CN115212263A - Ampelopsis grossedentata dropping pill and preparation method thereof - Google Patents
Ampelopsis grossedentata dropping pill and preparation method thereof Download PDFInfo
- Publication number
- CN115212263A CN115212263A CN202210977078.3A CN202210977078A CN115212263A CN 115212263 A CN115212263 A CN 115212263A CN 202210977078 A CN202210977078 A CN 202210977078A CN 115212263 A CN115212263 A CN 115212263A
- Authority
- CN
- China
- Prior art keywords
- ampelopsis grossedentata
- extraction
- dripping
- pill
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006187 pill Substances 0.000 title claims abstract description 78
- 241001018563 Nekemias grossedentata Species 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 33
- 238000004519 manufacturing process Methods 0.000 claims abstract description 26
- 230000033228 biological regulation Effects 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 238000000605 extraction Methods 0.000 claims description 35
- 239000003921 oil Substances 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 23
- 239000000110 cooling liquid Substances 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 22
- 239000000203 mixture Substances 0.000 claims description 13
- 229920002594 Polyethylene Glycol 8000 Polymers 0.000 claims description 12
- 238000002844 melting Methods 0.000 claims description 12
- 230000008018 melting Effects 0.000 claims description 12
- 239000012153 distilled water Substances 0.000 claims description 11
- 239000011159 matrix material Substances 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 238000005303 weighing Methods 0.000 claims description 11
- 239000002202 Polyethylene glycol Substances 0.000 claims description 10
- 229920001223 polyethylene glycol Polymers 0.000 claims description 10
- 229920002562 Polyethylene Glycol 3350 Polymers 0.000 claims description 9
- JZZIHCLFHIXETF-UHFFFAOYSA-N dimethylsilicon Chemical compound C[Si]C JZZIHCLFHIXETF-UHFFFAOYSA-N 0.000 claims description 9
- 238000003809 water extraction Methods 0.000 claims description 9
- 241000563984 Ampelopsis Species 0.000 claims description 7
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 claims description 7
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 claims description 7
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 6
- 239000008118 PEG 6000 Substances 0.000 claims description 5
- 229920001030 Polyethylene Glycol 4000 Polymers 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 238000000194 supercritical-fluid extraction Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 238000003860 storage Methods 0.000 claims description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 3
- 239000001569 carbon dioxide Substances 0.000 claims description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 3
- 239000008213 purified water Substances 0.000 claims description 3
- 238000000926 separation method Methods 0.000 claims description 3
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 claims description 2
- 239000004353 Polyethylene glycol 8000 Substances 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 claims description 2
- 229940113116 polyethylene glycol 1000 Drugs 0.000 claims description 2
- 229940093430 polyethylene glycol 1500 Drugs 0.000 claims description 2
- 229940050929 polyethylene glycol 3350 Drugs 0.000 claims description 2
- 229940057838 polyethylene glycol 4000 Drugs 0.000 claims description 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims description 2
- 229940085678 polyethylene glycol 8000 Drugs 0.000 claims description 2
- 235000019446 polyethylene glycol 8000 Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000032683 aging Effects 0.000 abstract description 4
- 229930003935 flavonoid Natural products 0.000 abstract description 4
- 235000017173 flavonoids Nutrition 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 206010020772 Hypertension Diseases 0.000 abstract description 3
- 208000007536 Thrombosis Diseases 0.000 abstract description 3
- -1 flavonoid compounds Chemical class 0.000 abstract description 3
- 230000005764 inhibitory process Effects 0.000 abstract description 3
- 241000196324 Embryophyta Species 0.000 abstract description 2
- 230000009467 reduction Effects 0.000 abstract description 2
- 239000011573 trace mineral Substances 0.000 abstract description 2
- 235000013619 trace mineral Nutrition 0.000 abstract description 2
- 238000007689 inspection Methods 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 235000019198 oils Nutrition 0.000 description 22
- 239000000243 solution Substances 0.000 description 12
- 239000000758 substrate Substances 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- KJXSIXMJHKAJOD-LSDHHAIUSA-N (+)-dihydromyricetin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC(O)=C(O)C(O)=C1 KJXSIXMJHKAJOD-LSDHHAIUSA-N 0.000 description 6
