CN210465441U - Elastogram appearance and visual elastogram equipment - Google Patents
Elastogram appearance and visual elastogram equipment Download PDFInfo
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Abstract
The utility model provides an elastogram instrument and visual elastogram equipment, which relate to the technical field of medical detection, and comprise a coupling reed, an elastic element, a deformation measuring unit, a sample cup vibration unit and a controller; the controller is connected with the deformation measuring unit; one end of the coupling reed is connected with the elastic element, and the other end of the coupling reed is immersed in the liquid to be detected; the sample cup vibration unit is used for driving the sample cup filled with the liquid to be detected to vibrate; the deformation measuring unit is used for measuring the deformation of the elastic element when the sample cup vibrates; the controller is used for calculating the elastic value of the liquid to be measured according to the deformation quantity. The embodiment of the utility model provides a pair of elasticity diagram appearance can improve the degree of automation of elasticity diagram test, reduces the human factor influence to need not to carry out leveling to the test instrument and handle, be difficult for receiving the vibration interference influence, and then improve test data's stability and accuracy.
Description
Technical Field
The utility model belongs to the technical field of the medical science detects technique and specifically relates to an elasticity map appearance and visual elasticity map equipment are related to.
Background
The blood coagulation detection has important significance clinically, and the thrombelastogram instrument is used as a blood coagulation detection device and can evaluate the blood coagulation and fibrinolysis states and risks of patients and the like.
At present, more than 95% of the commercially available devices for measuring thrombus elasticity adopt a viscosity method, which measures the blood coagulation function according to the change of viscosity during the coagulation of a blood sample. However, the thromboelastogram apparatus measured by the viscosity method has the following disadvantages:
(1) the test process needs manual operation, and the sample cup, the reagent and the sample are added manually, so that the operation process is complex and is easily influenced by human factors;
(2) during the measurement process, the suspension wires are easily interfered by external vibration, and the vibration of the ground and the desktop can cause the jump of measurement data, so that the stability of the test data is poor;
(3) when the instrument is used, leveling processing is needed to keep the instrument in a horizontal state, otherwise, the suspension wire easily touches the taper sleeve in the measuring process, and the accuracy of measured data is further influenced.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model aims at providing an elasticity map appearance and visual elasticity map equipment can improve the degree of automation of elasticity map test, reduces the human factor influence to need not to adjust the level to the test instrument and handle, be difficult for receiving the vibration interference influence, and then improved test data's stability and accuracy.
In a first aspect, an embodiment of the present invention provides an elasticity chart apparatus, including: the device comprises a coupling reed, an elastic element, a deformation measuring unit, a sample cup vibration unit and a controller; the controller is connected with the deformation measuring unit; one end of the coupling reed is connected with the elastic element, and the other end of the coupling reed is immersed in the liquid to be detected; the sample cup vibration unit is used for driving the sample cup filled with the liquid to be detected to vibrate; the deformation measuring unit is used for measuring the deformation of the elastic element when the sample cup vibrates; the controller is used for calculating the elastic value of the liquid to be measured according to the deformation quantity.
In combination with the first aspect, an embodiment of the present invention provides a first possible implementation manner of the first aspect, where the deformation measuring unit includes a hall sensor or a photoelectric sensor.
In combination with the first aspect, embodiments of the present invention provide a second possible implementation manner of the first aspect, wherein the elastic element includes an elastic rod, an elastic wire, or an elastic sheet.
In combination with the first aspect, an embodiment of the present invention provides a third possible implementation manner of the first aspect, where the elastogram apparatus further includes: a sample adding device; the sample adding device comprises a sample adding needle and a mechanical arm unit; the mechanical arm unit is connected with the controller, and the sample adding needle is arranged on the mechanical arm unit; the mechanical arm unit is used for moving the sample adding needle to the position of the sample cup so as to add the liquid to be detected into the sample cup through the sample adding needle.
With reference to the third possible implementation manner of the first aspect, an embodiment of the present invention provides a fourth possible implementation manner of the first aspect, where the elastogram apparatus further includes: an incubation device; the incubation device comprises a first sample cup placing groove and a heating unit; the first sample cup placing groove is arranged on the sample cup vibration unit; the first sample cup placing groove is used for placing a sample cup filled with liquid to be detected; the heating unit is used for heating the sample cup so as to maintain the temperature of the liquid to be measured constant.
