CN114264803A - Probe, detection device and thrombelastogram instrument - Google Patents
Probe, detection device and thrombelastogram instrument Download PDFInfo
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- CN114264803A CN114264803A CN202111559943.4A CN202111559943A CN114264803A CN 114264803 A CN114264803 A CN 114264803A CN 202111559943 A CN202111559943 A CN 202111559943A CN 114264803 A CN114264803 A CN 114264803A
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Abstract
The invention provides a probe, a detection device and a thromboelastogram instrument, and relates to the technical field of blood detection. The probe comprises a vertical suspension wire and a probe, one end of the vertical suspension wire is integrally formed at the top of one end of the probe, and when the vertical suspension wire is driven to rotate, the vertical suspension wire and the probe can rotate coaxially. The probe is arranged in the detection device. The thrombelastogram instrument comprises the detection device. The probe is of an integrated structure, and a connecting piece between the vertical suspension wire and the probe is removed, so that the installation error of the vertical suspension wire and the probe during assembly is reduced; the whole weight of the probe is reduced, so that the probe has high sensitivity and high response speed when being subjected to blood viscoelasticity; and the vertical suspension wires and the probe do not have the interference of eccentric force when rotating, and the coaxiality is higher when rotating.
Description
Technical Field
The invention relates to the technical field of blood detection, in particular to a probe, a detection device and a thrombelastogram instrument.
Background
The thromboelastogram is an analyzer for monitoring a blood coagulation process from the whole dynamic process of platelet aggregation, blood coagulation, fibrinolysis and the like, and the principle is that whether the blood coagulation function is normal or not is judged according to the strength and the stability of a blood clot to form the blood clot based on the final result of the blood coagulation process. At present, a common thrombelastogram instrument on the market is mainly used on the basis of a probe, the probe comprises a vertical suspension wire and a probe, the vertical suspension wire is connected with the probe through connecting pieces such as a lock ring, and the probe is arranged in a detection device of the thrombelastogram instrument. In the blood coagulation process, the rotation amplitude of the probe is changed by the blood viscoelasticity of the blood clot, and the changed amplitude signal is subjected to data acquisition so as to draw a thrombus elasticity change curve.
The existing vertical suspension wire and the probe are designed in a split mode, the probe is required to be installed firstly and then connected with the vertical suspension wire through the connecting piece, the structure of the connecting piece is complex, and a large installation error can be generated in the installation process, so that the coaxiality of the vertical suspension wire and the probe during rotation is influenced; the arrangement of the connecting piece increases the overall weight of the vertical suspension wire and the probe, and influences the rotation of the probe; the connecting piece can also bring continuously variable eccentric force to the rotating probe and the vertical suspension wire; these adverse conditions make the change of the probe rotation amplitude unable to accurately reflect the change of the thrombus elasticity, and affect the final measurement result.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides a probe and a detection device.
The invention provides the following technical scheme:
the probe comprises a vertical suspension wire and a probe, wherein one end of the vertical suspension wire is integrally formed at the top of one end of the probe, and when the vertical suspension wire is driven to rotate, the vertical suspension wire and the probe can rotate coaxially.
On the other hand, the invention also provides a detection device, which comprises the probe, a fixed cylinder, a sensor support and a test cup, wherein the probe is arranged in the fixed cylinder, the vertical suspension wire is fixedly connected with the fixed cylinder, the probe is arranged in the sensor, the sensor is fixedly connected with the sensor support, the sensor support is fixedly connected with the fixed cylinder, one end of the probe, far away from the vertical suspension wire, is fixedly connected with the test cup, the sensor support is used for driving the detection device to coaxially rotate, and the sensor is used for sensing the change of the rotation amplitude of the probe.
In a possible implementation manner, the detection device is provided with a locking piece, a matching part is fixedly arranged on the fixed cylinder, and the locking piece is matched with the matching part to fixedly connect the vertical suspension wire with the fixed cylinder.
In a possible implementation manner, an extrusion part is fixedly arranged on the fixed cylinder, a cross groove is formed in the extrusion part, the vertical suspension wire penetrates through the matching part and is arranged at the center of the cross groove, and the locking part can be matched with the matching part to fix the vertical suspension wire at the center of the cross groove.
In a possible implementation mode, the diameter that the portion of squeezing is close to the cooperation portion is greater than the diameter of keeping away from the cooperation portion, locate in the retaining member with portion matched with spread groove is pushed, when the retaining member is fixed in on the cooperation portion, the retaining member extrudees the portion of squeezing, makes the cross recess contracts to the center.
