CN1151821C - Grape seed preparation and its extracting process - Google Patents
Grape seed preparation and its extracting process Download PDFInfo
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- CN1151821C CN1151821C CNB01128126XA CN01128126A CN1151821C CN 1151821 C CN1151821 C CN 1151821C CN B01128126X A CNB01128126X A CN B01128126XA CN 01128126 A CN01128126 A CN 01128126A CN 1151821 C CN1151821 C CN 1151821C
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- grape seed
- vitis viniferae
- seed oil
- oleum vitis
- acid
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Abstract
The present invention relates to an utilization method and an extraction method of plant seed oil, namely a grape seed oil preparation and an extraction method thereof. The grape seed oil preparation has the main active ingredient of grape seed oil, and comprises one kind or a plurality of kinds of carriers and/or excipient compositions which are acceptable in modern medicine. The grape seed oil preparation can at least be made into tablets, soft capsules, hard capsules, oral liquid, etc., has the functions of regulating blood fat, and has no toxic and side effect. The longer the administration time is, the more conspicuous effect the patients obtain. The extraction method of the grape seed oil adopts a two-step method (a physical extrusion method and an organic solvent leaching method), has the advantages of high productive efficiency, high oil yield, low cost, reliable technology, economy, easy implementation and wide application range, and can be adopted by large-scale enterprises, middle-scale enterprises and small-scale enterprises.
Description
Technical field: the present invention relates to a kind of utilization and extracting method of oil of plant, i.e. grape seed preparation and extracting method thereof.
Background technology: in prior art, Semen Vitis viniferae is the garbage in the Production of Wine.It is reported that its oil content is at 15-17%.January 19 2000 Christian era, Chinese invention patent CN1241623A discloses a kind of name and has been called " method of supercritical carbon dioxide extraction Oleum Vitis viniferae and procyanidolic oligomers ", number of patent application is 99111574.0, wherein disclose a kind of method with the carbon dioxide extraction Oleum Vitis viniferae, its shortcoming is equipment complexity, production cost height.In addition, in prior art, Oleum Vitis viniferae is still adopted the organic solvent lixiviate, its shortcoming is: consume a large amount of organic solvents, risk factor is many in the production, contaminated environment, and the organic solvent that exceeds standard residual in the product also influences product quality and purposes.For with the Oleum Vitis viniferae being active component and directly edible Oleum Vitis viniferae finished product is found to produce and report so far.
Summary of the invention: the present invention seeks to provides a kind of direct-edible at above-mentioned deficiency, has the grape seed preparation of functional food effect.
Another purpose of the present invention provides a kind of extracting method that adopts the Oleum Vitis viniferae that physics squeezing and pressing method and chemical extraction method combine.
Technical solution of the present invention is: grape seed preparation is main active ingredient with Oleum Vitis viniferae, contains the compositions of acceptable carrier on one or more modern medicines and/or excipient, can be made into tablet, soft capsule, hard capsule, oral liquid etc. at least.
Oleum Vitis viniferae contains following functional component (confirming through thin layer chromatography and spectrum analysis result) at least:
Linoleic acid＞60%
Oleic acid＞20%
Stearic acid＞0.8%
16 carbonic acid＞10%
20 carbonic acid＞0.2%
20 carbonic acid monoenoic acid＞0.2%
A kind of extracting method that extracts above-mentioned Oleum Vitis viniferae was divided into for two steps, and the first step adopts squeezing and pressing method to extract Oleum Vitis viniferae, and the Oleum Vitis viniferae that extrudes is stand-by through 140 ℃ of-160 ℃ of constant temperature 40 minutes; Second step added the extruding slag in 70% the ethanol 60 ℃-90 ℃ and extracted 2 hours, flung to ethanol, extracting solution was merged with the constant temperature Oleum Vitis viniferae be mixed, and use activated carbon decolorizing, and filtration gets the Oleum Vitis viniferae raw material.
The trade name of product of the present invention is: Portugal's essential oil soft-capsule, Portugal's quintessence oil hard capsule, Portugal's quintessence oil sheet, Portugal's quintessence oil oral liquid etc.
