CN115192539A - Wall-broken ganoderma lucidum spore powder capsule and preparation method thereof - Google Patents
Wall-broken ganoderma lucidum spore powder capsule and preparation method thereof Download PDFInfo
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- CN115192539A CN115192539A CN202210210538.XA CN202210210538A CN115192539A CN 115192539 A CN115192539 A CN 115192539A CN 202210210538 A CN202210210538 A CN 202210210538A CN 115192539 A CN115192539 A CN 115192539A
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- 239000000843 powder Substances 0.000 title claims abstract description 76
- 240000008397 Ganoderma lucidum Species 0.000 title claims abstract description 74
- 235000001637 Ganoderma lucidum Nutrition 0.000 title claims abstract description 74
- 239000002775 capsule Substances 0.000 title claims abstract description 43
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000008187 granular material Substances 0.000 claims abstract description 31
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 27
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 27
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 27
- 239000005913 Maltodextrin Substances 0.000 claims abstract description 24
- 229920002774 Maltodextrin Polymers 0.000 claims abstract description 24
- 229940035034 maltodextrin Drugs 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 20
- 238000007873 sieving Methods 0.000 claims abstract description 11
- 239000007779 soft material Substances 0.000 claims abstract description 11
- 238000001035 drying Methods 0.000 claims abstract description 10
- 238000000034 method Methods 0.000 claims abstract 6
- 239000000463 material Substances 0.000 claims description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 230000001965 increasing effect Effects 0.000 claims description 8
- 238000009835 boiling Methods 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 241000222336 Ganoderma Species 0.000 description 9
- 239000003814 drug Substances 0.000 description 4
- 230000004075 alteration Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000007963 capsule composition Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 206010016256 fatigue Diseases 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000009700 powder processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Toxicology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a wall-broken ganoderma lucidum spore powder capsule and a preparation method thereof, and the wall-broken ganoderma lucidum spore powder capsule comprises the following steps of performing wall-breaking treatment on ganoderma lucidum spore powder to obtain wall-broken ganoderma lucidum spore powder, controlling the wall-breaking rate to be more than 95%, and then sieving the wall-broken ganoderma lucidum spore powder with a 80-mesh sieve. And then mixing the wall-broken ganoderma lucidum spore powder and maltodextrin until the mixture is uniform, then adding sodium carboxymethylcellulose aqueous solution with proper concentration to prepare a wet soft material, then granulating, drying wet granules and encapsulating to obtain a finished product. The method has simple process and is beneficial to large-scale production.
Description
Technical Field
The invention belongs to the field of ganoderma lucidum spore powder processing engineering, and particularly relates to a wall-broken ganoderma lucidum spore powder capsule and a preparation method thereof.
Background
In recent years, with the rapid development of economy in China, the living standard of people is greatly improved, the incidence of diseases in modern society is increased year by year, and sub-health people are greatly increased, such as: people with low immunity, insomnia, lassitude, weakness and the like are greatly increased, and the health food is also younger. Compared with the prior art, the health-preserving and health-care consciousness of people is gradually enhanced, and health preserving become one of the hottest topics. The wild ganoderma lucidum has the auxiliary treatment effect on various diseases and has no toxic or side effect, so that the wild ganoderma lucidum is very suitable for being sold as a health-care product, and China has rich ganoderma lucidum variety resources and is a main production area of ganoderma lucidum. Along with the improvement of living standard, the health care consciousness of people is gradually enhanced, and the health care function of the lucid ganoderma is more and more favored by people. Ganoderma lucidum spore powder is increasingly popular with the whole people as one of the raw materials of functional health care products. At present, the types of ganoderma lucidum spore powder products in the market are few, most of the ganoderma lucidum spore powder products are brewing type ganoderma lucidum spore powder, but the brewing type ganoderma lucidum spore powder is inconvenient to carry and use, dosage cannot be controlled better, and the brewing type ganoderma lucidum spore powder is low in bioavailability and drug stability.
Disclosure of Invention
In order to solve the problems that the existing ganoderma lucidum spore powder is inconvenient to carry and use, the dosage cannot be controlled better, and meanwhile, the bioavailability of the ganoderma lucidum spore powder is not high and the stability of the medicine is not high, the invention provides a wall-broken ganoderma lucidum spore powder capsule and a preparation method thereof:
a wall-broken ganoderma lucidum spore powder capsule is characterized by comprising 890-910g of wall-broken ganoderma lucidum spore powder, 75-85g of maltodextrin and 18-22g of sodium carboxymethylcellulose according to the weight of every 1000g of finished wall-broken ganoderma lucidum spore powder capsule.
