parts of the traditional Chinese medicine liquid, and the traditional Chinese medicine liquid is sterilized at the temperature of 121 ℃ and under the pressure of 1.01KPa to prepare a traditional Chinese medicine culture medium for later use.
Further, in the step C, fermentation is carried out at the temperature of 28 ℃ and at the RPM of 200 for 240 hours.
Further, in the step D, the conditions of high temperature and high pressure sterilization are 121 ℃ and 1.01KPa high temperature and high pressure.
The invention has the beneficial effects that: the invention adopts a plurality of traditional Chinese medicine formulas effective in treating chronic colitis to decoct kudzuvine root, simmered divaricate saposhnikovia root, largehead atractylodes rhizome, simmered fleshy fruits, simmered tangerine peel, costustoot, raw white paeony root, honey-fried licorice root, chinese pulsatilla root, hairyvein agrimony, dendrobium, tuckahoe, coix seed, common yam rhizome, white hyacinth bean, codonopsis pilosula and raw astragalus root in proportion, and the finished product of the formula prepared by a fermentation process decomposes the micro toxicity in natural plant medicines by microorganisms, and the effective components in the medicines are circulated into components with smaller molecular weight and easier absorption through biological cells, thereby effectively improving the medicine effect and playing a powerful support for curing chronic colitis. Based on the above, the invention has good application prospect.
Detailed Description
A biologically fermented Chinese medicinal formulation for treating chronic colitis is prepared from radix Puerariae, radix Saposhnikoviae, atractylodis rhizoma, fructus Myristicae, pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali.
In example 1, the biological fermentation traditional Chinese medicine formula for treating chronic colitis comprises 12g of roasted kudzuvine root, 20g of roasted divaricate saposhnikovia root, 20g of bighead atractylodes rhizome, 15g of roasted meat fruit, 16g of roasted tangerine peel, 17g of costustoot, 16g of raw white paeony root, 20g of honey-fried licorice root, 20g of Chinese pulsatilla root, 18g of hairyvein agrimony, 16g of dendrobium, 10g of poria cocos, 15g of coix seed, 20g of common yam rhizome, 20g of white hyacinth bean, 12g of codonopsis pilosula and 12g of raw astragalus root.
In example 2, the bio-fermented traditional Chinese medicine formula for treating chronic colitis comprises 15g of roasted kudzuvine root, 18g of roasted divaricate saposhnikovia root, 18g of largehead atractylodes rhizome, 17g of roasted meat fruit, 20g of roasted tangerine peel, 20g of costustoot, 18g of raw white paeony root, 18g of honey-fried licorice root, 19g of Chinese pulsatilla root, 17g of hairyvein agrimony, 20g of dendrobium, 15g of poria cocos, 20g of coix seed, 18g of common yam rhizome, 19g of white hyacinth bean, 15g of codonopsis pilosula and 15g of raw astragalus root.
In example 3, the bio-fermented traditional Chinese medicine prescription for treating chronic colitis comprises 20g of roasted radix puerariae, 20g of roasted radix saposhnikoviae, 20g of bighead atractylodes rhizome, 20g of roasted meat fruit, 15g of roasted tangerine peel, 15g of elecampane, 15g of raw radix paeoniae alba, 15g of honey-fried licorice root, 15g of Chinese pulsatilla root, 15g of hairyvein agrimonia herb and bud, 10g of dendrobe, 10g of poria cocos, 10g of coix seed, 10g of common yam rhizome, 10g of white hyacinth bean, 8g of codonopsis pilosula and 8g of raw astragalus membranaceus.
A preparation method of a biological fermentation traditional Chinese medicine prescription for treating chronic colitis comprises the following steps: weighing and mixing stewed radix Puerariae, stewed radix Saposhnikoviae, atractylodis rhizoma, stewed meat fruit, stewed pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali, decocting, and making into Chinese medicinal liquid; wherein, decocting into Chinese medicinal liquid, adding 3 parts of glucose into 100 parts of Chinese medicinal liquid, sterilizing at 121 deg.C and 1.01KPa under high temperature and high pressure, and making into Chinese medicinal culture medium. And B: adding 3 ml of sterile water into the screened bidirectional fermentation strain JCY-01 inclined plane to prepare strain suspension for later use; and C: b, inoculating the JCY-01 strain suspension in the step B into a traditional Chinese medicine culture medium in the step A and fermenting; wherein the fermentation is carried out at 28 deg.C and 200RPM for 240 hr. Step D: and C, sterilizing the traditional Chinese medicine fermentation liquor fermented in the step C at high temperature and high pressure to prepare a finished product of the traditional Chinese medicine fermentation liquor, wherein the conditions of high temperature and high pressure sterilization are 121 ℃ and 1.01 KPa.
