CN115154343A

CN115154343A - Composition and preparation for improving eye relaxation and dark circles, preparation method and application

Info

Publication number: CN115154343A
Application number: CN202211007469.9A
Authority: CN
Inventors: 杨明振
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-08-22
Filing date: 2022-08-22
Publication date: 2022-10-11
Anticipated expiration: 2042-08-22
Also published as: CN115154343B

Abstract

The invention discloses a composition for improving eye relaxation and dark circles, a preparation method and application, and belongs to the technical field of skin care products. The preparation is prepared from C20-22 alcohol phosphate, allantoin, betaine, glycerol polymethacrylate, sodium hyaluronate, coffee extract, antioxidant, sodium heparin, plant extract, triethanolamine, hydroxypropyl tetrahydropyrane triol, palmitoyl pentapeptide-4, dipotassium glycyrrhizinate, and phenoxyethanol. The raw materials complement and enhance the components, and the efficacy performance is effectively improved. The product can remove free radical dimension to repair and improve skin around eyes; repair and improvement of periocular skin from ocular blood microcirculation and skin metabolism dimensions; repair and improvement of periocular skin from the skin melanin deposition dimension; the skin is tightened by increasing the content dimensions of collagen fibers and elastic fibers in the skin around the eyes, the skin around the eyes is repaired and improved, the problems of eye looseness and dark circles are removed and improved in an all-round mode through four dimensions, the effect is obvious, and the skin is not easy to relapse.

Description

Composition and preparation for improving eye relaxation and dark eye circles as well as preparation method and application of composition and preparation

Technical Field

The invention belongs to the technical field of skin care products, and particularly relates to a composition for improving eye laxity and dark circles, a preparation method and application.

Background

Every person needs to blink for tens of thousands of times every day, and the eye skin is continuously extruded and stretched for a long time, so that the skin around the eyes can be quickly loosened.

The thinness of the eye skin is about 1/3 of the thickness of the facial skin, and the subcutaneous tissues are the blood vessels, lymph and other eye tissues. Like over fatigue of eyes, slow metabolism, blood circulation of capillary vessels forming stagnation, insufficient oxygen supply of tissues, and excessive accumulation of waste garbage in blood vessels and skin, the phenomenon is easily shown to form black eyes on the skin.

With the recent increase in social rhythm, lifestyle has also changed. The time for people to contact with electronic products such as televisions, computers, mobile phones and the like is longer and longer, and the eye skin relaxation and the formation of black eyes are easily aggravated when people face overtime work, stay up and boil all night, net play and net lessons for a long time.

Slight loose skin around the eyes and black eye circles can be adjusted along with self work and rest, early sleep can be achieved, the eye time can be shortened, and the eye-care health care product can be slowly relieved. The severe, persistent, periocular laxity and dark circles are difficult to remove once formed without external intervention.

At present, a laser activation method is generally adopted for severe intractable eye skin looseness and dark circles, and the laser mode cannot be accepted by all nations due to the special eye position and certain risk.

There are many related products on the market today, such as: eye cream and eye products with infrared light or blue light have the defects of single function and poor improvement effect.

Disclosure of Invention

The invention aims to provide a preparation capable of improving eye relaxation and dark circles, and the preparation can solve the technical problems of single function, poor improvement effect, risks in operation and the like of products in the prior art.

The invention is realized by the following technical scheme:

a composition for improving eye relaxation and dark circles is prepared from the following raw materials in percentage by mass:

0.2-0.6 wt% of C20-22 alcohol phosphate, 0.1-0.3 wt% of allantoin, 0.5-5 wt% of betaine, 0.5-4 wt% of glycerol polymethacrylate, 0.01-0.1 wt% of sodium hyaluronate, 1-2 wt% of coffee extract, 3.05-8.03 wt% of antioxidant, 0.1-0.2 wt% of sodium heparin, 5-7 wt% of plant extract, 0.2-0.3 wt% of triethanolamine, 2-6 wt% of hydroxypropyl tetrahydropyrane triol, 4-1 wt% of palmitoyl pentapeptide, 0.3-2 wt% of dipotassium glycyrrhizinate, 0.5-1 wt% of phenoxyethanol and the balance of solvent.

