CN110938329A - Hydrogen peroxide low-temperature plasma sterilization indicating ink - Google Patents
Hydrogen peroxide low-temperature plasma sterilization indicating ink Download PDFInfo
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- CN110938329A CN110938329A CN201911339997.2A CN201911339997A CN110938329A CN 110938329 A CN110938329 A CN 110938329A CN 201911339997 A CN201911339997 A CN 201911339997A CN 110938329 A CN110938329 A CN 110938329A
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
- C09D11/033—Printing inks characterised by features other than the chemical nature of the binder characterised by the solvent
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
- C09D11/037—Printing inks characterised by features other than the chemical nature of the binder characterised by the pigment
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- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/14—Printing inks based on carbohydrates
Abstract
The invention discloses hydrogen peroxide low-temperature plasma sterilization indicating ink which is prepared from the following raw materials in percentage by weight: 90-98% of color-changing ink and 2-10% of common ink; the color-changing ink is prepared from the following raw materials in percentage by weight: 0.008% -0.1% of crystal violet, 30% -50% of n-propanol, 0.5% -3% of water, 2% -10% of ethyl cellulose adhesive, 13% -35% of n-propyl acetate and 10% -35% of auxiliary agent; the common ink is prepared from the following raw materials in percentage by weight: 20.01 to 4 percent of oil-soluble yellow and 96 to 99.99 percent of normal propyl alcohol. The novel hydrogen peroxide low-temperature plasma sterilization indicating ink provided by the invention is unique in formula and very environment-friendly, uses an n-propanol-water system, and has the characteristics of full color, clear color change, easiness in distinguishing, good stability and the like.
Description
Technical Field
The invention relates to a chemical indicator ink, in particular to a hydrogen peroxide low-temperature plasma sterilization chemical indicator, and belongs to the technical field of medical instrument sterilization detection.
Background
Sterilization and disinfection are indispensable links before medical supplies and instruments are used. Many medical institutions or health service centers select a high-temperature pressure steam sterilization mode to sterilize, heat and sterilize instruments. However, with the continuous development of medical technology, new precision instruments of various special materials and structures are widely used. Since some medical devices cannot withstand the high temperature steam environment, low temperature sterilization techniques have been developed. Currently common low temperature sterilization means include ethylene oxide sterilization, hydrogen peroxide plasma sterilization, and formaldehyde vapor sterilization. Compared with the sterilization mode of ethylene oxide and formaldehyde, hydrogen peroxide sterilization is the most popular low-temperature sterilization technology due to the characteristics of safety and environmental protection (decomposition products are water and oxygen). The method comprises the steps of gasifying hydrogen peroxide to diffuse the hydrogen peroxide to a sterilization cabinet, effectively penetrating and covering the inner surface and the outer surface of the medical instrument, and then sterilizing the medical instrument by utilizing the strong oxidizing property of the hydrogen peroxide. The sterilization indicator is used to monitor whether the sterilization process is sufficiently effective. As a common sterilization monitoring technology, a chemical indicator generally adopts the principle that color-changing ink changes color before and after sterilization to indicate the sterilization process.
At present, chemical indicators for hydrogen peroxide plasma sterilization generally have the defects of poor color change stability, difficult color change, complex ink system, high toxicity of used solvents, heavy metal elements and the like. For example, a hydrogen peroxide indicator is available, which requires a combination of at least one transition metal salt and a colorant to achieve a significant color change, and uses methanol, which is highly toxic, as a solvent, and is likely to cause a significant hazard to manufacturing personnel, medical staff, patients, and the environment when put into production and used in large quantities. And the adopted solvent system of the hydrogen peroxide sterilization plasma color-changing ink contains tri-n-propanolamine which has strong smell and certain irritant ammonia odor, and the ink also has great damage to human bodies and the environment.
