CN109045336A - A kind of ethylene oxide sterilizing indicant - Google Patents

A kind of ethylene oxide sterilizing indicant Download PDF

Info

Publication number
CN109045336A
CN109045336A CN201811099232.1A CN201811099232A CN109045336A CN 109045336 A CN109045336 A CN 109045336A CN 201811099232 A CN201811099232 A CN 201811099232A CN 109045336 A CN109045336 A CN 109045336A
Authority
CN
China
Prior art keywords
ethylene oxide
acid
sterilizing
indicant
sterilizing indicant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811099232.1A
Other languages
Chinese (zh)
Inventor
王卫
钟明伟
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Jusha Display Technology Co Ltd
Nanjing Jusha Medical Technology Co Ltd
Nanjing Jusha Commercial and Trading Co Ltd
Original Assignee
Nanjing Jusha Display Technology Co Ltd
Nanjing Jusha Medical Technology Co Ltd
Nanjing Jusha Commercial and Trading Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanjing Jusha Display Technology Co Ltd, Nanjing Jusha Medical Technology Co Ltd, Nanjing Jusha Commercial and Trading Co Ltd filed Critical Nanjing Jusha Display Technology Co Ltd
Priority to CN201811099232.1A priority Critical patent/CN109045336A/en
Publication of CN109045336A publication Critical patent/CN109045336A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/20—Gaseous substances, e.g. vapours
    • A61L2/206—Ethylene oxide
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/50—Sympathetic, colour changing or similar inks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Engineering & Computer Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of ethylene oxide sterilizing indicants, belong to medical reagent technical field, including following components: azo active dyestuff 0.5%-5%, thickener 0.2%-10%, organic acid 1%-10%, aluminum magnesium silicate 1%-30%, isopropanol 10%-50%, auxiliary agent 1%-20%, surplus are water.A kind of ethylene oxide provided by the invention sterilizing indicant, uses azo active dyestuff to indicate ingredient, under the conditions of being exposed to ethylene oxide, the electron density of azo active dyestuff can change, so as to cause the variation of color.Color change time and depth can be adjusted by changing additive amount, the type of thickener, organic acid and auxiliary agent.The another present invention is isopropanol-water system, environmentally protective without containing hazardous solvents such as ester, ketone, benzene, aldehyde, ether, alkane.