Said invention provides a composition for improving relaxed eye and black eye, and said composition uses several complementary synergistic components with reasonable mixing ratio, and can effectively raise the effect performance of said composition.

Wherein the C20-22 alcohol phosphate is used as a surfactant; adding an antioxidant: glabridin, astaxanthin and ascorbic acid have super-strong effects of resisting oxidation, removing free radicals, inhibiting activity of tyrosinase, and effectively inhibiting generation of melanin. The added palm leaf tree extract can greatly promote the blood flow rate around eyes and quickly remove redundant water, toxins and wastes accumulated in eyes. The addition of sodium heparin can improve the dark skin around the eyes due to blood retention. Palmitoyl pentapeptide-4, which has uniquely ordered small molecule pentapeptides, is added to simulate the mechanism of the human body per se to generate collagen through TGF-beta, and simultaneously inhibit MMP (matrix metalloproteinase) to protect the collagen from being degraded. The two ingredients have synergistic effect, so that the effect of tightening the skin is achieved, the plumpness of the eye skin is improved, the eye circumference is tightened, and the eye skin is revived.

Preferably, the plant extract consists of 1wt% -3wt% of daemonorops draco extract, 1wt% -3wt% of palm leaf tree extract and 1wt% -3wt% of dendrobium stem extract.

Preferably, the antioxidant consists of glabridin 0.03-0.05 wt%, astaxanthin 2-5 wt% and ascorbic acid 1-3 wt%.

Preferably, the solvent is deionized water.

The main effects of the raw materials are as follows:

c20-22 alcohol phosphate ester: is anionic surfactant, and can be used as emulsifier in cosmetic.

Glabridin: resisting oxidation, and inhibiting activity of skin tyrosinase.

Ascorbic acid: has effects in resisting oxidation, preventing skin pigmentation, and promoting skin metabolism.

Daemonorops draco extract: improving skin microcirculation and enhancing skin metabolism. Promoting blood circulation and tissue regeneration, relieving pain and inhibiting bacteria, promoting wound healing, etc. Sanguis Draxonis contains tannin, reducing sugar and resin, and has effects of dispelling qi, relieving pain, dispelling pathogenic wind, dredging channels and promoting blood circulation.

Palm leaf extract: improving skin microcirculation and enhancing skin metabolism.

Dendrobium nobile extract: resisting aging, promoting blood circulation for removing blood stasis, and improving skin activity.

Sodium heparin: enhance microcirculation of skin and hair vessels and prevent blood retention.

And (3) coffee extract: accelerating the microcirculation of the skin and relieving edema.

Hydroxypropyl tetrahydropyran triol: promoting the production of skin collagen and preventing skin relaxation.

Palmitoyl pentapeptide-4: promoting skin elastic fiber cells and tightening skin.

Allantoin: is called an anti-irritant and can effectively relieve the irritation of the irritant; meanwhile, the vitamin C is also an antioxidant, and like other water-soluble vitamins, the vitamin C has the same capacity of gathering free radicals as vitamin C, so that the antioxidant capacity of cells can be enhanced. Can combine with a plurality of substances to form compound salt, has the functions of light protection, sterilization, corrosion prevention, pain relief and oxidation resistance, can keep the moisture of the skin, moisten and soften, and is a special additive of cosmetics such as beauty, hairdressing and the like. Has effects in caring skin, keeping moisture, softening cutin, resisting oxidation, and relieving inflammation.