- 244000269722 Thea sinensis Species 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 5
- 229910052711 selenium Inorganic materials 0.000 description 5
- 239000011669 selenium Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 240000008415 Lactuca sativa Species 0.000 description 3
- 235000019484 Rapeseed oil Nutrition 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000002826 coolant Substances 0.000 description 3
- KQILIWXGGKGKNX-UHFFFAOYSA-N dihydromyricetin Natural products OC1C(=C(Oc2cc(O)cc(O)c12)c3cc(O)c(O)c(O)c3)O KQILIWXGGKGKNX-UHFFFAOYSA-N 0.000 description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 239000008157 edible vegetable oil Substances 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 235000012045 salad Nutrition 0.000 description 3
- 229920002545 silicone oil Polymers 0.000 description 3
- 229940045860 white wax Drugs 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000021028 berry Nutrition 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 238000005057 refrigeration Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000776115 Ampelopsis glandulosa var. brevipedunculata Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an ampelopsis grossedentata extract, an ampelopsis grossedentata dropping pill and a production method thereof. The Ampelopsis grossedentata belongs to natural peculiar plants, contains 17 amino acids, 14 trace elements and flavonoid compounds with higher content which are required by a human body, has the function of improving the immunocompetence of the human body, and is particularly suitable for people with weak constitution and people with low immunity. The production method of the Ampelopsis grossedentata extract is easy to operate. The analysis of the components of the ampelopsis grossedentata inspection report obtained by the invention shows that the ampelopsis grossedentata inspection report has obvious effects on cold, inflammation inhibition, thrombus resistance, aging resistance, three-high blood pressure reduction, immunity regulation and the like; the ampelopsis grossedentata dropping pill prepared by the invention is a novel preparation which is convenient to carry and has good adherence, the application value of the ampelopsis grossedentata is improved, and the production process of the ampelopsis grossedentata dropping pill is simple to operate.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a ampelopsis grossedentata dropping pill and a preparation method thereof.
Background
With the development of society and the improvement of living standard of people, more and more people pay attention to health preservation, and the Ampelopsis grossedentata can extract a large amount of flavonoid compounds, and the Ampelopsis grossedentata extract is prepared into a biotechnological health food, so that the product application of the Ampelopsis grossedentata is promoted.
Ampelopsis grossedentata (Maoyanmei) is also called as amur tea/sweet tea/berry tea, belongs to Ampelopsis brevipedunculata and has strong vitality. Obvious small teeth are arranged on the edge of the appearance, the vein is obvious, the color is yellow green, the cluster umbellate inflorescence and the leaves are opposite, and the berries are spherical. When the tea is ripe, the tea is purple black, the diameter is 5-6 mm, the tea is sweet and light in taste and cool in nature, and the processed surface leaves have the characteristics of a layer of pure natural white frost, and have the effects of clearing away heat and toxic materials, resisting bacteria and diminishing inflammation, dispelling wind and removing dampness, strengthening bones and muscles, reducing blood pressure, reducing blood fat, protecting liver and the like; is a plant resource for both food and medicine. Through research on the extract by scientific research units such as Chinese medicine university, the active ingredients of the extract are flavonoid compounds such as ampelopsin and dihydromyricetin and the health-care function of trace element selenium of human body, and the extract has the functions of resisting oxidation, resisting aging, resisting radiation and viruses, protecting eyesight and improving human immunity. Selenium cannot be synthesized by a human body, so that the requirement of the human body on selenium is met, and the selenium needs to be supplemented every day to meet the requirement of the human body by 200 micrograms of selenium required by the human body according to the requirement of the world health organization. After the ampelopsis grossedentata is processed and extracted, polyethylene glycol solid matrix is added, the mixture is heated and melted into solution, suspension or emulsion, then the solution, the suspension or the emulsion is dripped into immiscible condensing agent, and liquid drops are contracted and condensed into solid state under the action of surface tension to prepare the preparation.
