CN115212274A - Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof - Google Patents
Biological fermentation traditional Chinese medicine prescription for treating chronic colitis and preparation method thereof Download PDFInfo
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- CN115212274A CN115212274A CN202210731994.9A CN202210731994A CN115212274A CN 115212274 A CN115212274 A CN 115212274A CN 202210731994 A CN202210731994 A CN 202210731994A CN 115212274 A CN115212274 A CN 115212274A
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Abstract
A biologically fermented Chinese medicinal formulation for treating chronic colitis is prepared from radix Puerariae Preparata, radix Saposhnikoviae Preparata, atractylodis rhizoma, fructus Caricae, pericarpium Citri Tangerinae Preparata, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali; a preparation method of a biological fermentation traditional Chinese medicine prescription for treating chronic colitis comprises four steps. The invention adopts a plurality of traditional Chinese medicine formula proportions effective in treating chronic colitis, and the finished product of the formula prepared by a fermentation process decomposes the micro toxicity in natural plant medicines by microorganisms, and the effective components in the medicines are circulated into components with smaller molecular weight and easier absorption by organism cells, thereby effectively improving the medicine effect and playing a powerful support for curing chronic colitis. Based on the above, the invention has good application prospect.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine formulas and preparation methods, in particular to a biological fermentation traditional Chinese medicine formula for treating chronic colitis and a preparation method.
Background
Chronic colitis is a chronic, recurrent and multiple disease, and inflammatory edema, ulcer and bleeding lesions of intestinal tracts are caused by various pathogenic reasons, and are generally limited to mucous membranes and submucosa, and frequently occur in rectum, sigmoid colon and even whole colon. The disease is characterized by long course of disease, repeated attack in chronic, abdominal pain and diarrhea as main symptoms, mucus and stool and constipation or diarrhea occur alternately, the time is good and good, and the disease is continuous, and can be seen at any age, but the disease is more common in young and strong years of 20 to 30 years old, and in recent years, the patients with serious symptoms are more common in middle-aged and elderly people, and the proportion of male and female is not obviously different. The research suggests that the pathogenic cause is often related to mental factors such as infection, hypoimmunity, heredity, food allergy, defense dysfunction and the like, and the common causes are also related to nonspecific colitis, irritable bowel syndrome, inflammatory bowel disease, antibiotics abuse, intestinal flora imbalance, small intestine malabsorption and the like.
At present, the treatment of chronic colitis generally adopts western medicine mode treatment, and the western medicine mode has the defect of treating both symptoms and root causes, so that patients after treatment often relapse due to the influence of various factors. The traditional Chinese medicine has the advantage of treating the root cause of diseases, but in the treatment of chronic colitis, no traditional Chinese medicine formula can effectively treat the chronic colitis in the currently known technology, so that the provision of the formula for treating the chronic colitis and the preparation method thereof are particularly necessary.
Disclosure of Invention
In order to overcome the defect that no prescription can effectively treat the chronic colitis and treat the primary and secondary symptoms, the invention provides a biological fermentation traditional Chinese medicine prescription for treating the chronic colitis and a preparation method thereof, wherein multiple prescriptions effective for the chronic colitis are mixed, natural plant medicines are used as culture media to carry out bidirectional selective fermentation with different strains, the micro-toxicity in the natural plant medicines is decomposed by microorganisms, and effective components in the medicines are circulated into components with smaller molecular weight and easier absorption through organism cells, so that the medicine effect is effectively improved, and the biological fermentation traditional Chinese medicine prescription for treating the chronic colitis and the preparation method thereof play a powerful support for curing the chronic colitis.
The technical scheme adopted by the invention for solving the technical problems is as follows:
a biological fermentation traditional Chinese medicine formula for treating chronic colitis is characterized in that the adopted traditional Chinese medicine raw materials comprise stewed kudzuvine root, stewed divaricate saposhnikovia root, largehead atractylodes rhizome, stewed fruit, stewed tangerine peel, costustoot, raw white paeony root, honey-fried licorice root, chinese pulsatilla root, hairyvein agrimony, dendrobium, indian buead, coix seed, common yam rhizome, white hyacinth bean, codonopsis pilosula, and raw astragalus root; the raw materials comprise, by weight, 10-30g of roasted radix puerariae, 15-35g of roasted divaricate saposhnikovia root, 10-30g of bighead atractylodes rhizome, 10-30g of roasted meat fruit, 10-25g of roasted dried orange peel, 10-25g of costustoot, 10-25g of raw white paeony root, 10-25g of honey-fried licorice root, 10-25g of Chinese pulsatilla root, 10-25g of hairyvein agrimony, 10-20g of dendrobium, 9-20g of poria cocos, 10-20g of coix seed, 10-20g of common yam rhizome, 10-20g of white hyacinth bean, 8-15g of codonopsis pilosula and 8-15g of raw astragalus membranaceus.