Betaine: also known as trimethylamine ethylene lactone, betanin, and betaine, is a quaternary ammonium derivative of glycine, which is a completely natural, edible amino acid. Betaine mainly has the capability of rapidly improving the moisture retention of skin and hair, has the unique performance of protecting cell membranes by a humectant, and can increase the solubility of active ingredients in water and reduce the irritation of a surfactant or fruit acid to the skin. Betaine also has antiallergic and skin irritation reducing effects.

Glycerin polymethacrylate: can be used as film forming agent and viscosity control agent in cosmetic worker. The glycerin polymethacrylate is a water-soluble transparent gel, is a transparent and multifunctional moisturizing substrate, and can increase skin feel and lubricity and improve moisturizing performance.

Sodium hyaluronate: has better high viscoelasticity, plasticity and permeability and good biocompatibility. It has been widely used in the production of cosmetics as a natural moisturizer.

Triethanolamine: TEOA, also known as TEOA, TEA. The alias is 2, 2-hydroxy triethylamine, trihydroxyethylamine, and the chemical formula (molecular formula) C ₆ H ₁₅ O ₃ N is colorless to light yellow viscous liquid with ammonia smell, is easily dissolved in water and ethanol, is alkaline, has the pH value of the aqueous solution of about 10.5, is a chemical raw material with wide application, and is used as a vulcanization active agent of non-carbon black reinforced rubber materials, an emulsifying agent of oils and waxes, a metal cutting cooling agent, an antirust agent, a cement early strength agent, a neutralizing agent, an acid gas absorbent, a daily chemical product wetting agent and the like. It also has neutralizing effect in cosmetic, and can neutralize CP-940 to achieve thickening and moisturizing effects.

Dipotassium glycyrrhizinate: is white or quasi-white fine powder, has purity up to 98%, special sweet taste, good water solubility and pure taste. Dipotassium glycyrrhizinate has multiple effects of bacteriostasis, inflammation diminishing, detoxification, anti-allergy, deodorization and the like. The method can be widely applied to the industries of medicine, cosmetics, daily chemicals, food and the like. Can be used in eye drop and stomatitis. The corticosteroid can be activated (inhibiting metabolic enzymes). The effect of the corticosteroid compound is indirectly enhanced, the corticosteroid compound can be used for all cosmetics such as cream, water, emulsion, milk, honey and the like, can neutralize or reduce toxic substances of the cosmetics, can also prevent the anaphylactic reaction of some cosmetics, and is more suitable for high-grade hair or used in the cosmetics, and the market specification is that UV is more than or equal to 98 percent and HPLC is more than or equal to 76 percent (referring to the effective component of glycyrrhizic acid). The cosmetic has wide compatibility, can be frequently used together with other active agents, can accelerate the absorption of the skin to the active agents to enhance the effect, and can be used for sun protection, assisting whitening, relieving itching, regulating sebum, growing hair and protecting hair and the like. Can be used for preventing dermatitis, xerosis cutis, sunburn, erythra, and throat moistening. Spot-removing agent, and antiallergic agent. Can be used for resisting allergy, preventing sunburn, caring skin lotion, and removing speckle cream and lotion.

Phenoxyethanol: is an organic compound frequently used in skin care products, can be prepared by etherification of ethylene glycol and phenol, and is commonly used in skin care creams and sunscreen creams. Phenoxyethanol is a colorless oily liquid with antibacterial efficacy (commonly used with quaternary ammonium salts), and is often used as a highly toxic substitute for sodium azide in biolofibre solutions because 2-phenoxyethanol is less toxic and chemically inert to copper and lead. It is commonly used as a preservative in cosmetics, skin care products, vaccines and pharmaceuticals.

A preparation for improving eye laxity and dark circles is prepared from the composition for improving eye laxity and dark circles.

