CN111471353A - Pressure steam sterilization water-based organic ink and preparation method and application thereof - Google Patents

Pressure steam sterilization water-based organic ink and preparation method and application thereof Download PDF

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Publication number
CN111471353A
CN111471353A CN202010494248.3A CN202010494248A CN111471353A CN 111471353 A CN111471353 A CN 111471353A CN 202010494248 A CN202010494248 A CN 202010494248A CN 111471353 A CN111471353 A CN 111471353A
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China
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pressure steam
steam sterilization
organic
ink
acid
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CN202010494248.3A
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Chinese (zh)
Inventor
赵可龙
侯纪民
韩宝福
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Shinva Medical Instrument Co Ltd
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Shinva Medical Instrument Co Ltd
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Priority to CN202010494248.3A priority Critical patent/CN111471353A/en
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/50—Sympathetic, colour changing or similar inks
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/26—Accessories or devices or components used for biocidal treatment
    • A61L2/28—Devices for testing the effectiveness or completeness of sterilisation, e.g. indicators which change colour
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
    • C09D11/033—Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/10—Printing inks based on artificial resins
    • C09D11/106—Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/10—Printing inks based on artificial resins
    • C09D11/106—Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C09D11/107—Printing inks based on artificial resins containing macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds from unsaturated acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D11/00—Inks
    • C09D11/02—Printing inks
    • C09D11/14—Printing inks based on carbohydrates

Abstract

The invention provides pressure steam sterilization water-based organic ink and a preparation method and application thereof, wherein the pressure steam sterilization water-based organic ink is prepared from the following raw materials: 20-50 wt% of a connecting material; 0.1 wt% -2 wt% of organic dye; 5 to 20 weight percent of polysaccharide substance; 5 wt% -20 wt% of an acidity control agent; 30-50 wt% of aqueous system solvent; the aqueous system solvent consists of water and an organic solvent; the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol. Compared with the prior art, the pressure steam sterilization water-based organic ink provided by the invention adopts a water-based system solvent, is matched with other components with specific contents, realizes better interaction, has the advantages of low VOCs (volatile organic compounds) emission, no heavy metal and avoidance of heavy metal pollution, and can be widely applied to printing of products such as indicator cards, indicator labels (adhesive tapes), paper plastic bags and the like, and the color of the products can be changed after pressure steam sterilization, thereby playing an indicating role.

Description

Pressure steam sterilization water-based organic ink and preparation method and application thereof
Technical Field
The invention relates to the technical field of printing ink, in particular to pressure steam sterilization water-based organic printing ink and a preparation method and application thereof.
Background
In the daily work of hospitals, various instruments and tools are often required to be disinfected and sterilized. With the continuous improvement of the awareness of people on health, the demand of various medical supplies is increasing, the products need to be strictly sterilized before use, and the sterilization process also relates to the fields of medical treatment, medicines, foods, sanitary supplies and the like. Therefore, higher demands are made on routine examination and rapid identification of the sterilization effect.
The pressure steam sterilization is a preferred sterilization mode for high-temperature and high-humidity resistant instruments used in hospitals. According to the national sterilization standard of medical instruments, hospital medical care personnel are required to place a corresponding chemical indicator card for sterilization at the same time when the instruments are sterilized every time, observe the color change of the indicator card, and conveniently judge whether set sterilization parameters are reached by the medical care personnel, and package or pack the instruments by using corresponding labels, adhesive tapes, paper-plastic bags and other products; the indication card is used for a corresponding sterilization mode, so that medical personnel can conveniently judge whether sterilization parameters are met; the indicating label (adhesive tape) is used for corresponding sterilization modes, only judges whether the sterilization is carried out or not and belongs to sterilization process indicators; the paper plastic bag is used for wrapping sterilized articles and is provided with indication printing ink, so that a user can conveniently judge whether the sterilized articles are sterilized.
The currently used ink is organic ink, contains a large amount of organic solvent, can cause the discharge of VOCs with very high concentration, and is harmful to the health of production personnel. VOCs have complex components, special smell, permeability, volatilization, fat solubility and other characteristics, and can cause a plurality of uncomfortable symptoms of a human body; it also has toxic, irritant and teratogenic effects, especially benzene, toluene, xylene, formaldehyde are the most harmful to human health, and long-term exposure can cause anemia and leukemia; in addition, VOCs gas can also cause lesions in the respiratory, renal, pulmonary, hepatic, nervous, digestive and hematopoietic systems; with the increase of the concentration of VOCs, the human body can have symptoms of nausea, headache, convulsion, coma and the like.