In a possible embodiment, the side of the fitting part away from the locking part is provided with a chamfer groove, and the chamfer groove facilitates the vertical suspension wire to be assembled in the cross groove.
In a possible implementation mode, the sensor is provided with a sensing metal sheet, and the sensing metal sheet is used for sensing the change of the rotation amplitude of the probe.
In a possible implementation mode, the test cup comprises a cup cover and a cup body, the cup cover is arranged on the cup body, a blood sample is filled in the cup body, and the probe is arranged in the cup cover.
In one possible embodiment, the probe is connected with the cup cover in an interference fit manner.
In another aspect, the invention further provides a thromboelastogram apparatus, which comprises the detection device.
Compared with the prior art, the invention has the beneficial effects that:
according to the probe provided by the embodiment of the invention, the vertical suspension wire and the probe are of an integrally formed structure, and a connecting piece between the vertical suspension wire and the probe is removed, so that the installation error of the vertical suspension wire and the probe during assembly is reduced; the whole weight of the probe is reduced, so that the probe has high sensitivity and high response speed when being subjected to blood viscoelasticity; and the vertical suspension wires and the probe do not have the interference of eccentric force when rotating, and the coaxiality is higher when rotating.
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible and comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
FIG. 1 is a schematic diagram of a probe according to an embodiment of the present invention;
FIG. 2 shows a cross-sectional view of a test device according to an embodiment of the present invention;
FIG. 3 is a schematic view showing the structures of a locking member and a fixing cylinder according to an embodiment of the present invention;
fig. 4 shows a cross-sectional view of a detection device according to an embodiment of the present invention during measurement.
Description of the main element symbols:
100-probe; 110-vertical suspension wires; 120-a probe; 200-a detection device; 210-a sensor; 211-inductive metal sheet; 220-a sensor holder; 230-a retaining member; 240-fixed cylinder; 241-a mating portion; 242-pressing part; 243-cross slot; 244-chamfered groove; 250-a test cup; 251-a cup cover; 252-cup body; 260-channel tray; 270-a bearing; 280-probe protection sleeve.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the accompanying drawings are illustrative only for the purpose of explaining the present invention, and are not to be construed as limiting the present invention.
In the description of the present invention, it is to be understood that the terms "central," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," "counterclockwise," "axial," "radial," "circumferential," and the like are used in the orientations and positional relationships indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
In the present invention, unless otherwise expressly stated or limited, the terms "mounted," "connected," "secured," and the like are to be construed broadly and can, for example, be fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
In the present invention, unless otherwise expressly stated or limited, the first feature "on" or "under" the second feature may be directly contacting the first and second features or indirectly contacting the first and second features through an intermediate. Also, a first feature "on," "over," and "above" a second feature may be directly or diagonally above the second feature, or may simply indicate that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature may be directly under or obliquely under the first feature, or may simply mean that the first feature is at a lesser elevation than the second feature.
Example one
Referring to fig. 1, a probe 100 according to an embodiment of the invention is provided. The probe 100 is used for reflecting the change of the viscoelastic force of blood in the blood coagulation process.
As shown in FIG. 1, the probe 100 includes a vertical suspension wire 110 and a probe head 120. The vertical suspension wire 110 and the probe 120 are of an integrated structure, and one end of the vertical suspension wire 110 is integrally formed at the top of one end of the probe 120. The suspension wires 110 and the probe 120 can rotate coaxially without external interference, and the rotation axis is the central axis of the suspension wires 110.
The suspension wires 110 and the probe 120 may be integrally formed by machining, for example, by casting the suspension wires 110 and the probe 120. The probe 120 is a metal probe, and the probe 120 may be made of copper-nickel-zinc alloy or the like.
The probe 100 is of an integrated structure, the arrangement of a connecting piece is omitted, and the installation error of the vertical suspension wire 110 and the probe 120 during assembly is reduced; the whole weight of the probe 100 is reduced, so that when the probe 100 is subjected to blood viscoelasticity, the sensitivity is high and the response speed is high; and the vertical suspension wires 110 and the probe 120 have no interference of eccentric force when rotating, and the coaxiality is higher when rotating.
Example two
Referring to fig. 2 to 4, the present invention further provides a detecting device 200. The test device 200 is used to monitor and analyze the coagulation status of a blood sample to map a thromboelastogram.