The preparation method of the capsule of the wall-broken ganoderma lucidum spore powder comprises the following steps:
1) Breaking the wall of the ganoderma lucidum spore powder to obtain wall-broken ganoderma lucidum spore powder, sieving with a 80-mesh sieve, sieving maltodextrin with the 80-mesh sieve, and blending sodium carboxymethylcellulose with pure water to obtain 1.5-2.5% sodium carboxymethylcellulose solution;
2) Adding maltodextrin into the wall-broken ganoderma lucidum spore powder in an equivalent increasing mode, and mixing for 15 minutes each time to the set total amount of materials, so that the mixed materials are uniformly mixed and have uniform color;
3) Introducing the mixed materials into a trough type mixer, adding the prepared sodium carboxymethylcellulose solution, and mixing for 30 minutes to obtain a uniformly mixed soft material;
4) Adding the uniformly mixed soft material into a swing type granulator with a 20-mesh sieve to prepare wet granules;
5) Drying wet granules in a high-efficiency box-type fluidized bed dryer until the water content in the granules is less than or equal to 5%, and grading the dried granules by using a vibrating screen with 16 meshes;
6) And filling the qualified granules into a No. 0 hollow capsule by using a capsule filling machine, wherein the filling amount is 0.25 g/granule, so as to obtain the wall-broken ganoderma lucidum spore powder capsule.
Preferably, the wall-breaking rate of the ganoderma lucidum spore powder in the step 1) is more than 95%.
Preferably, the mass ratio of the maltodextrin to the wall-broken ganoderma lucidum spore powder in the step 2) is 8.
Preferably, the mass ratio of the mixed material in the step 3) to the sodium carboxymethyl cellulose solution is 1.
Preferably, the drying temperature in the step 5) is 50-70 ℃, and the drying time is 4-6 hours.
Compared with the prior art, the invention has the beneficial effects that:
the capsule of the wall-broken ganoderma lucidum spore powder and the preparation method thereof have advanced technology, the ganoderma lucidum spore powder is subjected to wall-breaking treatment, so that the effective components of the ganoderma lucidum spore can be better absorbed by human bodies, and the absorption rate of the effective components reaches more than 90%; mixing the wall-broken ganoderma lucidum spore powder with a small amount of maltodextrin serving as an auxiliary material, selecting maltodextrin with the DE value of MD20 specification, enhancing the adhesiveness of the wall-broken ganoderma lucidum spore powder, and simultaneously reducing the addition amount of other adhesives; the auxiliary materials are only added with maltodextrin and sodium carboxymethyl cellulose which have higher safety coefficient and lower sugar index, so that the range of people using the auxiliary materials is wider, and the auxiliary materials can be used by people with limited sugar intake, such as diabetes; the wall-broken ganoderma lucidum spore powder capsule prepared by the invention is a capsule formulation, the product is convenient to carry and simple to use, the dosage can be better controlled, the bioavailability of the capsule type medicine is high, and the stability of the medicine can be effectively improved.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Example 1
A capsule of wall-broken Ganoderma spore powder comprises wall-broken Ganoderma spore powder 900g, maltodextrin 80g, and sodium carboxymethylcellulose 20g, based on the weight of each 1000g of the capsule.
The preparation method of the capsule of the wall-broken ganoderma lucidum spore powder comprises the following steps:
1) Performing wall breaking treatment on ganoderma lucidum spore powder to obtain wall-broken ganoderma lucidum spore powder, wherein the wall breaking rate of the ganoderma lucidum spore powder is more than 95%, then sieving with a 80-mesh sieve, sieving maltodextrin with the 80-mesh sieve, and blending sodium carboxymethylcellulose with pure water to obtain a sodium carboxymethylcellulose solution with the concentration of 2%;
2) Adding maltodextrin into the wall-broken ganoderma lucidum spore powder in an equivalent increasing mode, mixing for 15 minutes each time until the total amount of the set materials is reached, wherein the mass ratio of the maltodextrin to the wall-broken ganoderma lucidum spore powder is 8;
3) Introducing the mixed materials into a trough type mixing machine, adding the prepared sodium carboxymethyl cellulose solution, and mixing for 30 minutes to obtain a uniformly mixed soft material, wherein the mass ratio of the mixed materials to the sodium carboxymethyl cellulose solution is 1;
4) Adding the uniformly mixed soft material into a swing type granulator with a 20-mesh sieve to prepare wet granules;
5) Drying wet granules in a high-efficiency box-type fluidized bed dryer at 50 ℃ for 4 hours until the water content in the granules is less than or equal to 5%, and grading the dried granules by using a vibrating type sieve with 16 meshes;
6) And filling the qualified granules into a No. 0 hollow capsule by using a capsule filling machine, wherein the filling amount is 0.25 g/granule, so as to obtain the wall-broken ganoderma lucidum spore powder capsule.