With the increasing importance of the country on environmental protection, the development of solvent type printing ink is more and more limited, and the discharge and treatment of VOCs are limited; there is therefore a trend to develop corresponding aqueous inks. Meanwhile, as the ink is applied to medical sterilization products, the ink cannot contain heavy metals, particularly lead substances, and the existence of the heavy metals can pollute instruments and cause the risk of infection of patients in the operation process.
Disclosure of Invention
In view of the above, the invention aims to provide pressure steam sterilization aqueous organic ink and a preparation method and application thereof, the color of the pressure steam sterilization aqueous organic ink provided by the invention can be changed after sterilization, so that an indication effect is achieved, the pressure steam sterilization aqueous organic ink has the advantages of low VOCs (volatile organic compounds) emission, no heavy metal and avoidance of heavy metal pollution, and can be widely applied to printing of products such as indication cards, indication labels (adhesive tapes), paper plastic bags and the like.
The invention provides pressure steam sterilization water-based organic ink which is prepared from the following raw materials:
20-50 wt% of a connecting material;
0.1 wt% -2 wt% of organic dye;
5 to 20 weight percent of polysaccharide substance;
5 wt% -20 wt% of an acidity control agent;
30-50 wt% of aqueous system solvent;
the aqueous system solvent consists of water and an organic solvent; the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol.
Preferably, the binder is selected from one or more of shellac resin, aqueous acrylic resin, polyvinyl butyral resin, polyvinyl alcohol, aqueous polyurethane resin, alkyd resin and rosin resin.
Preferably, the organic dye is selected from one or more of congo red, solvent red, disperse red, methylene blue, indigo and prussian blue.
Preferably, the polysaccharide substance is selected from one or more of starch, dextrin, sodium alginate, acacia, agar, agarose, galactan and pectin.
Preferably, the acidity control agent is selected from one or more of phthalic acid, salicylic acid, acrylic acid, adipic acid, formic acid, citric acid, hydrochloric acid, sulfuric acid, phosphoric acid and boric acid.
Preferably, the mass ratio of water to the organic solvent in the aqueous system solvent is 1: (0.5 to 1.5).
The invention also provides a preparation method of the pressure steam sterilization water-based organic ink, which comprises the following steps:
a) dissolving the connecting material in an aqueous system solvent, adding an organic dye, a polysaccharide substance and an acid control agent, and mixing to obtain the pressure steam sterilization aqueous organic ink.
Preferably, the mixing in step a) is performed by stirring; the stirring temperature is 15-35 ℃, the rotating speed is 10-50 r/min, and the time is 3-6 h.
The invention also provides an indicator material for pressure steam sterilization monitoring, comprising:
a substrate;
a color-changeable ink layer compounded on the substrate;
a protective layer compounded on the color-changeable ink layer;
the color-changeable ink layer is formed by the pressure steam sterilization water-based organic ink in the technical scheme.
Preferably, the thickness of the color-changeable ink layer is 3 to 15 filaments.
The invention provides pressure steam sterilization water-based organic ink and a preparation method and application thereof, wherein the pressure steam sterilization water-based organic ink is prepared from the following raw materials: 20-50 wt% of a connecting material; 0.1 wt% -2 wt% of organic dye; 5 to 20 weight percent of polysaccharide substance; 5 wt% -20 wt% of an acidity control agent; 30-50 wt% of aqueous system solvent; the aqueous system solvent consists of water and an organic solvent; the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol. Compared with the prior art, the pressure steam sterilization water-based organic ink provided by the invention adopts a water-based system solvent, is matched with other components with specific contents, realizes better interaction, has the advantages of low VOCs (volatile organic compounds) emission, no heavy metal and avoidance of heavy metal pollution, and can be widely applied to printing of products such as indicator cards, indicator labels (adhesive tapes), paper plastic bags and the like, and the color of the products can be changed after pressure steam sterilization, thereby playing an indicating role.
In addition, the pressure steam sterilization water-based organic ink provided by the invention changes color through a mutation principle, has a visual and accurate indication effect, is clearer and clearer, and avoids subjective factors judged by medical staff; meanwhile, the monitoring is simple and easy to implement, the requirements of different sterilization temperature requirements can be met, and the standard of sterilization application in hospitals is achieved.
