CN115154569A - A Chinese medicinal composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis - Google Patents
A Chinese medicinal composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis Download PDFInfo
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- CN115154569A CN115154569A CN202210944912.9A CN202210944912A CN115154569A CN 115154569 A CN115154569 A CN 115154569A CN 202210944912 A CN202210944912 A CN 202210944912A CN 115154569 A CN115154569 A CN 115154569A
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Abstract
The invention relates to a Chinese medicinal composition for the treatment of chronic active hepatitis B and its prevention and cure cirrhosis, the prescription of the invention is rational to make up the medicine, mainly support the body resistance to consolidate the constitution, nourish liver and kidney, protect the liver function, and with the function of promoting blood circulation and removing blood stasis, make support the body resistance to consolidate the constitution medicine and walk but not guard against, and with the effects of clearing away heat, promoting diuresis and detoxicating at the same time, nourish liver yin, sooth the liver and move qi, in order to help support the body resistance to consolidate the constitution medicine and protect and its recovery liver function; the stomach harmonizing medicine can eliminate the symptom of weakened gastrointestinal digestion function caused by the blood stasis of the gastrointestinal vein Cong Quzhang and the like caused by liver cirrhosis, and the medicines have synergistic effect, can be used for each stage of hepatitis B treatment, particularly chronic active hepatitis B, strengthen the body resistance and eliminate pathogenic factors, complement each other, treat the existing symptom and play a role in preventing and treating liver cirrhosis.
Description
Technical Field
The invention belongs to the technical field of medicine application, and particularly relates to a traditional Chinese medicine composition for treating chronic active hepatitis B and preventing and treating cirrhosis.
Background
Chronic active hepatitis B, called chronic active hepatitis B for short, is mainly caused by hepatitis B virus infection and is transformed from acute active hepatitis B, and the chronic active hepatitis B is mainly characterized by gradual decline of labor capacity, hypodynamia, anorexia, aversion to oil, continuous and obvious abdominal distension, and frequent gingival bleeding and nasal bleeding.
At present, although a plurality of medicines for treating the diseases exist, some medicines have unsatisfactory curative effect and high price, and are difficult to accept by common people.
Disclosure of Invention
Based on the background, the invention provides a traditional Chinese medicine composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis.
The technical scheme of the invention is as follows:
a Chinese medicinal composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis comprises radix Cyathulae, saviae Miltiorrhizae radix, radix Glehniae, radix Ophiopogonis, rhizoma Polygonati Odorati, herba Dendrobii, radix rehmanniae Preparata, radix Angelicae sinensis, radix Paeoniae alba, radix Gentianae Marcrophyllae, radix Isatidis, rhizoma Polygonati, radix Codonopsis, alismatis rhizoma, fructus crataegi preparata, massa Medicata Fermentata, herba Artemisiae Scopariae, atractylodis rhizoma, polygoni Multiflori radix, carapax Trionycis, carthami flos, rhizoma Sparganii, curcumae rhizoma, pericarpium Citri Reticulatae viride, rhizoma Cyperi, radix Curcumae, cortex Cinnamomi, curcuma rhizome, concha Ostreae, rhizoma Zingiberis recens, fructus Jujubae, radix astragali, ecliptae herba, fructus Lycii, and fructus Toosendan.
Preferably, the weight ratio of each raw material medicine is as follows:
1 part of medicinal cyathula root, 30 parts of salvia miltiorrhiza, 10 parts of radix glehniae, 10 parts of radix ophiopogonis, 6 parts of polygonatum odoratum, 6 parts of dendrobium, 12 parts of radix rehmanniae, 12 parts of prepared rehmannia root, 10 parts of angelica, 15 parts of white peony root, 10 parts of gentiana macrophylla, 10 parts of radix isatidis, 20 parts of rhizoma polygonati, 10 parts of codonopsis pilosula, 10 parts of rhizoma alismatis, 10 parts of scorched hawthorn fruit, 10 parts of medicated leaven, 10 parts of oriental wormwood, 10 parts of scorched bighead atractylodes rhizome, 15 parts of polygonum multiflorum, 15 parts of eclipta alba, 15 parts of turtle shell, 6 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 6 parts of green tangerine peel, 6 parts of rhizoma cyperi, 6 parts of radix curcumae, 3 parts of cinnamon, 6 parts of curcuma longa, 15 parts of raw oyster, 6 parts of ginger, 4 parts of Chinese date, 30 parts of astragalus mongholicus, 10 parts of fructus lycii and 10 parts of szechwan chinaberry fruit.
