CN106266437A - A kind of Integrated TCM preparation treating bacillary dysentery and preparation method - Google Patents
A kind of Integrated TCM preparation treating bacillary dysentery and preparation method Download PDFInfo
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Abstract
The invention discloses a kind of Integrated TCM preparation treating bacillary dysentery and preparation method, belong to pharmaceutical technology field；The raw material of Integrated TCM preparation effective ingredient of the present invention consists of: furazolidone, trimethoprim, Sulfamethoxazole, hair leaf Engelhardtia roxburghiana, Radix Fici pumilae, Radix Tinosporae, Herba Hydrocotylis Nepalensis, Rhizoma Dioscoreae, Herba Potentillae Chinensis, Cortex myricae nanae radicis, Radix Gerberae Delavayi, Testa dolichoris, Radix desmodiik microphylli, red, Herba Selaginellae Uncinatae, Radix Rubi Setchuenensis and Fructus Castanopsis Tibetanae；Integrated TCM preparation of the present invention is combined formulated by Chinese medicine and Western medicine, more better than general simple Chinese medicine or western medicine, treatment bacillary dysentery had significant curative effect, and drug effect is gentle, with strong points, taking convenience, good absorbing effect, can effectively improve body function, improve immunity.
Description
Art
The present invention relates to pharmaceutical technology field, particularly relate to a kind of Integrated TCM preparation treating bacillary dysentery and system
Preparation Method.
Background technology
Bacillary dysentery is called for short bacillary dysentery, also known as shigellosis, is the infectious intestinal disease that causes of Shigella.Shigella dysenteriae warp
After digestive tract infection human body, cause inflammation and the ulcer of colonic mucosa, and discharge toxin and enter blood.Clinical manifestation mainly have heating,
Stomachache, diarrhoea, tenesmus, mucus bloody purulent stool, simultaneously with whole body toxemia synptom, severe patient can cause septic shock and
Toxic encephalopthy.Bacillary dysentery distributes throughout the year, and Xia Qiu is common, is the commonly encountered diseases of China, frequently-occurring disease.
Pathogen causes the pathogen of bacillary dysentery to be shigella dysenteriae, also known as dysentery bacterium, belongs to enterobacteriaceae shigella dysenteriae
Belong to, for amphimicrobian gram negative bacilli, have pili, atrichia, pod membrane and tooth born of the same parents, do not have power, be most appropriate to aerobe
Long.By antigenic structure different with biochemical reaction shigella dysenteriae is divided into 4 groups (Shigella dysenteriae, Shigella flexneri, shigella boydii,
Song Shi shigella dysenteriae) and 51 serotypes.Whether shigella dysenteriae falls ill after entering body and bacterial number, pathogenicity and resistance of human body
Relevant, the virulence of Shigella dysenteriae is the strongest, can cause serious symptoms, and Song Shi Shigella infection is many in the outbreak that is not true to type, Fu Shi will
Congratulate bacterium infection and easily transfer to chronic, as long as virulent shigella dysenteriae 10～100 antibacterials enter human bodies and can cause morbidity, some
The factors such as chronic disease, fatigue, eating and drinking too much at one meal may result in resistance of human body and decline, and beneficially shigella dysenteriae invades.Shigella dysenteriae is invaded
After entering Intestinal epithelial cells and lamina propria, cause inflammatory reaction and thin vessels circulatory disturbance, cause intestinal mucosa inflammation, necrosis and
Ulcer, pathological changes is mainly involved rectum, sigmoid colon, can be involved whole colon and terminal ileum time serious.The equal energy of all shigella dysenteriaes
Producing endotoxin and extracellular toxin, endotoxin can cause general reaction such as heating, toxemia, septic shock and important organ function
Exhaustion, extracellular toxin has enterotoxin, neurotoxin and cytotoxin, causes corresponding clinical symptoms respectively.Crowd is to dysentery bacterium
The most susceptible, preschooler is ill many, relevant with bad health habit；Adult patient Abwehrkraft des Koepers reduces, is infected by contact with
How relevant chance is, without consolidating immunity in addition after suffering from homotype bacillary dysentery, and nothing between different floras and between different serotypes dysentery bacterium
Cross immunity, therefore cause repeated infection or infect and repeated multiple times morbidity again.
Treatment bacillary dysentery is nothing more than Chinese medicine and two kinds of Western medicine, western medicine quick result, but drug dependence at present
By force, curing the symptoms, not the disease, and treatment by Chinese herbs has no side effect, but it is relatively slow to take effect, the course for the treatment of is longer, and have needs long-term taking, therefore, grinds
Studying carefully the medicine that a kind of Chinese medicine and western medicine combines is necessary to alleviate the misery of patient.