Drawings
FIG. 1 is a schematic diagram showing the indicating effect of the pressure steam sterilization chemical indicator card in example 1 of the present invention;
FIG. 2 is a schematic diagram showing the indicating effect of the pressure steam sterilization chemical indicator card in example 2 of the present invention;
fig. 3 is a schematic diagram of the indicating effect of the pressure steam sterilization chemical indicator card in embodiment 3 of the present invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the following embodiments of the present invention, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides pressure steam sterilization water-based organic ink which is prepared from the following raw materials:
20-50 wt% of a connecting material;
0.1 wt% -2 wt% of organic dye;
5 to 20 weight percent of polysaccharide substance;
5 wt% -20 wt% of an acidity control agent;
30-50 wt% of aqueous system solvent;
the aqueous system solvent consists of water and an organic solvent; the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol.
In the present invention, the pressure steam sterilization aqueous organic ink comprises a binder, an organic dye, a polysaccharide substance, an acidity control agent and an aqueous solvent, and preferably comprises a binder, an organic dye, a polysaccharide substance, an acidity control agent and an aqueous solvent. In the present invention, the binder is preferably selected from one or more of shellac resin, aqueous acrylic resin, polyvinyl alcohol, aqueous urethane resin, alkyd resin and rosin resin, more preferably aqueous acrylic resin or polyvinyl alcohol. The source of the binder is not particularly limited in the present invention, and commercially available products of the above shellac resin, aqueous acrylic resin, polyvinyl alcohol, aqueous urethane resin, alkyd resin and rosin resin, which are well known to those skilled in the art, may be used. In the present invention, the pressure steam sterilized aqueous organic ink includes 20 wt% to 50 wt% of the binder, preferably 29 wt% to 39 wt%.
In the present invention, the organic dye is selected from one or more of congo red, solvent red, disperse red, methylene blue, indigo and prussian blue, and more preferably, two of congo red and indigo, two of solvent red and prussian blue, or two of disperse red methylene blue. The source of the organic dye is not particularly limited in the present invention, and commercially available azo dyes as described above, which are well known to those skilled in the art, may be used. In the present invention, the pressure steam sterilized aqueous organic ink includes 0.1 wt% to 2 wt% of the organic dye, preferably 1 wt%. Therefore, the amount of the organic dye used in the pressure steam sterilization water-based organic ink provided by the invention is less.
In the present invention, the polysaccharide substance is preferably selected from one or more of starch, dextrin, sodium alginate, gum arabic, agar, agarose, galactan, and pectin, and more preferably starch, sodium alginate, or gum arabic. The source of the polysaccharide substance in the present invention is not particularly limited, and commercially available products of the above-mentioned starch, dextrin, sodium alginate, gum arabic, agar, agarose, galactan and pectin, which are well known to those skilled in the art, can be used. In the present invention, the pressure steam sterilization aqueous organic ink contains 5 wt% to 20 wt% of polysaccharide substance, preferably 10 wt% to 15 wt%.
In the present invention, the acidity control agent is selected from one or more of phthalic acid, salicylic acid, acrylic acid, adipic acid, formic acid, citric acid, hydrochloric acid, sulfuric acid, phosphoric acid, and boric acid, and more preferably phthalic acid or salicylic acid. The source of the acid-controlling agent in the present invention is not particularly limited, and commercially available products of the above-mentioned organic acids and inorganic acids, which are well known to those skilled in the art, may be used. In the present invention, the pressure steam sterilized aqueous organic ink includes 5 wt% to 20 wt% of the acid control agent, preferably 10 wt% to 15 wt%.
In the present invention, the aqueous system solvent consists of water and an organic solvent; wherein the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol, preferably ethanol, n-propanol or isopropanol. The source of the organic solvent is not particularly limited in the present invention, and commercially available products of the above-mentioned methanol, ethanol, n-propanol, isopropanol and n-butanol, which are well known to those skilled in the art, may be used. In the present invention, the mass ratio of water to the organic solvent in the aqueous system solvent is preferably 1: (0.5 to 1.5), more preferably 1: 1.
compared with the solvent type ink system (comprising high-hazard substances such as toluene, xylene, butyl acetate, cyclohexanone and the like, and all organic solvents) in the prior art, the aqueous system solvent is low in hazard, low in VOCs discharge amount and environment-friendly. In the present invention, the pressure steam sterilized aqueous organic ink includes 30 wt% to 50 wt% of the aqueous system solvent, preferably 40 wt%.