Therefore, how to avoid the defects that the existing product is not environment-friendly, has adverse effect on human bodies, has stable color change performance, is difficult to judge monitoring results, has misjudgment on the monitoring results and the like is a problem to be solved in the industry.
Disclosure of Invention
The invention provides novel hydrogen peroxide low-temperature plasma sterilization indicating ink which is unique and very environment-friendly in formula, uses an n-propanol-water system, and has the characteristics of full color, clear color change, easiness in distinguishing, good stability and the like, and aims to solve the problems that the existing product is not environment-friendly, has adverse effect on human bodies, is unstable in color change performance, is not easy to judge monitoring results, and can make misjudgment on the monitoring results.
The invention provides hydrogen peroxide low-temperature plasma sterilization indicating ink which is prepared from the following raw materials in percentage by weight:
90-98% of color-changing ink and 2-10% of common ink;
wherein:
the color-changing printing ink is prepared from the following raw materials in percentage by weight:
0.008% -0.1% of crystal violet (CAS number is 548-62-9), 30% -50% of n-propanol, 0.5% -3% of water, 2% -10% of ethyl cellulose adhesive, 13% -35% of n-propyl acetate and 10% -35% of auxiliary agent;
the common ink is prepared from the following raw materials in percentage by weight:
0.01-4% of oil-soluble yellow 2 (CAS number 60-11-7) and 96-99.99% of n-propanol.
Preferably, the auxiliary agent is prepared from the following raw materials in percentage by weight:
30-45% of plasticizer, 2-9% of defoaming agent, 14-25% of light stabilizer, 7-20% of ultraviolet absorbent, 1-10% of antioxidant and 15-23% of flatting agent.
Preferably, the plasticizer is one or a combination of two of propylene glycol adipate polyester, dioctyl phthalate or dioctyl adipate; the defoaming agent is one or the combination of two of defoaming agent B-461, defoaming agent B-462 or defoaming agent B-456; the light stabilizer is one or the combination of two of light stabilizer 622, light stabilizer 770 and light stabilizer 783; the ultraviolet absorbent is one or the combination of two of UV-326, UV-9 or UV-531; the antioxidant is one or a combination of two of antioxidant 300, antioxidant 1010 and antioxidant 1076; the leveling agent is one or a combination of two of propylene glycol, butanediol, sorbitol, glycerol or polyethylene glycol.
The invention also provides a preparation method of the hydrogen peroxide low-temperature plasma sterilization indicating ink, which comprises the following steps:
step 1: preparation of color-changing inks
Weighing the raw materials according to the proportion of the color-changing printing ink, uniformly mixing the n-propanol and the water, adding the crystal violet pigment, stirring by using a glass rod to completely dissolve the crystal violet pigment, adding the n-propyl acetate, and uniformly stirring by using the glass rod to obtain a dark blue solution; adding ethyl cellulose and an auxiliary agent into the dark blue solution, and stirring the mixture on a stirrer to obtain the color-changing printing ink with uniform brightness and good leveling property, wherein the viscosity of the color-changing printing ink is 70-100 mPa.s;
step 2: preparation of ordinary ink
Mixing the oil-soluble yellow 2 with n-propanol, and stirring with a glass rod to dissolve completely to obtain common ink of a yellow solution;
and step 3: preparation of hydrogen peroxide low-temperature plasma sterilization indicating ink
And adding the common ink into the color-changing ink, placing the color-changing ink on a stirrer, stirring to obtain a blue adhesive, and filtering the blue adhesive to obtain the hydrogen peroxide low-temperature plasma sterilization indicating ink with uniform purity and brightness when the viscosity value reaches 70-120 mPa.s.
Preferably, in the step 1, the stirrer is used for stirring at a rotating speed of 450r/min-600r/min for 10min-25 min.
Preferably, the stirring time of the glass rod is 2min-10 min.
Preferably, in the step 3, the stirrer is stirred and dissolved for 15min to 30min at the rotating speed of 500r/min to 650 r/min.
