CN115144575A - Detection probe for thromboelastogram - Google Patents
Detection probe for thromboelastogram Download PDFInfo
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- CN115144575A CN115144575A CN202210768996.5A CN202210768996A CN115144575A CN 115144575 A CN115144575 A CN 115144575A CN 202210768996 A CN202210768996 A CN 202210768996A CN 115144575 A CN115144575 A CN 115144575A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
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Abstract
The invention relates to the technical field of thrombus elastogram detection, in particular to a detection probe for a thrombus elastogram, which comprises: the first end of the elastic wire is fixed with the driving mechanism, the second end of the elastic wire is fixed with the probe, and the elastic wire is vertical to the axial direction of the probe; the second end of the elastic wire drives the probe to do circular motion around the axis of the probe; a first cavity is formed between the shell of the detection probe and the lower end cover, and a first clamp spring is arranged at the part of the first shaft section of the probe, which is positioned in the first cavity; when the probe is inserted into the sample cup, the shell bears the axial force of the first clamp spring; when the probe is pulled out of the sample cup, the lower end cover bears the axial force of the first clamp spring. The invention not only ensures the probe to be reliably fixed, but also ensures that the probe has only extremely small rotation resistance when swinging in a small amplitude during testing, so that the probe is insensitive to the levelness of equipment installation, and the bearing is prevented from bearing excessive axial force to cause abrasion, thereby avoiding the increase of the rotation resistance and the influence on the detection precision.
Description
Technical Field
The invention relates to the technical field of thromboelastogram detection, in particular to a detection probe for a thromboelastogram.
Background
The human body has a complex and perfect blood coagulation, anticoagulation and fibrinolysis system and a fine regulation mechanism thereof, and blood in blood vessels can not bleed and can not coagulate to form thrombus under normal physiological conditions. However, once the system and its regulatory mechanisms are disrupted, bleeding or thrombosis may result.
The Thromboelastogram (TEG) instrument is an analyzer capable of dynamically monitoring the whole blood coagulation process, can comprehensively reflect the interaction among platelets, blood coagulation factors, fibrinogen, a fibrinolysis system and other cell components in the whole process from blood coagulation to fibrinolysis of a patient by detecting a small amount of whole blood, has accurate data and simple and convenient operation, and is mainly used for comprehensively detecting the whole process of blood coagulation and fibrinolysis and the functions of the platelets. In particular, it can simplify the diagnosis of blood coagulation dysfunction and guide blood component transfusion during operation, and is an international universal device for liver transplantation operation. Blood coagulation and platelet function analyzers are increasingly applied to cardiovascular surgery, liver transplantation operation and other operations with large bleeding amount, and the fields of pediatrics, intensive care, hemostasis research and the like, and become important, accurate and rapid clinical hemostasis tests gradually.
Currently, three thrombus elasticity measurement techniques are developed around the measurement of blood viscoelasticity, which are described as follows:
(1) Haemonetics thrombelastogram apparatus (TEG) of America
The TEG measurement principle is as follows: a blood sample cup containing blood is specially prepared, and is oscillated with certain amplitude and frequency under the temperature environment of 37 ℃ (as shown in figure 1). The elastic force change of the blood clot is monitored by a probe which is suspended by a metal wire and soaked in the blood sample, and in the blood coagulation process, after the blood clot couples a blood sample cup and the probe, the shearing force generated by the rotation of the blood sample cup can be transmitted to the probe in the blood sample, so that the motion amplitude of the probe has a direct relation with the strength of the formed blood clot. When the blood clot is retracted or dissolved, the coupling of the probe and the blood clot is released, the movement of the blood sample cup is no longer transmitted to the probe. The rotation of the probe is converted into an electronic signal by the electromagnetic sensor, and the electronic signal is acquired by the data processing system to generate the thrombelastogram.
(2) Rotary thromboelastometer (ROTEM) of German Tem
The principle of the ROTEM measurement is as follows: the probe is immersed in the blood sample in the measuring cup, the probe head and the measuring cup are coupled through the blood, and the probe is driven by the spring to oscillate at an initial amplitude of 4.75 degrees in a period of 12 seconds. The probe is free to move when the blood is in a liquid state without coagulation, and the greater the force of the clot to resist rotation of the probe as the clot of blood increases in strength. The rotation amplitude of the probe is in inverse proportion to the strength of the blood clot, the dynamic change of the probe movement is detected and recorded by the optical displacement sensor, and finally the thrombelastogram and a series of detection indexes are generated by a computer.
