CN115093747B - Chemical indicating ink for pressure steam sterilization and preparation method thereof - Google Patents
Chemical indicating ink for pressure steam sterilization and preparation method thereof Download PDFInfo
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- CN115093747B CN115093747B CN202210823158.3A CN202210823158A CN115093747B CN 115093747 B CN115093747 B CN 115093747B CN 202210823158 A CN202210823158 A CN 202210823158A CN 115093747 B CN115093747 B CN 115093747B
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- ink
- pressure steam
- steam sterilization
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Classifications
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/10—Printing inks based on artificial resins
- C09D11/101—Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
- C09D11/033—Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
Abstract
The invention discloses chemical indicating ink for pressure steam sterilization and a preparation method thereof, and belongs to the technical field of UV (ultraviolet) light curing pressure steam sterilization. Aiming at the problems of infection of patients and discharge of high-concentration VOCs (volatile organic compounds) caused by instrument pollution caused by the existing heavy metal salt ink or organic solvent ink, the invention provides chemical indicating ink for pressure steam sterilization, which comprises the following components in percentage by mass: 50-70% of connecting material, 0.1-1% of organic dye, 10-30% of catalyst, 1-5% of catalyst carrier, 0.5-1.5% of stabilizer, 0.3-0.6% of flatting agent and 3-30% of solvent; the organic dye is azo dye, and the solvent is n-propanol, isopropanol or ethanol. The chemical indicating ink disclosed by the invention has the advantage of low VOCs (volatile organic compounds) emission, and can be widely applied to printing of products such as indicating cards, indicating labels, chemical PCD (polycrystalline Diamond), B-D (boron-D) test objects and the like.
Description
Technical Field
The invention relates to the technical field of UV (ultraviolet) photocuring pressure steam sterilization, in particular to chemical indicating ink for pressure steam sterilization and a preparation method thereof.
Background
In the daily work of hospitals, various medical instruments, appliances and the like are usually required to be disinfected and sterilized. With the continuous improvement of the health awareness level of people, the requirements of various medical supplies are more and more, the medical supplies need to be strictly sterilized before use, and the sterilization process also relates to the fields of medical treatment, medicines, sanitary products, foods and the like. This places even greater demands on routine testing and rapid identification of the effectiveness of the sterilization.
According to the national standard for sterilization of medical instruments, medical staff in hospitals are required to place corresponding chemical indicator cards when sterilizing the medical instruments every pot, so that the medical staff can observe the color change of the chemical indicator cards and judge whether set sterilization parameters are reached. Meanwhile, products such as corresponding chemical indicating labels, B-D test objects, chemical PCD and the like are also widely applied to detection of the pressure steam sterilization effect.
With the environmental protection being more and more regarded by the country, the development of solvent-based inks and the discharge and disposal of VOCs are strictly limited, and therefore, there is a trend to develop chemical indicator inks for UV light curing pressure steam sterilization.
The chemical indicating ink for UV light curing pressure steam sterilization is applied in the pressure steam sterilization process of medical products, and thus the ink cannot contain heavy metals, especially, cannot contain lead species. When the ink is dissolved or heavy metals are present, there is a potential risk of contamination of the instrument, resulting in infection of the patient during the procedure. At present, the common ink is heavy metal salt ink or organic solvent ink, contains a large amount of organic solvent, can cause the discharge of high-concentration VOCs, and is harmful to the health of production personnel.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: the chemical indicating ink is different from the conventional indicating ink, an alcohol solvent is adopted, and the VOCs emission amount of the solvent is very low, so that the prepared chemical indicating ink has the advantage of low VOCs emission, and can be widely applied to printing of products such as an indicating card, an indicating label, chemical PCD, B-D test objects and the like.
The technical scheme of the invention is as follows:
in one aspect, the invention provides a chemical indicating ink for pressure steam sterilization, which comprises the following components in percentage by mass: 50-70% of a binder, 0.1-1% of an organic dye, 10-30% of a catalyst, 1-5% of a catalyst carrier, 0.5-1.5% of a stabilizer, 0.3-0.6% of a flatting agent and 3-30% of a solvent; the organic dye is azo dye (including monoazo dye and polyazo dye), and mainly provides an initial color before sterilization and a final color after sterilization in the ink; the solvent is n-propanol, isopropanol or ethanol.