With reference to the third possible implementation manner of the first aspect, an embodiment of the present invention provides a fifth possible implementation manner of the first aspect, where the elastogram apparatus further includes: a sample cup supply device; the sample cup supply device includes: the second sample cup placing groove and the cup feeding unit; the second sample cup placing groove is used for placing empty sample cups; the cup feeding unit is used for obtaining empty sample cups from the second sample cup placing grooves and placing the empty sample cups to a first preset position.
With reference to the fifth possible implementation manner of the first aspect, an embodiment of the present invention provides a sixth possible implementation manner of the first aspect, wherein the elastogram apparatus further includes: a sample cup transfer device; this appearance cup conveyer includes: a sample cup grabbing unit and a conveying guide rail; the sample cup grabbing unit is movably arranged on the conveying guide rail; the sample cup grabbing unit is used for grabbing a sample cup from a first preset position; the conveying guide rail is used for conveying the sample cups grabbed by the sample cup grabbing unit to a second preset position.
With reference to the first aspect and one of the first to fifth possible implementation manners of the first aspect, the present invention provides a seventh possible implementation manner of the first aspect, wherein the liquid to be tested is a mixed liquid of a blood sample and a coagulation reagent.
With reference to the seventh possible implementation manner of the first aspect, an embodiment of the present invention provides an eighth possible implementation manner of the first aspect, wherein the elastogram apparatus further includes: a sample and reagent supply; the sample and reagent supply apparatus includes: the test tube storage tray, the rotating unit and the code scanning unit are arranged on the test tube storage tray; a sample test tube and a reagent test tube are placed on the test tube storage tray, a blood sample is placed in the sample test tube, a blood coagulation reagent is placed in the reagent test tube, and corresponding identification codes are respectively arranged on the sample test tube and the reagent test tube; the code scanning unit is arranged on one side of the test tube storage tray; the rotating unit is used for driving the test tube storage disc to rotate so as to transfer different test tubes to the scanning range of the code scanning unit; the code scanning unit is used for scanning and reading the identification codes in the scanning range so as to acquire the information of the current test tube.
In a second aspect, an embodiment of the present invention further provides a visual elastogram device, including the elastogram apparatus provided in the first aspect and one of the possible implementation manners, and further including a display; the display is connected with the controller; the display is used for displaying the elasticity value of the liquid to be measured.
The embodiment of the utility model provides a following beneficial effect has been brought:
the embodiment of the utility model provides an elasticity diagram appearance and visual elasticity diagram equipment, this elasticity diagram appearance includes coupling reed, elastic element, deformation measuring unit, appearance cup vibration unit and controller; the controller is connected with the deformation measuring unit; one end of the coupling reed is connected with the elastic element, and the other end of the coupling reed is immersed in the liquid to be detected; the sample cup vibration unit is used for driving the sample cup filled with the liquid to be detected to vibrate; the deformation measuring unit is used for measuring the deformation of the elastic element when the sample cup vibrates; the controller is used for calculating the elastic value of the liquid to be measured according to the deformation quantity. The elasticity chart instrument replaces a torsion wire in a conventional elasticity chart instrument with a coupling reed, calculates the elasticity value of liquid to be measured by measuring the vibration amplitude of the coupling reed, is different from the mode of calculating the elasticity value of the liquid to be measured by measuring the rotation angle of the torsion wire in the conventional test instrument, is a brand new measurement mode, does not need to level the instrument before testing, and can effectively reduce the influence of vibration interference. And through setting up mechanical control structure, make the acquisition of sample cup, add the sample, conveying sample cup, incubate to the test, whole process realizes the automation, improves the degree of automation of elastogram test, has reduced the influence of human factor, and then improves test data's stability and accuracy.
Additional features and advantages of the disclosure will be set forth in the description which follows, or in part may be learned by the practice of the above-described techniques of the disclosure, or may be learned by practice of the disclosure.