(3) Platelet function analyzer from Sienco USA (Sonoclot)
The Sonoclot working principle is as follows: the disposable hollow probe connected with the ultrasonic sensor is immersed in a sample (0.4 ml of blood or plasma) to be detected in the detection cup to a certain depth, vertically oscillates at the amplitude of 1 mu m and the frequency of 200Hz, generates a certain resistance to the free vibration of the probe due to the viscoelasticity of the sample, and the resistance of a blood clot to the probe is gradually increased along with the progress of blood coagulation, and a resistance signal of the probe is obtained by a data acquisition system and displayed in a blood coagulation curve (Sonoclotsigniture) mode to reflect the viscoelasticity change in the whole blood coagulation process.
At present, the most widely used principle of thromboelastography is the principle of suspension wires, and the structure is shown in figure 1. Principle of the following were used:
(1) The sample cup is connected with the motor through a transmission mechanism; the sample cover is fixedly connected with the probe, the probe is fixedly connected with the fan-shaped magnetic conduction sheet, and the probe is fixedly connected with the lower end of the thin steel wire; the upper end of the thin steel wire is fixedly connected with the frame; the coil circuit board is fixedly connected with the frame.
(2) Step motor with + -rotational speed (omega) 1 ) The sample cup is driven to rotate left and right through a transmission mechanism at a small angle.
(3) The sample cup drives the blood sample to rotate at a speed of +/-rotation (omega) 2 ) Small angle left and right rotation, the more blood coagulates, omega 1 And omega 2 The closer together.
(4) The blood sample drives the sample cover to rotate at a speed of +/-omega 3 ) Small angle left and right rotation, the more blood coagulates, omega 2 And omega 3 The closer together;
(5) The sample cover, the fan-shaped magnetic conductive sheet and the probe rotate at +/-rotation speed (omega) 3 ) Rotating left and right at a small angle to twist the thin steel wire. When the torsional elasticity of the thin steel wire is equal to the viscosity of the blood sample, the sample cover reaches the maximum rotation angle. Therefore, the rotation angle of the sample cover is positively correlated with the coagulation degree of the blood sample;
(6) The coil circuit board is provided with a coil, which comprises an excitation coil and a feedback coil. A sine excitation signal is input into the excitation coil, and a sine feedback signal is induced in the feedback coil through the magnetic conduction of the fan-shaped magnetic conduction sheet. When the relative positions of the fan-shaped magnetic conductive sheet and the coil circuit board are different, the amplitudes of the induced feedback signals are different. Therefore, the rotating angle of the fan-shaped magnetic conducting sheet can be judged according to the amplitude of the feedback signal. This angle is positively correlated to the extent of coagulation of the blood sample.
In the prior art, the classic suspension wire principle has the following defects:
(1) Equipment fixing needs to be leveled to it is vertical to guarantee to hang the silk, avoids rotating part and fixed part friction to influence the measuring accuracy.
(2) The vertical size of the equipment is large, and the structure of the equipment is complex.
(3) When the probe is combined with the sample cover, a special structure is required to clamp the probe so as to avoid the influence of stress damage or elastic fatigue of the suspension wire on the detection precision.
Disclosure of Invention
In order to solve the technical problems that errors occur when the thromboelastogram detects the viscoelasticity of blood and the detection errors occur due to the abrasion of a bearing of a probe in the prior art, one embodiment of the invention provides a detection probe for the thromboelastogram, which comprises:
the first end of the elastic wire is fixed with the driving mechanism, the second end of the elastic wire is fixed with the probe, and the elastic wire is perpendicular to the axial direction of the probe;
the second end of the elastic wire drives the probe to do circular motion around the axis of the probe;
a first cavity is formed between the shell of the detection probe and the lower end cover, and a first clamp spring is arranged at the part, located in the first cavity, of the first shaft section of the probe;
when the probe is inserted into the sample cup, the shell bears the axial force of the first clamp spring; when the probe is pulled out of the sample cup, the lower end cover bears the axial force of the first clamp spring.
In a preferred embodiment, the shell is internally provided with a clamping part, and the first cavity is formed between the lower surface of the clamping part and the lower end cover;
when the probe is inserted into the sample cup, the lower surface of the clamping part in the shell is abutted to the first clamping spring to bear the axial force of the first clamping spring.
In a preferred embodiment, the second shaft section of the probe is provided with bearings, wherein,
the first end face of the bearing is provided with a second clamp spring for axially positioning the bearing outer ring and the bearing sleeve;
and a third clamp spring is arranged on the second end face of the bearing and used for axially positioning the inner ring of the bearing and the probe.
In a preferred embodiment, the first elastic sheet is arranged on the first end face of the bearing, and the second elastic sheet is arranged on the second end face of the bearing;
when the probe is inserted into the sample cup or pulled out of the sample cup, the first elastic sheet and the second elastic sheet limit the axial movement of the bearing, so that the first clamp spring is limited in a cavity between the shell and the lower end cover.