The dropping pill is a pill form embedded in matrix (matrix injection), the matrix embedding is to disperse the main component in the state of molecular state, colloidal state, microcrystalline or amorphous state and the like in another water-soluble material to form solid dispersion, which can change the absorption of different drugs, improve the bioavailability and improve the pharmacokinetic property and has the following advantages: (1) the composition has the advantages of improving bioavailability, (2) quick release effect and reducing in-vivo inactivation, (3) increasing the stability of the medicament, (4) being used for local administration, (5) being capable of replacing enteric coating, suppository and the like, (6) reducing toxic and side effects, (7) accurate dosage and (8) convenient production. Although the dripping pills have a series of advantages, because the medicine carrying amount of the dripping pills is small, the effective components or effective parts of the traditional Chinese medicines which are prepared into the dripping pills need to be refined and collected, so the components of the dripping pills are clear, and the quality is easy to control. The invention aims to develop a health-care ampelopsis grossedentata series product which is beneficial to human health by taking ampelopsis grossedentata and polyethylene glycol as raw materials.
Disclosure of Invention
The invention aims to provide a Ampelopsis grossedentata extract and an Ampelopsis grossedentata dropping pill and a production method thereof, wherein the extraction method comprises three extraction methods, namely 1 supercritical extraction equipment, 2 ultrasonic alcohol extraction and 3 ultrasonic distilled water extraction, the effective components of the Ampelopsis grossedentata are extracted by using the three extraction methods, and then alcohol and distilled water are removed by a reduced pressure concentrator to obtain a concentrate of the effective components of the Ampelopsis grossedentata. In order to realize the purpose, the invention adopts the technical scheme that:
a Ampelopsis grossedentata dropping pill comprises 1-20% of Ampelopsis grossedentata extract and polyethylene glycol, and the dropping pill is prepared by the steps of dropping pill particle size: 2 mm-6 mm and the aperture of the dripper: 1 mm-4 mm in size to achieve the regulation of the dripping pill dosage, the polyethylene glycol types include but are not limited to polyethylene glycol-1000, polyethylene glycol-1500, polyethylene glycol-3350, polyethylene glycol-4000, polyethylene glycol-6000, polyethylene glycol-8000 or polyethylene glycol mixture.
A production method of Ampelopsis grossedentata dropping pill comprises weighing polyethylene glycol and Ampelopsis grossedentata extract according to a formula, heating and stirring until completely fused and uniformly dispersed, placing into a liquid storage barrel of a dropping pill machine, continuously stirring and keeping the temperature for thirty minutes, finely adjusting according to the inside and outside diameter of a dropper of the liquid storage barrel, uniformly dropping into a cooling liquid at a proper dropping speed, collecting after the dropping pill is completely shrunk and cooled to be formed, removing the redundant cooling liquid on the surface of the dropping pill by using an oil throwing machine, and placing and naturally drying to obtain the finished product.
Further, the extraction is supercritical extraction preparation, carbon dioxide supercritical equipment is used for extraction, 50% -90% of edible ethanol is added into 1-5 times of the edible ethanol for extraction, the pressure of the extraction condition is 350bar, the temperature is 45 ℃, the extraction time is set to be 60-120 minutes, the extract in the separation tank is collected, and the ethanol is removed through a rotary evaporator, so that the Ampelopsis grossedentata supercritical extract can be obtained.