A method for preparing a preparation for improving eye laxity and dark circles, which comprises the following steps:

selecting triethanolamine and sodium hyaluronate according to corresponding mass fractions, and dispersing in a solvent accounting for 2-3wt% of the total mass of the preparation to obtain a material A;

selecting C20-22 alcohol phosphate, allantoin, betaine, glycerol polymethacrylate and the rest solvent according to corresponding mass fractions, uniformly mixing, heating and stirring, cooling to 50-60 ℃, adding the material A, stirring, cooling to 40-45 ℃, adding a coffee extract, an antioxidant, a plant extract, sodium heparin, hydroxypropyl tetrahydropyrane triol, palmitoyl pentapeptide-4, dipotassium glycyrrhizinate and phenoxyethanol, and uniformly mixing.

Preferably, in the heating and stirring step, the heating temperature is 85 to 90 ℃.

Preferably, in the heating and stirring step, the stirring time is 10-25min.

Preferably, in the heating and stirring step, the time for adding the material A and stirring is 10-15min.

An application of a preparation for improving eye laxity and dark circles in preparing products for tightening the eye periphery and removing the dark circles.

Compared with the prior art, the invention at least has the following technical effects:

the invention provides a composition for improving eye relaxation and dark circles, which effectively improves the efficacy performance of the composition by using various complementary synergistic components with reasonable mixture ratio.

Wherein, the C20-22 alcohol phosphate is used as a surfactant; adding an antioxidant: glabridin, astaxanthin and ascorbic acid have super strong antioxidation, free radical eliminating effect, activity of tyrosinase inhibiting, and melanin generation inhibiting effects. The added palm leaf tree extract can greatly promote the blood flow rate around eyes and quickly remove redundant water, toxins and wastes accumulated in eyes. The addition of sodium heparin can improve the dark skin around the eyes due to blood retention. Palmitoyl pentapeptide-4 which has uniquely ordered small molecule pentapeptide is added to simulate the mechanism of human body to generate collagen through TGF-beta, and simultaneously inhibit MMP (matrix metalloproteinase) to protect the collagen from being degraded. The two ingredients have synergistic effect, so that the effect of tightening the skin is achieved, the plumpness of the eye skin is improved, the eye circumference is tightened, and the eye skin is revived.

The product can remove and improve the problems of loose eyes and dark circles in all directions from four dimensions. Firstly, because a large amount of peroxide free radicals are generated on the electronic product and eye skin in a long-time overload way, the free radicals influence the normal self-repair of the eye skin, and the eye skin is repaired and improved from the dimension of removing the free radicals; secondly, the repair and improvement of the skin around the eyes are carried out from the dimension of blood microcirculation and skin metabolism of the eyes; thirdly, repairing and improving the skin around the eyes from the dimension of skin melanin deposition; fourthly, the dimension of increasing the content of collagen fibers and elastic fibers in the skin around the eyes is used for tightening the skin and repairing and improving the skin around the eyes.

And (III) the product of the application is a preferable efficacy combination and supplements the effects of the product to thoroughly improve the problems of loose eye skin and dark circles.

And (IV) the product effectively improves the efficacy performance of the composition through multiple complementary synergistic components with reasonable mixture ratio. Has obvious effects of tightening skin around eyes and removing dark eye circles, and is not easy to relapse after being decocted all the time.

Drawings

FIG. 1 is a graph showing the results of comparison before and after treatment of patient 1 using the product prepared in example 3;

FIG. 2 is a graph showing the results of comparison before and after treatment of patient 2 using the product prepared in example 3;

FIG. 3 is a graph showing the results of comparison before and after treatment of patient 3 using the product prepared in example 3;

FIG. 4 is a graph showing comparative results before and after treatment of patient 4 using the product prepared in example 3;

FIG. 5 is a graph showing the results of comparison before and after treatment of patient 5 using the product prepared in example 3;

FIG. 6 is a graph showing comparative results before and after treatment of patient 6 using the product prepared in example 3;

FIG. 7 is a graph showing the results of comparison before and after treatment of patient 7 using the product prepared in example 3;

FIG. 8 is a graph showing the results of comparison before and after treatment of patient 8 using the product prepared in example 3;

FIG. 9 is a graph showing the results of comparison before and after treatment of patient 9 using the product prepared in example 3;

FIG. 10 is a graph showing comparative results before and after treatment of patient 10 using the product prepared in example 3;

FIG. 11 is a graph showing comparative results before and after treatment of patient 11 using the product prepared in example 3;

FIG. 12 is a graph comparing results before and after treatment for patient 12 using the product prepared in example 3.

