CN1151322A - 造血前体细胞保护剂 - Google Patents
造血前体细胞保护剂 Download PDFInfo
- Publication number
- CN1151322A CN1151322A CN 95121410 CN95121410A CN1151322A CN 1151322 A CN1151322 A CN 1151322A CN 95121410 CN95121410 CN 95121410 CN 95121410 A CN95121410 A CN 95121410A CN 1151322 A CN1151322 A CN 1151322A
- Authority
- CN
- China
- Prior art keywords
- cell
- tsp
- protective agent
- cfu
- hemopoietic forebody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
CFU-MK | CFU-GEMM | HPP-CFC | CFU-GM | BFU-E | |
1.对照组 | 31±2.5 | 34±7 | 8±2 | 40±3 | 53±3 |
2.TSP(1μg/ml) | 15±2* | 16±3* | 3±1* | 36±3 | 54±2 |
3.TSP(5μg/ml) | 8±1* | 17±3* | 2±1* | 36±3 | 56±2 |
4.小分子量肝素(1IU/ml) | 42±3 | 37±4 | 9±2 | 38±4 | ′ |
5.TSP(5μg/ml)+小分子量肝素(1IU/ml) | 27±3 | 33±4 | 9±2 | 39±4 | ′ |
6.TSP1-174(1μg/ml) | 23±2 | 27±4 | 5±1 | 37±3 | ′ |
7.TSP1-174(5μg/ml) | 16±2* | 22±2* | 3±1* | 35±4 | ′ |
8.TSP1-174(1μg/ml)+小分子量肝素(1IU/ml) | 33±3 | 32±4 | 9±2 | 37±4 | ′ |
9.TSP1-174(5μg/ml)+小分子量肝素(1IU/ml) | 29±2 | 35±2 | 7±1 | 36±3 | ′ |
单个核细胞数 | CFU-GEMM | CFU-GM | CFU-MK | BFU-E | |
对照组初始值PBS孵育三天后1.PBS再孵育一天2.5-FU孵育一天 | 1072.5×1062.1×1061.2×106 | 468±13365±21112±15* | 1234±561054±46432±32* | 668±22570±18201±3* | 842±50680±46185±23* |
TSP组初始值TSP孵育三天后1.PBS再孵育一天2.5-FU孵育一天 | 1071.9×1061.6×1061.3×106 | 415±34324±23304±25 | 1050±76980±46890±50 | 570±44550±33401±28 | 940±62925±35890±40 |
Claims (9)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN95121410A CN1069213C (zh) | 1995-12-08 | 1995-12-08 | 造血前体细胞保护剂 |
PCT/CN1996/000106 WO1997021446A1 (fr) | 1995-12-08 | 1996-12-06 | Composition pharmaceutique pour la protection des cellules souches hematopoietiques, et applications |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN95121410A CN1069213C (zh) | 1995-12-08 | 1995-12-08 | 造血前体细胞保护剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1151322A true CN1151322A (zh) | 1997-06-11 |
CN1069213C CN1069213C (zh) | 2001-08-08 |
Family
ID=5082434
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN95121410A Expired - Fee Related CN1069213C (zh) | 1995-12-08 | 1995-12-08 | 造血前体细胞保护剂 |
Country Status (2)
Country | Link |
---|---|
CN (1) | CN1069213C (zh) |
WO (1) | WO1997021446A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112316148A (zh) * | 2019-08-01 | 2021-02-05 | 成都夸常奥普医疗科技有限公司 | 包含血浆的半流体的应用、包含该半流体和活性成分的药物组合物及其制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5192744A (en) * | 1990-01-12 | 1993-03-09 | Northwestern University | Method of inhibiting angiogenesis of tumors |
US5155038A (en) * | 1990-02-22 | 1992-10-13 | W. R. Grace & Co.-Conn. | Use of thrombospondin to promote wound healing |
US5200397A (en) * | 1990-02-22 | 1993-04-06 | W. R. Grace & Co.-Conn. | Use of peptide analogs of thrombospondin for the inhibition of angiogenic activity |
US5357041A (en) * | 1991-12-06 | 1994-10-18 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin |
-
1995
- 1995-12-08 CN CN95121410A patent/CN1069213C/zh not_active Expired - Fee Related
-
1996
- 1996-12-06 WO PCT/CN1996/000106 patent/WO1997021446A1/zh active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CN1069213C (zh) | 2001-08-08 |
WO1997021446A1 (fr) | 1997-06-19 |
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Legal Events
Date | Code | Title | Description |
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C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: LU YAN Free format text: FORMER OWNER: BEITE BIOLOGICAL TECHNOLOGY CO., LTD., SHANGHAI Effective date: 20041126 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20041126 Address after: 300193 Tianjin City Bai Causeway Road Nankai District Verde 2-2-601 Patentee after: Lu Yan Address before: 105 room 1033, 200030 Zhao Bang Road, Shanghai Patentee before: Beite Biology Technology Co., Ltd., Shanghai |
|
DD01 | Delivery of document by public notice |
Addressee: Lu Yan Document name: Notification to Pay the Fees |
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C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20010808 Termination date: 20100108 |