Preferably, the binder adopts UV gloss oil (composed of acrylic resin, monomer, photoinitiator, auxiliary agent and solvent), and the UV gloss oil mainly plays a role in enhancing the adhesive force and the fluidity of the ink in the ink.
More preferably, the organic dye adopts one or more of Congo red, solvent red 23, solvent red 1 and disperse red.
Preferably, the catalyst adopts an organic reducing substance or a metal salt, and the organic reducing substance or the metal salt mainly plays a role in controlling the color change rate of the ink in the ink; the organic reducing substance adopts thiourea or thiocarbamide; the metal salt is sodium alginate, potassium alginate or calcium alginate.
Preferably, the catalyst carrier adopts one or two of alumina powder and silica gel, and the catalyst carrier does not have the function of a catalyst, so that the catalyst component can be uniformly dispersed in the ink, the strength of the catalyst is increased, the organic dye can be adsorbed, the contact area of the catalyst and the organic dye is enlarged, and the color change of the organic dye is accelerated.
Preferably, the stabilizer is one or more of calcium silicate, calcium hydroxide and titanium dioxide, and the stabilizer mainly plays a role in maintaining the initial color of the ink before sterilization to be free from the influence of external factors (such as temperature and humidity).
Preferably, the leveling agent adopts polyether modified silicone oil, and can improve the leveling property and uniformity of all components of the ink, so that the ink forms a flat, smooth and uniform ink layer in printing, and the conditions of bottom leakage and edge feathering are avoided; the solvent is one or more of ethanol, isopropanol and n-propanol.
On the other hand, the invention also provides a preparation method of the chemical indicating ink for pressure steam sterilization, which comprises the steps of mixing the organic dye and the connecting material, adding the catalyst, the stabilizer, the catalyst carrier, the flatting agent and the solvent, uniformly stirring, and grinding to obtain the chemical indicating ink for pressure steam sterilization.
After the indication ink is subjected to a pressure steam sterilization process at 121-135 ℃, the indication ink achieves corresponding color, and the color change mechanism of the indication ink is that organic dye has nitrogen-nitrogen double bonds (-N = N-) and can be broken under the dual action of high-temperature steam and a catalyst, so that the organic dye is subjected to color change.
Compared with the prior art, the invention has the following beneficial effects:
the color of the indicating ink can be changed after the indicating ink is sterilized, and the indicating ink is used for indicating whether a product is sterilized or not, the chemical indicating ink is different from the conventional indicating ink, an alcohol solvent is adopted, and the VOCs emission amount of the solvent is very low, so that the prepared chemical indicating ink for pressure steam sterilization has the advantages of low VOCs emission, simple and feasible preparation process, no heavy metal and the like, is environment-friendly, and can be widely applied to printing of products such as an indicating card, an indicating label, chemical PCD (Poly Crystal Diamond), a B-D (B-D) test object and the like; the risk of heavy metal exposure of hospital personnel is also reduced, and a good working environment is provided for medical personnel. The ink can be widely applied to printing modes such as silk screens, intaglio printing, flexible printing and the like. The indicating ink can meet the requirements of different sterilization temperature requirements, meets the standard of sterilization application in hospitals, adopts the principle of color change as sudden change instead of gradual change, has more visual and accurate result judgment and clearer result judgment, and reduces the artificial subjective factors of medical staff.
Detailed Description
In order to make those skilled in the art better understand the technical solutions in the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the preferred embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
In this embodiment, a pressure steam sterilization chemical indicator card is prepared by coating ink on coated paper by screen printing, and coating a film on the ink, wherein the ink comprises the following components in percentage by weight: 60% of UV gloss oil, 0.5% of disperse red 137, 30% of sodium alginate, 5% of silica gel, 1% of calcium hydroxide, 0.5% of polyether modified silicone oil and 3% of n-propanol.