In a preferred embodiment, the outer circle of the bearing sleeve is sleeved with a sliding sleeve, so that the bearing sleeve drives the bearing to slide in the sliding sleeve.
In a preferred embodiment, a second cavity is formed between the first end surface of the bearing and the upper end cover, and the first elastic sheet is arranged in the second cavity;
when the probe is inserted into the sample cup, the bearing presses the first elastic sheet to enable the bearing to slide in a buffering mode.
In a preferred embodiment, a second cavity is formed between the upper end face of the bearing sleeve and the upper end cover, and the first elastic sheet is arranged in the second cavity;
when the probe is dismounted into the sample cup, the bearing sleeve presses the first elastic sheet to enable the bearing to slide in a buffering mode.
In a preferred embodiment, a third cavity is formed between the second end surface of the bearing and the upper surface of the clamping portion, and the second elastic sheet is arranged in the third cavity;
when the probe is pulled out of the sample cup, the bearing presses the second elastic sheet to enable the bearing to slide in a buffering mode.
In a preferred embodiment, a third cavity is formed between the lower end surface of the bearing sleeve and the upper surface of the clamping portion, and the second elastic sheet is arranged in the third cavity;
when the probe is pulled out of the sample cup, the bearing sleeve extrudes the second elastic sheet to enable the bearing to slide in a buffering mode.
According to an embodiment of the present invention, there is provided a detection probe for thromboelastography, the detection probe comprising:
the probe is fixed with the second end of the elastic wire, and the elastic wire is perpendicular to the axial direction of the probe; wherein, the first end of the elastic wire is fixed with the driving mechanism;
wherein the probe is configured to move in an arc about the axis of the probe in response to the second end of the elastic wire;
a first clamp spring is arranged on a first shaft section of the probe, wherein the first clamp spring is positioned in a first cavity between a shell and a lower end cover of the detection probe;
when the probe is inserted into a sample cup, the shell bears the axial force of the first clamp spring; when the probe is pulled out of the sample cup, the lower end cover bears the axial force of the first clamp spring.
The technical scheme provided by the embodiment of the invention has the beneficial effects that at least:
according to the detection probe for the thrombelastogram, provided by the invention, when a sample cup cover is arranged, the probe moves up and down, and the first elastic sheet, the second elastic sheet and the first clamp spring are combined to effectively prevent the axial force of the bearing, so that the bearing is prevented from being damaged.
According to the detection probe for the thrombelastogram, provided by the invention, when a sample cup cover is not provided, the probe moves up and down, the first elastic sheet and the second elastic sheet jointly act, and the bearing sleeve, the bearing and the probe are elastically fixed at the middle position of the sliding sleeve, so that the axial sliding of the bearing is effectively prevented, and the bearing is prevented from being damaged.
According to the detection probe for the thromboelastogram, when the probe swings, the first elastic sheet and the second elastic sheet act together, the first clamp spring is basically located in the middle of the shell and the lower end cover, and the bearing only bears the gravity of the probe and the gravity of the sample cover in the axial direction of the probe and can rotate freely.
The detection probe for the thromboelastogram, provided by the invention, not only ensures that the probe is reliably fixed, but also ensures that the probe has only extremely small rotation resistance when swinging in a small amplitude during testing, so that the probe is insensitive to the levelness of equipment installation, and the problem that the rotation resistance is increased and the detection precision is influenced because a bearing is worn due to the bearing of an overlarge axial force is avoided.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings needed to be used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of a prior art suspension wire for thromboelastogram detection;
FIG. 2 is a schematic structural diagram of a detection device for thromboelastography in accordance with an embodiment of the present invention;
FIG. 3 is a schematic view showing the internal structure of a detecting unit for thromboelastography in accordance with an embodiment of the present invention;
FIG. 4 is a schematic diagram of a laser detection principle of the detection device for thromboelastography according to one embodiment of the invention;
FIG. 5 is a sectional view showing the internal structure of a detecting unit for thromboelastography in accordance with an embodiment of the present invention;
FIG. 6 is a sectional view of the internal structure of a detection probe of the detection device for thromboelastography according to one embodiment of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The terms "first," "second," "third," "fourth," and the like in the description and in the claims, as well as in the drawings, if any, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the invention described herein are, for example, capable of operation in sequences other than those illustrated or otherwise described herein. Moreover, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
Referring to fig. 2, a schematic structural diagram of a thromboelastogram detecting device according to an embodiment of the present invention includes a lower housing 100, an upper housing 200, and a detecting probe 300.
