CN115177612A - A composition with hair growth promoting effect - Google Patents

A composition with hair growth promoting effect Download PDF

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CN115177612A
CN115177612A CN202210917373.XA CN202210917373A CN115177612A CN 115177612 A CN115177612 A CN 115177612A CN 202210917373 A CN202210917373 A CN 202210917373A CN 115177612 A CN115177612 A CN 115177612A
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dihydromyricetin
theanine
hair
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唐德松
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Hangzhou Fenghe Plant Technology Co ltd
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Hangzhou Fenghe Plant Technology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia

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Abstract

The invention discloses a composition with hair growth promoting effect, which contains a component A or a component A and a component B, wherein the component A is dihydromyricetin or a plant extract containing dihydromyricetin or powder obtained by crushing a plant containing dihydromyricetin, and the component B is theanine or a plant extract containing theanine or powder obtained by crushing a plant containing theanine; the component A and the component B are respectively 10-100 parts of component A and 0-100 parts of component B in parts by mass of dihydromyricetin and theanine. The dihydromyricetin and the theanine are combined, so that the hair conditioner can effectively regulate qi and blood, nourish hair, prevent hair loss, and has the functions of hair care and hair increase on pathological alopecia (alopecia areata and seborrheic alopecia). The composition has simple composition, convenient use and high safety, can be used for a long time, and is particularly suitable for treating pathological alopecia.

