CN115197522B - 高含水高透氧硅水凝胶、角膜接触镜及角膜接触镜制备方法 - Google Patents
高含水高透氧硅水凝胶、角膜接触镜及角膜接触镜制备方法 Download PDFInfo
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Abstract
本发明公开了一种高含水高透氧硅水凝胶、角膜接触镜及角膜接触镜制备方法,所述高含水高透氧硅水凝胶以重量份数计,由以下组分聚合反应而成:硅氧烷单体30‑70份,亲水性单体30‑50份,交联剂0.2‑1.0份,引发剂0.3‑2份,溶剂10‑40份,辅助材料5‑20份。本发明硅水凝胶配方中硅氧烷单体MCS‑M11和MCR‑M11与作为亲水性单体的丙烯酸类化合物有良好的溶解性,解决了硅水凝胶镜片中硅材料与亲水性单体溶解性不好的问题;与丙烯氧基封端氧化乙烯‑二甲基硅氧烷‑氧化乙烯ABA嵌段共聚物相结合,提高了镜片的透氧性。本发明采用三官能团交联剂增加了镜片柔韧性,解决了传统硅水凝胶镜片韧性不好的问题。生物相容剂或助溶剂的加入进一步提高了镜片的含水率和佩戴舒适度。
Description
技术领域
本发明涉及硅水凝胶技术领域,具体涉及一种高含水高透氧硅水凝胶及采用该硅水凝胶制备的角膜接触镜,本发明同时还涉及所述角膜接触镜的制备方法。
背景技术
软性隐形眼镜(SCL)材质是亲水性合成高分子化合物,镜片柔软,富有弹性,舒适性好,最初使用时无明显异物感。根据材质的不同,软性隐形眼镜又可分为水凝胶隐形眼镜与硅水凝胶隐形眼镜,水凝胶隐形眼镜的主要材质为聚甲基丙烯酸2-羟乙酯,由于含水率较低,一般会向其中添加N-乙烯基吡咯酮(NVP)、N ,N-二甲基丙烯酰胺(DMAA)、甲基丙烯酸(MAA)等一种以上的亲水性单体以提升含水率,但同时水凝胶隐形眼镜的张力、韧度却因此降低;硅水凝胶隐形眼镜主要材质为亲水性含硅聚合材料和亲水性单体,其极大地提高了隐形眼镜的透氧率,满足眼睛对氧的需求而显著提升了配戴效果,克服了水凝胶自身低透氧率的局限,因此越来越受到消费者的欢迎。但硅水凝胶由于其本身含水量的局限,导致表面亲水性不够好而影响配戴效果,如出现干涩,低舒适感,蛋白质沉淀等问题。
发明内容
本发明的目的之一是提供一种高含水高透氧硅水凝胶,以解决现有硅水凝胶由于本身含水量低而影响佩戴效果的技术问题。
本发明的目的之二是提供一种采用上述高含水高透氧硅水凝胶制成的角膜接触镜。
本发明的目的之三是提供一种上述角膜接触镜的制备方法。
为实现其目的,本发明采用如下技术方案:
一种高含水高透氧硅水凝胶,其以重量份数计,由以下组分聚合反应而成:
硅氧烷单体:30-70份;
亲水性单体:30-50份;
交联剂:0.2-1.0份;
引发剂:0.3-2份;
溶剂:10-40份
辅助材料:5-20份;
其中,所述硅氧烷单体为对称的单甲基丙烯酰氧基丙基改性聚二甲基硅氧烷(MCS-M11)或不对称单甲基丙烯氧丙基端聚二甲基硅氧烷(MCR-M11)与丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物和(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA)的混合物;硅氧烷单体可以提高接触镜透氧性,结构中Si-Si及Si-O间形成通道,可使氧气更好地通过,提高透氧量。
所述辅助材料为生物相容剂或助溶剂。
作为本发明技术方案的优选,所述亲水性单体为甲基丙烯酸和N-乙烯吡咯烷酮(NVP),或甲基丙烯酸和N-乙烯吡咯烷酮(NVP)与甲基丙烯酸羟乙酯、丙烯酸羟丙酯(HBA)、甲基丙烯酸甲酯、N,N-二甲基丙烯酰胺(DMAA)中的至少一种。
进一步地,所述交联剂为三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)、三羟甲基丙烷三丙烯酸酯(TMPTA)或乙氧基化三羟甲基丙烷三丙烯酸酯(TMP3EOTA)中的一种或几种。