A preparation method of a biological fermentation traditional Chinese medicine prescription for treating chronic colitis is characterized by comprising the following steps: weighing and mixing stewed radix Puerariae, stewed radix Saposhnikoviae, atractylodis rhizoma, stewed meat fruit, stewed pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali, decocting, and making into Chinese medicinal liquid; and B, step B: adding 3 ml of sterile water into the screened bidirectional fermentation strain JCY-01 inclined plane to prepare a strain suspension for later use; and C: b, inoculating the JCY-01 strain suspension in the step B into the traditional Chinese medicine culture medium in the step A and fermenting; step D: and C, sterilizing the traditional Chinese medicine fermentation liquor fermented in the step C at high temperature and high pressure to prepare a finished product of the traditional Chinese medicine fermentation liquor.
Further, in the step A, in the decoction of the traditional Chinese medicine liquid, 3 parts of glucose are added into 100 parts of the traditional Chinese medicine liquid, and the traditional Chinese medicine liquid is sterilized at the temperature of 121 ℃ and under the pressure of 1.01KPa to prepare a traditional Chinese medicine culture medium for later use.
Further, in the step C, fermentation is carried out at the temperature of 28 ℃ and at the RPM of 200 for 240 hours.
Further, in the step D, the conditions of high temperature and high pressure sterilization are 121 ℃ and 1.01KPa high temperature and high pressure.
The invention has the beneficial effects that: the invention adopts a plurality of traditional Chinese medicine formulas effective in treating chronic colitis to decoct kudzuvine root, simmered divaricate saposhnikovia root, largehead atractylodes rhizome, simmered fleshy fruits, simmered tangerine peel, costustoot, raw white paeony root, honey-fried licorice root, chinese pulsatilla root, hairyvein agrimony, dendrobium, tuckahoe, coix seed, common yam rhizome, white hyacinth bean, codonopsis pilosula and raw astragalus root in proportion, and the finished product of the formula prepared by a fermentation process decomposes the micro toxicity in natural plant medicines by microorganisms, and the effective components in the medicines are circulated into components with smaller molecular weight and easier absorption through biological cells, thereby effectively improving the medicine effect and playing a powerful support for curing chronic colitis. Based on the above, the invention has good application prospect.
Detailed Description
A biologically fermented Chinese medicinal formulation for treating chronic colitis is prepared from radix Puerariae, radix Saposhnikoviae, atractylodis rhizoma, fructus Myristicae, pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali.
In example 1, the biological fermentation traditional Chinese medicine formula for treating chronic colitis comprises 12g of roasted kudzuvine root, 20g of roasted divaricate saposhnikovia root, 20g of bighead atractylodes rhizome, 15g of roasted meat fruit, 16g of roasted tangerine peel, 17g of costustoot, 16g of raw white paeony root, 20g of honey-fried licorice root, 20g of Chinese pulsatilla root, 18g of hairyvein agrimony, 16g of dendrobium, 10g of poria cocos, 15g of coix seed, 20g of common yam rhizome, 20g of white hyacinth bean, 12g of codonopsis pilosula and 12g of raw astragalus root.
In example 2, the bio-fermented traditional Chinese medicine formula for treating chronic colitis comprises 15g of roasted kudzuvine root, 18g of roasted divaricate saposhnikovia root, 18g of largehead atractylodes rhizome, 17g of roasted meat fruit, 20g of roasted tangerine peel, 20g of costustoot, 18g of raw white paeony root, 18g of honey-fried licorice root, 19g of Chinese pulsatilla root, 17g of hairyvein agrimony, 20g of dendrobium, 15g of poria cocos, 20g of coix seed, 18g of common yam rhizome, 19g of white hyacinth bean, 15g of codonopsis pilosula and 15g of raw astragalus root.