Further, the production method comprises the steps of weighing 70g of medicinal substrate PEG3350 and 25g of PEG8000, completely melting the medicinal substrate PEG3350 and the medicinal substrate PEG8000 on a water bath kettle at the temperature of 60-85 ℃, adding 5g of the Ampelopsis grossedentata supercritical extract, uniformly stirring, pouring into a charging groove of a dripping pill machine, stirring, keeping the temperature for 30 minutes, dripping into dimethyl silicon oil cooling liquid at the speed of 35-45 drops/min at the drop distance of 5-10cm, taking out after the dripping pills are completely shrunk and condensed and formed, and removing the cooling liquid on the surfaces of the dripping pills by using an oil slinging machine to obtain the Ampelopsis grossedentata dripping pills.
Further, the extraction is ultrasonic alcohol preparation, 50 to 90 percent of edible ethanol is added into 50 times of the edible ethanol for extraction for 1 to 3 times, and the extracting solution is combined, filtered and concentrated to obtain 8 to 10g of concentrated solution; the ultrasonic alcoholic extract of Ampelopsis grossedentatac is obtained.
Further, the production method comprises the steps of weighing medicinal substrates PEG4000 with the amount of 55g and PEG8000 35g, completely melting the medicinal substrates PEG4000 and PEG8000 g in a water bath kettle at the temperature of 60-85 ℃, adding 10g of the Ampelopsis grossedentata ultrasonic alcohol extraction extract, uniformly stirring, pouring into a charging tank of a dripping pill machine, stirring, keeping the temperature for 30 minutes, dripping into dimethyl silicon oil cooling liquid at the speed of 30-40 drops/min at the drop distance of 5-10cm, taking out after the dripping pills are completely shrunk and condensed and formed, and removing the cooling liquid on the surfaces of the dripping pills by using an oil slinging machine to obtain the Ampelopsis grossedentata dripping pills.
Further, the extraction is distilled water extraction, RO purified water is added into the distilled water in an amount which is 20 to 50 times of the amount of the distilled water for extraction for 1 to 3 times, and the extracting solution is combined, filtered and concentrated to obtain 8 to 10g of concentrated solution; the ultrasonic water extraction extract of the Ampelopsis grossedentata is obtained.
Further, the production method comprises the steps of weighing 150g of medicinal substrate PEG 6000, completely melting the medicinal substrate PEG 6000 on a water bath kettle at the temperature of 60-85 ℃, adding 30g of Ampelopsis grossedentata ultrasonic water extraction extract, uniformly stirring, pouring the mixture into a charging groove of a dripping pill machine, stirring, keeping the temperature for 30 minutes, dripping the mixture into dimethyl silicon oil cooling liquid at the speed of 25-35 drops/min at the drop distance of 5-10cm, taking out after the dripping pills are completely shrunk and condensed and formed, and removing the cooling liquid on the surfaces of the dripping pills by using an oil slinger to obtain the Ampelopsis grossedentata dripping pills.
The invention has the beneficial effects that: the ampelopsis grossedentata dropping pill has obvious effects on cold, inflammation inhibition, thrombosis resistance, aging resistance, high blood pressure, high blood sugar, high blood fat and high blood sugar and immunity regulation; the ampelopsis grossedentata dropping pill prepared by the invention is a novel preparation which is convenient to carry and has good adherence, the application value of the ampelopsis grossedentata is improved, and the production process of the ampelopsis grossedentata dropping pill is simple to operate.
Detailed Description
In order that the invention may be more fully understood, reference will now be made to the accompanying examples. The preferred embodiments of the present invention are given in the examples. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The technical solution of the present patent will be further described in detail with reference to the following embodiments.
The invention provides a Ampelopsis grossedentatac extract and an Ampelopsis grossedentatac dropping pill and a production method thereof, the extraction method comprises three types of 1, supercritical extraction equipment, 2, ultrasonic alcohol extraction and 3, ultrasonic distilled water extraction, the three types of modes are utilized to extract the active ingredients of the Ampelopsis grossedentatac, and then alcohol and distilled water are removed through a reduced pressure concentration instrument to obtain the concentrate of the active ingredients of the Ampelopsis grossedentatac.