Summary of the invention
The invention provides a kind of Integrated TCM preparation treating bacillary dysentery and preparation method；Chinese medicine and western medicine of the present invention
Combined formulated in conjunction with preparation by Chinese medicine and Western medicine, more better than general simple Chinese medicine or western medicine, right
Treatment bacillary dysentery has significant curative effect, and drug effect is gentle, with strong points, taking convenience, and good absorbing effect can be effective
Improve body function, improve immunity.
For achieving the above object, technical scheme is implemented as follows:
A kind of Integrated TCM preparation treating bacillary dysentery, makes the former of described Integrated TCM preparation effective ingredient
Material forms and parts by weight are:
Furazolidone 0.1～0.2 part, trimethoprim 0.1～0.2 part, Sulfamethoxazole 0.1～0.5 part, hair leaf Engelhardtia roxburghiana 31
～47 parts, Radix Fici pumilae 30～46 parts, Radix Tinosporae 30～46 parts, Herba Hydrocotylis Nepalensis 29～45 parts, Rhizoma Dioscoreae 28～44 parts, Herba Potentillae Chinensis 28～
44 parts, Cortex myricae nanae radicis 27～43 parts, Radix Gerberae Delavayi 27～43 parts, Testa dolichoris 27～43 parts, Radix desmodiik microphylli 26～42 parts, red 26～
42 parts, Herba Selaginellae Uncinatae 25～41 parts, Radix Rubi Setchuenensis 24～40 parts and Fructus Castanopsis Tibetanae 24～40 parts.
Make described Integrated TCM preparation effective ingredient raw material composition and parts by weight be:
Furazolidone 0.12～0.18 part, trimethoprim 0.12～0.18 part, Sulfamethoxazole 0.2～0.4 part, Mao Yehuang
Qi 35～43 parts, Radix Fici pumilae 34～42 parts, Radix Tinosporae 34～42 parts, Herba Hydrocotylis Nepalensis 33～41 parts, Rhizoma Dioscoreae 32～40 parts, Herba Potentillae Chinensis
32～40 parts, Cortex myricae nanae radicis 31～39 parts, Radix Gerberae Delavayi 31～39 parts, Testa dolichoris 31～39 parts, Radix desmodiik microphylli 30～38 parts, red
30～38 parts, Herba Selaginellae Uncinatae 29～37 parts, Radix Rubi Setchuenensis 28～36 parts and Fructus Castanopsis Tibetanae 28～36 parts.
Make described Integrated TCM preparation effective ingredient raw material composition and parts by weight be:
Furazolidone 0.2 part, trimethoprim 0.2 part, Sulfamethoxazole 0.3 part, hair leaf Engelhardtia roxburghiana 39 parts, Radix Fici pumilae 38 parts,
Radix Tinosporae 38 parts, Herba Hydrocotylis Nepalensis 37 parts, Rhizoma Dioscoreae 36 parts, Herba Potentillae Chinensis 36 parts, Cortex myricae nanae radicis 35 parts, Radix Gerberae Delavayi 35 parts, Testa dolichoris 35
Part, Radix desmodiik microphylli 34 parts, red 34 parts, Herba Selaginellae Uncinatae 33 parts, Radix Rubi Setchuenensis 32 parts and Fructus Castanopsis Tibetanae 32 parts.
The preparation method of a kind of Integrated TCM preparation treating bacillary dysentery, including the extraction work of following western medicine composition
Skill step:
(1) Western medicine furazolidone is put into container, add the distilled water of 1～2 times amount, dilution, be placed in microwave dryer
Interior with 5～8 DEG C of temperature oven drying at low temperatures, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
(2) Western medicine trimethoprim is put into container, add the ethanol of 1～2 times amount, dilution, be placed in microwave dryer
With 5～8 DEG C of temperature oven drying at low temperatures, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
(3) Western medicine Sulfamethoxazole is put into medicinal cupping, stir with blender, put into after 70 DEG C of baking oven is dried cold
But, extraction is ground into powder, obtains the fine powder of 200 mesh, standby；
(4) fine powder that above-mentioned steps (1)～(3) obtain is put into container mixing, standby.