Compared with the prior art, the invention has the advantages that:
1. the invention adopts the normal propyl alcohol-water as a solvent system, and the gas volatilized in the preparation process can not cause great damage to the environment pollution and the human health.
2. The indicating ink disclosed by the invention is bright and full, strong in adhesive force, good in flexibility, high in reaction sensitivity with hydrogen peroxide, thorough in color change, and good in stability before and after color change, and can be widely applied to indicating cards, sterilization bags, indicating adhesive tapes and indicating labels.
3. The indicating ink disclosed by the invention is simple in preparation method, high in benefit and suitable for large-scale popularization and production.
4. The indicating ink disclosed by the invention has the function of monitoring the sterilization of practical medical instruments, and can be used for rapidly and accurately judging results.
5. The indicating ink can be printed on substrates such as sterilization bags, white laminated printing materials and the like to manufacture corresponding sterilization monitoring products.
Drawings
FIG. 1 is a schematic view of a sterilization indicator card printed with the indicator ink of the present invention for displaying sterilization;
FIG. 2 is a schematic diagram showing the blue ink on the left indicator card changing to yellow on the right indicator card after vaporizing hydrogen peroxide.
Detailed Description
The present invention will be described in further detail by way of examples, which are provided only for illustrating the present invention and are not to be construed as limiting the scope of the present invention.
The hydrogen peroxide low-temperature plasma sterilization indicating ink provided by the invention mainly comprises two parts, namely color-changing ink and common ink. The crystal violet in the color-changing ink becomes colorless after being oxidized by hydrogen peroxide, and the oil-soluble yellow 2 in the common ink cannot be oxidized and remains. Through the configuration of different raw materials of the following examples, hydrogen peroxide plasma sterilization indicating inks with slightly different performances can be prepared.
Example 1
In this embodiment, the hydrogen peroxide low-temperature plasma sterilization indicating ink is specifically prepared from the following raw materials in percentage by weight:
the color-changing ink is 90% and the ordinary ink is 10%. Wherein the content of the first and second substances,
color-changing ink: 0.05% of crystal violet (CAS number 548-62-9), 35% of n-propanol, 2% of water, 10% of ethyl cellulose, 20% of n-propyl acetate and 32.95% of auxiliary agent. The auxiliary agent consists of 40 percent of plasticizer, 4.4 percent of defoaming agent, 17 percent of light stabilizer, 14 percent of ultraviolet absorbent, 7.1 percent of antioxidant and 17.5 percent of flatting agent.
Ordinary ink: 0.05 percent of oil-soluble yellow 2 (CAS number 60-11-7) and 99.95 percent of n-propanol.
Weighing the raw materials according to the proportion, uniformly mixing anhydrous n-propanol and water at the normal temperature of 20-30 ℃, adding the crystal violet pigment, stirring for 6min by using a glass rod to completely dissolve the crystal violet pigment, then adding n-propyl acetate, and stirring for 3min by using the glass rod to obtain a dark blue solution. And adding the ethyl cellulose and the auxiliary agent into the dark blue solution, and placing the solution on a stirrer to be dissolved for 12min at the rotating speed of 550r/min to obtain the color-changing ink with uniform brightness and good leveling property and the viscosity value of 75 mPa.s.
And (3) mixing the oil-soluble yellow 2 with the anhydrous n-propanol for preparing the common ink at the normal temperature of 20-28 ℃, and stirring for 8min by using a glass rod to completely dissolve the oil-soluble yellow 2 to obtain the common ink of a yellow solution.
Adding the common ink into the color-changing ink in proportion at the normal temperature of 20-28 ℃, putting the color-changing ink on a stirrer to be dissolved for 20min at the rotating speed of 650r/min to obtain a blue adhesive, and filtering the blue adhesive to obtain the hydrogen peroxide low-temperature plasma sterilization indicating ink with uniform purity and brightness when the viscosity value reaches 115 mPa.s.