Description

A composition with hair growth promoting effect
Technical Field
The invention relates to a composition, in particular to a composition with a hair-increasing effect.
Background
After the hair grows to a certain degree in the growth period, the hair enters the catagen and the rest period, normal physiological shedding occurs, the hair in the growth period and the catagen is in dynamic balance, and the normal hair volume is maintained. If the hair growth homeostasis is disrupted and the amount of hair in the anagen phase is less than that in the catagen and telogen phases, the hair gradually thins, even becomes bald, called non-physiological alopecia. The non-physiological alopecia includes pathological alopecia (alopecia areata, seborrheic alopecia, etc.) and drug-induced alopecia (radiotherapy and chemotherapy alopecia).
For the treatment of alopecia, chemical medicines have the defects of side effects with different degrees and easy relapse after medicine withdrawal, and the adoption of Chinese herbal medicine components can avoid corresponding problems. The Chinese medicine literature of ancient and modern times is different in the typing of the reasons of alopecia, and the like have analyzed the related literatures of alopecia in the analysis of the Chinese medicine symptoms and the prescription rules of alopecia and white hair (J. Chinese medicine, 2016, 31 (9): 3785-3788), and there are 27 kinds of alopecia and white hair syndromes in total, wherein liver and kidney deficiency, qi stagnation and blood stasis, liver qi stagnation, heart and liver blood deficiency, damp-heat accumulation, qi and blood deficiency, blood heat, spleen deficiency and excessive dampness, kidney essence deficiency and essence and blood deficiency occur more than 10 times frequently, and 6 visceral disease sites are summarized from the syndromes, namely liver, kidney, heart, spleen, stomach and gallbladder. The traditional Chinese medicine theory considers that the main reasons of alopecia are as follows: deficiency of liver and kidney and impairment of spleen and stomach lead to deficiency of qi and blood or emotional disorder to cause qi stagnation and blood stasis, and hair is lost due to malnutrition. Therefore, the traditional Chinese medicine for treating alopecia mainly adopts the treatment principles of liver cultivation, kidney tonifying, qi and blood benefiting, blood circulation activating, blood stasis removing and the like. The Chinese medicinal composition is prepared from fleece-flower root, chinese angelica, prepared rehmannia root, szechuan lovage rhizome, glossy privet fruit, indian buead, south dodder seed, barbary wolfberry fruit, raw rehmannia root, yerbadetajo herb, white paeony root, danshen root, membranous milkvetch root, liquoric root, mulberry, largehead atractylodes rhizome, red paeony root, black sesame, arborvitae tops, safflower, pilose asiabell root, tree peony bark, oriental waterplantain rhizome, chinese date, chinese thorowax root, common floweringquince fruit, malaytea scurfpea fruit, incised notopterygium rhizome, divaricate saposhnikovia root, hawthorn fruit, twotooth achyranthes root, puncturevine caltrop fruit, chrysanthemum, honey-fried licorice root, peach seed, common macrocarpium fruit and siberian solomonseal rhizome in sequence according to the use frequency.
At present, the prior relevant hair increasing patents adopting the Chinese herbal medicines comprise: application No. 201010033855.6A composition with hair blackening and hair increasing effects comprises Aloe, semen Fagopyri Esculenti, polygoni Multiflori radix, and citric acid; application No. 201410513367.3, publication No. CN104187707A, a health food with hair growth promoting effect, which comprises buckwheat, tryptophan, methionine, isoleucine, tricholoma matsutake, russula vinosa, black sesame, black bean, polygonum multiflorum, black fungus, honeysuckle and red date; application number 201810356135.X and publication number 108379192A relate to a hair-increasing shampoo, which is composed of cortex dictamni, a conditioner, beer, cacumen biotae, water, a Chinese yam extract, a salvia miltiorrhiza extract and a rose extract. There are also some medicines which adopt other components, such as application No. 201510065971.9, publication No. CN104666995A, a medicine for treating alopecia and having hair growth promoting effect, mainly comprising crude salt, water extract of cake after oil extraction of oil tea fruit, product of alcohol fermentation and acetic acid fermentation of glutinous rice and oil extracted from fruit of Theaceae plants; application No. 201910968748.3, publication No. CN110585046A an anti-dandruff, anti-dandruff and anti-alopecia component and product, containing salicylic acid or salicylic acid derivatives; application No. 201610808247.5, publication No. 107456406A, an oily scalp hair-blackening essential oil comprises rosemary oil, geranium essential oil, lavender essential oil, lignum Santali albi oil, cananga oil, lemon oil, eucalyptus essential oil, patchouli oil, clary sage essential oil, and jojoba oil.
Disclosure of Invention
The invention aims to solve the technical problem of providing a novel composition with hair-increasing effect, and the hair-increasing effect is safe and reliable.
In order to solve the technical problems, the invention discloses a composition with hair growth promoting effect, which comprises a component A or a component A and a component B, wherein the component A is dihydromyricetin or a plant extract containing dihydromyricetin or powder of a crushed plant containing dihydromyricetin, the component B is theanine or a plant extract containing theanine or powder of a crushed plant containing theanine,