In the formula, the kudzu root has the effects of ascending the clear and descending the turbid; radix Saposhnikoviae has the effects of dispersing liver-qi, dispersing spleen-qi, and eliminating dampness; radix aucklandiae has the effects of promoting the circulation of qi and removing food retention, calming the liver and spleen, yu Zhezhong; the meat and fruit has the effects of warming the middle-jiao and promoting the circulation of qi, warming the stomach and consolidating the intestines, and warming the cold; the rhizoma Atractylodis has effects of invigorating qi, invigorating spleen, eliminating dampness, and promoting diuresis; the roasted pericarpium citri reticulatae has the effects of promoting the secretion of digestive juice and simultaneously removing pneumatosis in the intestinal canal in time, thereby improving the appetite of people; the costustoot has the effects of promoting qi circulation, relieving pain, strengthening spleen and promoting digestion; radix Paeoniae alba has effects of suppressing liver yang, softening liver, relieving pain, astringing yin and nourishing blood; radix Glycyrrhizae Preparata has effects of invigorating spleen, invigorating qi, and regulating stomach; the Chinese pulsatilla root has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery; herba et Gemma Agrimoniae has effects of astringing to stop bleeding, relieving diarrhea with astringents, killing parasite and relieving itching; herba Dendrobii has effects of invigorating stomach, promoting fluid production, nourishing yin and clearing heat; poria has effects of inducing diuresis to alleviate edema, invigorating spleen and relieving diarrhea; the coix seed has the effects of inducing diuresis to alleviate edema, invigorating spleen and relieving diarrhea; rhizoma Dioscoreae has effects of invigorating spleen, benefiting stomach, and promoting digestion; the white hyacinth bean has the effects of invigorating spleen, eliminating dampness, promoting urination and reducing swelling; radix Codonopsis has effects of invigorating qi and blood, invigorating spleen and regulating stomach; radix astragali has effects of invigorating qi, consolidating superficial resistance, inducing diuresis and removing toxic substance.
The method for fermenting the Chinese medicaments in each formula is bidirectional solid state fermentation, wherein the bidirectional solid state fermentation is bidirectional selective fermentation by using natural plant medicaments as culture media and different strains, so that the micro-toxicity in the natural plant medicaments can be decomposed by microorganisms, and effective components can be circulated into components with smaller molecular weight and easier absorption through organism cells; moreover, since human cells are evolved from archaebacterial cells in the first place over the billions of years, raw materials obtained by biological bidirectional fermentation conform to the homologous principle of the same origin, and the components are more suitable for being directly utilized by human cells than chemically synthesized components. The invention has the effects of ascending the clear and removing turbid urine, warming the stomach and intestines under the combined action of a plurality of prescriptions; different in courtesy, or astringe, or warm and smooth; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can effectively play a good treatment role, and can effectively support the treatment of chronic colitis.
Having thus shown and described the fundamental principles and essential features of the invention, and its advantages, it will be apparent to those skilled in the art that it is not limited by the details of the foregoing exemplary embodiments, but is capable of numerous other specific forms of practicing the invention without departing from the spirit or essential characteristics thereof.
Furthermore, it should be understood that although the present description refers to embodiments, the embodiments do not include only one independent technical solution, and such description is only for clarity, and those skilled in the art should take the description as a whole, and the technical solutions in the embodiments may be appropriately combined to form other embodiments that can be understood by those skilled in the art.
Claims (5)
1. A biological fermentation traditional Chinese medicine formula for treating chronic colitis is characterized in that the adopted traditional Chinese medicine raw materials comprise stewed kudzuvine root, stewed divaricate saposhnikovia root, largehead atractylodes rhizome, stewed fruit, stewed tangerine peel, costustoot, raw white paeony root, honey-fried licorice root, chinese pulsatilla root, hairyvein agrimony, dendrobium, indian buead, coix seed, common yam rhizome, white hyacinth bean, codonopsis pilosula, and raw astragalus root; the raw materials comprise, by weight, 10-30g of roasted radix puerariae, 15-35g of roasted divaricate saposhnikovia root, 10-30g of bighead atractylodes rhizome, 10-30g of roasted meat fruit, 10-25g of roasted dried orange peel, 10-25g of costustoot, 10-25g of raw white paeony root, 10-25g of honey-fried licorice root, 10-25g of Chinese pulsatilla root, 10-25g of hairyvein agrimony, 10-20g of dendrobium, 9-20g of poria cocos, 10-20g of coix seed, 10-20g of common yam rhizome, 10-20g of white hyacinth bean, 8-15g of codonopsis pilosula and 8-15g of raw astragalus membranaceus.
2. The preparation method of the biofermentation traditional Chinese medicine prescription for treating chronic colitis according to claim 1, characterized in that it comprises the following steps, step A: weighing and mixing stewed radix Puerariae, stewed radix Saposhnikoviae, atractylodis rhizoma, stewed meat fruit, stewed pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali, decocting, and making into Chinese medicinal liquid; and B: adding 3 ml of sterile water into the screened bidirectional fermentation strain JCY-01 inclined plane to prepare a strain suspension for later use; and C: b, inoculating the JCY-01 strain suspension liquid in the step B into the traditional Chinese medicine culture medium in the step A and fermenting; step D: and C, sterilizing the traditional Chinese medicine fermentation liquor fermented in the step C at high temperature and high pressure to prepare a finished product of the traditional Chinese medicine fermentation liquor.