The invention also provides a medicament prepared from the traditional Chinese medicine composition.
Preferably, the medicament is a granular oral formulation.
The pharmacology of the formula of the invention is as follows:
radix Cyathulae is neutral in nature, and enters liver and kidney meridians, and has effects of removing blood stasis, dredging channels, promoting joint movement, and inducing diuresis for treating stranguria;
the red sage root is slightly cold in nature, enters heart and liver channels, activates blood and removes stasis, clears heart and relieves restlessness, cools blood and eliminates carbuncle;
radix glehniae is slightly cold in nature and enters lung and stomach channels, and has the effects of nourishing yin, clearing away lung-heat, tonifying stomach and promoting fluid production;
the dwarf lilyturf tuber is slightly cold in nature, enters heart, lung and stomach channels, nourishes yin, promotes the production of body fluid, moistens lung and clears heart;
the polygonatum odoratum is neutral in nature, enters lung and stomach channels, nourishes yin, moistens lung, nourishes stomach and promotes the production of body fluid;
the dendrobium is slightly cold in nature, enters stomach channels and kidney channels, benefits stomach, promotes fluid production, nourishes yin and clears heat;
the rehmannia root is cold in nature, and has the effects of entering heart, liver and kidney channels, clearing heat, promoting fluid production, nourishing yin and nourishing blood;
the prepared rhizome of rehmannia is warm in nature, enters liver and kidney channels, and has the effects of enriching blood, nourishing yin, replenishing vital essence and filling marrow;
the angelica has mild nature, enters liver, heart and spleen channels, enriches blood and activates blood, regulates menstruation and relieves pain, and moistens intestines and relieves constipation;
white peony root, radix paeoniae alba is warm in nature, enters liver, spleen and kidney channels, dispels wind-damp, and tonifies kidney and spleen;
the large-leaved gentian has mild nature, enters stomach, liver and gallbladder meridians, tonifies lung and yin, removes stasis and relieves pain, and stops bleeding;
the isatis root is cold in nature, enters heart and stomach channels, clears away heat and toxic materials, cools blood and relieves sore throat;
the sealwort is neutral in nature, and has effects of nourishing lung, nourishing yin, tonifying spleen and qi, and nourishing spleen and kidney;
radix Codonopsis is neutral in nature, and has effects in invigorating spleen and stomach channels, invigorating spleen, replenishing qi, and nourishing lung;
rhizoma alismatis is cold in nature, enters kidney and bladder channels, promotes diuresis, excretes dampness, discharges heat, dissolves turbidity and reduces lipid;
the charred hawthorn is slightly warm in nature and enters stomach, spleen and liver channels, and has the effects of promoting digestion, relieving stasis, promoting blood circulation and removing blood stasis;
medicated leaven is warm in nature, and has effects of invigorating spleen and stomach, promoting digestion and regulating stomach function;
herba Artemisiae Scopariae is cold in nature, and has effects in invigorating spleen, stomach, liver and gallbladder channels, clearing away cold-dampness, promoting bile flow, and eliminating jaundice;
the charred rhizoma Atractylodis Macrocephalae has warm nature, enters spleen and stomach channels, tonifies qi and spleen, eliminates dampness and promotes diuresis;
the fleece-flower root has warm property, enters liver, heart and kidney channels, is used for detoxifying, eliminating carbuncle and relaxing bowel;
carapax Trionycis, being slightly cold in nature, enters liver and kidney meridians, has effects in nourishing yin, suppressing yang, relieving fever, removing dampness, softening and resolving hard mass;
safflower is warm in nature, enters heart and liver meridians, promotes blood circulation, passes through meridians, removes stasis and relieves pain;
the rhizoma sparganii is neutral in nature, enters liver and spleen channels, breaks blood and promotes qi circulation, and eliminates food stagnation and relieves pain;
the zedoary has warm nature, enters liver and spleen channels, promotes qi circulation, breaks blood, removes food retention and relieves pain;