Detailed Description

Embodiments of the present invention will be described in detail with reference to the following examples, but those skilled in the art will understand that the following examples are merely illustrative of the present invention and should not be construed as limiting the scope of the present invention, and that the specific conditions not specified in the examples are carried out according to conventional conditions or conditions suggested by the manufacturer, and that the reagents or equipment used are not specified by the manufacturer, and are all conventional products available through commercial purchase.

The technical scheme of the invention is as follows:

a composition for improving eye relaxation and dark circles is prepared from the following raw materials in parts by mass: 0.2 to 0.6 weight percent of 20 to 22 alcohol phosphate, 0.1 to 0.3 weight percent of allantoin, 0.5 to 5 weight percent of betaine, 0.5 to 4 weight percent of glycerol polymethacrylate, 0.01 to 0.1 weight percent of sodium hyaluronate, 1 to 2 weight percent of coffee extract, 0.03 to 0.05 weight percent of glabridin, 0.1 to 0.2 weight percent of sodium heparin, 1 to 3 weight percent of sanguis draconis extract, 0.2 to 0.3 weight percent of triethanolamine, 2 to 5 weight percent of astaxanthin, 2 to 6 weight percent of hydroxypropyl tetrahydropyrane triol, 1 to 4 weight percent of palmitoyl pentapeptide, 1 to 3 weight percent of palm leaf extract, 1 to 3 weight percent of dendrobium nobile extract, 1 to 3 weight percent of ascorbic acid, 0.3 to 2 weight percent of dipotassium glycyrrhizinate, 0.5 to 1 weight percent of phenoxyethanol and the balance of deionized water.

A preparation method of a preparation for improving eye laxity and dark circles comprises the following steps;

pre-dispersing triethanolamine, sodium hyaluronate and deionized water accounting for 2wt% of the total weight of the preparation to obtain a material A;

mixing C20-22 alcohol phosphate, allantoin, betaine, glycerol polymethacrylate and the rest deionized water, stirring and heating to 85-90 ℃, keeping the temperature and stirring for 10-25min, cooling to 50-60 ℃, adding the material A, keeping the temperature and stirring for 10-15min, cooling to 45 ℃, adding coffee extract, glabridin, heparin sodium, daemonorops draco extract, astaxanthin, hydroxypropyl tetrahydropyrane triol, palmitoyl pentapeptide-4, palm leaf tree extract, dendrobium nobile extract, ascorbic acid, dipotassium glycyrrhizate, phenoxyethanol, and uniformly stirring to obtain the preparation for improving loose eyes and black eye circles.

Example 1

A composition for improving eye relaxation and dark circles is prepared from the following raw materials in percentage by mass: 0.2wt% of c20-22 alcohol phosphate, 0.1wt% of allantoin, 0.5wt% of betaine, 4wt% of glycerol polymethacrylate, 0.1wt% of sodium hyaluronate, 1wt% of coffee extract, 0.03wt% of glabridin, 0.2wt% of sodium heparin, 1wt% of daemonorops draco extract, 0.2wt% of triethanolamine, 5wt% of astaxanthin, 2wt% of hydroxypropyl tetrahydropyrane triol, 4 1wt% of palmitoyl pentapeptide, 1wt% of palm leaf tree extract, 1wt% of dendrobium stem extract, 3wt% of ascorbic acid, 0.3wt% of dipotassium glycyrrhizinate, 1wt% of phenoxyethanol and the balance of deionized water to 100wt%.