Description

A kind of ethylene oxide sterilizing indicant
Technical field
The present invention relates to a kind of ethylene oxide to be used to indicate ethylene oxide sterilizing knot with sterilizing indicant more particularly to one kind The indicant of fruit belongs to medical reagent technical field.
Background technique
The effective sterilizing of medical treatment packet is the key link for avoiding sufferer postoperative infection.Currently used sterilization method is high pressure Steam sterilizing, but for the instrument of some non-refractories, such as optical instrument, electronic equipments, scope, dialyzer, ethylene oxide Sterilizing is main mode.If changing colour unstable or putting after the medical treatment packet containing ethylene oxide sterilizing instruction ink is sterilized Instruction ink colors change after setting a period of time, will all will lead to clinical erroneous judgement, to cause human and material resources, time On waste, while also affecting the normal work of department, therefore need to occur a kind of discoloration stabilization, environmentally protective ring at present Oxidative ethane indicates ink.At present ethylene oxide sterilizing indicator on the market mainly using acid-base indicator dyestuff as change colour at Point, the color that the Acid-base Gas of the pH of substrate, storage condition and production environment easily lead to instruction ink changes automatically.
Summary of the invention
The technical problem to be solved by the invention is to provide a kind of ethylene oxide sterilizings environmentally protective, discoloration is stable Indicant.
In order to solve the above technical problems, the technical solution adopted by the present invention are as follows:
A kind of ethylene oxide sterilizing indicant, including following components: azo active dyestuff 0.5%-5%, thickener 0.2%-10%, organic acid 1%-10%, aluminum magnesium silicate 1%-30%, isopropanol 10%-50%, auxiliary agent 1%-20%, surplus For water.
The azo active dyestuff has following structure formula,
In formula, R1Selected from-H ,-SO3Na ,-Cl ,-CH3,-NO2,-CONH2,-NH2,-N (CH2CH3)2,-NHCH2CH2OH ,- OCH2CH3In any one；
R2, R4, R5, R6Selected from-H ,-OH ,-CH3,-NO2,-SO3Any one in Na ,-COONa；
R3Selected from-H ,-OH ,-CH3In any one.
The thickener is by modified starch, guar gum, xanthan gum, Arabic gum, pectin, carragheen, gellan gum, locust bean One of glue, cellulose and gelatin or a variety of compositions.
The organic acid by maleic acid, ascorbic acid, caffeic acid, malic acid, ethylenediamine tetra-acetic acid, hydroxyacetic acid, One of lactic acid, gluconic acid, acetic acid, butyl octanoic acid or a variety of compositions.
The auxiliary agent is by titanium dioxide, magnesium bromide, C24-C34Aliphatic ester lotion and its derivative, acrylate copolymer One or more of lotion, bromocresol green, bromophenol blue, bromine cresols, ethyl alcohol composition.
The acrylate polymer emulsion includes Neocryl A-2099 or Neocryl A-2092.
The present invention uses azo active dyestuff to indicate ingredient, under the conditions of being exposed to ethylene oxide, azo active dyestuff Electron density can change, so as to cause the variation of color.The addition of change thickener, organic acid and auxiliary agent can be passed through Amount, type adjust color change time and depth.
The another present invention is isopropanol-water system, environmentally protective without containing hazardous solvents such as ester, ketone, benzene, aldehyde, ether, alkane.
Biggest advantage of the present invention is that instruction composition formula is environmentally protective, and color change results are intuitive, accurate and stable, be can satisfy The needs that hospital and industry monitor ethylene oxide sterilizing.
Specific embodiment
The present invention will be further explained below.
Embodiment 1
A kind of ethylene oxide sterilizing indicant, the weight composition of ingredient are as follows: azo active dyestuff 4.5%, pectin 1%, gelatin 0.5%, oxalic acid 1.0%, aluminum magnesium silicate 2%, isopropanol 35%, titanium dioxide 0.25%, Neocryl A-2099 10%, bromocresol green 0.3%, surplus is water.
Wherein azo active dyestuff structural formula are as follows:
Wherein Neocryl A-2099 is a kind of acrylate polymer emulsion, is Royal DSM product.
Embodiment 2
A kind of ethylene oxide sterilizing indicant, the weight composition of ingredient are as follows: azo active dyestuff 1%, Methyl cellulose Element 1.0%, gluconic acid 1.5%, aluminum magnesium silicate 5%, magnesium bromide 3%, isopropanol 15%, titanium dioxide 0.1%, Neocryl A-2092 15%, C24-C34Aliphatic ester lotion 2%, bromophenol blue 0.5%, surplus is water.
Wherein azo dyes structural formula are as follows:
Wherein Neocryl A-2092 is a kind of acrylate polymer emulsion, is Royal DSM product.
After the above component is stirred, it is ground to coating material of the partial size less than 3 μm of active constituent, is then blocked in white Adagio printing or silk-screen printing are on piece paper or plastic sheet to get ethylene oxide sterilizing indicant.
In use, above-mentioned ethylene oxide to be placed in packed together with sterilizing indicant, biological indicator and instrument subject to sterilization In material, and packed using Closed process.It is put in 3M STERI-VAC 5XL sterilizer and sterilizes after packaging.It goes out Bacterium temperature is 54 DEG C, ethylene oxide concentration 735mg/L, sterilization time 6h.Above-mentioned package is taken out after sterilizing, chemistry refers to Show that object discoloration is obvious, and biological indicator asepsis growth, it was demonstrated that the instrument in this packet has passed through sterilizing.By the instruction after sterilizing Object is placed in be placed 30 days at room temperature, and the indicant color that sterilizes is without any significant change.
It was found from above-mentioned test result: ethylene oxide sterilizing indicant changes colour stabilization in practical applications, is easy to deposit Storage and interpretation.
Embodiment 3
A kind of ethylene oxide sterilizing indicant, the weight composition of ingredient are as follows: azo active dyestuff 0.5%, it is modified to form sediment Powder 5%, guar gum 5%, ascorbic acid 5%, caffeic acid 2%, malic acid 3%, aluminum magnesium silicate 30%, isopropanol 10%, bromine phenol Indigo plant 0.2%, bromine cresols 0.5%, ethyl alcohol 0.3%, surplus is water.
Wherein azo active dyestuff structural formula are as follows: R1For-H；R2For-COONa；R3For-CH3；R4For-NO2；R5For-H, R6 For-OH.
Embodiment 4
A kind of ethylene oxide sterilizing indicant, the weight composition of ingredient are as follows: azo active dyestuff 5%, Arabic gum 0.2%, gluconic acid 1%, aluminum magnesium silicate 1%, isopropanol 50%, titanium dioxide 5%, magnesium bromide 5%, surplus is water.
Wherein azo active dyestuff structural formula are as follows: R1For-CONH2；R2For-CH3；R3For-OH；R4For-NO2；R5For- SO3Na, R6For-H.
The above is only a preferred embodiment of the present invention, it should be pointed out that: for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered It is considered as protection scope of the present invention.