The preparation method of the chemical indicator card of the embodiment comprises the following steps: and mixing the disperse red 137 with UV gloss oil, adding sodium alginate, silica gel, calcium hydroxide, polyether modified silicone oil and n-propanol, uniformly stirring, and grinding for several times by a three-roll grinder until uniformly dispersed indicating ink (the ink fineness is less than 5 microns) is formed. And then coating the printing ink on laminating base paper coated with a BOPP film through a screen printer (screen cloth is 200 meshes), printing the printing ink with the thickness of 8-12 wires, curing the printing ink through a UV lamp for 1s, coating a PET film on the printing ink layer, and cutting to obtain the pressure steam sterilization chemical indicator card for the sterilization process of a pressure steam sterilizer. The result shows that the UV light curing pressure steam sterilization chemical organic ink completely changes from red to yellow after being heated at the temperature of 121 ℃ for 16.5min or at the temperature of 128 ℃ for 8min or at the temperature of 135 ℃ for 4 min. And, the chemical indicating ink for pressure steam sterilization of the present example was maintained at 60 ℃ and 80% humidity for 72 hours with a slight change in initial color; the chemical indicating ink for pressure steam sterilization of this example slightly changed in initial color during dry heating at 140 ℃ for 30 min.
Example 2
In this example, a pressure steam sterilization chemical indicator label was prepared by coating ink on paper by gravure printing or the like and laminating the ink on the upper layer. The ink comprises the following components in percentage by weight: 50% of UV gloss oil, 1% of Congo red, 15% of thiourea, 2% of alumina powder, 1.5% of calcium silicate, 0.5% of polyether modified silicone oil and 30% of isopropanol.
The preparation method of the chemical indicating label of the embodiment comprises the following steps: mixing Congo red and UV gloss oil, then respectively adding thiourea, alumina powder, calcium silicate, polyether modified silicone oil and isopropanol, uniformly stirring, and then grinding for several times by a three-roll grinder until uniformly dispersed indicating ink (the ink fineness is less than 5 mu m) is formed. And then coating the printing ink on laminating base paper coated with a BOPP film through a gravure press (a printing roller is 15 wires and 60 lines), wherein the printing thickness is 8-12 wires, curing is carried out through a UV lamp for 1s, and then a PET film is coated on the printing ink layer. And die cutting to obtain the pressure steam sterilization chemical indicator label for the sterilization procedure of the pressure steam sterilizer. The results show that the chemical indicator ink used for pressure steam sterilization changed completely from red to yellow after 2min at 134 ℃. And, the chemical indicating ink for pressure steam sterilization of the present example was maintained at 60 ℃ and 80% humidity for 72 hours with a slight change in initial color; the initial color of the chemical indicating ink for pressure steam sterilization of this example slightly changed during dry heating at 134 ℃ for 30 min.
Example 3
In this example, a test article for pressure steam sterilization B-D was prepared, and an ink was applied to paper by gravure printing or the like, and then a film was formed on the ink. The ink comprises the following components in percentage by weight: 70% of UV gloss oil, 58.2% of disperse red, 10% of thiocarbamide, 1% of silica gel, 0.5% of calcium hydroxide, 0.3% of polyether modified silicone oil and 18% of ethanol.
The preparation method of the pressure steam sterilization B-D test object in the embodiment comprises the following steps: mixing the disperse red 58 and the UV gloss oil, adding the thiocarbamide, the silica gel, the calcium hydroxide, the polyether modified silicone oil and the ethanol, uniformly stirring, and then grinding for a plurality of times by a three-roll grinder until uniformly dispersed indicating ink (the fineness of the ink is less than 5 mu m) is formed. And then coating the printing ink on laminating base paper coated with a BOPP film through a flexographic printing machine (an anilox roller is 200 meshes), printing the printing ink with the thickness of 6-10 filaments, curing the printing ink through a UV lamp for 1s, and then coating a PET film on the printing ink layer. And cutting to obtain a pressure steam sterilization B-D test object for the B-D test procedure of the pressure steam sterilizer. The results show that the UV light curing pressure steam sterilization chemical organic ink changed completely from red to yellow at 134 ℃ for 3.5min. And, the chemical indicating ink for pressure steam sterilization of the present example was maintained at 60 ℃ and 80% humidity for 72 hours with a slight change in initial color; the chemical indicating ink for pressure steam sterilization of this example slightly changed in initial color during dry heating at 134 ℃ for 30 min.