In order to make the aforementioned objects, features and advantages of the present disclosure more comprehensible, preferred embodiments accompanied with figures are described in detail below.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
Fig. 1 is a schematic structural view of an elastograph instrument provided in an embodiment of the present invention;
fig. 2 is a schematic structural diagram of another elastogram instrument provided by an embodiment of the present invention;
FIG. 3 is a schematic view of the corresponding relationship between the elasticity chart instrument and the TEG5000 instrument;
fig. 4 is a schematic structural diagram of a visual elastogram device provided by an embodiment of the present invention.
Icon: 10-a coupling reed; 11-a resilient element; 12-a deformation measuring unit; 13-sample cup vibration unit; 14-a controller; 15-liquid to be measured; 16-sample cup; 21-a sample cup supply device; 22-a sample cup transport; 23-sample and reagent supply means; 24-a sample application device; 25-an incubation device; 26-a measuring device; 41-elasticity chart instrument; 42-a display; 100-visual elastogram device.
Detailed Description
To make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and obviously, the described embodiments are some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.
The blood coagulation detection has important significance clinically, and the thrombelastogram instrument as a blood coagulation detection device has the following functions: assessing the state and risk of coagulation and fibrinolysis of the patient; monitoring the effect of anticoagulant drugs such as heparin; guiding preoperative preparation, monitoring the coagulation dynamics in the whole process, and analyzing the reason of postoperative bleeding; blood transfusion is guided; evaluating treatment with an antiplatelet agent.
The methodologies for detecting blood coagulation include immunological methods, substrate color development methods and coagulation methods. The coagulation method is classified into a current method, an optical method, and a magnetic bead method (also called a viscosity method). The immunological method is to prepare an antibody using a pure-colored test substance as an antigen, and then to perform a reaction using the antigen-antibody, and commonly used methods include an immunodiffusion method, an arrow electrophoresis method, an ELLSA method, and an immunoturbidimetric method. The immunodiffusion method has long testing time and low sensitivity; the arrow electrophoresis method is complex to operate and is not suitable for clinical application; the ELLSA method is mainly suitable for clinical hemostasis and thrombus component detection; immunoturbidimetry reagents are expensive. The substrate color method estimates the content and activity of a measured substance by measuring the change in absorbance of a colored substrate, which may also be called a biochemical method and is also mainly used clinically for hemostasis and thrombus component detection.
The coagulation method includes an amperometric method, an optical method (nephelometric turbidimetry and turbidimetric projection method), and a magnetic bead method (also called a viscosity method). The blood forms fibrinogen and fibrin during coagulation, the fibrin has conductivity, and the amperometry is based on this irrational feature. However, the current method is inferior in reliability and has a single property, and has been gradually replaced by an optical method and a magnetic bead method. The optical method is based on the change of the turbidity of blood sample during the plasma coagulation process, which results in the change of the absorption and scattering degree of light. The result of the optical detection is susceptible to optical anomalies (e.g., jaundice, chyle, hemolysis, turbidity, etc.), the smoothness of the test cup, air bubbles generated during sample application, and the like.
Most of the currently available methods for measuring the elasticity of thrombus employ a viscosity method, which measures the blood coagulation function based on the change of viscosity during the coagulation of blood sample. The two sides of the test cup are provided with a group of driving devices, the test cup rotates left and right at a fixed frequency, fibrin is continuously increased in the blood coagulation process, the viscosity of a blood sample is increased, the cup cover placed in the sample drives the probe to rotate left and right, and the instrument detects the blood sample by detecting the motion state of the probe. The largest market holder of thromboelastography instruments is based on the principle (viscosity method) of TEG5000 by haeminoetics corporation, usa. Long-term research shows that the traditional instrument has poor stability, and most of the reasons are to detect the twisted wire of the core component, the processing diameter of the twisted wire is between 0.2mm and 0.4mm, the stability of the test state is kept only by gravity, and the suspension wire is interfered by the horizontal effect and the surrounding environment in the vertical movement process.
Generally, in the prior art, the thromboelastogram instrument measured by a viscosity method needs to be leveled when in use, and the problems that the test process is easily influenced by human factors and is easily interfered by external vibration exist, so that the stability of test data is poor, and the accuracy is low.
Based on this, the embodiment of the utility model provides a pair of elasticity chart appearance and visual elasticity chart equipment can improve test data's stability and accuracy.