Claims (6)

1. a kind of ethylene oxide sterilizing indicant, it is characterised in that: including following components: azo active dyestuff 0.5%-5%, Thickener 0.2%-10%, organic acid 1%-10%, aluminum magnesium silicate 1%-30%, isopropanol 10%-50%, auxiliary agent 1%- 20%, surplus is water.
2. a kind of ethylene oxide according to claim 1 sterilizing indicant, it is characterised in that: the azo active dyestuff Have following structure formula,
In formula, R1Selected from-H ,-SO3Na ,-Cl ,-CH3,-NO2,-CONH2,-NH2,-N (CH2CH3)2,-NHCH2CH2OH ,- OCH2CH3In any one；
R2, R4, R5, R6Selected from-H ,-OH ,-CH3,-NO2,-SO3Any one in Na ,-COONa；
R3Selected from-H ,-OH ,-CH3In any one.
3. a kind of ethylene oxide according to claim 1 sterilizing indicant, it is characterised in that: the thickener is by being modified One of starch, guar gum, xanthan gum, Arabic gum, pectin, carragheen, gellan gum, locust bean gum, cellulose and gelatin or A variety of compositions.
4. a kind of ethylene oxide according to claim 1 sterilizing indicant, it is characterised in that: the organic acid is by along fourth Enedioic acid, ascorbic acid, caffeic acid, malic acid, ethylenediamine tetra-acetic acid, hydroxyacetic acid, lactic acid, gluconic acid, acetic acid, oxalic acid, One of butyl octanoic acid or a variety of compositions.
5. a kind of ethylene oxide according to claim 1 sterilizing indicant, it is characterised in that: the auxiliary agent is by titanium dioxide Titanium, magnesium bromide, C24-C34Aliphatic ester lotion and its derivative, acrylate polymer emulsion, bromocresol green, bromophenol blue, bromine One or more of cresols, ethyl alcohol composition.
6. a kind of ethylene oxide according to claim 1 sterilizing indicant, it is characterised in that: the acrylate copolymer Lotion includes Neocryl A-2099 or Neocryl A-2092.
CN201811099232.1A 2018-09-20 2018-09-20 A kind of ethylene oxide sterilizing indicant Pending CN109045336A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811099232.1A CN109045336A (en) 2018-09-20 2018-09-20 A kind of ethylene oxide sterilizing indicant

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811099232.1A CN109045336A (en) 2018-09-20 2018-09-20 A kind of ethylene oxide sterilizing indicant

Publications (1)

Publication Number Publication Date
CN109045336A true CN109045336A (en) 2018-12-21

Family

ID=64763349

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811099232.1A Pending CN109045336A (en) 2018-09-20 2018-09-20 A kind of ethylene oxide sterilizing indicant

Country Status (1)