As shown in fig. 2, the detecting device 200 includes the probe 100, a sensor 210, a sensor holder 220, a locking member 230, a fixing cylinder 240, and a test cup 250. The probe 100 is arranged in the fixed cylinder 240, and the vertical suspension wire 110 is fixed on the fixed cylinder 240 through the retaining member 230; the fixed cylinder 240 is fixedly connected with the sensor bracket 220, and the sensor bracket 220 is fixedly connected with the sensor 210; when the sensor holder 220 drives the probe 100, the locker 230, the fixing cylinder 240, the sensor 210 and the test cup 250 to coaxially rotate, the sensor 210 is used to detect the rotation change of the probe 120.
In some embodiments, as shown in fig. 3, a fitting portion 241 and a pressing portion 242 are provided at an end of the fixing cylinder 240 away from the probe 120, the pressing portion 242 is located above the fitting portion 241, a cross-shaped groove 243 is provided on the pressing portion 242, a through hole is provided on the fitting portion 241, and the suspension wire 110 is disposed in the cross-shaped groove 243 through the through hole.
The center of the cross groove 243 is located on the axis of the central axis of the pressing portion 242, and the center of the through hole is located on the axis of the central axis of the fitting portion 241. The center of the cross groove 243 corresponds to the center of the through hole.
Be equipped with the screw thread on the cooperation portion 241, be equipped with corresponding screw thread on the retaining member 230, cooperation portion 241 with retaining member 230 passes through screw thread fixed connection. The extruding part 242 is of a circular truncated cone structure, the diameter of the extruding part 242 close to one end of the matching part 241 is large, and the locking part 230 is provided with a connecting groove matched with the extruding part 242 in shape. When the locking member 230 is connected to the matching portion 241 through a screw, as the locking member 230 moves downward, the connecting groove presses the pressing portion 242, so that the cross-shaped groove 243 on the pressing portion 242 gradually shrinks toward the center until the suspension wire 110 is fixed to the center of the cross-shaped groove 243.
In some embodiments, the matching portion 241 and the pressing portion 242 are fixedly connected by welding, but not limited thereto, and it is understood that in other embodiments, the matching portion 241 and the pressing portion 242 may also be fixedly connected by way of integral molding, which may further improve the connection precision of the matching portion 241 and the pressing portion 242.
In some embodiments, the side of the fitting portion 241 away from the locking member 230 is provided with a chamfered groove 244, and the diameter of the chamfered groove 244 near the probe 120 is larger, so that the suspension wires 110 can pass through the through holes and be arranged in the cross-shaped groove 243.
The probe 120 is disposed in the fixed cylinder 240 through the vertical suspension wire 110, the probe 120 is disposed in the sensor 210, and the sensor 210 is located at one end of the probe 120 close to the vertical suspension wire 110. The sensor 210 is used for detecting the change of the rotation amplitude of the probe 120 and transmitting the electrical signal of the change data to an upper computer (not shown) through a circuit.
In some embodiments, the sensor 210 is provided with a sensing metal sheet 211, because the probe 120 is a metal probe, the sensing metal sheet 211 can sense the rotation change of the probe 120, so that the measurement result of the blood sample can be obtained by analyzing the amplitude of the rotation change of the probe 120.
The sensor bracket 220 is arranged on the outer side of the sensor 210, the sensor 210 is fixedly connected with the sensor bracket 220, and the sensor bracket 220 is fixedly connected with the fixed cylinder 240. The sensor holder 220 can drive the fixing cylinder 240, the locking member 230, the suspension wires 110 and the sensor 210 to coaxially rotate. The vertical suspension wires 110 and the probe 120 are integrally formed, so that the vertical suspension wires 110 drive the probe 120 to coaxially rotate under the condition of no interference of other external forces.
The detection device 200 is further provided with a channel tray 260, the channel tray 260 is arranged below the sensor 210, and the channel tray 260 is connected with the sensor bracket 220 through a bearing 270. The bearing 270 can keep the channel tray 260 stationary while the sensor holder 220 rotates. The channel tray 260 is used to support the sensor holder 220.
A probe protecting sleeve 280 is arranged below the channel tray 260, and the probe head 120 of the probe 100 is arranged in the probe protecting sleeve 280 in a penetrating manner. The probe protection sleeve 280 is used to prevent blood sample from splashing onto the probe head 120 and contaminating the probe head 120.