Example 2
A capsule of wall-broken Ganoderma spore powder comprises wall-broken Ganoderma spore powder 895g, maltodextrin 85g, and sodium carboxymethylcellulose 20g, based on the weight of wall-broken Ganoderma spore powder capsule per 1000 g.
The preparation method of the capsule of the wall-broken ganoderma lucidum spore powder comprises the following steps:
1) Performing wall breaking treatment on ganoderma lucidum spore powder to obtain wall-broken ganoderma lucidum spore powder, wherein the wall breaking rate of the ganoderma lucidum spore powder is more than 95%, then sieving with a 80-mesh sieve, sieving maltodextrin with the 80-mesh sieve, and blending sodium carboxymethylcellulose with pure water to obtain a sodium carboxymethylcellulose solution with the concentration of 2%;
2) Adding maltodextrin into the wall-broken ganoderma lucidum spore powder in an equivalent increasing mode, mixing for 15 minutes each time until the total amount of the set materials is reached, wherein the mass ratio of the maltodextrin to the wall-broken ganoderma lucidum spore powder is 8;
3) Introducing the mixed materials into a trough type mixing machine, adding the prepared sodium carboxymethyl cellulose solution, and mixing for 30 minutes to obtain a uniformly mixed soft material, wherein the mass ratio of the mixed materials to the sodium carboxymethyl cellulose solution is 1;
4) Adding the uniformly mixed soft material into a swing type granulator with a 20-mesh sieve to prepare wet granules;
5) Drying wet granules in a high-efficiency box-type fluidized bed dryer at 60 ℃ for 4 hours until the water content in the granules is less than or equal to 5%, and grading the dried granules by using a vibrating type sieve with 16 meshes;
6) And filling the qualified granules into a No. 0 hollow capsule by using a capsule filling machine, wherein the filling amount is 0.25 g/granule, so as to obtain the wall-broken ganoderma lucidum spore powder capsule.
Example 3
A capsule of wall-broken Ganoderma spore powder comprises wall-broken Ganoderma spore powder 905g, maltodextrin 77g, and sodium carboxymethylcellulose 18g, based on the weight of wall-broken Ganoderma spore powder capsule per 1000 g.
The preparation method of the capsule of the wall-broken ganoderma lucidum spore powder comprises the following steps:
1) Performing wall breaking treatment on ganoderma lucidum spore powder to obtain wall-broken ganoderma lucidum spore powder, wherein the wall breaking rate of the ganoderma lucidum spore powder is more than 95%, then sieving with a 80-mesh sieve, sieving maltodextrin with the 80-mesh sieve, and blending sodium carboxymethylcellulose with pure water to obtain a sodium carboxymethylcellulose solution with the concentration of 2%;
2) Adding maltodextrin into the wall-broken ganoderma lucidum spore powder in an equivalent increasing mode, mixing for 15 minutes each time until the total amount of the set materials is reached, wherein the mass ratio of the maltodextrin to the wall-broken ganoderma lucidum spore powder is 8;
3) Introducing the mixed materials into a trough type mixing machine, adding the prepared sodium carboxymethyl cellulose solution, and mixing for 30 minutes to obtain a soft material which is uniformly mixed, wherein the mass ratio of the mixed materials to the sodium carboxymethyl cellulose solution is 1;
4) Adding the uniformly mixed soft material into a swing type granulator with a 20-mesh sieve to prepare wet granules;
5) Drying wet granules in a high-efficiency box-type fluidized bed dryer at 70 deg.C for 3 hr until water content in the granules is less than or equal to 5%, and grading the dried granules with 16 mesh sieve of vibration type;
6) And filling the qualified granules into a No. 0 hollow capsule by using a capsule filling machine, wherein the filling amount is 0.25 g/granule, so as to obtain the wall-broken ganoderma lucidum spore powder capsule.
The results of examples 1 to 3 were examined as in table 1 below:
TABLE 1
The foregoing is only an embodiment of the present invention, and it should be noted that a person skilled in the art may make various changes, modifications, substitutions and alterations to the embodiment without departing from the technical principles of the present invention, and such changes, modifications, substitutions and alterations should also be regarded as the protection scope of the present invention.
Claims (6)
1. The wall-broken ganoderma lucidum spore powder capsule is characterized by comprising 890-910g of wall-broken ganoderma lucidum spore powder, 75-85g of maltodextrin and 18-22g of sodium carboxymethylcellulose according to the weight of every 1000g of finished wall-broken ganoderma lucidum spore powder capsule.