The mechanical structure and the circuit structure of the detection apparatus for thromboelastography of the present invention are disposed in the lower case 100 and the upper case 200. The mechanical structure of the probe of the detection apparatus for thromboelastography of the present invention is arranged in the detection probe 300.
Referring to fig. 3, which is a schematic diagram illustrating an internal structure of a detection apparatus for thromboelastography according to an embodiment of the present invention, an elastic wire 101, a driving mechanism 102 (a mechanism within a dotted frame in fig. 3), and a signal detection unit are disposed in a lower housing 100 of the detection apparatus for thromboelastography according to an embodiment of the present invention.
According to an embodiment of the present invention, a first end of the elastic wire 101 is fixed with the driving mechanism, a second end of the elastic wire is fixed with the probe 103, and the elastic wire 101 is perpendicular to the axial direction of the probe 103.
When the probe is used, the head of the probe 103 is inserted into the sample cover and fixedly connected with the sample cover through interference, the sample cup is fixed, the elastic wire 101 is driven by the driving mechanism 102 to do reciprocating swing motion, and the probe 103 is driven by the elastic wire 101 to do small-angle rotation.
According to an embodiment of the present invention, the drive mechanism 102 comprises: a stepper motor 1021, a fixing assembly, and a slider 1025. The fixing assembly comprises a first extreme position clamping block 1023 and a second extreme position clamping block 1024, and a screw mandrel 1026 is arranged between the first extreme position clamping block 1023 and the second extreme position clamping block 1024.
The block 1025 is disposed on the screw 1026 so as to be able to slide back and forth between a first limit position and a second limit position (in the direction indicated by the double-headed arrow a in fig. 3).
In some preferred embodiments according to the present invention, the stepping motor 1021 drives the speed reducer 1022 to operate, and the speed reducer 1022 drives the slider 1025 to slide on the lead screw 1026, so as to realize the reciprocating sliding of the slider between the first limit position and the second limit position.
In a further preferred embodiment according to the present invention, the slider 1025 has a fixed end 1027, a first end of the elastic wire 101 is inserted into a small hole of the fixed end 1027 and fixed in a manner enabling free sliding, and a second section of the elastic wire 101 is fixed to the probe 103. For example, the first end of the elastic wire 101 is inserted into a small hole of the fixed end 1027, and the length of the elastic wire 101 is adjusted by sliding until the elastic wire between the fixed end 1027 and the probe 103 is in a pulled-up state without bending deformation, and the first end of the elastic wire is fixed to the fixed end 1027.
According to the embodiment of the present invention, the driving mechanism 102 drives the first end of the elastic wire 101 to swing between the first limit position and the second limit position, and the second end of the elastic wire 101 drives the probe 103 to make an arc motion around the axis of the probe 103 (as shown by the double-headed arrow b in fig. 3)
According to the embodiment of the invention, the detection device for the thrombelastogram further comprises a signal detection component for detecting the rotation angle of the probe.
Specifically, the signal detection assembly includes: a laser transmitter 105 and a laser receiver 107. And a laser emitter 105 for emitting laser light to the tip of the probe 103. And the laser receiver 107 is used for receiving the laser spot reflected by the tail end of the probe 103 and detecting the moving position of the spot.
Referring to fig. 4, a schematic diagram of a laser detection principle of a detection apparatus for thromboelastography in an embodiment of the present invention is shown, and with reference to fig. 3 and 4, in an embodiment of the present invention, when the first end of the elastic wire 101 is driven by the fixing end 1027 to be in the first limit position, the laser transmitter 105 transmits a laser signal, and after the laser 1051 is transmitted through the end of the probe 103, the laser receiver 107 receives the first spot position 1071 of the laser spot reflected by the end of the probe 103.
When the first end of the elastic wire 103 reaches the second limit position under the driving of the driving mechanism 102, the probe 103 rotates a certain angle, the laser transmitter 105 transmits a laser signal, and after the laser 1051 is transmitted by the tail end of the probe 103, the laser receiver 107 receives the second spot position 1072 of the laser spot reflected by the tail end of the probe 103. From the first spot position 1071 and the second spot position 1072, the angle of rotation of the probe 3 is calculated 103.
In some preferred embodiments, the end of the probe 103 has a cut 1031 that faces the laser transmitter 105 and laser receiver 107. The laser transmitter 105 transmits a laser signal to the cut surface 1031, and the laser receiver receives the laser signal returned from the cut surface 1031.
Further, a mirror surface is disposed on the cut surface 1031, the laser transmitter 105 transmits a laser signal to the mirror surface, and the laser receiver receives a laser signal returned from the cut surface.