The method comprises the following specific steps of aiming at the ampelopsis grossedentata extraction process:
the method comprises the following steps of (1) obtaining a raw material Ampelopsis grossedentata, crushing the raw material Ampelopsis grossedentata, and putting the crushed raw material Ampelopsis grossedentata into an extraction tank, wherein the extraction mode is divided into three extraction modes;
1. extracting with 50-50 times of edible ethanol for 1-3 times, mixing extractive solutions, filtering, and concentrating to obtain 8-10 g concentrated solution; the Ampelopsis grossedentata extract is obtained.
2. Adding 20-50 times of RO purified water, extracting for 1-3 times, mixing the extractive solutions, filtering, and concentrating to obtain 8-10 g concentrated solution; the Ampelopsis grossedentata extract is obtained.
3. Extracting by using carbon dioxide supercritical equipment, adding 1-5 times of 50-90% of edible ethanol for extraction, setting the extraction condition pressure to be 350bar and the extraction temperature to be 45 ℃ and the extraction time to be 60-120 minutes, collecting the extract in a separation tank, and removing the ethanol by using a rotary evaporator to obtain the Ampelopsis grossedentata extract.
The first embodiment is as follows:
the ampelopsis grossedentata dropping pill and the production method thereof are as follows:
supercritical extraction of the Ampelopsis grossedentata: 5g, medicinal substrate PEG 3350:70g, medicinal substrate PEG 8000:25g of the total weight of the mixture;
material melting temperature: 60-85 deg.C
Oil bath temperature: upper limit: lower limit of 85 ℃:60 ℃; the temperature of the dripper: upper limit: lower limit of 85 ℃:65 ℃;
refrigeration temperature: upper limit: lower limit of 10 ℃:0 ℃; cooling agent: edible oil (rapeseed oil, salad oil \8230;), food-medicine white wax oil, and dimethyl silicone oil.
The drop pitch is as follows: 5 cm-20 cm, the dropping speed is 45 drops/min;
the specific production method comprises the following steps: weighing 70g medicinal matrix PEG3350 and 25g PEG8000, melting completely in water bath at 85 deg.C, adding 5g Ampelopsis grossedentata extract, stirring, pouring into charging tank of dripping pill machine, stirring, maintaining temperature for 30 min, dripping into dimethyl silicon oil cooling liquid at a dripping distance of 10cm at a speed of 35-45 drops/min, shrinking and condensing for molding, taking out, and removing cooling liquid on dripping pill surface with oil slinging machine.
Example two:
the ampelopsis grossedentata dropping pill and the production method thereof are as follows:
ultrasonic alcohol extraction of Ampelopsis grossedentata: 10g, pharmaceutical base PEG 3350:55g, medicinal matrix PEG 8000:35g of a soybean milk powder;
material melting temperature: 60-85 deg.C
Oil bath temperature: upper limit: lower limit of 85 ℃:60 ℃; the dripper temperature: upper limit: lower limit of 85 ℃:65 ℃;
refrigeration temperature: upper limit: lower limit of 10 ℃:0 ℃; cooling agent: edible oil (rapeseed oil, salad oil \8230;), food-medicine white wax oil, and dimethyl silicone oil.
The drop pitch is as follows: 5 cm-20 cm, the dropping speed is 40 drops/min;
the specific production method comprises the following steps: weighing 55g of medicinal substrate PEG3350 and PEG8000 35g, completely melting in a water bath at 85 ℃, adding 10g of Ampelopsis grossedentata extract, uniformly stirring, pouring into a charging tank of a dripping pill machine, stirring, keeping the temperature for 30 minutes, dripping into dimethyl silicon oil cooling liquid at a speed of 30-40 drops/min at a drop distance of 10cm, taking out after the dripping pills are completely shrunk and condensed and formed, and removing the cooling liquid on the surfaces of the dripping pills by using an oil slinging machine to obtain the dripping pill.