2. The preparation method of the sporoderm-broken ganoderma lucidum spore powder capsule according to claim 1, which is characterized by comprising the following steps:
1) Breaking the wall of the ganoderma lucidum spore powder to obtain wall-broken ganoderma lucidum spore powder, sieving with a 80-mesh sieve, sieving maltodextrin with the 80-mesh sieve, and blending sodium carboxymethylcellulose with pure water to obtain 1.5-2.5% sodium carboxymethylcellulose solution;
2) Adding maltodextrin into the wall-broken ganoderma lucidum spore powder in an equivalent increasing mode, and mixing for 15 minutes each time to the set total amount of materials, so that the mixed materials are uniformly mixed and have uniform color;
3) Introducing the mixed materials into a trough type mixer, adding the prepared sodium carboxymethylcellulose solution, and mixing for 30 minutes to obtain a uniformly mixed soft material;
4) Adding the uniformly mixed soft material into a swing type granulator with a 20-mesh sieve to prepare wet granules;
5) Drying the wet granules in a high-efficiency box-type boiling dryer until the water content in the granules is less than or equal to 5%, and grading the dried granules by using a vibrating screen with 16 meshes;
6) And filling the qualified granules into a No. 0 hollow capsule by using a capsule filling machine, wherein the filling amount is 0.25 g/granule, so as to obtain the wall-broken ganoderma lucidum spore powder capsule.
3. The method for preparing the sporoderm-broken ganoderma lucidum spore powder capsule according to claim 2, wherein the sporoderm-broken rate of the ganoderma lucidum spore powder in the step 1) is more than 95%.
4. The method for preparing the capsule of the wall-broken ganoderma lucidum spore powder according to claim 2, wherein the mass ratio of the maltodextrin to the wall-broken ganoderma lucidum spore powder in the step 2) is 8.
5. The method for preparing the wall-broken ganoderma lucidum spore powder capsule according to claim 2, wherein the mass ratio of the mixed material in the step 3) to the sodium carboxymethyl cellulose solution is 1.
6. The method for preparing the capsule of sporoderm-broken ganoderma lucidum spore powder according to claim 2, wherein the drying temperature in the step 5) is 50-70 ℃, and the drying time is 4-6 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210210538.XA CN115192539A (en) | 2022-03-03 | 2022-03-03 | Wall-broken ganoderma lucidum spore powder capsule and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210210538.XA CN115192539A (en) | 2022-03-03 | 2022-03-03 | Wall-broken ganoderma lucidum spore powder capsule and preparation method thereof |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931197A (en) * | 2006-09-11 | 2007-03-21 | 张连龙 | Health product and medicine containing glossy ganoderma and selenium |
| CN105012529A (en) * | 2015-08-14 | 2015-11-04 | 慧谷生命科技湖北有限公司 | Ginseng ganoderma lucidum spore powder capsules and preparation method thereof |
| US20160317594A1 (en) * | 2015-04-30 | 2016-11-03 | Yuming Huang | Method for breaking sporoderm of ganoderma spore powder and products obtained by the same |
| CN111991358A (en) * | 2020-09-25 | 2020-11-27 | 华润三九医药股份有限公司 | Pseudo-ginseng powder formula particle and preparation method thereof |
| CN112168803A (en) * | 2020-10-11 | 2021-01-05 | 绿之韵生物工程集团有限公司 | Ganoderma spore powder capsule and its processing method |
-
2022
- 2022-03-03 CN CN202210210538.XA patent/CN115192539A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1931197A (en) * | 2006-09-11 | 2007-03-21 | 张连龙 | Health product and medicine containing glossy ganoderma and selenium |
| US20160317594A1 (en) * | 2015-04-30 | 2016-11-03 | Yuming Huang | Method for breaking sporoderm of ganoderma spore powder and products obtained by the same |
| CN105012529A (en) * | 2015-08-14 | 2015-11-04 | 慧谷生命科技湖北有限公司 | Ginseng ganoderma lucidum spore powder capsules and preparation method thereof |
| CN111991358A (en) * | 2020-09-25 | 2020-11-27 | 华润三九医药股份有限公司 | Pseudo-ginseng powder formula particle and preparation method thereof |
| CN112168803A (en) * | 2020-10-11 | 2021-01-05 | 绿之韵生物工程集团有限公司 | Ganoderma spore powder capsule and its processing method |
Non-Patent Citations (2)
| Title |
|---|
| 通化承诚药业有限公司: "卓亚牌 破壁灵芝孢子粉" * |
| 陈秀鹏: "[国食健字G20120436]金奥力牌破壁灵芝孢子粉胶囊" * |
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Application publication date: 20221018 |