To facilitate understanding of the present embodiment, a elastograph instrument disclosed in the embodiments of the present invention will be described in detail first.
The first embodiment is as follows:
as shown in fig. 1, which is a schematic structural diagram of an elastography apparatus provided in an embodiment of the present invention, as can be seen from fig. 1, the elastography apparatus includes a coupling reed 10, an elastic element 11, a deformation measuring unit 12, a sample cup vibration unit 13, and a controller 14. Wherein the controller 14 is connected to the deformation measuring unit 12, and one end of the coupling reed 10 is connected to the elastic member 11, and the other end of the coupling reed 10 is immersed in the liquid 15 to be measured.
Here, the liquid 15 to be measured is a liquid to be measured for its elasticity, and is generally a liquid having certain viscoelasticity, and may be, for example, an oil (edible oil, gasoline, engine oil, etc.), an aqueous solution, a colloid, or the like.
In practical operation, the liquid 15 to be measured is contained in the sample cup 16, and the material of the sample cup 16 may be glass, plastic, etc. Then, a sample cup 16 containing a liquid 15 to be measured is placed on the sample cup vibration unit 13. In one embodiment, the vibrating unit is provided with a fixing member for fixing the sample cup 16.
The coupling reed 10 is a spring piece, which is easy to bend only in one direction, i.e., the plane with the minimum rigidity, and has large tensile rigidity and bending rigidity in the other direction, and the material of the coupling reed 10 can be phosphor bronze, tin bronze and the like, so that the coupling reed 10 is less prone to vibration interference compared with a twisted wire.
When the test is started, the sample cup vibration unit 13 drives the sample cup 16 containing the liquid 15 to be tested to vibrate, wherein the vibration mode can be that the sample cup moves back and forth on a horizontal plane along a certain direction, for example, the sample cup moves back and forth, and reaches a certain frequency, so that the vibration effect is realized. When the sample cup 16 vibrates, the liquid 15 to be measured in the sample cup 16 is driven to vibrate, and viscous force exists between the liquid 15 to be measured and the coupling reed 10 because the liquid 15 to be measured is in contact with a part of the coupling reed 10. If the viscoelasticity of the liquid 15 to be measured is larger, the viscous force between the liquid 15 to be measured and the coupling reed 10 is larger, and accordingly, the deformation amount of the coupling reed 10 is larger.
In this elastograph, the elastic element 11 acts to receive and transmit vertical loads, and to moderate and suppress impacts caused by uneven road surfaces. The elastic element 11 has two basic effects in operation: the elastic effect and the inelastic effect, wherein the elastic effect refers to the property that the deformation of the elastic element 11 is only shown by the influence of the load, and the specific parameters are the rigidity and the sensitivity of the load and the deformation. In at least one possible embodiment, the elastic element 11 may be an elastic rod, an elastic wire or an elastic sheet. In this embodiment, the elastic member 11 is connected to one end of the coupling reed 10, and the deformation of the coupling reed 10 is transmitted to the elastic member 11, so that the amount of deformation of the elastic member 11 is measured to be equivalent to the amount of deformation of the coupling reed 10.
In addition, the deformation measuring unit 12 is a device for measuring the amount of deformation, and when the sample cup vibrating unit 13 drives the sample cup 16 containing the liquid 15 to be measured to vibrate, the deformation measuring unit 12 measures the amount of deformation of the elastic element 11. In one of the possible embodiments, the deformation measuring unit 12 can be a hall sensor, where the hall sensor is a magnetic field sensor made according to the hall effect; in another possible embodiment, the deformation measuring unit 12 may also be a photoelectric sensor, which is a device that converts an optical signal into an electrical signal. After the deformation measuring unit 12 measures the deformation data, the controller 14 obtains the deformation data, and calculates an elastic value of the liquid 15 to be measured according to the deformation.
Thus, the utility model provides an elasticity diagram appearance to the coupling reed 10 replaces the silk of turning round in the conventional elasticity diagram instrument, calculates the elasticity value of the liquid 15 that awaits measuring through the vibration amplitude of measuring coupling reed 10, and it is different from among the conventional test instrument through measuring the mode of turning round silk rotating angle and calculating the liquid 15 elasticity value that awaits measuring. In addition, the coupling reed 10 is not prone to vibration interference, and the problem that the coupling reed touches a taper sleeve in the measuring process does not exist, so that the elastograph instrument does not need to be leveled before testing, and the influence of vibration interference can be effectively reduced.