The pressure steam sterilization water-based organic ink provided by the invention adopts a water-based system solvent, is matched with other components with specific contents, realizes better interaction, can be well applied to various printed matters, is very convenient to use, can change in color after pressure steam sterilization, further plays an indicating role, has the advantages of low VOCs (volatile organic compounds) emission, no heavy metal, avoidance of heavy metal pollution and reduction of infection risk, and can be widely applied to printing of products such as indicator cards, indicator labels (adhesive tapes), paper plastic bags and the like.
The invention also provides a preparation method of the pressure steam sterilization water-based organic ink, which comprises the following steps:
a) dissolving the connecting material in an aqueous system solvent, adding an organic dye, a polysaccharide substance and an acid control agent, and mixing to obtain the pressure steam sterilization aqueous organic ink.
In the present invention, the binder, the aqueous solvent, the organic dye, the polysaccharide substance and the acidity control agent are the same as those described in the above technical solution, and are not described herein again.
In the present invention, the mixing mode is preferably stirring, and both the technical schemes of manual stirring or mechanical stirring well known to those skilled in the art can be adopted; the stirring temperature is preferably 15-35 ℃, and more preferably 25 ℃; the rotating speed of the stirring is preferably 10 r/min-50 r/min, and more preferably 30 r/min; the stirring time is preferably 3 to 6 hours, and more preferably 4 to 5 hours.
The preparation method provided by the invention is simple in process, mild in condition and suitable for large-scale industrial production.
The invention also provides an indicator material for pressure steam sterilization monitoring, comprising:
a substrate;
a color-changeable ink layer compounded on the substrate;
a protective layer compounded on the color-changeable ink layer;
the color-changeable ink layer is formed by the pressure steam sterilization water-based organic ink in the technical scheme.
In the present invention, the substrate preferably comprises a coated base paper or a synthetic paper plastic; further obtained indicating materials comprise products such as indicating cards, labels, adhesive tapes, paper-plastic bags and the like.
In the invention, the color-changeable ink layer is formed by the pressure steam sterilization water-based organic ink in the technical scheme; the formation may be by flexographic or gravure printing followed by drying as is well known to those skilled in the art. In the present invention, the temperature for drying is preferably 80 to 120 ℃, more preferably 100 ℃.
In the present invention, the thickness of the variable color ink layer is preferably 3 to 15 filaments, and more preferably 8 to 10 filaments.
In the invention, the protective layer is preferably an organic coating layer, UV gloss oil or an anti-sticking layer; the organic film coating layer preferably comprises a gum PP film or a gum PET film; the color-changeable ink layer is coated by a film coating machine, and the main function is to prevent the color-changeable ink layer from contacting with an instrument and reduce pollution; the anti-sticking layer is preferably prepared by an anti-sticking agent. In the present invention, the thickness of the protective layer is preferably 15 to 62 filaments.
The pressure steam sterilization water-based organic ink provided by the invention changes color by a mutation principle, and the indicating material applying the pressure steam sterilization water-based organic ink has visual and accurate indicating effect, is clearer and clearer, and avoids subjective factors judged by medical staff; meanwhile, the monitoring is simple and easy to implement, the requirements of different sterilization temperature requirements can be met, and the standard of sterilization application in hospitals is achieved.
The invention provides pressure steam sterilization water-based organic ink and a preparation method and application thereof, wherein the pressure steam sterilization water-based organic ink is prepared from the following raw materials: 20-50 wt% of a connecting material; 0.1 wt% -2 wt% of organic dye; 5 to 20 weight percent of polysaccharide substance; 5 wt% -20 wt% of an acidity control agent; 30-50 wt% of aqueous system solvent; the aqueous system solvent consists of water and an organic solvent; the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol. Compared with the prior art, the pressure steam sterilization water-based organic ink provided by the invention adopts a water-based system solvent, is matched with other components with specific contents, realizes better interaction, has the advantages of low VOCs (volatile organic compounds) emission, no heavy metal and avoidance of heavy metal pollution, and can be widely applied to printing of products such as indicator cards, indicator labels (adhesive tapes), paper plastic bags and the like, and the color of the products can be changed after pressure steam sterilization, thereby playing an indicating role.