The preparation method of a kind of Integrated TCM preparation treating bacillary dysentery, including the extraction work of following Chinese medicine ingredients
Skill step:
(1) Chinese medicine hair leaf Engelhardtia roxburghiana, Radix Fici pumilae, Rhizoma Dioscoreae and Radix Gerberae Delavayi are mixed in proportion and put into container, add 5～8
The distilled water of times amount, heated and boiled 2～3 hours, to extract, filter, obtain filtrate, heating is concentrated into pasty state, puts into the baking of 70 DEG C of baking oven
Cooling down after Gan, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
(2) Chinese medicine Radix Tinosporae, Herba Potentillae Chinensis and red being mixed in proportion are put into container, carry out pulverization process, grind into powder,
Arrived the fine powder of 180 mesh, standby；
(3) Herba Hydrocotylis Nepalensis and Radix Rubi Setchuenensis are cleaned, immerse 3 times amount 60% alcohol solution dipping 1～2 hours, add
Heat is extracted 3 hours, reclaims ethanol, filters, obtains filtrate, standby；
(4) Chinese medicine Cortex myricae nanae radicis is cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby；
(5) Chinese medicine Testa dolichoris, Radix desmodiik microphylli, Herba Selaginellae Uncinatae and Fructus Castanopsis Tibetanae are mixed in proportion put into container, add 3～6 times
The distilled water of amount, heated and boiled 1～2 hours, extract, filter, obtain filtrate, standby；
(6) fine powder that above-mentioned steps (1)～(5) obtained, filtrate, juice mix, stirring and dissolving uniformly after, heating
It is condensed into thick paste, standby.
The preparation method of a kind of Integrated TCM preparation treating bacillary dysentery, by described Western medicine fine powder and traditional Chinese medicine thick paste
Mixing, add the deionized water of 2～3 times after mixing, after stirring and dissolving is uniform, heating is concentrated into pasty state, extracts and makes sheet
Agent, obtains the Integrated TCM preparation of described treatment bacillary dysentery.
The property of medicine of Chinese medicine and western medicine used by the present invention is as follows:
Furazolidone: for yellow powder or crystalline powder, odorless, first tasteless after micro-hardship, atomic water and the ethanol of being dissolved in, micro-
It is dissolved in chloroform, insoluble in ether, is soluble in dimethylformamide and nitromethane.Be mainly used in bacterium disease, enteritis it can also be used to
Typhoid fever, paratyphoid fever, giardiasis and trichomonal vaginitis.
Trimethoprim: for white or off-white color crystalline powder, odorless, bitter in the mouth, the most molten in chloroform, at ethanol or acetone
Middle slightly soluble, the most insoluble in water, the most readily soluble.Normal and sulphonamides share (applying compound preparation) in treatment pulmonary more
Infection, acute/chronic bronchitis, bacillary dysentery, urinary tract infection, pyelonephritis, enteritis, typhoid fever, malaria etc., share with Multiple Classes of Antibiotics,
This product individually can be applicable to the gold of escherichia coli, proteus mirabilis, bacillus canalis capsulatus, Enterobacter, coagulase-negative
Pure urinary tract infection caused by Staphylococcus aureus.
Sulfamethoxazole: for white crystalline powder, odorless, mildly bitter flavor, the most insoluble in water, at dilute hydrochloric acid, hydrogen-oxygen
Change in sodium test solution or ammonia solution readily soluble.For acute bronchitis, pulmonary infection, urinary tract infection, typhoid fever, brucellosis, bacterium
Dysentery etc..
Hair leaf Engelhardtia roxburghiana: puckery, cool in nature.Restrain astringent or styptic treatment for spontaneous sweating, antidiarrheal, hemostasis.Main chronic diarrhea chronic dysentery, proctoptosis, traumatic hemorrhage.
Radix Fici pumilae: bitter in the mouth, cold in nature.Expelling wind and removing dampness, channels sootheing and network vessel quickening.Main air pain of dampness syndrome, sciatica, lumbar muscle strain, water
Swollen, malaria, amenorrhea, postnatal blood stasis stomachache, chronic nephritis, chronic enteritis, traumatic injury.
Radix Tinosporae: bitter in the mouth, cold in nature；Return spleen, kidney channel.Heat-clearing and toxic substances removing, reducing swelling and alleviating pain.Main laryngopharynx swelling and pain, aphthous stomatitis, in vain
Larynx, mumps, heat syndrome cough aphonia, epigastric pain, dysentery, carbuncle furunculosis, venom.
Herba Hydrocotylis Nepalensis: acrid in the mouth, warm in nature, nontoxic.Control traumatic injury, flu, expectorant blood of coughing." Traditional Chinese Medicine in Sichuan will " carries: " lung heat clearing
Heat, dissipates heat in blood.Control haematemesis, traumatic injury and cold cough.”
Rhizoma Dioscoreae: sweet in the mouth, property is put down；Return lung, spleen, kidney channel.Spleen reinforcing, supports lung, reinforces the kidney, benefit essence.Main diarrhea due to hypofunction of the spleen, lack of appetite edema,
Cough and asthma due to lung deficiency, quenches one's thirst, and seminal emission, leukorrhagia, frequent micturition of suffering from a deficiency of the kidney, carbuncle, scrofula are controlled in external.
Herba Potentillae Chinensis: bitter in the mouth, property is put down, nontoxic；Return liver, spleen, stomach, large intestine channel.Eliminating pathogenic heat from blood to cure dysentery, heat-clearing and toxic substances removing.Main chronic dysentery is more than,
Bloody dysentery is suffered from abdominal pain, bleeding hemorrhoids, sore and toxic.