The utility model provides an elasticity chart appearance, this elasticity chart appearance includes coupling reed, elastic element, deformation measuring unit, appearance cup vibration unit and controller; the controller is connected with the deformation measuring unit; one end of the coupling reed is connected with the elastic element, and the other end of the coupling reed is immersed in the liquid to be detected; the sample cup vibration unit is used for driving the sample cup filled with the liquid to be detected to vibrate; the deformation measuring unit is used for measuring the deformation of the elastic element when the sample cup vibrates; the controller is used for calculating the elastic value of the liquid to be measured according to the deformation quantity. The elasticity chart instrument does not need to be leveled before testing, is simpler and more convenient to operate, can effectively reduce the influence of vibration interference, and further improves the stability and accuracy of test data.
Example two:
this embodiment provides another elastography instrument, which is implemented on the basis of the elastography instrument shown in fig. 1.
In this embodiment, the elastograph instrument includes a coupling reed, an elastic element, a deformation measurement unit, a sample cup vibration unit, and a controller, where the controller is connected to the deformation measurement unit, one end of the coupling reed is connected to the elastic element, and the other end of the coupling reed is immersed in the liquid to be measured. On the basis, the elasticity chart instrument also comprises a sample adding device; the sample adding device comprises a sample adding needle and a mechanical arm unit.
The mechanical arm unit is connected with the controller, and the sample adding needle is arranged on the mechanical arm unit. In actual operation, the controller controls the mechanical arm unit to operate correspondingly so as to move the sample adding needle to the position of the sample cup, and liquid to be detected is added into the sample cup through the sample adding needle, so that automation of sample adding operation is realized.
In some cases, the elasticity value of the liquid to be tested is affected by its temperature, and in order to measure a more stable elasticity value, it is necessary to keep the temperature of the liquid to be tested relatively stable. In one possible embodiment, an incubation device may be further added to the elastograph apparatus, wherein the incubation device comprises a first cup holding groove and a heating unit.
Here, the first sample cup placing groove for placing the sample cup containing the liquid to be measured is provided on the above-described sample cup vibration unit. That is, the sample cup vibration unit is further provided with a first sample cup placement slot, and a sample prepared for sample addition is placed in the first sample cup placement slot to be tested. And the heating unit is used for heating the sample cup so as to maintain the temperature of the liquid to be measured constant. Therefore, in the process of testing the liquid to be tested, the liquid to be tested is always kept at a constant temperature, and the stability of test data is improved.
In order to improve the testing efficiency, in one possible embodiment, a sample cup supply device and a sample cup conveying device can be further arranged in the elastograph so as to realize automatic acquisition and automatic conveying of the sample cups. Wherein, this appearance cup feeding mechanism includes: the sample cup placing device comprises a second sample cup placing groove and a cup feeding unit, wherein the second sample cup placing groove is used for placing an empty sample cup; the cup feeding unit is used for obtaining empty sample cups from the second sample cup placing grooves and placing the empty sample cups to a first preset position. The sample cup transfer device includes: the sample cup grabbing device comprises a sample cup grabbing unit and a conveying guide rail, wherein the sample cup grabbing unit is movably arranged on the conveying guide rail. The sample cup grabbing unit is used for grabbing a sample cup from a first preset position; the conveying guide rail is used for conveying the sample cups grabbed by the sample cup grabbing unit to a second preset position.
In another possible embodiment, the liquid to be tested is a mixture of a blood sample and a blood coagulation reagent. Moreover, the elasticity chart instrument further comprises: sample and reagent supply means. Wherein the sample and reagent supply device comprises: test tube storage tray, rotary unit and sweep a yard unit. The sample test tube and the reagent test tube have been placed on this test tube storage tray, and the blood sample has been placed in this sample test tube, has placed blood coagulation reagent in this reagent test tube, all is provided with the identification code that corresponds on this sample test tube and this reagent test tube, here, this identification code and test tube one-to-one, and each test tube corresponds unique identification code, can distinguish different test tubes and sample or reagent wherein according to this identification code.