the component A and the component B are respectively 10-100 parts of component A and 0-100 parts of component B in parts by mass of dihydromyricetin and theanine.
Further, the component A and the component B are respectively 50-100 parts of the component A and 20-100 parts of the component B according to the mass parts of dihydromyricetin and theanine.
Further, the plant containing dihydromyricetin is ampelopsis grossedentata or hovenia dulcis thunb, and is preferably ampelopsis grossedentata.
Further, the plants containing theanine are albino tea, yellow tea, and BAOJING HUANG tea, wherein the albino tea is selected from Anji white tea and Jiande white tea; the yellow tea is LONGYONGHUANG tea, JINYUNHUANG tea, and NINGBOHUANG tea; the Anji white tea is preferably selected from whitening tea.
Further, the composition also comprises pharmaceutically acceptable auxiliary materials.
Further, the composition is any one of powder, tablet, capsule, pill, dripping pill, spirit, suspension, aqua, cream and ointment.
Further, the composition is a tablet.
Further, the composition is a capsule.
The dihydromyricetin used in the invention has the functions of protecting liver and kidney, benefiting qi and nourishing blood; the theanine has effects of regulating emotion and resolving stagnation of liver-qi, and can be used for effectively regulating qi and blood, nourishing hair, preventing hair loss, and caring and increasing hair for pathological alopecia (alopecia areata and seborrheic alopecia). The dihydromyricetin is mainly derived from plants with high content of dihydromyricetin such as Ampelopsis grossedentata or semen Hoveniae, and can also be derived from chemical synthesis; theanine is mainly derived from high theanine content tea such as albino tea, etiolated tea, etc., and can also be derived from chemical synthesis and microbial synthesis. The composition has simple composition, convenient use and high safety, can be used for a long time, and is particularly suitable for treating pathological alopecia. Can be made into various dosage forms for oral administration or external application.
Drawings
FIG. 1 is a graph showing a comparison of hair conditions before and after half a year when tablets of the composition obtained in example 3 were administered in accordance with example 8.
Detailed Description
The present invention will be further explained with reference to examples. The following examples are provided only for illustrating the present invention and are not intended to limit the scope of the present invention.
Example 1
A composition tablet with hair growth promoting effect prepared from purified dihydromyricetin and theanine
Tablet composition, in 1000 tablets:
composition (I) Weights (g)
Dihydromyricetin (purity 98%) 102
Theanine (purity 40%) 250
Starch 148
(1) Crushing and sieving: crushing starch, and sieving with a 65-mesh sieve;
(2) Mixing: placing dihydromyricetin and theanine in a mixer, mixing for 5min, adding the sieved starch in step (1), and mixing for 10min;
(3) And (3) granulating: granulating by using a dry granulating machine;
(4) Tabletting: and (3) tabletting the granulated composition to obtain the composition tablet with the hair increasing effect.
The above tablet contains dihydromyricetin 100mg and theanine 100mg per tablet 0.5 g.
The using method comprises the following steps: twice a day in the morning and at night, two tablets are taken each time with meals.
Example 2
A composition tablet with hair growth promoting effect prepared from purified dihydromyricetin and theanine
The composition of the tablets is calculated by 1000 tablets.
Composition (A) Weight (g)
Dihydromyricetin (purity 98%) 122
Theanine (purity 40%) 200
Starch 178
(1) Crushing and sieving: pulverizing starch, and sieving with 65 mesh sieve;
(2) Mixing: placing dihydromyricetin and theanine in a mixer, mixing for 5min, adding sieved starch in step (1), and mixing for 10min;
(3) And (3) granulating: granulating by using a dry-method granulator;
(4) Tabletting: and (3) tabletting the granulated composition to obtain the tablet with the hair increasing effect.
The above tablet contains dihydromyricetin 120mg and theanine 80mg per tablet 0.5 g.
The using method comprises the following steps: twice a day in the morning and at night, two tablets are taken each time with meals.
Example 3
Composition tablet with hair growth promoting effect
The composition of the tablets is calculated by 1000 tablets.
Composition (I) Weight (g)
Ampelopsis grossedentata extract (dihydromyricetin content 50%) 160
Anji white tea extract (theanine content 20%) 250
Starch 90
(1) Crushing and sieving: crushing starch, and sieving with a 65-mesh sieve;
(2) Mixing: placing Ampelopsis Grossdentata extract and Anji white tea extract in a mixer, mixing for 5min, adding sieved starch in step (1), and mixing for 10min;
(3) Granulating: granulating by using a dry-method granulator;
(4) Tabletting: obtaining the tablet with hair-increasing effect.
The above tablet contains dihydromyricetin 80mg and theanine 50mg per tablet 0.5 g.
The using method comprises the following steps: twice a day in the morning and at night, two tablets are taken each time with meals.
Example 4
Composition tablet with hair growth promoting effect
The composition of the tablets is calculated by 1000 tablets.
Composition (I) Weights (g)
Semen Hoveniae extract (dihydromyricetin content 40%) 200
Anji white tea extract (theanine content 20%) 250
Starch 50
(1) Crushing and sieving: pulverizing starch, and sieving with 65 mesh sieve;
(2) Mixing: mixing Ampelopsis grossedentata extract and Anji white tea extract in a mixer for 5min, adding the sieved starch in step (1), and mixing for 10min;
(3) And (3) granulating: granulating by using a dry granulating machine;