Example three:
the ampelopsis grossedentata dropping pill and the production method thereof are as follows:
ultrasonic distilled water extraction of the ampelopsis grossedentata: 20g, pharmaceutical matrix PEG 6000:150g
Material melting temperature: 60-85 deg.C
Oil bath temperature: upper limit: lower limit of 85 ℃:60 ℃; the dripper temperature: upper limit: lower limit of 85 ℃:65 ℃;
refrigerating temperature: upper limit: lower limit of 10 ℃:0 ℃; cooling agent: edible oil (rapeseed oil, salad oil \8230;), food-medicine white wax oil, and dimethyl silicone oil. (ii) a
The drop pitch is as follows: 5 cm-20 cm, the dropping speed is 35 drops/min;
the specific production method comprises the following steps: weighing 150g of medicinal matrix PEG 6000, completely melting in a water bath at 85 ℃, adding 10g of Ampelopsis grossedentata extract, stirring and mixing uniformly, pouring into a charging groove of a pill dropping machine, stirring, keeping the temperature for 30 minutes, dropping into dimethyl silicon oil cooling liquid at a speed of 25-35 drops/min at a drop distance of 10cm, taking out after the pills are completely contracted, condensed and formed, and removing the cooling liquid on the surfaces of the pills by using an oil throwing machine.
Data comparison shows that 20.54% of total flavonoids and 64.28% of dihydromyricetin can be extracted from the Ampelopsis grossedentata by the first method.
The produced ampelopsis grossedentata dropping pill has obvious effects on cold, inflammation inhibition, thrombosis resistance, aging resistance, high blood pressure, high blood sugar and high blood fat reduction and immunity regulation; the ampelopsis grossedentata dropping pill prepared by the invention is a novel preparation which is convenient to carry and has good adherence, the application value of the ampelopsis grossedentata is improved, and the production process of the ampelopsis grossedentata dropping pill is simple to operate.
The above embodiments are only for illustrating the invention and are not to be construed as limiting the invention, and those skilled in the art can make various changes and modifications without departing from the spirit and scope of the invention, therefore, all equivalent technical solutions also belong to the scope of the invention, and the scope of the invention is defined by the claims.
Claims (8)
1. A Ampelopsis grossedentata dropping pill is characterized in that: comprises 1 to 20 percent of Ampelopsis grossedentata extract and polyethylene glycol, and the dropping pill is prepared by the following steps of dropping pill particle size: 2 mm-6 mm and the aperture of the dripper: 1 mm-4 mm in size to achieve the regulation of the dripping pill dosage, the polyethylene glycol types include but are not limited to polyethylene glycol-1000, polyethylene glycol-1500, polyethylene glycol-3350, polyethylene glycol-4000, polyethylene glycol-6000, polyethylene glycol-8000 or polyethylene glycol mixture.
2. A production method of the ampelopsis grossedentata dropping pill is characterized in that: weighing polyethylene glycol and Ampelopsis grossedentata extract according to a formula, heating and stirring the mixture until the mixture is completely fused and uniformly dispersed, placing the mixture into a liquid storage barrel of a pill dropping machine, continuously stirring and keeping the temperature for thirty minutes, carrying out fine adjustment according to the inside and outside diameter of a dropper of the liquid storage barrel, dropping the mixture into cooling liquid at a proper dropping speed and a uniform speed, collecting the mixture after the pills are completely shrunk and cooled and formed, removing the redundant cooling liquid on the surfaces of the pills by using an oil throwing machine, and placing and naturally drying the mixture to obtain a finished product.
3. The method for producing the ampelopsis grossedentata dropping pill according to claim 2, wherein the method comprises the following steps: the extraction is supercritical extraction preparation, carbon dioxide supercritical equipment is used for extraction, 50-90% of edible ethanol is added into 1-5 times of the edible ethanol for extraction, the pressure of the extraction condition is 350bar, the temperature is 45 ℃, the extraction time is set to be 60-120 minutes, the extract in the separation tank is collected, and the ethanol is removed through a rotary evaporator, so that the ampelopsis grossedentata supercritical extract can be obtained.