Country Link
CN (1) CN109045336A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111378328A (en) * 2020-04-23 2020-07-07 南京巨鲨显示科技有限公司 Indicator and indicator card for low-temperature ethylene oxide sterilization
CN111410869A (en) * 2020-04-23 2020-07-14 南京巨鲨显示科技有限公司 Indicator and indicator label for low-temperature ethylene oxide sterilization
CN113429828A (en) * 2021-06-22 2021-09-24 山东新华医疗器械股份有限公司 Water-based environment-friendly ethylene oxide sterilization indicating ink and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1367384A (en) * 2001-12-31 2002-09-04 阎宁 Oxirane sterilization chemical indicator composition, its preparation method and application
US20080267811A1 (en) * 2004-03-30 2008-10-30 Sakura Color Products Corporation Ink Composition for Sensing Gas Exposure and Gas Exposure Indicator
CN105885541A (en) * 2016-06-02 2016-08-24 南京巨鲨显示科技有限公司 Ethylene oxide sterilization indicating ink and preparing method thereof
CN106318016A (en) * 2016-08-19 2017-01-11 南京巨鲨显示科技有限公司 Antioxidant ethylene oxide indicative ink

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1367384A (en) * 2001-12-31 2002-09-04 阎宁 Oxirane sterilization chemical indicator composition, its preparation method and application
US20080267811A1 (en) * 2004-03-30 2008-10-30 Sakura Color Products Corporation Ink Composition for Sensing Gas Exposure and Gas Exposure Indicator
CN105885541A (en) * 2016-06-02 2016-08-24 南京巨鲨显示科技有限公司 Ethylene oxide sterilization indicating ink and preparing method thereof
CN106318016A (en) * 2016-08-19 2017-01-11 南京巨鲨显示科技有限公司 Antioxidant ethylene oxide indicative ink

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
冯新德: "《高分子辞典》", 30 June 1998, 中国石化出版社 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111378328A (en) * 2020-04-23 2020-07-07 南京巨鲨显示科技有限公司 Indicator and indicator card for low-temperature ethylene oxide sterilization
CN111410869A (en) * 2020-04-23 2020-07-14 南京巨鲨显示科技有限公司 Indicator and indicator label for low-temperature ethylene oxide sterilization
CN113429828A (en) * 2021-06-22 2021-09-24 山东新华医疗器械股份有限公司 Water-based environment-friendly ethylene oxide sterilization indicating ink and preparation method thereof

Similar Documents

Publication Publication Date Title
CN109045336A (en) A kind of ethylene oxide sterilizing indicant
CN102947698B (en) Indicant for sterilization process
EP1374918B1 (en) Ethylene oxide sterilization indicator inks
JP3290132B2 (en) Composition for chemical indicator and sheet to which the composition is adhered
KR100437566B1 (en) Disinfectant composition comprising alcohol, chlorhexidine and an organic acid
EP1378746B1 (en) Sterilization indicator
JP4109201B2 (en) Hydrogen peroxide indicator, peracetic acid indicator, and method using the same
EP1609488B1 (en) Packaging material with indicator for hydrogen peroxide sterilization
CA2152820C (en) Stable liquid compositions and their use
CN101932342A (en) Sterilizing composition
CN109324040A (en) A kind of hydrogen peroxide plasma sterilizing indicating means
CN107652780A (en) A kind of environment-friendly type color shifting ink of hydrogen peroxide low-temperature plasma sterilizing
CN111471346A (en) Peroxide sterilization water-based organic ink and preparation method and application thereof
CN107868508B (en) Pressure steam sterilization chemical indicator and preparation method thereof
CN113429828A (en) Water-based environment-friendly ethylene oxide sterilization indicating ink and preparation method thereof
CN111410869A (en) Indicator and indicator label for low-temperature ethylene oxide sterilization
CN115637075A (en) Formula and preparation method of pressure steam sterilization indicating ink
JPS5940122B2 (en) Oxydiacetaldehyde substances
CN105638773A (en) Multielement nanometer spray for operating room instrument sterilization and preparing method thereof
CN103796682B (en) Film-forming composition and the application in treatment herpes thereof
CN105885541A (en) Ethylene oxide sterilization indicating ink and preparing method thereof
CN106318016A (en) Antioxidant ethylene oxide indicative ink
CN109645230A (en) A kind of rosin lysate bacteriostatic agent and its preparation method and application
CN109125773B (en) Plasma sterilization indicator
CN102846489B (en) Polyhexamethyleneguanidine hydrochloride iodine medicine bath liquid and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20181221