进一步地,所述生物相容剂为2-甲基丙烯酰氧乙基磷酸胆碱(MPC),所述助溶剂为聚乙二醇PEG-400或聚乙二醇PEG-200。
进一步地,所述溶剂为正丁醇、正己醇、正壬醇或异丙醇中的任意一种。
进一步地,所述引发剂为偶氮二异丁腈、过氧化苯甲酰中的一种或几种。
采用上述高含水高透氧硅水凝胶可制成角膜接触镜,制备方法为:将所述硅氧烷单体、亲水性单体、交联剂、引发剂、溶剂、辅助材料按配方量混合后搅拌均匀,注入角膜接触镜模具中,在加热条件下引发聚合反应,得到硅水凝胶角膜接触镜。
相比于现有技术,本发明具有以下有益效果:
1、本发明硅水凝胶配方中对称的单甲基丙烯酰氧基丙基改性聚二甲基硅氧烷(MCS-M11)和不对称单甲基丙烯氧丙基端聚二甲基硅氧烷(MCR-M11)与丙烯酸类化合物有良好的溶解性,解决了硅水凝胶镜片中硅材料与亲水性单体溶解性不好的问题;与丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物相结合,提高了镜片的透氧性。
2、本发明采用三官能团交联剂三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)、三羟甲基丙烷三丙烯酸酯(TMPTA)或乙氧基化三羟甲基丙烷三丙烯酸酯(TMP3EOTA),增加了镜片柔韧性,解决了传统硅水凝胶镜片韧性不好的问题。
3、本发明隐形眼镜材料中含有生物相容剂2-甲基丙烯酰氧乙基磷酸胆碱,具有较佳的亲水性与生物兼容性,提高了隐形眼镜材料的含水率,使隐形眼镜镜片具有适中的含水率,并增加配带舒适度;同样地,助溶剂PEG-400或PEG-200的加入也可提高镜片的含水率。
附图说明
图1为本发明实施例1制备的角膜接触镜在投影仪下的成像图;
图2为本发明实施例2制备的角膜接触镜在投影仪下的成像图;
图3为本发明实施例3制备的角膜接触镜在投影仪下的成像图;
图4为本发明实施例4制备的角膜接触镜在投影仪下的成像图;
图5为本发明实施例5制备的角膜接触镜在投影仪下的成像图;
图6为本发明实施例1制备的角膜接触镜的光透射比检测图;
图7为本发明实施例2制备的角膜接触镜的光透射比检测图;
图8为本发明实施例3制备的角膜接触镜的光透射比检测图;
图9为本发明实施例4制备的角膜接触镜的光透射比检测图;
图10为本发明实施例5制备的角膜接触镜的光透射比检测图。
具体实施方式
以下结合附图和具体实施例对本发明的高含水高透氧硅水凝胶、角膜接触镜及角膜接触镜的制备方法进行详细说明。
实施例1
本实施例中高含水高透氧硅水凝胶是以2.5g对称的单甲基丙烯酰氧基丙基改性聚二甲基硅氧烷(MCS-M11),0.5g(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA),1.5g丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物,1g甲基丙烯酸,1.5gN-乙烯吡咯烷酮(NVP),1g丙烯酸羟丙酯(HBA)为原料,加入0.04g的乙氧基化三羟甲基丙烷三丙烯酸酯(TMP3EOTA)交联剂,0.05g的偶氮二异丁腈,0.5g2-甲基丙烯酰氧乙基磷酸胆碱(MPC),2g正己醇,采用常规方法聚合得到。
将各组分按上述配方量混合后搅拌均匀,滴注入角膜接触镜模具中,搅拌30min以上热固化引发聚合反应,然后置于纯化水中脱模,得到硅水凝胶角膜接触镜。
采用本实施例方法制得的硅水凝胶角膜接触镜经灭菌后检测,含水量为62%,折射率为1.388-1.393,透光率:95.3%,DK值为98。其在投影仪下的成像图如图1所示,该成像图是镜片在纯化水中观察镜片产生的,镜片越透亮就说明镜片的透光率越高。光透射比检测图如图6所示。
实施例2