In addition, the code scanning unit is arranged on one side of the test tube storage tray. The rotating unit is used for driving the test tube storage disc to do rotating motion so as to transfer different test tubes to the scanning range of the code scanning unit. And the code scanning unit is used for scanning and reading the identification codes in the scanning range to acquire the information of the current test tube. That is, when a certain sample or reagent is needed, the code scanning unit reads the identification code on the test tube within the scanning range by rotating the test tube storage tray, so as to identify the current information of the test tube, including the type of liquid in the test tube, until the needed sample or reagent is found, so that the information can be provided to the sample adding device to add the needed sample or reagent into the sample cup.
The elasticity chart appearance that this embodiment provided, through setting up mechanical control structures such as sample cup feeding mechanism, sample cup conveyer, sample and reagent feeding mechanism, application of sample device and hatching device, make the whole process realization automation of test is hatched to the acquisition of sample cup, sample interpolation, sample cup conveying, sample, need not personnel's operation, improved the degree of automation of elasticity chart test, reduced the influence of human factor, and then improved test data's stability and accuracy.
Example three:
the embodiment provides another elastography instrument for detecting the elasticity of thrombus, referring to fig. 2, which is a schematic structural diagram of the elastography instrument, and as can be seen from fig. 2, the elastography instrument comprises: a sample cup supply device 21, a sample cup transfer device 22, a sample and reagent supply device 23, a sample adding device 24, an incubation device 25, and a measurement device 26.
In this embodiment, the sample cup supplying device 21 comprises a base device for accommodating the sample cup, a positioning device for the sample cup and a cup feeding device for the sample cup. The sample cup base is used for containing a plurality of sample cups, and the limiting structures of the sample cups are fixed on the sample cup base so as to ensure that the sample cups have relative fixed positions in the moving process. In addition, the cup feeding device of the sample cup is used for ensuring that the sample cup placed on the base of the sample cup can move up and down or horizontally to a designated position, so that the movable arm assembly can grab the sample cup.
Further, the cuvette conveyer 22 includes a guide base, a transverse and longitudinal movement guide, a driving motor, and a gripping reaction cup mechanism. The guide rail base is used for fixing the moving guide rail; the transverse and longitudinal moving guide rails are used for ensuring that the position of the reaction cup grabbing mechanism is accurate and stable when the reaction cup grabbing mechanism grabs the reaction cup. In addition, the driving motor provides power for the grabbing reaction cup mechanism. The grabbing reaction cup mechanism conveys the reaction cup to a sample adding position from a sample containing cup base device, and is responsible for conveying the sample cup to a sample cup placing groove and waiting for detection after the sample and the reagent are added.
The sample and reagent supply device 23 includes a sample and reagent tray, a rotation mechanism, and a code scanning mechanism. Furthermore, the sample and reagent discs are distributed in a circle, and a plurality of grooves are arranged on the sample and reagent discs for placing sample tubes and reagent tubes. Wherein, rotary mechanism provides power in order to drive sample and reagent dish circular motion. The code scanning mechanism is responsible for scanning the identification codes on the samples and the reagents so as to distinguish different samples and reagents. In this embodiment, the sample is a blood sample, and the reagent is a blood coagulation reagent for accelerating coagulation of blood.
Further, the sample adding device 24 includes a sample adding needle and a rotary mechanical arm. And the sample adding needle is responsible for adding samples and reagents into the sample cup according to a certain quantity, and the rotary mechanical arm has a horizontal rotation function and can vertically move so as to ensure that the reagents and the samples are accurately added into the sample cup.
In addition, the incubation device 25 includes a sample cup placing groove, a sample cup heating device, and a sample cup driving device. The sample cup placing grooves are transversely arranged, a plurality of reaction cups can be placed at the same time, and the sample cup heating device ensures that the temperature of the sample is constant in the test process. The sample cup driving device is powered by an electric motor to drive the sample cup to do linear motion.