In example 3, the bio-fermented traditional Chinese medicine prescription for treating chronic colitis comprises 20g of roasted radix puerariae, 20g of roasted radix saposhnikoviae, 20g of bighead atractylodes rhizome, 20g of roasted meat fruit, 15g of roasted tangerine peel, 15g of elecampane, 15g of raw radix paeoniae alba, 15g of honey-fried licorice root, 15g of Chinese pulsatilla root, 15g of hairyvein agrimonia herb and bud, 10g of dendrobe, 10g of poria cocos, 10g of coix seed, 10g of common yam rhizome, 10g of white hyacinth bean, 8g of codonopsis pilosula and 8g of raw astragalus membranaceus.
A preparation method of a biological fermentation traditional Chinese medicine prescription for treating chronic colitis comprises the following steps: weighing and mixing stewed radix Puerariae, stewed radix Saposhnikoviae, atractylodis rhizoma, stewed meat fruit, stewed pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali, decocting, and making into Chinese medicinal liquid; wherein, decocting into Chinese medicinal liquid, adding 3 parts of glucose into 100 parts of Chinese medicinal liquid, sterilizing at 121 deg.C and 1.01KPa under high temperature and high pressure, and making into Chinese medicinal culture medium. And B: adding 3 ml of sterile water into the screened bidirectional fermentation strain JCY-01 inclined plane to prepare strain suspension for later use; and C: b, inoculating the JCY-01 strain suspension in the step B into a traditional Chinese medicine culture medium in the step A and fermenting; wherein the fermentation is carried out at 28 deg.C and 200RPM for 240 hr. Step D: and C, sterilizing the traditional Chinese medicine fermentation liquor fermented in the step C at high temperature and high pressure to prepare a finished product of the traditional Chinese medicine fermentation liquor, wherein the conditions of high temperature and high pressure sterilization are 121 ℃ and 1.01 KPa.
In the formula, the kudzu root has the effects of ascending the clear and descending the turbid; radix Saposhnikoviae has the effects of dispersing liver-qi, dispersing spleen-qi, and eliminating dampness; radix aucklandiae has the effects of promoting the circulation of qi and removing food retention, calming the liver and spleen, yu Zhezhong; the meat and fruit has the effects of warming the middle-jiao and promoting the circulation of qi, warming the stomach and consolidating the intestines, and warming the cold; the rhizoma Atractylodis has effects of invigorating qi, invigorating spleen, eliminating dampness, and promoting diuresis; the roasted pericarpium citri reticulatae has the effects of promoting the secretion of digestive juice and simultaneously removing pneumatosis in the intestinal canal in time, thereby improving the appetite of people; the costustoot has the effects of promoting qi circulation, relieving pain, strengthening spleen and promoting digestion; radix Paeoniae alba has effects of suppressing liver yang, softening liver, relieving pain, astringing yin and nourishing blood; radix Glycyrrhizae Preparata has effects of invigorating spleen, invigorating qi, and regulating stomach; the Chinese pulsatilla root has the effects of clearing away heat and toxic materials, cooling blood and stopping dysentery; herba et Gemma Agrimoniae has effects of astringing to stop bleeding, relieving diarrhea with astringents, killing parasite and relieving itching; herba Dendrobii has effects of invigorating stomach, promoting fluid production, nourishing yin and clearing heat; poria has effects of inducing diuresis to alleviate edema, invigorating spleen and relieving diarrhea; the coix seed has the effects of inducing diuresis to alleviate edema, invigorating spleen and relieving diarrhea; rhizoma Dioscoreae has effects of invigorating spleen, benefiting stomach, and promoting digestion; the white hyacinth bean has the effects of invigorating spleen, eliminating dampness, promoting urination and reducing swelling; radix Codonopsis has effects of invigorating qi and blood, invigorating spleen and regulating stomach; radix astragali has effects of invigorating qi, consolidating superficial resistance, inducing diuresis and removing toxic substance.
The method for fermenting the Chinese medicaments in each formula is bidirectional solid state fermentation, wherein the bidirectional solid state fermentation is bidirectional selective fermentation by using natural plant medicaments as culture media and different strains, so that the micro-toxicity in the natural plant medicaments can be decomposed by microorganisms, and effective components can be circulated into components with smaller molecular weight and easier absorption through organism cells; moreover, since human cells are evolved from archaebacterial cells in the first place over the billions of years, raw materials obtained by biological bidirectional fermentation conform to the homologous principle of the same origin, and the components are more suitable for being directly utilized by human cells than chemically synthesized components. The invention has the effects of ascending the clear and removing turbid urine, warming the stomach and intestines under the combined action of a plurality of prescriptions; different in courtesy, or astringe, or warm and smooth; the traditional Chinese medicine composition has the advantages that the traditional Chinese medicine composition can effectively play a good treatment role, and can effectively support the treatment of chronic colitis.