The detection device 200 is further provided with a test cup 250, the test cup 250 comprises a cup cover 251 and a cup body 252, the cup cover 251 is covered on the cup body 252, a cavity for accommodating the probe 120 is arranged on the cup cover 251, and the probe 120 is arranged in the cavity. The cup 252 contains a blood sample, the outside of the chamber is in contact with the blood sample, and the chamber prevents the probe 120 from directly contacting the blood sample, thereby preventing the probe 120 from being contaminated by the blood sample.
The cap 251 and the probe 120 are in interference fit, and when there is no blocking of the viscoelasticity of the blood sample, the probe 120 can drive the cap 251 to rotate coaxially. When the viscoelastic resistance of the blood sample exists, the viscoelastic force of the blood sample changes the rotation amplitude of the cup cover 251, and further changes the rotation amplitude of the probe 120.
In some embodiments, one end of the probe 120, which is inserted into the cup cover 251, is a conical structure, and the conical structure is used for guiding the probe 120 when the probe is inserted into the cavity of the cup cover 251, so as to ensure that the axis of the probe 120 and the axis of the cavity of the cup cover 251 are in the same straight line.
In some embodiments, a thermostatic plate (not shown) is disposed below the test cup 250, and the thermostatic plate is used for keeping the blood in the test cup 250 to a temperature close to that of the human body, so as to ensure that the detection result of the blood coagulation process is accurate. It is understood, however, that in other embodiments, a thermostatic device may be disposed inside the test cup 250 to achieve the effect of keeping blood at a constant temperature.
When the detection device 200 is used, an operator places the suspension wire 110 in the cross-shaped groove 243 through the chamfer groove 244, and rotates the locking member 230, so that the threads of the locking member 230 are matched with the threads of the matching portion 241, and the locking member 230 presses the pressing portion 242, and after the pressing portion 242 is pressed, the cross-shaped groove 243 on the pressing portion 242 contracts towards the center until the suspension wire 110 is fixed on the center line of the cross-shaped groove 243. So that the locker 230, the fixing cylinder 240, and the probe 100 can be coaxially rotated without any other external force.
A blood sample is injected into the cup body 252, the cup cover 251 is covered on the cup body 252, and one end of the probe 120, which is far away from the vertical suspension wire 110, is inserted into the cup cover 251 and is in interference fit with the cup cover 251, so that the probe and the cup cover 251 can coaxially rotate.
The sensor holder 220 can drive the sensor 210, the fixed cylinder 240, the locking member 230, the probe 100 and the measuring cup lid 251 to rotate along a certain rotation range. When the viscosity of the blood is not changed, the parts rotate coaxially with the central axis of the vertical suspension wire 110 as an axis and the rotation amplitudes are the same; when a blood clot is formed, the cup cover 251 is subjected to rotary motion resistance generated by blood viscoelasticity, and the rotary amplitude is reduced, so that the rotary amplitude of the probe 120 is reduced; the sensor holder 220, the sensor 210, the suspension wires 110, the fixing member and the locking member 230 still move according to the input rotation amplitude.
Because the rotation amplitudes of the suspension wires 110 and the probe 120 are different, the sensing metal sheet 211 measures the change of the rotation amplitude of the probe 120, the sensor 210 transmits an electric signal with a changed value to an upper computer through a circuit, and the thromboelastogram of a blood sample can be drawn through analysis.
According to the detection device 200, the process of assembling the vertical suspension wire 110 on the fixed cylinder 240 is simple, a connecting piece is not arranged between the vertical suspension wire 110 and the probe 120, the coaxiality of the vertical suspension wire 110 and the probe 120 is high during rotation, eccentric force interference is avoided during rotation detection of the probe 120, and the change of the rotation amplitude of the probe 120 can accurately reflect the change of the blood viscoelasticity, so that an accurate thromboelastogram is drawn.
EXAMPLE III
The invention also provides a thromboelastogram instrument. The thromboelastography instrument is provided with a plurality of the detection devices 200. The thromboelastogram can simultaneously measure the coagulation process of a plurality of blood samples so as to ensure the accuracy of measurement.
When the blood coagulation process of blood is measured, if only one blood sample is measured, the measurement result may not be guaranteed to be accurate due to interference of external factors, so that multiple blood samples of the same blood are often required to be detected, and a final result is obtained after comparison and analysis.