In addition, the pressure steam sterilization water-based organic ink provided by the invention changes color through a mutation principle, has a visual and accurate indication effect, is clearer and clearer, and avoids subjective factors judged by medical staff; meanwhile, the monitoring is simple and easy to implement, the requirements of different sterilization temperature requirements can be met, and the standard of sterilization application in hospitals is achieved.
To further illustrate the present invention, the following examples are provided for illustration. The raw materials used in the following examples of the present invention are all commercially available products.
Example 1
(1) The formula comprises the following components:
39 wt% of polyvinyl alcohol;
disperse Red 880.5 wt%;
10 wt% of starch;
10 wt% of phthalic acid;
20 wt% of water;
20 wt% of isopropanol;
methylene blue 0.5 wt%.
(2) The preparation process comprises the following steps:
dissolving polyvinyl alcohol in a mixed solution of water and isopropanol, adding disperse red 88 and methylene blue, then respectively adding starch and phthalic acid, and stirring at 25 ℃ and a rotation speed of 30r/min for 4-5 h to obtain the pressure steam sterilization water-based organic ink.
Coating the pressure steam sterilization water-based organic ink provided by the embodiment 1 of the invention on laminating base paper in a flexible board printing mode, wherein the coating speed is 25m/min, the drying temperature is 100 ℃, an ink layer with the thickness of 8-10 filaments is formed, and then a PP film is adopted to carry out laminating on the ink layer, so that the pressure steam sterilization chemical indicator card is obtained; further used for the pressure steam sterilization procedure. The results show that the above-mentioned pressure steam sterilization chemical indicator card changed color from purple to green after being used in the pressure steam sterilization procedure (134 ℃, 4min), as shown in fig. 1.
As can be seen from the figure 1, after the pressure steam sterilization chemical indicator card is used in a pressure steam sterilization process, the color change based on a sudden change principle (non-uniform color change without intermediate color) is realized, the color change based on a non-gradual change principle is realized, the indicating effect is visual and accurate, the clarity is better, and the artificial subjective factors of medical personnel are reduced.
Example 2
(1) The formula comprises the following components:
29 wt% of water-based acrylic resin;
congo red 0.5 wt%;
15 wt% of sodium alginate;
15 wt% of phthalic acid;
20 wt% of water;
20 wt% of ethanol;
0.5 wt% of indigo.
(2) The preparation process comprises the following steps:
dissolving the water-based acrylic resin in a mixed solution of water and ethanol, adding Congo red and indigo, then respectively adding sodium alginate and phthalic acid, and stirring at 25 ℃ and 30r/min for 4-5 h to obtain the pressure steam sterilized water-based organic ink.
Coating the pressure steam sterilization water-based organic ink provided by the embodiment 2 of the invention on laminating base paper in a flexible board printing mode, wherein the coating speed is 25m/min, the drying temperature is 100 ℃, an ink layer with the thickness of 8-10 filaments is formed, and then a PP film is adopted to carry out laminating on the ink layer, so that the pressure steam sterilization chemical indicator card is obtained; further used for the pressure steam sterilization procedure. The results show that the color of the chemical indicator card for pressure steam sterilization changes from purple to green after being used for five types of indicators (121 ℃, 20 min; 135 ℃, 7min) for pressure steam sterilization, which is shown in figure 2.
Example 3
(1) The formula comprises the following components:
29 wt% of water-based acrylic resin;
solvent red 1 wt%;
15 wt% of Arabic gum;
15 wt% of salicylic acid;
20 wt% of water;
20 wt% of n-propanol;
prussian blue 0.5 wt%.
(2) The preparation process comprises the following steps:
dissolving the water-based acrylic resin in a mixed solution of water and n-propanol, adding the solvents of red and prussian blue, respectively adding arabic gum and salicylic acid, and stirring at 25 ℃ and 30r/min for 4-5 h to obtain the pressure steam sterilized water-based organic ink.
Coating the pressure steam sterilization water-based organic ink provided by the embodiment 3 of the invention on laminating base paper in a gravure printing mode, wherein the coating speed is 25m/min, the drying temperature is 100 ℃, an ink layer with the thickness of 8-10 threads is formed, and then a PET film is adopted to carry out laminating on the ink layer, so that the pressure steam sterilization chemical indicator card is obtained; further used for the pressure steam sterilization procedure. The results show that the above-mentioned pressure steam sterilization chemical indicator card changed color from purple to green after being used in the pressure steam sterilization procedure (134 ℃, 18min), as shown in fig. 3.