A preparation for improving slack eyes and dark circles is prepared from the composition for improving the slack eyes and the dark circles.

mixing C20-22 alcohol phosphate, allantoin, betaine, glycerol polymethacrylate and the rest deionized water, stirring and heating to 85 ℃, keeping the temperature and stirring for 25min, cooling to 60 ℃, adding the material A, keeping the temperature and stirring for 10min, cooling to 45 ℃, adding coffee extract, glabridin, heparin sodium, daemonorops draco extract, astaxanthin, hydroxypropyl tetrahydropyrane triol, palmitoyl pentapeptide-4, palm leaf tree extract, dendrobium nobile extract, ascorbic acid, dipotassium glycyrrhetate and phenoxyethanol, and stirring uniformly to obtain the preparation for improving eye relaxation and black eye circles.

Example 2

A composition for improving eye relaxation and dark circles is prepared from the following raw materials in parts by mass: 0.6wt% of c20-22 alcohol phosphate, 0.3wt% of allantoin, 5wt% of betaine, 0.5wt% of glycerol polymethacrylate, 0.01wt% of sodium hyaluronate, 2wt% of coffee extract, 0.05wt% of glabridin, 0.1wt% of sodium heparin, 3wt% of daemonorops draco extract, 0.3wt% of triethanolamine, 2wt% of astaxanthin, 6wt% of hydroxypropyl tetrahydropyrane triol, 4wt% of palmitoyl pentapeptide, 3wt% of palm leaf tree extract, 3wt% of dendrobium stem extract, 1wt% of ascorbic acid, 2wt% of dipotassium glycyrrhizinate, 0.5wt% of phenoxyethanol, and the balance of deionized water to 100wt%.

pre-dispersing triethanolamine, sodium hyaluronate and deionized water accounting for 3wt% of the total weight of the preparation to obtain a material A;

mixing C20-22 alcohol phosphate, allantoin, betaine, glycerol polymethacrylate and the rest deionized water, stirring and heating to 90 ℃, keeping the temperature and stirring for 10min, cooling to 50 ℃, adding the material A, keeping the temperature and stirring for 15min, cooling to 45 ℃, adding coffee extract, glabridin, heparin sodium, daemonorops draco extract, astaxanthin, hydroxypropyl tetrahydropyrane triol, palmitoyl pentapeptide-4, palm leaf tree extract, dendrobium nobile extract, ascorbic acid, dipotassium glycyrrhetate and phenoxyethanol, and stirring uniformly to obtain the preparation for improving eye relaxation and black eye circles.

Example 3

A composition for improving eye relaxation and dark circles is prepared from the following raw materials in percentage by mass: c20-22 alcohol phosphate 0.5wt%, allantoin 0.2wt%, betaine 0.3wt%, glycerol polymethacrylate 3wt%, sodium hyaluronate 0.1wt%, coffee extract 2wt%, glabridin 0.05wt%, sodium heparin 0.2wt%, daemonorops draco extract 3wt%, triethanolamine 0.2wt%, astaxanthin 5wt%, hydroxypropyl tetrahydropyrane triol 5wt%, palmitoyl pentapeptide-4 3wt%, palm leaf tree extract 3wt%, dendrobium stem extract 3wt%, ascorbic acid 3wt%, dipotassium glycyrrhizinate 0.3wt%, phenoxyethanol 0.5wt%, and the balance of deionized water to 100wt%.

mixing C20-22 alcohol phosphate, allantoin, betaine, glycerol polymethacrylate and the rest deionized water, stirring and heating to 85-90 ℃, keeping the temperature and stirring for 10-25min, cooling to 50-60 ℃, adding the material A, keeping the temperature and stirring for 10-15min, cooling to 45 ℃, adding coffee extract, glabridin, heparin sodium, dawn extract, astaxanthin, hydroxypropyl tetrahydropyrane triol, palmitoyl pentapeptide-4, palm leaf tree extract, dendrobium nobile extract, ascorbic acid, dipotassium glycyrrhetate and phenoxyethanol, and stirring uniformly to obtain the preparation for improving the loose eyes and black eye circles.