pericarpium Citri Reticulatae viride is warm in nature, and has effects in soothing liver, breaking qi, removing food stagnation and resolving stagnation;
the Chinese medicinal composition has the effects of calming down the exterior of the liver, spleen and triple energizer, soothing liver, relieving depression, regulating qi, relieving epigastric distention, regulating menstruation and relieving pain;
the radix curcumae is cold in nature, enters liver, heart and lung channels, promotes blood circulation, relieves pain, promotes qi circulation, relieves depression, clears heart and cools blood;
cinnamon bark, cortex cinnamomi, the kidney, spleen, heart and liver meridians are heated, the internal heat is supplemented, the yang is assisted, the cold is dispelled, the pain is relieved, the meridians are warmed, the pulse is promoted, and the fire is led to the origin;
turmeric has warm nature, enters spleen and liver channels, breaks blood and promotes qi circulation, and clears meridians to stop pain;
the ginger has warm property, enters lung, spleen and stomach channels, dispels cold, relieves exterior syndrome, warms middle energizer, stops vomiting and detoxifies;
the raw oyster is slightly cold in nature, enters liver, gallbladder and kidney channels, has the effects of tranquilizing mind, suppressing yang hyperactivity, nourishing yin, softening hardness and dissipating stagnation;
the Chinese dates have warm property, enter spleen, stomach and heart channels, tonify middle-jiao and qi, nourish blood and tranquilize mind;
the astragalus membranaceus is warm in nature, enters lung and spleen channels, tonifies qi, strengthens exterior, induces diuresis, expels pus, heals sore and promotes tissue regeneration;
herba Ecliptae is cold in nature, enters kidney and liver meridians, and has effects of nourishing liver and kidney, cooling blood and stopping bleeding;
the medlar has mild nature, enters liver and kidney channels, nourishes liver and kidney, and benefits essence and improves eyesight;
chuan Lian Zi is cold in nature, enters liver channel, stomach channel, small intestine channel and bladder channel, and has effects of activating qi-flowing, relieving pain, killing parasites and relieving itching.
Liver disease belongs to the category of jaundice, accumulation, hypochondriac pain and abdominal mass in traditional Chinese medicine. The main causes of liver disease are emotional factors, affection of damp-heat or pathogenic toxin, or imbalance of yin and yang in the body caused by improper diet and excessive drinking. In traditional Chinese medicine, the liver belongs to wood, has the property of joyful movement and governs liver to smooth flow of qi. Emotional changes such as emotional discomfort, anger and worry about depression and anger can cause qi stagnation, liver qi stagnation, transverse adverse flow of qi affecting the stomach and spleen dysfunction in transportation. Qi is the commander of blood and blood is the mother of qi, so qi stagnation leads to blood stasis and blood stasis leads to hypochondriac accumulation. In the course of liver disease, the deficiency of spleen and kidney is the intrinsic cause, while diet, emotion, exogenous pathogenic factors are the extrinsic factors, and the combination of the interior and exterior causes liver disease. Spleen deficiency is due to liver-wood-gram earth, or congenital deficiency. For a long time due to spleen deficiency, dysfunction of transportation and transformation may produce qi stagnation, blood stasis, damp-heat or even yin deficiency. Liver and kidney are homologous, liver failure in nourishment, liver yin deficiency, mother-organ qi theft, kidney water recovery deficiency, water failure in wood, liver and kidney deficiency, water dampness failure in distribution, blood stasis and internal stagnation. In the late stage of disease, qi and blood failure, yin and yang impairment, viscera function failure and death. Namely, the deficiency of healthy qi of the body can cause the exogenous dampness-heat and epidemic toxin, and the pathogenic qi invades the liver and gallbladder, which can cause the liver to lose the flow of qi, the liver-wood-earth and the weakness of the spleen and stomach, and the deficiency of the liver and kidney, heat damaging the yin and the nutrient, viscera, qi and blood, and yin and yang.