Cortex myricae nanae radicis: sour-puckery flavor, warm in nature.Control dysentery, diarrhoea, dyspepsia, metrorrhagia, hemorrhage of rectum, proctoptosis, rheumatalgia,
Traumatic injury impairment caused by overstrain." Yunnan Chinese herbal medicine " carries: " convergence, hemostasis, antiinflammatory.Prevent and treat dysentery, internal hemorrhage, rheumatalgia, metrorrhagia.”
Radix Gerberae Delavayi: acrid in the mouth, micro-hardship, property is put down.Clearing away heat-damp and promoting diuresis, activating QI to eliminate phlegm, sends long-pending parasite killing.Controlling dysentery, stomachache, flu is coughed
Coughing, abundant expectoration of panting, dyspepsia, ascariasis, tonsillitis, external can be stopped blooding.
Testa dolichoris: sweet in the mouth, hardship, warm in nature；Return spleen, large intestine channel.Relieve summer heat removing dampness, invigorating the spleen and regulating the stomach.Accumulateing in main heat-damp in summer, vomiting is let out
Rush down, uncomfortable in chest indigestion and loss of appetite, beriberi edema, women's leukorrhagia." Anhui medical material " carries: " spleen reinforcing removing dampness, antidiarrheal dysentery.Control and tell on alimentary toxicosis
Drop, solve alcoholism.”
Radix desmodiik microphylli: sweet in the mouth, hardship, cool in nature；Return liver, bladder, large intestine channel.Clearing away heat-damp and promoting diuresis, relieving cough and asthma, subduing swelling and detoxicating.Main
Stranguria caused by urinary stone, stomachache, jaundice, dysentery, cough, asthma, infantile malnutrition, venom, ulcerative carbuncle scrofula, dermatitis rhus, hemorrhoid.
Red: sour in the mouth, hardship, property is put down.Regulate the flow of vital energy, invigorate blood circulation, eliminate the phlegm, dampness removing.Main regurgitation acid regurgitation, pulmonary tuberculosis hemoptysis, jaundice, dysentery,
Pain in chest and hypochondrium, osteopatia sprain, bones and muscles pain, amenorrhea.
Herba Selaginellae Uncinatae: lightly seasoned, property is put down.Clearing away heat-damp and promoting diuresis, removing toxic substances, repercussive, hemostasis.Harness the Yellow River subcutaneous ulcer, dysentery, edema, rheumatic arthralgia, cough
Cough haematemesis, retropharyngeal abscess, anal fistula, knife injury, scald.
Radix Rubi Setchuenensis: sour in the mouth, one-tenth, property is put down.Removing heat from blood, invigorates blood circulation.Control over-strained hemoptysis, hemoptysis, menoxenia, dysentery, scrofula, bone
Folding." catalogue planted by Guizhou medicine " carries: " Herb: clearing away heat and cooling blood, hemostasis, synthetism.Control dysentery, proctoptosis, vicarious menstruation, hemoptysis, fracture.”
Fructus Castanopsis Tibetanae: sweet in the mouth, property is put down.Thick intestinal, dysentery relieving.Main dysentery.
The present invention compared with prior art, has the advantages that
Integrated TCM preparation of the present invention is combined formulated by Chinese medicine and Western medicine, than general simple Chinese medicine or
Western medicine is better, has significant curative effect to treatment bacillary dysentery, and drug effect is gentle, with strong points, taking convenience,
Good absorbing effect, can effectively improve body function, improves immunity.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further elaborated.
Embodiment 1
The raw material of Integrated TCM preparation effective ingredient of the present invention forms and weight is:
Furazolidone 0.18g, trimethoprim 0.18g, Sulfamethoxazole 0.4g, hair leaf Engelhardtia roxburghiana 43g, Radix Fici pumilae 42g, Jin Guo
Olive 42g, Herba Hydrocotylis Nepalensis 41g, Rhizoma Dioscoreae 40g, Herba Potentillae Chinensis 40g, Cortex myricae nanae radicis 39g, Radix Gerberae Delavayi 39g, Testa dolichoris 39g, Radix desmodiik microphylli
38g, red 38g, Herba Selaginellae Uncinatae 37g, Radix Rubi Setchuenensis 36g and Fructus Castanopsis Tibetanae 36g.
The preparation method of a kind of Integrated TCM preparation treating bacillary dysentery, including the extraction work of following western medicine composition
Skill step:
(1) Western medicine furazolidone is put into container, add the distilled water of 1～2 times amount, dilution, be placed in microwave dryer
Interior with 5～8 DEG C of temperature oven drying at low temperatures, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
(2) Western medicine trimethoprim is put into container, add the ethanol of 1～2 times amount, dilution, be placed in microwave dryer
With 5～8 DEG C of temperature oven drying at low temperatures, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
(3) Western medicine Sulfamethoxazole is put into medicinal cupping, stir with blender, put into after 70 DEG C of baking oven is dried cold
But, extraction is ground into powder, obtains the fine powder of 200 mesh, standby；
(4) fine powder that above-mentioned steps (1)～(3) obtain is put into container mixing, standby.