And (3) experimental comparison:

example 3 was used as an experimental example, and the following 3 comparative examples were designed and compared.

The preparation of 3 comparative examples was the same as that of example 3.

The specific experimental and comparative example raw materials used are as follows:

the first test: evaluation of skin firming Effect

The deep cause of skin relaxation is the decrease in the activity of fibroblasts, and the decrease in the secretion of collagen and elastin, which leads to sagging and sagging of the skin.

This experiment was used to evaluate the effect of the formulation prepared from the composition on fibroblast proliferation.

The ability to tighten the skin can be evaluated to some extent, and the proliferation of fibroblasts can be detected by the MTT method.

The test operation method is as follows:

fibroblast cells (RAB-iCell-s 010, saiboubangui), were digested with 0.25% trypsin and cell suspension concentration was adjusted to 120/ml, and inoculated uniformly into 48-well plates, 100. Mu.l was added dropwise to each well, and the marginal wells were filled with a pentaphosphate buffer. After culturing in a C20 incubator for 24 hours, the culture supernatant was aspirated, 100. Mu.l of a medium (bovine serum) diluent containing 50% of the sample was added to each well, and 8 duplicate wells were provided for each of the four samples of Experimental example, comparative example 1, comparative example 2, and comparative example 3, and a blank control group without the added sample was provided. After culturing for 48 hours, respectively, sucking out the culture supernatant, adding 100 mu l of DMEM culture solution into each well, adding 5mg/ml of MTT solution, culturing for 4 hours in a C02 incubator, carefully sucking out the culture supernatant, adding 150 mu l of DMSO into each well, shaking on a shaker for 15min to dissolve crystals, and measuring the absorbance (A) value at 490nm by using an enzyme-linked immunosorbent assay.

The test results are shown in table 1 below.

TABLE 1 Effect of various compositions on skin fibroblast growth

The above can be seen from table 1: the skin-tightening composition in the experimental example has the effect of obviously promoting the proliferation of skin fibroblasts, namely has the functions of tightening skin and removing wrinkles.

And (2) testing II: and (3) evaluation of black eye removal effect:

in order to verify that the preparation has the effects of tightening skin and removing dark circles.

30 volunteers (aged 40-50 years with dark circles and similar degree of skin laxity around the eyes) were randomly assigned to 2 groups of 15 people each.

The test operation method comprises the following steps:

the product (group one is a comparative example: skin lotion without specific efficacy, experimental example for group two) is used 2 times per day around eyes, 0.8g (eyes) is used once, the product is continuously used for four weeks, the change degree of the eye skin is observed every week, the product is stopped for 4 weeks, and the change degree of the eye skin is observed every week.

TABLE 2 comparative test results (group one)

TABLE 3 Experimental examples test results (group two)

The results of the above tables 2 and 3 show that: the use effect comparison of volunteers on the experimental examples and the comparative examples proves that the experimental examples can achieve the effects of removing black eye circles and tightening eye skins through the advantage combination of the effective components.

The preparation protected by the application starts with the dimensionalities of removing free radicals, inhibiting melanin sedimentation and the microcirculation environment of eye skin, and the content of collagen fibers and elastic fibers in skin, and the like, can fundamentally solve the problems of eye skin looseness and black eye circles, does not solve the surface phenomenon, and can achieve the effect of treating both symptoms and root causes.

Clinical cases:

patient 1: liu Jie, age 48 years old, loose skin on the lower eyelid. Symptoms disappeared after 3,3 months using this example.

Patient 2: ma Shi, age 43 years old, with loose skin on the lower eyelid, and mild dark circles. Using this example 3,2 half-months of symptoms disappeared.

Patient 3: liu Jie, age 63 years old, loose skin around eyes. The improvement effect of the skin laxity around the eyes was remarkable after 3,3 months using this example.