In order to maintain the stability of the laser transmitter 105, the laser transmitter 105 is fixed to the laser transmitter fixing bracket 104 according to an embodiment of the present invention. In order to ensure that the information of the received laser is accurate, the laser receiver 107 is a photometric circuit board.
Referring to fig. 5, which is a cross-sectional view illustrating the internal structure of a detecting apparatus for thromboelastography according to an embodiment of the present invention, in conjunction with fig. 3 to 5, the detecting apparatus for thromboelastography further includes: a control circuit board 108. The drive mechanism also includes a drive circuit board 1028.
The control circuit board 108 is disposed on the lower side of the driving circuit board 1028, and is connected to the control circuit board connector 109 through the driving circuit board, so that the control circuit board 108 sends instructions to the driving mechanism. Specifically, the control circuit board 108 sends a command to the driving circuit board 1028, and the driving circuit board 1028 controls the stepping motor 1021 of the driving mechanism 102 to execute the relevant command (for example, forward operation or reverse operation), so as to complete the sliding of the driving slider 1025 between the first limit position and the second limit position.
When the sliding block 1025 moves, the sliding block 1025 touches the micro switch 106, and after the control circuit board 108 detects a signal of the micro switch 106, an instruction is sent to the driving circuit board 1028, and the driving circuit board 1028 drives the stepping motor 1021 to work in the reverse direction, so that the sliding block 1025 moves in the reverse direction, namely, the sliding block 1023 moves towards the first limit position. After the stepping motor 1021 moves reversely for a fixed number of steps, the control circuit board 108 sends a command to the driving circuit board 1028, and the driving circuit board 1028 drives the stepping motor 1021 to work reversely again, i.e., to move to the second limit position clamping block 1024. The fixed number of steps of the stepping motor 1021 can be modified in the program to determine the swing angle of the elastic wire 101.
The control circuit board 108 and the laser receiver 107 (photometric circuit board) are connected with the control circuit board connector 110 through the photometric circuit board, and receive the light spot information returned by the signal detection assembly, and calculate the rotation angle of the probe 103. Specifically, the control circuit board 108 receives the first spot position 1071 and the second spot position 1072 collected by the laser receiver 107, and calculates the angle of rotation of the probe 103.
According to an embodiment of the present invention, in use, the first end 1011 of the elastic wire 101 is first inserted into the small hole of the fixed end 1027, and the length of the elastic wire 101 is adjusted until the first end 1011 of the elastic wire 101 is pulled to the second end 1012 of the elastic wire 101 without bending deformation, so as to fix the first end 1011 of the elastic wire to the fixed end 1027.
When the upper housing 200 is covered on the lower housing 100, the power supply is turned on, the control circuit board 108 controls the stepping motor 1021 to execute a related work instruction (for example, a forward work instruction), the stepping motor 1021 executes the instruction, and the slide block 102 is driven to slide on the screw rod 1026 to the first limit position. The laser transmitter 105 emits laser light, and after the laser light is reflected by the end of the probe 103, the laser receiver 107 (photometric circuit board) collects a first spot position 1071.
The circuit board 108 controls the stepping motor 1021 to execute a relevant work instruction (for example, a reverse work instruction), the stepping motor 1021 executes the instruction, and the driving slider 102 slides on the lead screw 1026 from the first limit position to the second limit position. The laser emitter 105 emits laser light, which is reflected by the end of the probe 103, and the laser receiver 107 (photometric circuit board) collects the second spot position 1072.
The control circuit board 108 receives the first light spot position 1071 and the second light spot position 1072 acquired by the laser receiver 107, and calculates the rotation angle of the probe 103, wherein when the viscoelasticity of the sample to be tested is small, the rotation angle of the probe 103 is large; when the viscoelasticity of the sample to be tested is large, the angle of rotation of the probe 103 is small. The swing angle of the probe 1 is inversely related to the viscoelasticity of the tested sample, and the control circuit board 108 calculates the viscoelasticity of the tested sample and outputs the viscoelasticity to an external instrument such as a display device through the communication power supply connector 111.
In some preferred embodiments, the rotation angle of the needle 103 can be directly outputted, and the viscoelasticity of the sample to be measured can be calculated by an external device.
Referring to fig. 6, which is a cross-sectional view illustrating the internal structure of a test probe of a test apparatus for thromboelastography according to an embodiment of the present invention, a test probe 300 for thromboelastography is provided according to an embodiment of the present invention.