The pressure steam sterilization water-based organic ink provided by the invention adopts a water-based system, and has the advantage of low VOCs emission; meanwhile, the medical nursing liquid does not contain heavy metals, so that the exposure risk of lead and other metals of medical personnel is avoided, and the infection risk can be reduced; and the color is changed by the mutation principle, so that subjective factors judged by medical personnel are avoided.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein (e.g., non-color shifting dyes may be added to adjust for initial and final color shifts; this is also within the scope of patent protection).

Claims (10)

1. The pressure steam sterilization water-based organic ink is prepared from the following raw materials:
20-50 wt% of a connecting material;
0.1 wt% -2 wt% of organic dye;
5 to 20 weight percent of polysaccharide substance;
5 wt% -20 wt% of an acidity control agent;
30-50 wt% of aqueous system solvent;
the aqueous system solvent consists of water and an organic solvent; the organic solvent is selected from one or more of methanol, ethanol, n-propanol, isopropanol and n-butanol.
2. The pressure steam sterilization aqueous organic ink as claimed in claim 1, wherein the binder is selected from one or more of shellac resin, aqueous acrylic resin, polyvinyl butyral resin, polyvinyl alcohol, aqueous polyurethane resin, alkyd resin and rosin resin.
3. Pressure steam sterilized aqueous organic ink according to claim 1, wherein the organic dye is selected from one or more of Congo Red, solvent Red, disperse Red, methylene blue, indigo and Prussian blue.
4. The pressure steam sterilization aqueous organic ink according to claim 1, wherein the polysaccharide substance is one or more selected from the group consisting of starch, dextrin, sodium alginate, gum arabic, agar, agarose, galactan, and pectin.
5. Pressure steam sterilized aqueous organic ink according to claim 1, wherein the acidity control agent is selected from one or more of phthalic acid, salicylic acid, acrylic acid, adipic acid, formic acid, citric acid, hydrochloric acid, sulfuric acid, phosphoric acid and boric acid.
6. The pressure steam sterilized aqueous organic ink as set forth in claim 1, wherein the aqueous system solvent has a water-organic solvent mass ratio of 1: (0.5 to 1.5).
7. A method for preparing the pressure steam sterilized aqueous organic ink as claimed in any one of claims 1 to 6, comprising the steps of:
a) dissolving the connecting material in an aqueous system solvent, adding an organic dye, a polysaccharide substance and an acid control agent, and mixing to obtain the pressure steam sterilization aqueous organic ink.
8. The method according to claim 7, wherein the mixing in step a) is performed by stirring; the stirring temperature is 15-35 ℃, the rotating speed is 10-50 r/min, and the time is 3-6 h.
9. An indicator material for pressure steam sterilization monitoring, comprising:
a substrate;
a color-changeable ink layer compounded on the substrate;
a protective layer compounded on the color-changeable ink layer;
the color-changeable ink layer is formed by the pressure steam sterilization aqueous organic ink according to any one of claims 1 to 6.
10. The indicator material for pressure steam sterilization monitoring of claim 9, wherein the thickness of the layer of variable color ink is 3 to 15 filaments thick.
CN202010494248.3A 2020-06-03 2020-06-03 Pressure steam sterilization water-based organic ink and preparation method and application thereof Pending CN111471353A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112625506A (en) * 2020-12-28 2021-04-09 天津麒宇科技有限公司 Water-based pressure steam sterilization indicating ink and preparation method thereof
DE102022120672A1 (en) 2021-10-22 2023-04-27 NSTI - Northern Scientific Tech and Integration GmbH Solvent resistant ink for printing on non-absorbent surfaces

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2325670A (en) * 1997-05-30 1998-12-02 Staedtler Fa J S Ink for application of variable colour marks
JP2009031273A (en) * 2007-06-26 2009-02-12 Nichiyu Giken Kogyo Co Ltd Sterilization detection indicator composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2325670A (en) * 1997-05-30 1998-12-02 Staedtler Fa J S Ink for application of variable colour marks
JP2009031273A (en) * 2007-06-26 2009-02-12 Nichiyu Giken Kogyo Co Ltd Sterilization detection indicator composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112625506A (en) * 2020-12-28 2021-04-09 天津麒宇科技有限公司 Water-based pressure steam sterilization indicating ink and preparation method thereof
DE102022120672A1 (en) 2021-10-22 2023-04-27 NSTI - Northern Scientific Tech and Integration GmbH Solvent resistant ink for printing on non-absorbent surfaces

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