本实施例中高含水高透氧硅水凝胶是以1.5g不对称单甲基丙烯氧丙基端聚二甲基硅氧烷(MCR-M11),1.5g(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA),0.5g丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物,0.5g甲基丙烯酸,4gN-乙烯吡咯烷酮(NVP),0.2gPEG-400,加入0.05g的三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)交联剂,0.06g的偶氮二异丁腈,4g正丁醇,采用常规方法聚合得到。
将各组分按上述配方量混合后搅拌均匀,滴注入角膜接触镜模具中,搅拌30min以上热固化引发聚合反应,然后置于纯化水中脱模,得到硅水凝胶角膜接触镜。
采用本实施例方法制得的硅水凝胶角膜接触镜经灭菌后检测,含水量为63%,折射率为1.385-1.390,透光率:95.6%,DK值为113。其在投影仪下的成像图如图2所示,该成像图是镜片在纯化水中观察镜片产生的,镜片越透亮就说明镜片的透光率越高。光透射比检测图如图7所示。
实施例3
本实施例中高含水高透氧硅水凝胶是以2g不对称单甲基丙烯氧丙基端聚二甲基硅氧烷(MCR-M11),2g(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA),0.5g丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物,0.5g甲基丙烯酸,4gN-乙烯吡咯烷酮(NVP),0.8gN,N-二甲基丙烯酰胺(DMAA)为原料,加入0.05g的三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)交联剂,0.06g的偶氮二异丁腈,0.3g2-甲基丙烯酰氧乙基磷酸胆碱(MPC),4g正壬醇,采用常规方法聚合得到。
将各组分按上述配方量混合后搅拌均匀,滴注入角膜接触镜模具中,搅拌30min以上热固化引发聚合反应,然后置于纯化水中脱模,得到硅水凝胶角膜接触镜。
采用本实施例方法制得的硅水凝胶角膜接触镜经灭菌后检测,含水量为65%,折射率为1.388-1.395,透光率:93.3%,DK值为96。其在投影仪下的成像图如图3所示,该成像图是镜片在纯化水中观察镜片产生的,镜片越透亮就说明镜片的透光率越高。光透射比检测图如图8所示。
实施例4
本实施例中高含水高透氧硅水凝胶是以2.5g对称的单甲基丙烯酰氧基丙基改性聚二甲基硅氧烷(MCS-M11),2.0g(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA),0.5g丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物,0.5g甲基丙烯酸,4gN-乙烯吡咯烷酮(NVP),0.5gN,N-二甲基丙烯酰胺(DMAA)为原料,加入0.05g的三羟甲基丙烷三丙烯酸酯(TMPTA)交联剂,0.04g的过氧化苯甲酰,0.1g2-甲基丙烯酰氧乙基磷酸胆碱(MPC),2g正丁醇,采用常规方法聚合得到。
将各组分按上述配方量混合后搅拌均匀,滴注入角膜接触镜模具中,搅拌30min以上热固化引发聚合反应,然后置于纯化水中脱模,得到硅水凝胶角膜接触镜。
采用本实施例方法制得的硅水凝胶角膜接触镜经灭菌后检测,含水量为63%,折射率为1.387-1.395,透光率:97.4%,DK值为95。其在投影仪下的成像图如图4所示,该成像图是镜片在纯化水中观察镜片产生的,镜片越透亮就说明镜片的透光率越高。光透射比检测图如图9所示。
实施例5