The preparation method of a kind of Integrated TCM preparation treating bacillary dysentery, including the extraction work of following Chinese medicine ingredients
Skill step:
(1) Chinese medicine hair leaf Engelhardtia roxburghiana, Radix Fici pumilae, Rhizoma Dioscoreae and Radix Gerberae Delavayi are mixed in proportion and put into container, add 5～8
The distilled water of times amount, heated and boiled 2～3 hours, to extract, filter, obtain filtrate, heating is concentrated into pasty state, puts into the baking of 70 DEG C of baking oven
Cooling down after Gan, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
(2) Chinese medicine Radix Tinosporae, Herba Potentillae Chinensis and red being mixed in proportion are put into container, carry out pulverization process, grind into powder,
Arrived the fine powder of 180 mesh, standby；
(3) Herba Hydrocotylis Nepalensis and Radix Rubi Setchuenensis are cleaned, immerse 3 times amount 60% alcohol solution dipping 1～2 hours, add
Heat is extracted 3 hours, reclaims ethanol, filters, obtains filtrate, standby；
(4) Chinese medicine Cortex myricae nanae radicis is cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby；
(5) Chinese medicine Testa dolichoris, Radix desmodiik microphylli, Herba Selaginellae Uncinatae and Fructus Castanopsis Tibetanae are mixed in proportion put into container, add 3～6 times
The distilled water of amount, heated and boiled 1～2 hours, extract, filter, obtain filtrate, standby；
(6) fine powder that above-mentioned steps (1)～(5) obtained, filtrate, juice mix, stirring and dissolving uniformly after, heating
It is condensed into thick paste, standby.
The preparation method of a kind of Integrated TCM preparation treating bacillary dysentery, by described Western medicine fine powder and traditional Chinese medicine thick paste
Mixing, add the deionized water of 2～3 times after mixing, after stirring and dissolving is uniform, heating is concentrated into pasty state, extracts and makes sheet
Agent, obtains the Integrated TCM preparation of described treatment bacillary dysentery.
Usage and dosage: oral, every day 2 times, each 1 (every 0.5g), warm water delivery service；Within 2～5 days, can fully recover, sick
Feelings severe patient is followed the doctor's advice the meal with wine amount of adding.
Embodiment 2
The raw material of Integrated TCM preparation effective ingredient of the present invention forms and weight is:
Furazolidone 0.2g, trimethoprim 0.2g, Sulfamethoxazole 0.3g, hair leaf Engelhardtia roxburghiana 39g, Radix Fici pumilae 38g, Radix Tinosporae
38g, Herba Hydrocotylis Nepalensis 37g, Rhizoma Dioscoreae 36g, Herba Potentillae Chinensis 36g, Cortex myricae nanae radicis 35g, Radix Gerberae Delavayi 35g, Testa dolichoris 35g, Radix desmodiik microphylli
34g, red 34g, Herba Selaginellae Uncinatae 33g, Radix Rubi Setchuenensis 32g and Fructus Castanopsis Tibetanae 32g.
The Integrated TCM formulation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 3
The raw material of Integrated TCM preparation effective ingredient of the present invention forms and weight is:
Furazolidone 0.12g, trimethoprim 0.12g, Sulfamethoxazole 0.2g, hair leaf Engelhardtia roxburghiana 35g, Radix Fici pumilae 34g, Jin Guo
Olive 34g, Herba Hydrocotylis Nepalensis 33g, Rhizoma Dioscoreae 32g, Herba Potentillae Chinensis 32g, Cortex myricae nanae radicis 31g, Radix Gerberae Delavayi 31g, Testa dolichoris 31g, Radix desmodiik microphylli
30g, red 30g, Herba Selaginellae Uncinatae 29g, Radix Rubi Setchuenensis 28g and Fructus Castanopsis Tibetanae 28g.
The Integrated TCM formulation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.
Embodiment 4
The raw material of Integrated TCM preparation effective ingredient of the present invention forms and weight is:
Furazolidone 0.1g, trimethoprim 0.1g, Sulfamethoxazole 0.1g, hair leaf Engelhardtia roxburghiana 31g, Radix Fici pumilae 30g, Radix Tinosporae
30g, Herba Hydrocotylis Nepalensis 29g, Rhizoma Dioscoreae 28g, Herba Potentillae Chinensis 28g, Cortex myricae nanae radicis 27g, Radix Gerberae Delavayi 27g, Testa dolichoris 27g, Radix desmodiik microphylli
26g, red 26g, Herba Selaginellae Uncinatae 25g, Radix Rubi Setchuenensis 24g and Fructus Castanopsis Tibetanae 24g.