Having thus shown and described the fundamental principles and essential features of the invention, and its advantages, it will be apparent to those skilled in the art that it is not limited by the details of the foregoing exemplary embodiments, but is capable of numerous other specific forms of practicing the invention without departing from the spirit or essential characteristics thereof.
Furthermore, it should be understood that although the present description refers to embodiments, the embodiments do not include only one independent technical solution, and such description is only for clarity, and those skilled in the art should take the description as a whole, and the technical solutions in the embodiments may be appropriately combined to form other embodiments that can be understood by those skilled in the art.
Claims (5)
1. A biological fermentation traditional Chinese medicine formula for treating chronic colitis is characterized in that the adopted traditional Chinese medicine raw materials comprise stewed kudzuvine root, stewed divaricate saposhnikovia root, largehead atractylodes rhizome, stewed fruit, stewed tangerine peel, costustoot, raw white paeony root, honey-fried licorice root, chinese pulsatilla root, hairyvein agrimony, dendrobium, indian buead, coix seed, common yam rhizome, white hyacinth bean, codonopsis pilosula, and raw astragalus root; the raw materials comprise, by weight, 10-30g of roasted radix puerariae, 15-35g of roasted divaricate saposhnikovia root, 10-30g of bighead atractylodes rhizome, 10-30g of roasted meat fruit, 10-25g of roasted dried orange peel, 10-25g of costustoot, 10-25g of raw white paeony root, 10-25g of honey-fried licorice root, 10-25g of Chinese pulsatilla root, 10-25g of hairyvein agrimony, 10-20g of dendrobium, 9-20g of poria cocos, 10-20g of coix seed, 10-20g of common yam rhizome, 10-20g of white hyacinth bean, 8-15g of codonopsis pilosula and 8-15g of raw astragalus membranaceus.
2. The preparation method of the biofermentation traditional Chinese medicine prescription for treating chronic colitis according to claim 1, characterized in that it comprises the following steps, step A: weighing and mixing stewed radix Puerariae, stewed radix Saposhnikoviae, atractylodis rhizoma, stewed meat fruit, stewed pericarpium Citri Tangerinae, radix aucklandiae, radix Paeoniae alba, radix Glycyrrhizae Preparata, radix Pulsatillae, herba et Gemma Agrimoniae, herba Dendrobii, poria, coicis semen, rhizoma Dioscoreae, semen lablab album, radix Codonopsis, and radix astragali, decocting, and making into Chinese medicinal liquid; and B: adding 3 ml of sterile water into the screened bidirectional fermentation strain JCY-01 inclined plane to prepare a strain suspension for later use; and C: b, inoculating the JCY-01 strain suspension liquid in the step B into the traditional Chinese medicine culture medium in the step A and fermenting; step D: and C, sterilizing the traditional Chinese medicine fermentation liquor fermented in the step C at high temperature and high pressure to prepare a finished product of the traditional Chinese medicine fermentation liquor.
3. The preparation method of the biofermentation traditional Chinese medicine prescription for treating chronic colitis according to claim 2, wherein in the step A, 3 parts of glucose are added into 100 parts of the traditional Chinese medicine decoction, and the traditional Chinese medicine culture medium is prepared by high temperature and high pressure sterilization under the conditions of 121 ℃ and 1.01KPa for standby.
4. The method for preparing a fermented Chinese medicinal preparation for treating chronic colitis according to claim 2, wherein in step C, the fermentation is performed at 28 ℃ and 200RPM for 240 hours.
5. The preparation method of the biofermentation traditional Chinese medicine prescription for treating chronic colitis according to claim 2, wherein in the step D, the conditions of autoclaving are 121 ℃ and 1.01KPa autoclaving.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007125A (en) * | 2007-01-24 | 2007-08-01 | 李怀涛 | Proprietary Chinese medicine for treating ulcerative colitis |
| CN101703749A (en) * | 2009-11-13 | 2010-05-12 | 秦中文 | Chinese medicament for treating chronic colonitis |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101007125A (en) * | 2007-01-24 | 2007-08-01 | 李怀涛 | Proprietary Chinese medicine for treating ulcerative colitis |
| CN101703749A (en) * | 2009-11-13 | 2010-05-12 | 秦中文 | Chinese medicament for treating chronic colonitis |
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Application publication date: 20221021 |