Comparative example 1
The difference from example 2 is that: comparative example 1 no alumina powder was added. The color of the finally prepared chemical indicating ink for pressure steam sterilization changes from initial red to orange in saturated steam at 134 ℃ for 10min, but the color of the finally prepared chemical indicating ink does not change completely, i.e. the color is yellow. On the other hand, the color of the ink of example 2 changed from red to yellow, and it was found that the color change of the organic dye was accelerated by the catalyst carrier at the same treatment temperature and time.
Comparative example 2
The difference from example 2 is that: comparative example 2 no thiourea was added. The color of the finally prepared chemical indicating ink for pressure steam sterilization is changed from initial red to light red in saturated steam at 134 ℃ for 10min, namely the initial color and the end color are still in the same color system, and the color change is not obvious. On the other hand, the ink of example 2 changed from red to yellow, and it was found that the catalyst could control the ink discoloration rate in the ink at the same treatment temperature and time.
Comparative example 3
The difference from example 2 is that: comparative example 3 no calcium silicate was added. The temperature is 60 ℃ and the humidity is 80%, the chemical indicating ink for pressure steam sterilization prepared in the comparative example 3 is kept for 72 hours, the initial color red is deepened, and the color difference is obvious; and in the dry heating process of 134 ℃ and 30min, the chemical indicating ink for pressure steam sterilization prepared in the comparative example 3 is dark red in initial color and obvious in color difference. Under the same humidity and temperature conditions, the initial color of the ink of example 2 only slightly changes, which shows that the addition of the stabilizer in the ink can maintain the initial color of the ink before sterilization from changing under the influence of external factors (such as temperature and humidity).
Although the present invention has been described in detail by referring to the preferred embodiments, the present invention is not limited thereto. Various equivalent modifications or substitutions of the embodiments of the present invention can be made by those skilled in the art, and the modifications or substitutions can be easily made within the scope of the present invention/any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (4)
1. The chemical indicating ink for pressure steam sterilization is characterized by comprising the following components in percentage by mass: 50-70% of connecting material, 0.1-1% of organic dye, 10-30% of catalyst, 1-5% of catalyst carrier, 0.5-1.5% of stabilizer, 0.3-0.6% of flatting agent and 3-30% of solvent; the organic dye is azo dye, and the solvent is n-propanol, isopropanol or ethanol; the catalyst carrier adopts one or two of alumina powder and silica gel; the stabilizer is one or more of calcium silicate and calcium hydroxide; the connecting material adopts UV gloss oil; the catalyst adopts organic reducing substances or metal salts, the organic reducing substances adopt thiourea or thiocarbamide, and the metal salts adopt sodium alginate, potassium alginate or calcium alginate.
2. The chemical indicating ink for pressure steam sterilization according to claim 1, wherein the organic dye is one or more of congo red, solvent red 23, solvent red 1, and disperse red.
3. The chemical indicating ink for pressure steam sterilization according to claim 1, wherein the leveling agent is polyether-modified silicone oil.
4. The method for preparing chemical indicating ink for pressure steam sterilization according to any one of claims 1 to 3, wherein the chemical indicating ink for pressure steam sterilization is prepared by mixing an organic dye with a binder, adding a catalyst, a stabilizer, a catalyst carrier, a leveling agent and a solvent, stirring uniformly, and then grinding.
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| CN202210823158.3A CN115093747B (en) | 2022-07-14 | 2022-07-14 | Chemical indicating ink for pressure steam sterilization and preparation method thereof |
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| CN115093747B true CN115093747B (en) | 2022-11-08 |
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| CN115093747A (en) | 2022-09-23 |
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