Effect: contain higher unsaturated fatty acid (more than 90%) in Portugal's quintessence oil, 13 kinds of trace element, various active compositions such as potassium hydrogen tartrate, flavonoid, polysaccharide, anthocyanin, aminoacid, carotene, vitamin A, B1, B2, effect with blood lipid regulation, blood-enriching face-nourishing, strengthening physique, refreshing, especially the blood lipid regulation effect is outstanding especially.
Clinical trial: according to the human trial program, wherein by nearly three months of the 206th hospital of the Chinese People's Liberation Army respectively to 12 hyperlipidemia patients examination clothes (detailed directions: one time 2,2 times on the one.Observe every patient respectively, treat preceding, back 15 days, 30 days, 45 days, 60 days Blood Lipid situations of treatment), has tangible blood lipid regulation effect, TC (serum total cholesterol) descends and reaches 24.6%, TG (triglyceride) descends and reaches 23%, effective to most hyperlipidemia patients, especially to hypercholesterolemia serum patient.Total effective 85%, have tangible blood lipid regulation effect.Time of Administration is long more, and effect is obvious more.Have no side effect.
Effect: blood lipid regulation.
Usage: one time 2,2 times on the one.
Advantage of the present invention is: 1, be that active component is made directly edible grape seed preparation with the Oleum Vitis viniferae, turn waste into wealth, started a kind of new type functional health food with blood lipid regulation.2, adopt the physics squeezing and pressing method Semen Vitis viniferae directly can be squeezed, and need not pulverize in advance, operation is simple, equipment is easily gone, production efficiency is high, and Oleum Vitis viniferae has been carried out slightly carrying, avoided again in a large number with an organic solvent simultaneously, contaminated environment, influenced the deficiency of product quality; The Semen Vitis viniferae extruding slag of dual-purpose organic solvent method after to squeezing further extracts, reduced the organic solvent use amount, overcome the deficiency that there is Residual oil in the physics squeezing and pressing method again, guaranteed the oil yield of Oleum Vitis viniferae.3, production efficiency height, the oil yield height, cost is low, and technology is reliable, economy and facility.4, applied widely, large, medium and small enterprise all can adopt.
Below in conjunction with embodiment the present invention is described in further detail, but be not limited thereto protection domain.
The specific embodiment:
Embodiment 1 Oleum Vitis viniferae extracting method
The Semen Vitis viniferae 100kg that will meet ingredient requirement with clear water clean, oven dry, advance in the extruder and squeeze, the Oleum Vitis viniferae that extrudes is stand-by through 140 ℃ of-160 ℃ of constant temperature 40 minutes; The extruding slag added in 70% the ethanol 60 ℃-70 ℃ and extracted 2 hours, fling to ethanol with extracting solution constant temperature and Oleum Vitis viniferae mix homogeneously, use activated carbon decolorizing, filtration gets 5kg Oleum Vitis viniferae (Portugal's quintessence oil) raw material.Reach 98% through gas chromatographic analysis Oleum Vitis viniferae purity.
Embodiment 2 Portugal's essential oil soft-capsules
Prescription:
Smart raw material 985 grams in Portugal
Vitamin E 15 grams
Make per 1000 (every 1g)
Technology: raw material → mixing → pelleting → wash ball drying → select ball → inner packing → outer package → finished product
↑
Glue
Embodiment 3 Portugal's quintessence oil hard capsules
Prescription: raw oil 60 grams
Vitamin E 0.6 gram
Lactose 10 grams
Cyclodextrin 210 grams
Micropowder silica gel 20 grams
3% starch slurry is an amount of
Magnesium stearate 1%
Make per 1000 (every 0.3g)
Technology: batch mixing (80 order) → system soft material → granulation (20 order) → granulate (16 order)
→ dress hard capsule (1# hard capsule) → pressure PVC → finished product.