(4) Tabletting: and (3) tabletting the granulated composition to obtain the tablet with the hair-increasing effect.
The above tablet contains dihydromyricetin 80mg and theanine 50mg per tablet 0.5 g.
The using method comprises the following steps: twice a day, two tablets each time, and taken with meal.
Example 5
A preparation method of tablet with hair growth promoting effect comprises pulverizing raw materials, and making into powder
The composition of the tablets is calculated by 1000 tablets.
Composition (I) Weight (g)
Vine tea powder (grain size 80 mesh, 20% dihydromyricetin content) 250
Anji white tea powder (particle size 80 mesh, theanine content 4%) 250
(1) Mixing: mixing pulverized powder of Ampelopsis Grossdentata and Anji white tea in a mixer for 5min;
(2) And (3) granulating: granulating by using a dry granulating machine;
(3) Tabletting: tabletting the granulated composition to obtain the tablet with the hair increasing effect;
the above tablet contains dihydromyricetin 50mg and theanine 10mg per tablet 0.5 g.
The using method comprises the following steps: taken with meals three times a day, two tablets each time.
Example 6
Composition tablet with hair growth promoting effect prepared from pulverized raw materials
The composition of the tablets is calculated by 1000 tablets.
Composition (A) Weights (g)
Vine tea powder (grain size 100 mesh, 25% dihydromyricetin content) 200
Anji white tea powder (particle size 100 mesh, theanine content 4%) 250
Starch 50
(1) Mixing: mixing pulverized Ampelopsis Grossdentata and Anji white tea in a mixer for 5min; adding starch, and mixing for 10min;
(2) Granulating: granulating by using a dry granulating machine;
(3) Tabletting: tabletting the granulated composition to obtain the tablet with the hair increasing effect;
each tablet contains 0.5g of dihydromyricetin 50mg and theanine 10mg.
The using method comprises the following steps: the composition is taken with meal, three times a day in the morning, at noon and at night, and two tablets each time.
Example 7
A preparation method of tablet with hair growth promoting effect from purified dihydromyricetin
And (4) the composition of the tablets is calculated by 1000 tablets.
Composition (A) Weights (g)
Dihydromyricetin (purity 98%) 102
Starch 398
(1) Mixing: mixing Ampelopsis Grossdentata powder and starch in a mixer for 10min;
(2) Granulating: granulating by using a dry-method granulator;
(3) Tabletting: tabletting the granulated composition to obtain the tablet with the hair-increasing effect;
the above tablet contains dihydromyricetin 100mg and 0.5g per tablet.
The using method comprises the following steps: twice a day in the morning and at night, two tablets are taken each time with meals.
Example 8
The tablets of the composition obtained in example 3 were evaluated for efficacy
Subject: white hair, partially bald scalp, between the ages of 30-50 years, was selected as 20 individuals at random, 17 men and 3 women.
The experimental method comprises the following steps: by oral administration, the subject takes 2 tablets at a time, 2 times a day in the morning and evening, and 4 tablets a day with meals.
Experiment time: the total test period is 6 months in month.
The evaluation criteria are divided into effective, improving and ineffective, and specifically comprise the following steps:
the effect is shown: stopping alopecia and growing hair again;
improvement: alopecia ceases, with intermittent or mostly long hair;
and (4) invalidation: alopecia is not controlled and continues.
The experimental results are as follows: in 20 cases, the effect is 18 cases, the improvement is 4 cases, and the total effective rate is 100%. The longest apparent time is 2 months, and the shortest one is 1 week.
Typical cases 1: wei Zhi, male 45 years old. Hair loss and hair thinning occur 3 years ago, and the luster of the scalp at the bottom of the hair can be seen, and the tablet is taken 2 times a day with meals and with warm water. After 1 month, hair loss was stopped, after 3 months, new black vellus hairs appeared at the open hair, and the hairs became dense within half a year, and reference was made to a comparison chart shown in fig. 1 before and after taking.
Typical case 2 among them: li Jie, male, 39 years old. After 5 years, the hair loss is increased, the hair in water floats more after washing hair, the hair is increased and decreased in the future, the hair is remained a little, the scalp of a patient is bright, the hair is a little, the hair is shaved by a shaver, the condition of the hair head is kept, after the tablet is taken, the growth of hair vellus hairs is accelerated in one week, and the hair shaving frequency is obviously increased.
Example 9
Evaluation of efficacy of the tablet obtained in example 7
Subjects: white hair, partially bald scalp, between the ages of 30-50 years, was selected as 20 individuals at random, 18 men and 2 women.
The experimental method comprises the following steps: by oral administration, the subject takes 2 tablets at a time, 2 times a day in the morning and evening, and 4 tablets a day with meals.
Experiment time: the total test period is 6 months in months.
The criteria were the same as in example 8.
The experimental results are as follows: of the 20 cases, 12 cases were significant, 5 cases were improved, and 3 cases were ineffective, and the total effective rate was 85%. The longest significant time is 5 months, and the shortest is 3 weeks.
From the efficacy evaluation of examples 8 and 9, when only dihydromyricetin is used as the main component, the hair growth promoting effect is obvious, but after theanine is added, the total effective rate is higher, and the effective time is shorter.