3. The preparation method of the biofermentation traditional Chinese medicine prescription for treating chronic colitis according to claim 2, wherein in the step A, 3 parts of glucose are added into 100 parts of the traditional Chinese medicine decoction, and the traditional Chinese medicine culture medium is prepared by high temperature and high pressure sterilization under the conditions of 121 ℃ and 1.01KPa for standby.
4. The method for preparing a fermented Chinese medicinal preparation for treating chronic colitis according to claim 2, wherein in step C, the fermentation is performed at 28 ℃ and 200RPM for 240 hours.
5. The preparation method of the biofermentation traditional Chinese medicine prescription for treating chronic colitis according to claim 2, wherein in the step D, the conditions of autoclaving are 121 ℃ and 1.01KPa autoclaving.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210731994.9A CN115212274A (en) | 2022-06-27 | 2022-06-27 | Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210731994.9A CN115212274A (en) | 2022-06-27 | 2022-06-27 | Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN115212274A true CN115212274A (en) | 2022-10-21 |
Family
ID=83609178
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210731994.9A Pending CN115212274A (en) | 2022-06-27 | 2022-06-27 | Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115212274A (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101007125A (en) * | 2007-01-24 | 2007-08-01 | 李怀涛 | Proprietary Chinese medicine for treating ulcerative colitis |
CN101703749A (en) * | 2009-11-13 | 2010-05-12 | 秦中文 | Chinese medicament for treating chronic colonitis |
-
2022
- 2022-06-27 CN CN202210731994.9A patent/CN115212274A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101007125A (en) * | 2007-01-24 | 2007-08-01 | 李怀涛 | Proprietary Chinese medicine for treating ulcerative colitis |
CN101703749A (en) * | 2009-11-13 | 2010-05-12 | 秦中文 | Chinese medicament for treating chronic colonitis |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN102579912B (en) | Chinese medicinal capsules special for treating acute mastitis and preparation method thereof | |
CN112494577B (en) | Traditional Chinese medicine microecological preparation for treating piglet diarrhea and preparation method thereof | |
CN102178911B (en) | Chinese medicine preparation used for dispelling wind and eliminating dampness, dredging collaterals and stopping pains for people with deficiency of yang and phlegm dampness constitution, and preparation method and application of preparation | |
CN104436131A (en) | Pharmaceutical composition used for treating swine dysentery and preparation method of pharamceutical composition | |
CN102166320B (en) | Traditional Chinese medicine preparation for eliminating toxins and relieving stagnation of people with toxic stagnation physique and preparation method and application thereof | |
CN100493586C (en) | Oral liquid for treating breast cancer, liver cancer or lung caner, and preparation thereof | |
CN115364178A (en) | Medicinal and edible enzyme suitable for people with high uric acid and gout and preparation method thereof | |
CN104208239A (en) | Traditional Chinese medicine composition for preventing and treating poultry escherichia coli disease, microecological preparation, and preparation method | |
CN109045229A (en) | The Chinese medicine composition and preparation method thereof for treating urarthritis | |
CN104042847A (en) | Lipid-lowering pills for treating hyperlipidaemia and preparation method thereof | |
CN102150850B (en) | Debitterized pomelo peel processed powder | |
CN103830564A (en) | Oral medicine for treating chronic nasosinusitis | |
CN103083606A (en) | Three-time biological fermentation Chinese herbal medicine oral liquid for recovering intestines and stomach and preparation method of three-time biological fermentation Chinese herbal medicine oral liquid | |
CN102178866B (en) | Chinese medicinal preparation for dispelling damp, promoting blood circulation, softening hard mass and eliminating stagnation for people with qi-depression and blood-stagnation physique, preparation method thereof and application thereof | |
CN104826012A (en) | Traditional Chinese medicine preparation for pituitary tumor surgery postoperative nursing and preparation method thereof | |
CN102133283B (en) | Medicine for treating constipation and preparation method thereof | |
CN115212274A (en) | Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof | |
CN103735710B (en) | Traditional Chinese medicine composition for treating recessive mastitis of dairy cows and preparation method thereof | |
CN103356880A (en) | Chinese patent medicine for promoting gastrointestinal motility and its preparation method | |
CN109674999A (en) | A kind of Radix Astragali, rhizoma zingiberis composite extract and its preparation method and application | |
CN114470144B (en) | Prostate eliminating soup for inhibiting prostate fibrosis and preparation method thereof | |
CN106266437A (en) | A kind of Integrated TCM preparation treating bacillary dysentery and preparation method | |
CN104001044A (en) | Traditional Chinese medicine composition treating hyperlipidemia | |
CN117866696A (en) | Process for preparing cathartic food based on purified and extracted hemp seed oil and formula thereof | |
CN105166546A (en) | Milk cow compound feed and making method thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221021 |