The thrombelastogram instrument can be provided with a plurality of detection devices 200 for simultaneous detection so as to reduce external interference factors. The coaxiality of the probe 100 during rotation is obviously higher than that of a split probe in the prior art, the rotation change of the probe head 120 can be accurately reflected, and the measurement results of the detection devices 200 are stable and high in consistency. And no additional connecting piece is arranged between the vertical suspension wire 110 and the probe 120, so that no installation error exists, and the overall weight is light, thereby reducing the inconsistency of the detection results of all the detection devices 200 caused by external factors.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made to the above embodiments by those of ordinary skill in the art within the scope of the present invention.
Claims (10)
1. The probe is characterized by comprising a vertical suspension wire and a probe, wherein one end of the vertical suspension wire is integrally formed at the top of one end of the probe, and when the vertical suspension wire is driven to rotate, the vertical suspension wire and the probe can rotate coaxially.
2. A detection device, characterized by, including the probe of claim 1, a fixed cylinder, a sensor support and a test cup, the probe is arranged in the fixed cylinder, the vertical suspension wire is fixedly connected with the fixed cylinder, the probe is arranged in the sensor, the sensor is fixedly connected with the sensor support, the sensor support is fixedly connected with the fixed cylinder, one end of the probe far away from the vertical suspension wire is fixedly connected with the test cup, the sensor support is used for driving the detection device to coaxially rotate, and the sensor is used for sensing the change of the rotation amplitude of the probe.
3. The detecting device for detecting the rotation of the motor rotor as claimed in claim 2, wherein the detecting device is provided with a locking member, a matching part is fixedly arranged on the fixed cylinder, and the locking member is matched with the matching part to fixedly connect the suspension wires with the fixed cylinder.
4. The detection device according to claim 3, wherein an extrusion portion is fixedly arranged on the fixed cylinder, a cross slot is arranged on the extrusion portion, the vertical suspension wire passes through the matching portion and is arranged at the center of the cross slot, and the locking member can be matched with the matching portion to fix the vertical suspension wire at the center of the cross slot.
5. The detecting device for detecting the rotation of the motor rotor according to the claim 4, wherein the diameter of the pressing portion close to the matching portion is larger than the diameter of the pressing portion far away from the matching portion, the locking member is internally provided with a connecting groove matched with the pressing portion, and when the locking member is fixed on the matching portion, the locking member presses the pressing portion to enable the cross-shaped groove to shrink towards the center.
6. The detecting device for detecting the rotation of the motor rotor as claimed in claim 4, wherein one side of the matching portion, which is far away from the locking member, is provided with a chamfered groove, and the chamfered groove facilitates the assembly of the vertical suspension wire in the cross groove.
7. The detecting device for detecting the rotation of the motor rotor as claimed in claim 2, wherein the sensor is provided with a sensing metal sheet which is used for sensing the change of the rotation amplitude of the probe.
8. The testing device of claim 2, wherein the testing cup comprises a cap and a cup, the cap is disposed on the cup, the cup contains a blood sample, and the probe is disposed in the cap.
9. The detecting device for detecting the rotation of the motor rotor as claimed in claim 8, wherein the probe is connected with the cup cover in an interference fit mode.
10. A thromboelastography device, comprising a detection device according to any of claims 2-9.
Priority Applications (1)
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CN202111559943.4A CN114264803A (en) | 2021-12-20 | 2021-12-20 | Probe, detection device and thrombelastogram instrument |
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CN202111559943.4A CN114264803A (en) | 2021-12-20 | 2021-12-20 | Probe, detection device and thrombelastogram instrument |
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CN202111559943.4A Pending CN114264803A (en) | 2021-12-20 | 2021-12-20 | Probe, detection device and thrombelastogram instrument |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115144574A (en) * | 2022-07-01 | 2022-10-04 | 苏州思迈德生物科技有限公司 | Detection device for thrombelastogram |
CN115144575A (en) * | 2022-07-01 | 2022-10-04 | 苏州思迈德生物科技有限公司 | Detection probe for thromboelastogram |
-
2021
- 2021-12-20 CN CN202111559943.4A patent/CN114264803A/en active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115144574A (en) * | 2022-07-01 | 2022-10-04 | 苏州思迈德生物科技有限公司 | Detection device for thrombelastogram |
CN115144575A (en) * | 2022-07-01 | 2022-10-04 | 苏州思迈德生物科技有限公司 | Detection probe for thromboelastogram |
CN115144574B (en) * | 2022-07-01 | 2024-04-19 | 苏州思迈德生物科技有限公司 | Detection device for thromboelastography |
CN115144575B (en) * | 2022-07-01 | 2024-04-19 | 苏州思迈德生物科技有限公司 | A test probe for thromboelastography |
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