Claims (10)

1. A composition having hair growth enhancing properties, comprising: the composition contains a component A or a component A and a component B, wherein the component A is dihydromyricetin or a plant extract containing dihydromyricetin or powder of a plant containing dihydromyricetin after being crushed, and the component B is theanine or a plant extract containing theanine or powder of a plant containing theanine after being crushed;
the component A and the component B are respectively 10-100 parts of component A and 0-100 parts of component B in parts by mass of dihydromyricetin and theanine.
2. The composition with hair growth promoting effect according to claim 1, characterized in that: the component A and the component B are respectively 50-100 parts of component A and 20-100 parts of component B in parts by mass of dihydromyricetin and theanine.
3. The composition with hair growth promoting effect according to claim 1 or 2, characterized in that: the plant containing dihydromyricetin is Ampelopsis grossedentata or Hovenia dulcis Thunb.
4. The composition with hair growth promoting effect according to claim 3, characterized in that: the plant containing dihydromyricetin is Ampelopsis grossedentata.
5. The composition with hair growth promoting effect according to claim 1 or 2, characterized in that: the plants containing theanine are albino tea, yellow tea, and guard gold tea.
6. The composition with hair growth promoting effect according to claim 5, wherein: the theanine-containing plant is Anji white tea.
7. The composition with hair growth promoting effect according to claim 1 or 2, characterized in that: the composition also comprises pharmaceutically acceptable auxiliary materials.
8. The composition with hair growth promoting effect according to claim 7, characterized in that: the composition is in the form of powder, tablet, capsule, pill, dripping pill, spirit, suspension, aqua, cream, or ointment.
9. The composition with hair growth promoting effect according to claim 8, characterized in that: the composition is a tablet.
10. The composition with hair growth promoting effect of claim 8, wherein: the composition is a capsule.
CN202210917373.XA 2022-08-01 2022-08-01 A composition with hair growth promoting effect Pending CN115177612A (en)

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Citations (4)

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Publication number Priority date Publication date Assignee Title
CN102742714A (en) * 2011-04-21 2012-10-24 北京龙裔生物科技有限公司 Cigarette addiction eliminating, heart-fire clearing and refreshing chewing gum
CN104797250A (en) * 2012-07-13 2015-07-22 发朵科技公司 Treating hair loss and delaying aging of skin
JP2015178485A (en) * 2014-02-25 2015-10-08 株式会社コーセー Hair restoration composition
WO2022013581A1 (en) * 2020-07-14 2022-01-20 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Nutritional supplement, suitable for oral administration, comprising dihydromyricetin, choline and one or more vitamins with antioxidant activity, for use in the maintenance of normal liver function

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102742714A (en) * 2011-04-21 2012-10-24 北京龙裔生物科技有限公司 Cigarette addiction eliminating, heart-fire clearing and refreshing chewing gum
CN104797250A (en) * 2012-07-13 2015-07-22 发朵科技公司 Treating hair loss and delaying aging of skin
JP2015178485A (en) * 2014-02-25 2015-10-08 株式会社コーセー Hair restoration composition
WO2022013581A1 (en) * 2020-07-14 2022-01-20 Uni-Pharma Kleon Tsetis Pharmaceutical Laboratories S.A. Nutritional supplement, suitable for oral administration, comprising dihydromyricetin, choline and one or more vitamins with antioxidant activity, for use in the maintenance of normal liver function

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
曹敏惠等: "《藤茶二氢杨梅素茶氨酸复合物的制备及抗氧化活性研究》", 《现代食品科技》 *

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