Patient 4: ding, age 38 years old, loose skin of the lower eyelid, and slight dark circles. Using this example, symptoms disappeared in 3,3 months.

Patient 5: wangzhi, age 32 years old, with loose skin on the lower eyelid. Using this example, 3,3 months, symptoms disappeared.

Patient 6: old, age 33 years, loose skin of the lower eyelid. Using this example, 3,3 months, symptoms disappeared.

Patient 7: lie, age 34 years, with loose skin on the lower eyelid. Using this example for 3,3 months, the symptoms disappeared.

Patient 8: wangzhi, age 36 years old, with loose skin on the lower eyelid. Using this example for 3,3 months, the symptoms disappeared.

Patient 9: thanks to certain age, 37 years old, severe dark circles under the eyes, loose skin of the lower eyelid. Using this example, 3,2 months, symptoms disappeared.

The patient 10: zhangzhi, age 41 years old, severe dark circles under the eyes, mild laxity of the skin of the lower eyelid. Using this example 2 for half a month, the symptoms disappeared.

Patient 11: liu Jie, the age of 43 years old, severe dark under-eye circles and loose skin in the lower eyes. Using this example, symptoms disappeared in 3,3 months.

Patient 12: li Shi, age 23 years old, moderate dark circles. With this example 3,1 month the symptoms disappeared.

The cases 1-8 are mainly used for treating eye bags; cases 9-12 are mainly treated for dark circles.

Finally, it should be noted that: the above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The composition for improving the relaxation and the dark circles of the eyes is characterized by being prepared from the following raw materials in percentage by mass:

0.2-0.6 wt% of C20-22 alcohol phosphate, 0.1-0.3 wt% of allantoin, 0.5-5 wt% of betaine, 0.5-4 wt% of glycerol polymethacrylate, 0.01-0.1 wt% of sodium hyaluronate, 1-2 wt% of coffee extract, 3.05-8.03 wt% of antioxidant, 0.1-0.2 wt% of sodium heparin, 5-7 wt% of plant extract, 0.2-0.3 wt% of triethanolamine, 2-6 wt% of hydroxypropyl tetrahydropyran triol, 4-1 wt% of palmitoyl pentapeptide, 0.3-2 wt% of dipotassium glycyrrhizinate, 0.5-1 wt% of phenoxyethanol and the balance of solvent.

2. The composition for improving laxity of the eyes and dark circles as claimed in claim 1, wherein the plant extract comprises 1wt% -3wt% of daemonorops draco extract, 1wt% -3wt% of palmetto tree extract and 1wt% -3wt% of dendrobium stem extract.

3. The composition for improving laxity and dark circles around eyes as claimed in claim 1, wherein the antioxidant is composed of glabridin 0.03wt% -0.05wt%, astaxanthin 2wt% -5wt% and ascorbic acid 1wt% -3 wt%.

4. The composition for improving relaxed eye and dark circles as claimed in claim 1, wherein the solvent is deionized water.

5. A preparation for improving eye laxity and dark circles, which is prepared from the composition for improving eye laxity and dark circles as claimed in any one of claims 1 to 4.

6. A method of preparing the formulation for improving ocular laxity and dark circles of claim 5, comprising:

7. The method for preparing a preparation for improving laxity and dark circles around eyes according to claim 6, wherein in the step of heating and stirring, the temperature is increased to 85-90 ℃.

8. The method for preparing the preparation for improving the laxity of the eyes and the dark circles according to claim 7, wherein in the step of heating and stirring, the stirring time is 10-25min.

9. The method for preparing the preparation for improving the laxity of the eyes and the dark circles according to claim 6, wherein in the step of heating and stirring, the material A is added and stirred for 10-15min.

10. Use of the preparation for improving eye laxity and dark circles according to claim 5 for preparing a product for tightening the eye periphery and removing dark circles.