Further, the measuring device 26 comprises a coupling reed, an elastic element, a deformation measuring unit, a sample cup vibration unit and a controller; the controller is connected with the deformation measuring unit; one end of the coupling reed is connected with the elastic element, and the other end of the coupling reed is immersed in the liquid to be measured. Furthermore, the measuring device 26 further comprises a measuring element moving unit connected to the deformation measuring unit, wherein the measuring element moving unit can provide vertical movement to drive the deformation measuring unit to move up and down, so that the coupling spring can be immersed in or separated from the liquid to be measured.
In actual measurement, after receiving a start measurement signal, the measuring member moving unit moves downward to feed the coupling reed into the sample cup. The sample cup moves back and forth, and the sample is not solidified and the generated viscoelasticity is small, so that at the initial measurement stage, the viscous force between the coupling reed and the sample is small, the coupling reed is basically in a static state, along with the beginning of sample solidification, the viscous force borne by the coupling reed is larger and larger, the forced vibration elastic deformation of the coupling reed is larger, the deformation is recorded by the deformation measurement unit, a group of corresponding relation curves of the viscous force and the deformation quantity of the coupling reed are formed, the change of the amplitude and the change of the elastic force accord with a certain fixed relation and are in a positive correlation relation, the relation curve of the elastic force and the deformation quantity can be further corresponded, and the elastic force of the liquid to be measured can be measured by continuously collecting the forced vibration amplitude of the elastic element.
In order to verify the performance of the elastogram instrument in the embodiment, the haemagraphs' TEG5000 is adopted as the calibration source, and the same sample is measured, and the corresponding relation of the measurement parameters of the obtained utility model and the american TEG5000 instrument is shown in fig. 3, wherein, the abscissa of fig. 3 is the TEG5000 elasticity test value, and the ordinate is the elasticity original data measured by the elastogram instrument, and both present a certain linear relation. Verified, the utility model provides a measurement value x of elastography appearance0Positively correlated with the A value measured by TEG5000, can be represented by the following formula:
x0＝C1A+C2A3。
wherein, C1、C2Is constant, A is the elasticity test value of TEG5000, x0The raw data representing the elastic force measured by the elastography instrument is usually a voltage value.
It can be seen that the embodiment of the utility model provides an elasticity map appearance has better test performance, and its test result is reliable.
Compared with the thrombus elasticity measuring device in the prior art, the elasticity chart instrument provided by the embodiment replaces a twisted wire in a conventional elasticity chart instrument with the coupling reed, calculates the elasticity value of the liquid to be measured by measuring the vibration amplitude of the coupling reed, does not need to level the instrument before testing, and can effectively reduce the influence of vibration interference. And through setting up mechanical control structure, make the acquisition of sample cup, add the sample, conveying sample cup, incubate to the test, whole process realizes the automation, improves the degree of automation of elastogram test, has reduced the influence of human factor, and then improves test data's stability and accuracy.
Example four:
the embodiment of the present invention further provides a visual elastogram device, as shown in fig. 4, for the structural schematic diagram of the visual elastogram device, as can be seen from fig. 4, the visual elastogram device 100 includes the elastogram apparatus 41 provided in the first embodiment, the second embodiment, the third embodiment and one of the possible implementation manners, and further includes the display 42. Wherein, the display 42 is connected with the controller, and the display 42 is used for displaying the elasticity value of the liquid to be measured. Therefore, when the elasticity value of the liquid to be measured is measured by the elasticity chart instrument 41, the elasticity data value can be timely obtained from the display 42, and the convenience is further realized.
The embodiment of the utility model provides a visual elastogram equipment, its realization principle and the technological effect who produces are the same with the embodiment of aforementioned elastogram appearance, and for brief description, the embodiment part of visual elastogram equipment does not mention, can refer to corresponding content in the aforesaid elastogram appearance embodiment.
Unless specifically stated otherwise, the relative steps, numerical expressions and numerical values of the components and steps set forth in these embodiments do not limit the scope of the present invention.
In all examples shown and described herein, any particular value should be construed as merely exemplary, and not as a limitation, and thus other examples of example embodiments may have different values.