本实施例中高含水高透氧硅水凝胶是以2.0g对称的单甲基丙烯酰氧基丙基改性聚二甲基硅氧烷(MCS-M11),1.5g(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA),0.5g丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物,0.5g甲基丙烯酸,4gN-乙烯吡咯烷酮(NVP),0.5gN,N-二甲基丙烯酰胺(DMAA),0.3g丙烯酸羟丙酯(HBA)为原料,加入0.05g的三羟甲基丙烷三丙烯酸酯(TMPTA)交联剂,0.05g的偶氮二异丁腈,0.1g2-甲基丙烯酰氧乙基磷酸胆碱(MPC),2g异丙醇,采用常规方法聚合得到。
将各组分按上述配方量混合后搅拌均匀,滴注入角膜接触镜模具中,搅拌30min以上热固化引发聚合反应,然后置于纯化水中脱模,得到硅水凝胶角膜接触镜。
采用本实施例方法制得的硅水凝胶角膜接触镜经灭菌后检测,含水量为64%,折射率为1.388-1.396,透光率:95.1%,DK值为105。其在投影仪下的成像图如图5所示,该成像图是镜片在纯化水中观察镜片产生的,镜片越透亮就说明镜片的透光率越高。光透射比检测图如图10所示。
以上硅水凝胶角膜接触镜镜片光透过率使用紫外分光光度计进行检测;折射率使用ATAGO全自动台式折光仪进行检测;透氧量使用隐形眼镜透氧测量仪(极谱法)检测,极谱法透氧仪可以测量水凝胶和非水凝胶,硬性和弹性接触镜材料的透氧系数,适用于测量各种光焦度和旋转对称几何镜片,硬性和非水凝胶弹性材料成品镜片的修正透氧系数(DK),同样适用于测定水凝胶和非水凝胶,硬性和弹性接触镜材料标准镜片的修正透氧系数。透氧系数一般高于87就说明镜片的透氧效果好。镜片含水量通过以下方法得到:
其中:M1为硅水凝胶湿体质量,M2为硅水凝胶烘干后干片质量。
本发明提供的硅水凝胶含水量高,更加透亮,由其制成的硅水凝胶接触镜镜片高透氧且具有更好的生物相容性,使得佩戴更加舒适。
Claims (7)
1.一种高含水高透氧硅水凝胶,其特征在于,以重量份数计,该硅水凝胶由以下组分聚合反应而成:
硅氧烷单体:30-70份;
亲水性单体:30-50份;
交联剂:0.2-1.0份;
引发剂:0.3-2份;
溶剂:10-40份
辅助材料:5-20份;
所述硅氧烷单体为对称的单甲基丙烯酰氧基丙基改性聚二甲基硅氧烷(MCS-M11)或不对称单甲基丙烯酰氧丙基端聚二甲基硅氧烷(MCR-M11)与丙烯氧基封端氧化乙烯-二甲基硅氧烷-氧化乙烯 ABA嵌段共聚物和(3-甲基丙烯酰氧基-2-羟基丙氧基)丙基二(三甲基甲硅烷氧基)甲基硅烷(SIGMA)的混合物;
所述交联剂为三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)、三羟甲基丙烷三丙烯酸酯(TMPTA)或乙氧基化三羟甲基丙烷三丙烯酸酯(TMP3EOTA)中的一种或几种;
所述辅助材料为生物相容剂和助溶剂。
2.如权利要求1所述的一种高含水高透氧硅水凝胶,其特征在于,所述亲水性单体为甲基丙烯酸和N-乙烯吡咯烷酮(NVP),或甲基丙烯酸和N-乙烯吡咯烷酮(NVP)与甲基丙烯酸羟乙酯、丙烯酸羟丙酯(HBA)、甲基丙烯酸甲酯、N,N-二甲基丙烯酰胺(DMAA)中的至少一种。
3.如权利要求1所述的一种高含水高透氧硅水凝胶,其特征在于,所述生物相容剂为2-甲基丙烯酰氧乙基磷酸胆碱(MPC),所述助溶剂为聚乙二醇PEG-400或聚乙二醇PEG-200。
4.如权利要求1所述的一种高含水高透氧硅水凝胶,其特征在于,所述溶剂为正丁醇、正己醇、正壬醇或异丙醇中的任意一种。
5.如权利要求1所述的一种高含水高透氧硅水凝胶,其特征在于,所述引发剂为偶氮二异丁腈或过氧化苯甲酰。
6.采用权利要求1中高含水高透氧硅水凝胶制成的角膜接触镜。
7.一种如权利要求6所述的高含水高透氧硅水凝胶角膜接触镜的制备方法,其特征在于,将所述硅氧烷单体、亲水性单体、交联剂、引发剂、溶剂、辅助材料按配方量混合后搅拌均匀,注入角膜接触镜模具中,在加热条件下引发聚合反应,得到硅水凝胶角膜接触镜。
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