The detection probe 300 for the thromboelastogram comprises an elastic wire 101, wherein a first end of the elastic wire 101 is fixed with a driving mechanism, a second end of the elastic wire 101 is fixed with a probe 103, and the elastic wire 101 is perpendicular to the axial direction of the probe 103. The second end of the elastic wire 101 drives the probe 103 to do circular arc motion around the axis of the probe 103. In particular, the process of rotating the probe 103 by the elastic wire 101 is described in detail above, and will not be described herein.
The detection probe 300 for thromboelastography according to an embodiment of the invention further comprises a housing 301, an upper end cap 302 and a lower end cap 303.
A first cavity 304 is formed between the shell 301 and the lower end cover 303 of the detection probe, and a first snap spring 305 is arranged at a part, located in the first cavity 304, of the first shaft section (section D in fig. 6) of the probe 103.
According to the embodiment of the present invention, a clamping portion 3011 is provided in the housing 301, and a first cavity 304 is formed between a lower surface of the clamping portion 3011 and the lower end cover 303.
According to an embodiment of the invention, the second shaft section (section E in fig. 6) of the probe 103 is arranged with a bearing 306. The bearing 306 is fixed in the bearing sleeve 308, and the sliding sleeve 307 is sleeved on the outer circle of the bearing sleeve 308, so that the bearing sleeve 308 drives the bearing 306 to slide in the sliding sleeve 307. Specifically, the bearing sleeve 308 slides up and down in the sliding sleeve 307, thereby driving the bearing 306 to slide up and down. The upper end cover 302 and the shell 301 are respectively arranged at the upper part and the lower part of the sliding sleeve 307 for limiting, and further, the lower part of the sliding sleeve 307 is limited by the clamping part 3011 of the shell 301.
According to the embodiment of the invention, the first end surface 3061 of the bearing 306 is provided with the second snap spring 309, and the second snap spring 309 is embedded into the steps of the outer ring of the bearing 306 and the inner side surface of the bearing sleeve 308, so that the outer ring of the bearing 306 and the bearing sleeve 308 are axially positioned.
In some preferred embodiments, the underside of the bearing sleeve 308 is provided with a detent to retain the outer race of the bearing 306. In some preferred embodiments, a washer 311 is disposed under the second clamp spring 309.
According to the embodiment of the invention, the second end surface 3062 of the bearing 306 is provided with a third clamp spring 310, and the third clamp spring 310 is embedded into the inner ring of the bearing 306 and the shaft shoulder of the probe 103, so that the inner ring of the bearing 306 and the probe 103 are axially positioned.
According to the embodiment of the invention, the first end surface 3061 of the bearing 306 is provided with the first elastic sheet 313, and the second end surface 3062 of the bearing 306 is provided with the second elastic sheet 315. When the bearing sleeve 308 drives the bearing 306 to slide in the sliding sleeve 307, the first elastic sheet 313 and the second elastic sheet 315 play a role in buffering the sliding of the bearing 306, so as to prevent the bearing 306 from being damaged in the sliding process.
In a preferred embodiment, the second cavity 312 is formed between the first end surface 3061 of the bearing 306 and the upper end cap 302, and the first resilient tab 313 is disposed within the second cavity 312.
In a preferred embodiment, a second cavity 312 is formed between the upper end surface of the bearing housing 308 and the upper end cap 302, the first resilient tab 313 is disposed within the second cavity 312.
In a preferred embodiment, a third cavity 314 is formed between the second end surface 3062 of the bearing 306 and the upper surface of the clamping portion 3011, and the second elastic piece 315 is disposed in the third cavity 314.
In a preferred embodiment, a third cavity 314 is formed between the lower end surface of the bearing sleeve 308 and the upper surface of the clamping portion 3011, and the second elastic piece 315 is disposed in the third cavity 314.
According to the embodiment of the invention, when the thromboelastogram detection is required, two situations are divided: in one case, the sample cup 400 has a sample cup lid 401, and in one case, the sample cup 400 has no sample cup lid 401. The following description will be made for the detection of the two cases.
In the case of a specimen cup cover 401 for the specimen cup 400.
According to an embodiment of the present invention, the sample cup 400 contains a sample (blood) 500 therein.
When the probe 103 is inserted into the sample cover 401 of the sample cup 400, the probe 103 generates resistance to the probe 103 by inserting the sample cup cover 401, the probe 103 drives the bearing 306 to move upward relative to the housing 301 under the action of the third clamp spring 310, and the bearing 306 presses the first elastic sheet 313, so that the bearing 306 slides in a buffering manner.
Meanwhile, the first snap spring 305 moves upwards in the first cavity 304, when the probe 103 moves upwards to a certain position, the first snap spring 305 is connected with the shell 301 in a low mode, the shell 301 bears the axial force of the first snap spring 305, and the bearing 306 is eliminated to bear the axial force.