Therefore, all liver diseases are located in the liver, but the pathogenesis is closely related to the spleen and kidney, and the function of the gallbladder, stomach and kidney can be affected with the progress of the disease. Therefore, according to pathogenesis and etiology of liver diseases, the traditional Chinese medicine takes monarch, minister, assistant and guide as principles and reasonably prepares medicines, and the astragalus, the tuber fleeceflower root, the eclipta alba, the codonopsis pilosula, the salvia miltiorrhiza, the white paeony root and the angelica are taken as monarch medicines, so that the traditional Chinese medicine aims to strengthen the body resistance and consolidate the constitution, tonify qi, invigorate the spleen and nourish the liver and kidney;
rhizoma cyperi, radix curcumae, turmeric, pericarpium citri reticulatae viride, szechwan chinaberry fruit, radix glehniae, radix ophiopogonis, polygonatum odoratum, dendrobium, medlar, radix cyathulae, rhizoma polygonati, rhizoma atractylodis macrocephalae, medicated leaven, scorched hawthorn fruit, dried rehmannia root and prepared rhizome of rehmannia are taken as ministerial drugs: wherein, the nutgrass galingale rhizome, the turmeric root-tuber, the green tangerine peel and the szechwan chinaberry fruit are combined to sooth the liver, promote the circulation of qi and relieve pain;
radix Glehniae, radix Ophiopogonis, rhizoma Polygonati Odorati, herba Dendrobii, and radix rehmanniae are combined for invigorating qi and nourishing yin;
fructus Lycii, radix Cyathulae, rhizoma Polygonati, and radix rehmanniae Preparata for strengthening and nourishing liver and kidney;
atractylodis rhizoma, massa Medicata Fermentata, fructus crataegi preparata, and fructus Jujubae for invigorating spleen and regulating stomach;
rhizoma sparganii, curcuma zedoary, turtle shell, oyster shell, safflower and cinnamon are used as adjuvant drugs for promoting blood circulation and removing blood stasis to prevent pathogenic qi from consuming blood and activating nutrient; the oriental wormwood, the large-leaved gentian, the oriental waterplantain rhizome and the indigowoad root are taken as guiding drugs to clear away heat, promote diuresis, detoxify and promote the liver and gallbladder to remove damp-heat.
The prescription of the invention is reasonable and combined, mainly strengthens the body resistance and nourishes the liver and kidney, protects the liver function, ensures that the medicine for strengthening the body resistance and consolidating the body resistance can not be kept by activating blood and dissolving stasis, has the effects of clearing heat, promoting diuresis and detoxifying, nourishes liver yin, soothes liver and promotes qi circulation, protects the medicine for strengthening the body resistance and consolidating the body resistance and recovers the liver function; the stomach harmonizing medicine is used for reducing gastrointestinal digestion function weakening symptoms caused by gastrointestinal vein Cong Quzhang blood stasis and the like caused by liver cirrhosis, all the medicines have synergistic effect, can be used for treating various stages of hepatitis B, particularly chronic active hepatitis B, and can strengthen vital qi to eliminate pathogenic factors to complement each other, thereby not only treating the existing symptoms, but also playing a role in preventing and treating the liver cirrhosis, and the stomach harmonizing medicine has obvious curative effect on symptoms caused by the hepatitis B and the liver cirrhosis, such as liver function damage, transaminase increase, liver pain, jaundice, splenomegaly, dysfunction of spleen and stomach and the like.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of exemplary embodiments according to the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of the stated features, steps, operations, and/or combinations thereof, unless the context clearly indicates otherwise.