In addition, in the description of the embodiments of the present invention, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
Finally, it should be noted that: the above-mentioned embodiments are only specific embodiments of the present invention, and are not intended to limit the technical solution of the present invention, and the protection scope of the present invention is not limited thereto, although the present invention is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: those skilled in the art can still modify or easily conceive of changes in the technical solutions described in the foregoing embodiments or make equivalent substitutions for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not substantially depart from the spirit and scope of the embodiments of the present invention, and are intended to be included within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. An elastography instrument, comprising: the device comprises a coupling reed, an elastic element, a deformation measuring unit, a sample cup vibration unit and a controller; the controller is connected with the deformation measuring unit; one end of the coupling reed is connected with the elastic element, and the other end of the coupling reed is immersed in liquid to be detected;
the sample cup vibration unit is used for driving the sample cup filled with the liquid to be detected to vibrate;
the deformation measuring unit is used for measuring the deformation amount of the elastic element when the sample cup vibrates;
and the controller is used for calculating the elastic value of the liquid to be measured according to the deformation quantity.
2. The elastography instrument of claim 1, wherein the deformation measuring unit comprises a hall sensor or a photosensor.
3. The elastography device of claim 1, wherein the elastic element comprises an elastic rod, an elastic wire, or an elastic sheet.
4. The elastography instrument of claim 1, further comprising: a sample adding device; the sample adding device comprises a sample adding needle and a mechanical arm unit; the mechanical arm unit is connected with the controller, and the sample adding needle is arranged on the mechanical arm unit;
the mechanical arm unit is used for moving the sample adding needle to the position of the sample cup so as to add the liquid to be detected into the sample cup through the sample adding needle.
5. The elastography instrument of claim 4, further comprising: an incubation device; the incubation device comprises a first sample cup placing groove and a heating unit; the first sample cup placing groove is arranged on the sample cup vibration unit;
the first sample cup placing groove is used for placing the sample cup filled with liquid to be detected;
the heating unit is used for heating the sample cup so as to maintain the temperature of the liquid to be measured constant.
6. The elastography instrument of claim 4, further comprising: a sample cup supply device; the sample cup supply device includes: the second sample cup placing groove and the cup feeding unit;
the second sample cup placing groove is used for placing empty sample cups;
the cup feeding unit is used for obtaining the empty sample cup from the second sample cup placing groove and placing the empty sample cup to a first preset position.
7. The elastography instrument of claim 6, further comprising: a sample cup transfer device; the sample cup transfer device includes: a sample cup grabbing unit and a conveying guide rail; the sample cup grabbing unit is movably arranged on the conveying guide rail;
the sample cup grabbing unit is used for grabbing a sample cup from the first preset position;
the conveying guide rail is used for conveying the sample cups grabbed by the sample cup grabbing unit to a second preset position.
8. The elastography device of any of claims 1-7, wherein the fluid to be measured is a mixture of a blood sample and a coagulation reagent.
9. The elastography instrument of claim 8, further comprising: a sample and reagent supply; the sample and reagent supply apparatus comprises: the test tube storage tray, the rotating unit and the code scanning unit are arranged on the test tube storage tray;
a sample test tube and a reagent test tube are placed on the test tube storage tray, a blood sample is placed in the sample test tube, a blood coagulation reagent is placed in the reagent test tube, and corresponding identification codes are respectively arranged on the sample test tube and the reagent test tube; the code scanning unit is arranged on one side of the test tube storage tray;
the rotating unit is used for driving the test tube storage disc to rotate so as to transfer different test tubes to the scanning range of the code scanning unit;
and the code scanning unit is used for scanning and reading the identification codes in the scanning range so as to acquire the information of the current test tube.
10. A visual elastogram device, comprising: the elastography device of any of claims 1-9, further comprising a display; the display is connected with the controller;
the display is used for displaying the elasticity value of the liquid to be detected.
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| CN201921085111.1U CN210465441U (en) | 2019-07-11 | 2019-07-11 | Elastogram appearance and visual elastogram equipment |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110208511A (en) * | 2019-07-11 | 2019-09-06 | 北京森美希克玛生物科技有限公司 | Elastic force figure instrument and visualization elastic force figure equipment |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110208511A (en) * | 2019-07-11 | 2019-09-06 | 北京森美希克玛生物科技有限公司 | Elastic force figure instrument and visualization elastic force figure equipment |
| CN110208511B (en) * | 2019-07-11 | 2024-03-08 | 北京森美希克玛生物科技有限公司 | Elastography instrument and visualized elastography equipment |
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