In some preferred embodiments, when the probe 103 moves upward to a certain position, the first clamp spring 305 is in low contact with the lower surface of the clamping portion 3011 of the housing 301, the housing 301 bears the axial force of the first clamp spring 105, and the bearing 306 is prevented from bearing the axial force.
When the probe 103 is pulled out of the sample cover 401 of the sample cup 400, the probe 103 generates resistance to the probe 103 due to the pulling out of the sample cup cover 401, the probe 103 drives the bearing 306 to move downwards relative to the housing 301 under the action of the third snap spring 310, and the bearing 306 presses the second spring piece 315, so that the bearing 306 slides in a buffering manner.
Meanwhile, the first snap spring 305 moves downwards in the first cavity 304, when the probe 103 moves downwards to a certain position, the first snap spring 305 is connected with the lower end cover 303 in a low mode, the lower end cover 303 bears the axial force of the first snap spring 105, and the bearing 306 is eliminated to bear the axial force.
In some embodiments, the sample cup 400 has a sample cup lid 401 stop to prevent the sample cup lid 401 from being taken out when the probe 103 is pulled out.
For the case where specimen cup 400 does not have specimen cup lid 401.
According to an embodiment of the present invention, the sample cup 400 contains a sample (blood) 500 therein.
When the probe 103 is inserted into or pulled out of the sample cup 400, the axial force borne by the probe 103 is small due to the non-sample cup cover 401, and the first elastic sheet 313 and the second elastic sheet 315 limit the axial movement of the bearing 306 under the elastic action, so that the first snap spring 305 is limited in a cavity between the shell 301 and the lower end cover 303 and is not in contact with the shell 301 or the lower end cover 303. In some embodiments, the first clamp spring 305 is confined in the cavity between the clamping portion 3011 of the housing 301 and the lower end cover 303, and does not contact the lower surface of the clamping portion 3011 of the housing 301 or the lower end cover 303.
In some embodiments, when the probe 103 is inserted into the sample cup 400, the probe 103 drives the bearing 306 to move upward relative to the housing 301 under the action of the third latch spring 310, and the bearing 306 presses the first elastic sheet 313, so that the bearing 306 slides in a buffering manner.
In some embodiments, when the probe 103 is inserted into the sample cup 400, the probe 103 drives the bearing 306 to move downward relative to the housing 301 under the action of the third snap spring 310, and the bearing sleeve 308 presses the first elastic sheet 313 to make the bearing 306 slide in a buffering manner.
In some embodiments, when the probe 103 is pulled out of the sample cup 400, the probe 103 drives the bearing 306 to move downward relative to the housing 301 under the action of the third snap spring 310, and the bearing 306 presses the second spring piece 315, so that the bearing 306 slides in a buffering manner.
In some embodiments, when the probe 103 is pulled out of the sample cup 400, the probe 103 drives the bearing 306 to move downward relative to the housing 301 under the action of the third clamping spring 310, and the bearing sleeve 308 presses the second elastic sheet 315, so that the bearing 306 slides in a buffering manner.
When the probe is used, the head of the probe 103 is inserted into the sample cup 400 and fixedly connected with the sample cup through interference, the sample cup is fixed, the elastic wire 101 is driven by the driving mechanism 102 to do reciprocating swing motion, and the elastic wire 101 of the probe 103 is driven by the elastic wire 101 to do small-angle rotation.
The invention provides a detection device for a thrombelastogram, which adopts the principle that optical detection replaces classic suspension wires, the elastic wires actively swing to replace the rotation of a sample cup, no additional electromagnetic force is generated in the detection process, the influence of resistance generated by the electromagnetic force on the force generated by blood viscosity is eliminated, and the measurement is more accurate.
The invention provides a detection device for a thrombelastogram, which is characterized in that a horizontally arranged elastic wire actively swings to drive a probe to rotate around an axis at a small angle, a sample cup is still, and the detection device has the advantages of low requirement on equipment installation levelness, small volume, capability of vertical stress and the like.
When the detection probe for the thromboelastogram is used, the probe moves up and down under the condition of a sample cup cover, and the first elastic sheet, the second elastic sheet and the first clamp spring jointly act to effectively prevent the axial force of the bearing and avoid the damage of the bearing.
According to the detection probe for the thromboelastogram, provided by the invention, when no sample cup cover exists, the probe moves up and down, the first elastic sheet and the second elastic sheet jointly act, and the bearing sleeve, the bearing and the probe are elastically fixed at the middle position of the sliding sleeve, so that the axial sliding of the bearing is effectively prevented, and the bearing damage is avoided.