Example 1: a Chinese medicinal composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis comprises the following raw material medicaments in part by weight: 1 part of medicinal cyathula root, 30 parts of salvia miltiorrhiza, 10 parts of radix glehniae, 10 parts of radix ophiopogonis, 6 parts of polygonatum odoratum, 6 parts of dendrobium, 12 parts of radix rehmanniae, 12 parts of prepared rehmannia root, 10 parts of angelica, 15 parts of white peony root, 10 parts of gentiana macrophylla, 10 parts of radix isatidis, 20 parts of rhizoma polygonati, 10 parts of codonopsis pilosula, 10 parts of rhizoma alismatis, 10 parts of scorched hawthorn fruit, 10 parts of medicated leaven, 10 parts of oriental wormwood, 10 parts of scorched bighead atractylodes rhizome, 15 parts of polygonum multiflorum, 15 parts of eclipta alba, 15 parts of turtle shell, 6 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 6 parts of green tangerine peel, 6 parts of rhizoma cyperi, 6 parts of radix curcumae, 3 parts of cinnamon, 6 parts of curcuma longa, 15 parts of raw oyster shell, 6 parts of ginger, 4 parts of Chinese date, 30 parts of astragalus mongholicus, 10 parts of fructus lycii and 10 parts of szechwan chinaberry fruit.
In this example, the granules are processed into granules according to the conventional technology, and packaged in bags, wherein each bag is 15 g, and the medicine of the granules in this example is named as Gankang pill.
Example 2: clinical application data
100 patients with type b slow-alive liver treated from 5 months 2014 to 7 months 2018 were selected as subjects, wherein 58 of men and 52 of women were selected and aged from 28 to 74 years, 99 patients with type b slow-alive liver (major three positive) and 1 patient with type b slow-alive liver (minor three positive).
The treatment method comprises the following steps: the patient with type B chronic hepatitis is treated by the Gankang pill granule for 1 day 2 times, 1 bag once, 15 g bag, and is taken with warm boiled water half an hour after meal, with 1 month as the basic course of treatment.
The curative effect standard is as follows:
the improvement effect of clinical symptoms is divided into recovery, obvious effect, effective and ineffective;
and (3) healing: the clinical symptoms and physical signs disappear, and the health is recovered;
the effect is shown: substantial disappearance or significant improvement of clinical symptoms, signs;
the method has the following advantages: the clinical symptoms and physical signs are relieved or improved;
and (4) invalidation: the clinical symptoms and physical signs are not obviously improved or the disease condition is aggravated.
The treatment results are shown in table 1:
table 1: clinical therapeutic effect (%, n, case)
The composition can treat liver diseases from the aspects of antivirus, immunity regulation, anti-inflammation, liver protection, anti-fibrosis and the like, and can effectively treat symptoms such as liver function damage, transaminase increase, liver pain, jaundice, splenomegaly, dysfunction of spleen and stomach and the like caused by hepatitis B and liver cirrhosis.