Embodiment 4 Portugal's quintessence oil tablets
Prescription:
Raw oil 80 grams
Vitamin E 0.8 gram
Flavoring agent 8 grams
Lactose 260 grams
Cyclodextrin 365 grams
Micropowder silica gel 20 grams
Protein sugar 10 grams
5%HPMC liquid is an amount of
Magnesium stearate 1%
Make 1000 (every 0.8g)
Technology: mixing → system soft material → granulation (12-18 order) → granulate (16 order)
→ tabletting → coating → pressure PVC plate → finished product.
Embodiment 5 Portugal's quintessence oil oral liquids
Prescription:
Raw oil 2000 grams
Deionized water 7920 grams
Sodium benzoate 30 grams
Stearic acid monoglycerides 50 grams
Essence is an amount of
Make 1000 bottles (every bottle of 10ml)
Technology: batch mixing → emulsifying → high pressure homogenize → potting → lamp inspection → packing → finished product.
Claims (2)
1, a kind of grape seed preparation is characterized in that being made by Semen Vitis viniferae, and each effective ingredient is as follows:
Linoleic acid＞60%
Oleic acid＞20%
Stearic acid＞0.8%
16 carbonic acid＞10%
20 carbonic acid＞0.2%
20 carbonic acid monoenoic acid＞0.2%
2, a kind of extracting method that extracts the described Oleum Vitis viniferae of claim 1 is characterized in that: be divided into for two steps, the first step adopts squeezing and pressing method to extract Oleum Vitis viniferae, and the Oleum Vitis viniferae that extrudes is stand-by through 140 ℃ of-160 ℃ of constant temperature 40 minutes; Second step added the extruding slag in 70% the ethanol 60 ℃-90 ℃ and extracted 2 hours, flung to ethanol, extracting solution was merged with the constant temperature Oleum Vitis viniferae be mixed, and use activated carbon decolorizing, and filtration gets the Oleum Vitis viniferae raw material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01128126XA CN1151821C (en) | 2001-09-02 | 2001-09-02 | Grape seed preparation and its extracting process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB01128126XA CN1151821C (en) | 2001-09-02 | 2001-09-02 | Grape seed preparation and its extracting process |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1363363A CN1363363A (en) | 2002-08-14 |
| CN1151821C true CN1151821C (en) | 2004-06-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB01128126XA Expired - Lifetime CN1151821C (en) | 2001-09-02 | 2001-09-02 | Grape seed preparation and its extracting process |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813755A (en) * | 2012-08-22 | 2012-12-12 | 承德畅达生物科技有限公司 | Traditional Chinese medicine preparation for preventing and curing hyperlipemia and preparation method for traditional Chinese medicine preparation |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803732B (en) * | 2010-04-19 | 2012-08-22 | 无锡市天赐康生物科技有限公司 | Health-care food with blood-fat reduction assistance function and preparation method thereof |
| CN102268325A (en) * | 2011-06-22 | 2011-12-07 | 西北农林科技大学 | Cold-pressing extraction method of grape seed oil |
| CN104560378A (en) * | 2013-10-29 | 2015-04-29 | 中国科学院广州生物医药与健康研究院 | Blueberry seed oil as well as preparation method and application thereof |
| CN103652924B (en) * | 2013-12-12 | 2015-08-12 | 宁夏大学 | A kind of compound grape-seed fat capsule and preparation method thereof |
| CN103690578A (en) * | 2013-12-27 | 2014-04-02 | 王兴强 | Grape seed oil soft capsule and preparation method thereof |
| CN104957611A (en) * | 2015-06-22 | 2015-10-07 | 安庆市孝柱食品科技有限公司 | Sunflower seed oil oral liquid |
| CN105111065A (en) * | 2015-08-05 | 2015-12-02 | 常州市鼎日环保科技有限公司 | Method for using grape seeds to prepare conjugated linoleic acid |
-
2001
- 2001-09-02 CN CNB01128126XA patent/CN1151821C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102813755A (en) * | 2012-08-22 | 2012-12-12 | 承德畅达生物科技有限公司 | Traditional Chinese medicine preparation for preventing and curing hyperlipemia and preparation method for traditional Chinese medicine preparation |
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| Publication number | Publication date |
|---|---|
| CN1363363A (en) | 2002-08-14 |
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