According to the detection probe for the thromboelastogram, when the probe swings, the first elastic sheet and the second elastic sheet act together, the first clamp spring is basically located in the middle of the shell and the lower end cover, and the bearing only bears the gravity of the probe and the gravity of the sample cover in the axial direction of the probe and can rotate freely.
The detection probe for the thromboelastogram provided by the invention not only ensures the probe to be reliably fixed, but also ensures that the probe only has extremely small rotation resistance when swinging in a small range during testing, so that the probe is not sensitive to the levelness of equipment installation, and the increase of the rotation resistance caused by abrasion of a bearing due to the bearing of an overlarge axial force is avoided.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.
Claims (10)
1. A detection probe for thromboelastography, characterized in that it comprises:
the first end of the elastic wire is fixed with the driving mechanism, the second end of the elastic wire is fixed with the probe, and the elastic wire is vertical to the axial direction of the probe;
the second end of the elastic wire drives the probe to do circular motion around the axis of the probe;
a first cavity is formed between the shell of the detection probe and the lower end cover, and a first clamp spring is arranged at the part, located in the first cavity, of the first shaft section of the probe;
when the probe is inserted into a sample cup, the shell bears the axial force of the first clamp spring; when the probe is pulled out of the sample cup, the lower end cover bears the axial force of the first clamp spring.
2. The inspection probe of claim 1, wherein the housing has a clamping portion therein, and the lower surface of the clamping portion and the lower end cap form the first cavity therebetween;
when the probe is inserted into the sample cup, the lower surface of the clamping part in the shell is abutted to the first clamp spring to bear the axial force of the first clamp spring.
3. The inspection probe of claim 1 wherein the second shaft section of the probe is provided with bearings, wherein,
the first end face of the bearing is provided with a second clamp spring which is used for axially positioning the bearing outer ring and the bearing sleeve;
and a third clamp spring is arranged on the second end surface of the bearing and used for axially positioning the inner ring of the bearing and the probe.
4. The detection probe according to claim 3, wherein the first end face of the bearing is provided with a first spring plate, and the second end face of the bearing is provided with a second spring plate;
when the probe is inserted into the sample cup or pulled out of the sample cup, the first elastic sheet and the second elastic sheet limit the axial movement of the bearing, so that the first clamp spring is limited in a cavity between the shell and the lower end cover.
5. The inspection probe of claim 3 wherein a sliding sleeve is sleeved around the outer circumference of the bearing sleeve, such that the bearing sleeve drives the bearing to slide within the sliding sleeve.
6. The detection probe according to claim 5, wherein a second cavity is formed between the first end face of the bearing and the upper end cover, and the first spring plate is arranged in the second cavity;
when the probe is inserted into the sample cup, the bearing presses the first elastic sheet to enable the bearing to slide in a buffering mode.
7. The detection probe according to claim 5, wherein a second cavity is formed between the upper end face of the bearing sleeve and the upper end cover, and the first elastic sheet is arranged in the second cavity;
when the probe is dismounted into the sample cup, the bearing sleeve presses the first elastic sheet to enable the bearing to slide in a buffering mode.
8. The detection probe according to claim 5, wherein a third cavity is formed between the second end surface of the bearing and the upper surface of the clamping portion, and the second elastic sheet is arranged in the third cavity;
when the probe is pulled out of the sample cup, the bearing presses the second elastic sheet to enable the bearing to slide in a buffering mode.
9. The detection probe according to claim 5, wherein a third cavity is formed between the lower end surface of the bearing sleeve and the upper surface of the clamping portion, and the second elastic sheet is arranged in the third cavity;
when the probe is pulled out of the sample cup, the bearing sleeve extrudes the second elastic sheet to enable the bearing to slide in a buffering mode.
10. A detection probe for thromboelastography, the detection probe comprising:
the probe is fixed with the second end of the elastic wire, and the elastic wire is vertical to the axial direction of the probe; wherein the first end of the elastic wire is fixed with the driving mechanism;
wherein the probe is configured to move in an arc about the axis of the probe in response to the second end of the elastic wire;
a first clamp spring is arranged on a first shaft section of the probe, wherein the first clamp spring is positioned in a first cavity between a shell and a lower end cover of the detection probe;
when the probe is inserted into the sample cup, the shell bears the axial force of the first clamp spring; when the probe is pulled out of the sample cup, the lower end cover bears the axial force of the first clamp spring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210768996.5A CN115144575B (en) | 2022-07-01 | A test probe for thromboelastography |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210768996.5A CN115144575B (en) | 2022-07-01 | A test probe for thromboelastography |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN115144575A true CN115144575A (en) | 2022-10-04 |
| CN115144575B CN115144575B (en) | 2024-04-19 |
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