The invention mainly aims at strengthening body resistance and consolidating constitution, and nourishing liver and kidney, and protects liver function by the compatibility of monarch drugs; the medicine has the functions of promoting blood circulation to remove blood stasis, softening hardness to dissipate stagnation, dredging collaterals and relieving pain, and the like, so that the medicine for strengthening body resistance and consolidating the constitution can be kept away, and the liver fibrosis can be prevented and treated; the traditional Chinese medicine composition has the effects of clearing heat, promoting diuresis and removing toxicity, nourishing liver yin, soothing liver and promoting qi circulation, particularly clearing heat and removing toxicity to reduce transaminase, and can help the body resistance strengthening and constitution consolidating medicine to restore liver function; the stomach harmonizing medicine is used for reducing gastrointestinal digestion function weakening symptoms caused by gastrointestinal vein Cong Quzhang blood stasis and the like caused by liver cirrhosis, is suitable for hepatitis B, also suitable for other types of viral hepatitis such as self-immune liver, hepatitis A, hepatitis C and the like, and can effectively prevent and treat the liver cirrhosis.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (4)
1. A traditional Chinese medicine composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis is characterized by comprising medicinal cyathula root, salvia miltiorrhiza, coastal glehnia root, dwarf lilyturf tuber, fragrant solomonseal rhizome, dendrobium, rehmannia root, prepared rehmannia root, chinese angelica, white paeony root, large-leaved gentian, indigowoad root, manyflower solomonseal rhizome, pilose asiabell root, oriental waterplantain rhizome, scorched hawthorn fruit, medicated leaven, oriental wormwood, scorched largehead atractylodes rhizome, tuber fleeceflower root, turtle shell, safflower, common burreed rhizome, zedoary, green tangerine peel, nutgrass galingale rhizome, turmeric, raw oyster shell, ginger, chinese date, membranous milkvetch root, yerbadetajo herb, barbary wolfberry fruit and szechwan chinaberry fruit.
2. The traditional Chinese medicine composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis as claimed in claim 1, is characterized in that the weight ratio of the raw materials is as follows:
1 part of medicinal cyathula root, 30 parts of salvia miltiorrhiza, 10 parts of radix glehniae, 10 parts of radix ophiopogonis, 6 parts of polygonatum, 6 parts of dendrobium, 12 parts of rehmannia root, 12 parts of prepared rehmannia root, 10 parts of angelica, 15 parts of white peony root, 10 parts of gentiana macrophylla, 10 parts of isatis root, 20 parts of rhizoma polygonati, 10 parts of codonopsis pilosula, 10 parts of rhizoma alismatis, 10 parts of scorched hawthorn fruit, 10 parts of medicated leaven, 10 parts of oriental wormwood, 10 parts of scorched bighead atractylodes rhizome, 15 parts of polygonum multiflorum, 15 parts of eclipta alba, 15 parts of turtle shell, 6 parts of safflower, 10 parts of rhizoma sparganii, 10 parts of curcuma zedoary, 6 parts of green tangerine peel, 6 parts of rhizoma cyperi, 6 parts of radix curcumae, 3 parts of cinnamon, 6 parts of turmeric, 15 parts of raw oyster, 6 parts of ginger, 4 parts of Chinese date, 30 parts of astragalus root, 10 parts of wolfberry fruit and 10 parts of szechwan chinaberry fruit.
3. A medicament for treating chronic active hepatitis B and preventing and treating cirrhosis, characterized in that it is prepared from the Chinese medicinal composition of claim 1 or 2.
4. The composition for treating chronic active hepatitis B and preventing and treating liver cirrhosis as claimed in claim 3, which is a granular oral preparation.
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Citations (3)
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| CN1562160A (en) * | 2004-04-21 | 2005-01-12 | 金海清 | Composite medicine for treating hepatitis B complication |
| CN101185747A (en) * | 2007-10-17 | 2008-05-28 | 门连社 | Prescription for treating hepatic disease |
| CN107320682A (en) * | 2017-06-30 | 2017-11-07 | 谭文登 | A kind of medicine for treating hepatitis B |
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- 2022-08-08 CN CN202210944912.9A patent/CN115154569A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1562160A (en) * | 2004-04-21 | 2005-01-12 | 金海清 | Composite medicine for treating hepatitis B complication |
| CN101185747A (en) * | 2007-10-17 | 2008-05-28 | 门连社 | Prescription for treating hepatic disease |
| CN107320682A (en) * | 2017-06-30 | 2017-11-07 | 谭文登 | A kind of medicine for treating hepatitis B |
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| 薛文翰,苗春兰: "中药与拉咪呋啶并用治疗乙型病毒性肝炎临床分析", 中医药学刊 * |
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