The Integrated TCM formulation preparation method processing step of the present embodiment and usage and dosage are same as in Example 1.Toxicity
Test:
1, acute toxicity test:
(1) choose mice 48, male and female half and half, body weight 20～39g, carry out acute toxicity test.Mice is randomly divided into two
Group, i.e. experimental group and matched group, fasting 12 hours before experiment；
(2) the Integrated TCM preparation of the present invention is taken 1 to be dissolved in 10ml water, standby；
(3) take and step (2) normal saline, standby；
(4) the Integrated TCM formulation soln of the present invention in step (2) is taken by the perfusion amount pair that gavage volume is 5ml/kg
24 mices of experimental group carry out perfusion；Within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and
The toxic reaction of record mice and death toll；
(5) normal saline in step (3) is taken by matched group 24 of the perfusion amount that gavage volume is 5ml/kg
Mice carries out perfusion；Within one day, it is administered 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and records the poison of mice
Property reaction and death toll；
Test result indicate that: compare with matched group, after experimental group is administered, mice has no notable difference, tests Continuous Observation 14
My god, mouse systemic situation, diet, drinking-water, body weight increase the most normal.
2, long term toxicity test:
Choose mice 48, male and female half and half, body weight 20～39g, carry out long term toxicity test.The Chinese medicine and western medicine of the present invention is tied
Conjunction preparation takes 1 and is dissolved in 10ml water, carries out mice perfusion, every day 2 times by the perfusion amount that gavage volume is 5ml/kg, connects
After continuous medication 15 weeks, drug withdrawal 3 weeks, carries out laboratory observation.
Test result indicate that: Integrated TCM preparation of the present invention is to the hair of mice, behavior, defecation, body weight, internal organs weight
The indexs such as amount, hemogram, hepatic and renal function, blood glucose, blood fat all have no significant effect, and internal organs naked eyes do not find difference change, histology
Inspection result shows, Organs of Mice is the most all without substantially changing；Illustrate that Integrated TCM preparation of the present invention is to mice long-term prescription
Rear toxicity is little, does not also have difference reaction, application safety after drug withdrawal.Clinical data:
One, case selection:
As the Integrated TCM preparation for the treatment of bacillary dysentery, select bacillary dysentery patient 723 example made a definite diagnosis clinical
Observing, patient is randomly divided into treatment group, control group A and matched group B tri-groups, treatment group 241 example, wherein male 120 example, women
121 examples, age 16～69 years old, 42.5 years old mean age, average course of disease two weeks；Control group A 241 example, wherein male 121 example,
Women 120 example, age 17～66 years old, 41.5 years old mean age, average course of disease two weeks；Matched group B241 example, wherein male 119
Example, women 122 example, age 14～65 years old, 39.5 years old mean age, average course of disease two weeks.
Treatment group, control group A and the course of disease of tri-groups of cases of matched group B, degrees of symptoms are basically identical, without significance difference
Different, there is comparability.
Two, medicament selection:
Treatment group uses Integrated TCM preparation of the present invention, oral, every day 2 times, each 1 (every 0.5g), warm water
Take；Within 2～5 days, can fully recover, the person of being in a bad way follows the doctor's advice the meal with wine amount of adding.
Control group A takes Levofloxacin M. S. A, and oral, be grown up 1 0.1g～0.2g, 2 times on the one, can refer to doctor
Lead down, according to infecting the kind of disease and symptom suitably increases and decreases, every day research on maximum utilized quantity 0.6g, general 5～14 days of the course for the treatment of.
Matched group B takes Berberine Tablet, oral, adult, one time 1～3,3 times on the one.
Three, Outcome measure:
Cure: generate heat, suffer from abdominal pain, the symptom such as diarrhoea all disappears, and physical recovery is normal.It is effective: above-mentioned symptom is substantially alleviated,
Health is clearly better.Effective: above-mentioned symptom has been alleviated, health has taken a turn for the better.Invalid: by above-mentioned symptom after treatment without alleviating
Or increase the weight of.
Four, therapeutic outcome:
Result above shows, the cure rate for the treatment of group and total effective rate are apparently higher than control group A and matched group B.
Five, model case:
1, certain is permitted, female, 17 years old.Patient's abdominal distention, diarrhoea, tenesmus, slight dehydration, removes hospital admission, is diagnosed as antibacterial
Property dysentery, through taking Integrated TCM preparation for treating of the present invention, after taking 1 day, above-mentioned symptom substantially alleviates, after taking 3 days, on
State symptom all to disappear, recovery from illness, follow up a case by regular visits to after 1 month without recurrence.