4. The method for producing the ampelopsis grossedentata dripping pill according to claim 3, wherein the method comprises the following steps: the production method comprises weighing 70g medicinal matrix PEG3350, PEG8000 25g, melting completely in 60-85 deg.C water bath, adding 5g of the Ampelopsis grossedentata supercritical extract, stirring, pouring into a charging tank of dripping pill machine, stirring, holding for 30 min, dripping into dimethyl silicon oil cooling liquid at a dripping distance of 5-10cm at a speed of 35-45 drops/min, taking out after the dripping pill is completely shrunk and condensed, and removing the cooling liquid on the surface of the dripping pill with oil slinging machine to obtain the dripping pill.
5. The method for producing the ampelopsis grossedentata dropping pill according to claim 2, wherein the method comprises the following steps: the extraction is ultrasonic alcohol preparation, 50 to 90 percent of edible ethanol is added into 50 times of the edible ethanol for extraction for 1 to 3 times, and the extracting solution is merged, filtered and concentrated to obtain 8 to 10g of concentrated solution; the ultrasonic alcohol extract of Ampelopsis grossedentatac is obtained.
6. The method for producing the ampelopsis grossedentata dripping pill according to claim 5, wherein the method comprises the following steps: the production method comprises weighing medicinal matrix PEG4000 in an amount of 55g and PEG8000 35g, completely melting in a water bath at 60-85 deg.C, adding Ampelopsis grossedentata ultrasonic alcohol extraction extract 10g, stirring, mixing, pouring into a charging tank of a dripping pill machine, stirring, holding for 30 min, dripping into dimethyl silicon oil cooling liquid at a dripping distance of 5-10cm at a speed of 30-40 drops/min, taking out after the dripping pill is completely contracted and condensed, and removing the cooling liquid on the surface of the dripping pill by an oil slinging machine to obtain the dripping pill.
7. The method for preparing the ampelopsis grossedentata dripping pill according to claim 2, wherein the method comprises the following steps: the extraction is distilled water extraction, RO purified water is added into the distilled water in an amount which is 20 to 50 times of the amount of the distilled water for extraction for 1 to 3 times, and extracting solutions are combined, filtered and concentrated to obtain 8 to 10g of concentrated solution; the ultrasonic water extraction extract of the Ampelopsis grossedentata is obtained.
8. The method for preparing the ampelopsis grossedentata dropping pill according to claim 7, wherein the method comprises the following steps: the production method comprises weighing medicinal matrix PEG 6000 in an amount of 150g, completely melting in water bath at 60-85 deg.C, adding ultrasonic water extraction extract of Ampelopsis Grossdentata in an amount of 30g, stirring, pouring into a charging tank of dripping pill machine, stirring, maintaining the temperature for 30 min, dripping into dimethyl silicon oil cooling liquid at a dripping distance of 5-10cm at a speed of 25-35 drops/min, taking out after the dripping pill is completely shrunk and condensed, and removing the cooling liquid on the surface of the dripping pill with oil throwing machine to obtain the dripping pill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210977078.3A CN115212263A (en) | 2022-08-15 | 2022-08-15 | Ampelopsis grossedentata dropping pill and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210977078.3A CN115212263A (en) | 2022-08-15 | 2022-08-15 | Ampelopsis grossedentata dropping pill and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115212263A true CN115212263A (en) | 2022-10-21 |
Family