2, Shen, man, 25 years old.There is fear of cold, heating without obvious inducement in patient, with malaise, stomachache, diarrheal disease
Shape, is diagnosed as bacillary dysentery, and doctor gives Integrated TCM preparation for treating of the present invention, and after taking 1 day, symptom has taken a turn for the better,
After taking 2 days, symptom is clearly better, and after continuing to take 3 days, symptom all disappears, recovery from illness.
3, Fu, man, 42 years old.Patient suffers from abdominal pain, tenesmus, just lower viscous freezes, time have bitter taste, heating, remove examination in hospital, really
Examining as bacillary dysentery, used multiple Drug therapy, therapeutic effect is the best, later my institute's treatment, through taking Chinese and Western of the present invention
Medicine combines preparation for treating, and after taking 1 day, malaise symptoms substantially alleviates, and after continuing to take 2 days, malaise symptoms all disappears, health
Recover normal, recovery from illness, follow up a case by regular visits to after 2 months without recurrence.
4, Lu, female, 38 years old.Patient defecates shapeless, time have mucus, with Nausea and vomiting, abdominal part dull pain, after defecation,
Stomachache can be alleviated, and removes examination in hospital, is diagnosed as bacillary dysentery, and doctor gives Integrated TCM preparation for treating of the present invention, clothes
After 1 day, symptom has alleviated, and after taking 2 days, symptom substantially alleviates, and after continuing to take 1 day, symptom all disappears, recovery from illness.
5, Peng, female, 55 years old.Patient's loss of appetite, Nausea and vomiting, suffer from abdominal pain, the malaise symptoms such as diarrhoea, remove examination in hospital,
Being diagnosed as bacillary dysentery, doctor gives Integrated TCM preparation for treating of the present invention, and after taking 1 day, symptom has taken a turn for the better, and takes
After 2 days, symptom is clearly better, and after continuing to take 2 days, symptom all disappears, and physical recovery is normal, and recovery from illness followed up a case by regular visits to nothing after 1 month
Recurrence.
6, Lu, man, 61 years old.Patient suffers from acute dysentery, tormina, after heavily turn very, the symptoms such as vomiting, diarrhoea occur,
Removing hospital admission, be diagnosed as bacillary dysentery, doctor gives Integrated TCM preparation for treating of the present invention, and after taking 1 day, symptom has
Being alleviated, after taking 2 days, symptom is substantially alleviated, and after continuing to take 1 day, all diseases disappear entirely, recovery from illness.
Claims (6)
1. the Integrated TCM preparation treating bacillary dysentery, it is characterised in that: making described Integrated TCM preparation has
The raw material of effect composition forms and parts by weight are:
Furazolidone 0.1～0.2 part, trimethoprim 0.1～0.2 part, Sulfamethoxazole 0.1～0.5 part, hair leaf Engelhardtia roxburghiana 31～47
Part, Radix Fici pumilae 30～46 parts, Radix Tinosporae 30～46 parts, Herba Hydrocotylis Nepalensis 29～45 parts, Rhizoma Dioscoreae 28～44 parts, Herba Potentillae Chinensis 28～44
Part, Cortex myricae nanae radicis 27～43 parts, Radix Gerberae Delavayi 27～43 parts, Testa dolichoris 27～43 parts, Radix desmodiik microphylli 26～42 parts, red 26～42
Part, Herba Selaginellae Uncinatae 25～41 parts, Radix Rubi Setchuenensis 24～40 parts and Fructus Castanopsis Tibetanae 24～40 parts.
A kind of Integrated TCM preparation treating bacillary dysentery the most according to claim 1, it is characterised in that: make institute
State Integrated TCM preparation effective ingredient raw material composition and parts by weight be:
Furazolidone 0.12～0.18 part, trimethoprim 0.12～0.18 part, Sulfamethoxazole 0.2～0.4 part, hair leaf Engelhardtia roxburghiana 35
～43 parts, Radix Fici pumilae 34～42 parts, Radix Tinosporae 34～42 parts, Herba Hydrocotylis Nepalensis 33～41 parts, Rhizoma Dioscoreae 32～40 parts, Herba Potentillae Chinensis 32～
40 parts, Cortex myricae nanae radicis 31～39 parts, Radix Gerberae Delavayi 31～39 parts, Testa dolichoris 31～39 parts, Radix desmodiik microphylli 30～38 parts, red 30～
38 parts, Herba Selaginellae Uncinatae 29～37 parts, Radix Rubi Setchuenensis 28～36 parts and Fructus Castanopsis Tibetanae 28～36 parts.