ID=83614878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210977078.3A Pending CN115212263A (en) | 2022-08-15 | 2022-08-15 | Ampelopsis grossedentata dropping pill and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115212263A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708207A (en) * | 2009-12-10 | 2010-05-19 | 广西博科药业有限公司 | Medicinal composition for expelling phlegm and inhibiting cough and preparation method thereof |
| CN102727630A (en) * | 2012-06-29 | 2012-10-17 | 河南中医学院 | Plant extract dripping pill |
| CN104262427A (en) * | 2014-09-30 | 2015-01-07 | 桂林三宝药业有限公司 | Method for extracting rubusoside from sweet tea leaves |
| CN105876009A (en) * | 2016-04-28 | 2016-08-24 | 长沙湘资生物科技有限公司 | Medicinal exocarpium tea and process for preparing same |
-
2022
- 2022-08-15 CN CN202210977078.3A patent/CN115212263A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101708207A (en) * | 2009-12-10 | 2010-05-19 | 广西博科药业有限公司 | Medicinal composition for expelling phlegm and inhibiting cough and preparation method thereof |
| CN102727630A (en) * | 2012-06-29 | 2012-10-17 | 河南中医学院 | Plant extract dripping pill |
| CN104262427A (en) * | 2014-09-30 | 2015-01-07 | 桂林三宝药业有限公司 | Method for extracting rubusoside from sweet tea leaves |
| CN105876009A (en) * | 2016-04-28 | 2016-08-24 | 长沙湘资生物科技有限公司 | Medicinal exocarpium tea and process for preparing same |
Non-Patent Citations (1)
| Title |
|---|
| 刘畅,等: "藤茶生物活性成分及其制备工艺研究进展" * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101077110B (en) | Health-care tea and its making method | |
| CN108606190A (en) | A kind of blueberry draft composite plant beverage, preparation method and application | |
| CN101341997B (en) | Snow pear beverage and preparation technique | |
| CN109601795A (en) | Using penthorum chinense pursh as composition alcohol-decomposing beverage of primary raw material and preparation method thereof | |
| CN101288495A (en) | Raspberry fruit vinegar beverage and preparing process thereof | |
| CN107836523A (en) | A kind of preparation method of high stability peanut milk | |
| CN103783195B (en) | A kind of preparation method of barley green tea beverage | |
| CN109156672A (en) | A kind of Saussurea involucrata culture composite fruit juice drink | |
| CN115212263A (en) | Ampelopsis grossedentata dropping pill and preparation method thereof | |
| CN102579644B (en) | Compound Chinese hawthorn leaf total flavone dripping pill and preparation method thereof | |
| CN101223968A (en) | Preparing method of Chinese Date series food | |
| CN106974154A (en) | A kind of Laoyin tea and STEVIA REBAUDIANA method for preparing beverage | |
| CN102423070A (en) | Natto capsule and its preparation method | |
| CN101057694A (en) | Method for preparing eye-protecting beverage | |
| KR101881663B1 (en) | Earthworm fermented extracts and method for manuracturing thereof and natural cosmetics and functional health food comprising same | |
| CN111358719B (en) | Chinese herbal medicine lipstick with cheilitis prevention function and preparation method thereof | |
| CN108251248A (en) | It is a kind of for tree peony rice wine of female health preserving health care and preparation method thereof | |
| CN106962534A (en) | The jasmine tea formula and preparation technology of a kind of function of relieving summer heat | |
| CN115364141A (en) | Cyclocarya paliurus dripping pill and preparation method thereof | |
| CN103082277A (en) | Medicinal sweet potato Simon I leaf concentrated oral liquid and preparation method thereof | |
| CN110226628A (en) | A kind of Herba Plantaginis extract albumen special medicine purposes formula food | |
| CN109464367A (en) | A kind of daily lip gloss and preparation method thereof containing Chinese medical extract | |
| CN107927468A (en) | A kind of jujube fruit drink and its preparation process | |
| CN109287989A (en) | A kind of formula and preparation method of blackcurrant Fructus Hippophae extractum | |
| CN108186699A (en) | A kind of traditional Chinese medicine extraction composition dropping pills with anti-fatigue effect and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20221021 |