A kind of Integrated TCM preparation treating bacillary dysentery the most according to claim 1, it is characterised in that: make institute
State Integrated TCM preparation effective ingredient raw material composition and parts by weight be:
Furazolidone 0.2 part, trimethoprim 0.2 part, Sulfamethoxazole 0.3 part, hair leaf Engelhardtia roxburghiana 39 parts, Radix Fici pumilae 38 parts, Jin Guo
Olive 38 parts, Herba Hydrocotylis Nepalensis 37 parts, Rhizoma Dioscoreae 36 parts, Herba Potentillae Chinensis 36 parts, Cortex myricae nanae radicis 35 parts, Radix Gerberae Delavayi 35 parts, Testa dolichoris 35 parts, pigtail
Sub-grass roots 34 parts, red 34 parts, Herba Selaginellae Uncinatae 33 parts, Radix Rubi Setchuenensis 32 parts and Fructus Castanopsis Tibetanae 32 parts.
4. as described in any one of claims 1 to 3, treat a preparation method for the Integrated TCM preparation of bacillary dysentery, its
It is characterised by: include the extraction process step of following western medicine composition:
(1) Western medicine furazolidone is put into container, add the distilled water of 1～2 times amount, dilution, be placed in microwave dryer interior with 5
～8 DEG C of temperature oven drying at low temperatures, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
(2) Western medicine trimethoprim is put into container, adds the ethanol of 1～2 times amount, dilution, be placed in microwave dryer with 5～
8 DEG C of temperature oven drying at low temperatures, extraction is ground into powder, obtains the fine powder of 180 mesh, standby；
(3) Western medicine Sulfamethoxazole is put into medicinal cupping, stir with blender, put into after 70 DEG C of baking oven is dried and cool down, carry
Take and grind into powder, obtained the fine powder of 200 mesh, standby；
(4) fine powder that above-mentioned steps (1)～(3) obtain is put into container mixing, standby.
5. as described in any one of claims 1 to 3, treat a preparation method for the Integrated TCM preparation of bacillary dysentery, its
It is characterised by: include the extraction process step of following Chinese medicine ingredients:
(1) Chinese medicine hair leaf Engelhardtia roxburghiana, Radix Fici pumilae, Rhizoma Dioscoreae and Radix Gerberae Delavayi are mixed in proportion and put into container, add 5～8 times amount
Distilled water, heated and boiled 2～3 hours, extract, filter, obtain filtrate, heating is concentrated into pasty state, puts into after 70 DEG C of baking oven dries
Cooling, extraction is ground into powder, obtains the fine powder of 160 mesh, standby；
(2) Chinese medicine Radix Tinosporae, Herba Potentillae Chinensis and red being mixed in proportion are put into container, carry out pulverization process, grind into powder, obtained
The fine powder of 180 mesh, standby；
(3) Herba Hydrocotylis Nepalensis and Radix Rubi Setchuenensis are cleaned, immerse 3 times amount 60% alcohol solution dipping 1～2 hours, heating carries
Take 3 hours, reclaim ethanol, filter, obtain filtrate, standby；
(4) Chinese medicine Cortex myricae nanae radicis is cleaned, chopping, put into container, twist juice, filter impurity, stay juice standby；
(5) Chinese medicine Testa dolichoris, Radix desmodiik microphylli, Herba Selaginellae Uncinatae and Fructus Castanopsis Tibetanae are mixed in proportion put into container, add 3～6 times amount
Distilled water, heated and boiled 1～2 hours, extract, filter, obtain filtrate, standby；
(6) fine powder that above-mentioned steps (1)～(5) obtained, filtrate, juice mix, stirring and dissolving uniformly after, heating concentrates
Become thick paste, standby.
6. according to claim 4 or claim 5, treat the preparation method of the Integrated TCM preparation of bacillary dysentery, its
It is characterised by: described Western medicine fine powder and traditional Chinese medicine thick paste are mixed, after mixing, adds the deionized water of 2～3 times, stirring and dissolving
After Jun Yun, heating is concentrated into pasty state, extracts and makes tablet, obtains the Integrated TCM preparation of described treatment bacillary dysentery.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109137490A (en) * | 2018-06-27 | 2019-01-04 | 苏州市天翱特种织绣有限公司 | A kind of antibacterial modified method of cotton fiber |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1120450A (en) * | 1994-10-12 | 1996-04-17 | 骆根兴 | "Yiciling" concentrated medicinal capsule for effective treatment of diarrhoea |
| CN103845391A (en) * | 2012-12-06 | 2014-06-11 | 鲜丹科 | Weichangrexuezhi |
-
2016
- 2016-08-31 CN CN201610814691.8A patent/CN106266437A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1120450A (en) * | 1994-10-12 | 1996-04-17 | 骆根兴 | "Yiciling" concentrated medicinal capsule for effective treatment of diarrhoea |
| CN103845391A (en) * | 2012-12-06 | 2014-06-11 | 鲜丹科 | Weichangrexuezhi |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109137490A (en) * | 2018-06-27 | 2019-01-04 | 苏州市天翱特种织绣有限公司 | A kind of antibacterial modified method of cotton fiber |
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