Example 2
In this embodiment, the hydrogen peroxide low-temperature plasma sterilization indicating ink is specifically prepared from the following raw materials in percentage by weight:
the color-changing ink is 95% and the ordinary ink is 5%. Wherein:
color-changing ink: crystal violet (CAS number 548-62-9) 0.07%, n-propanol 45%, water 1.5%; 5% of ethyl cellulose adhesive; 25% of n-propyl acetate and 23.43% of an auxiliary agent (35% of a plasticizer, 8% of a defoaming agent, 23% of a light stabilizer, 10% of an ultraviolet absorber, 4% of an antioxidant and 20% of a leveling agent);
ordinary ink: 1% of oil-soluble yellow 2 (CAS number 60-11-7), 99% of n-propanol;
the preparation steps are the same as those of the example 1, and different stirring speeds and time are selected to obtain the color-changing ink with the viscosity value of 80 mPa.s, uniform brightness and good leveling property.
Example 3
In this embodiment, the hydrogen peroxide low-temperature plasma sterilization indicating ink is specifically prepared from the following raw materials in percentage by weight:
the color-changing ink was 97.5% and the ordinary ink was 2.5%. Wherein:
color-changing ink: crystal violet (CAS number 548-62-9) 0.085%, n-propanol 41%, water 2.2%; 7.8% of ethyl cellulose adhesive; 20% of n-propyl acetate, 28.915% of auxiliary agents (33% of plasticizer, 2.4% of defoaming agent, 14.8% of light stabilizer, 18% of ultraviolet absorber, 9.3% of antioxidant and 22.5% of flatting agent);
ordinary ink: 2.5% of oil-soluble yellow 2 (CAS number 60-11-7), and 97.5% of n-propanol;
the preparation steps are the same as those of the example 1, and different speeds and times are selected to obtain the color-changing ink with the viscosity value of 93 mPa.s, uniform brightness and good leveling property.
In addition to the above examples, the indicating ink of the present invention may be formulated from the following raw materials in the following table 1 by weight percent:
TABLE 1
The color-changing ink is prepared from the following raw materials in percentage by weight in the following table 2:
TABLE 2
Wherein, the common ink is prepared from the following raw materials in percentage by weight in the following table 3:
TABLE 3
The performance test of the hydrogen peroxide low-temperature plasma indicating ink disclosed by the embodiment of the invention comprises the following steps:
the basic physicochemical property test shows that the results of the performance tests of the example products such as sterilization time, discoloration effect, adhesion, stability and the like according to the CSSD test standard are shown in Table 4:
TABLE 4 energy measurement results of hydrogen peroxide plasma sterilization indicating ink
Therefore, the hydrogen peroxide plasma sterilization indicating ink prepared by the method completely meets the standard requirements of GB-18282.1-2015 and BS EN ISO 11140-1: 2014.
The crystal violet in the indicating ink is easy to dissolve in an organic solvent or water, and as shown in figures 1 and 2, the indicating ink can be prepared into an oily or aqueous indicating ink, and can be easily colorless under illumination or strong oxidants. The ink is prepared with some specific assistants and then printed on a sterilization bag or a white printing material, so that the ink can play a role of being easy to change color under the action of vaporized hydrogen peroxide strong oxidant, and the yellow color of the oil-soluble yellow 2 after printing is kept before and after sterilization under the strong oxidant. Therefore, two colors can indicate the sterilization result of the medical instrument, the two pigments are very suitable as important pigments of the indicating ink, and the prepared indicating card is preferably stored in a dark place.
The above-mentioned embodiments are mainly intended to illustrate the inventive concept, and it should be noted that those skilled in the art may make various changes and modifications without departing from the inventive concept, and all such changes and modifications are within the scope of the present invention.
Claims (7)
1. A hydrogen peroxide low-temperature plasma sterilization indicating ink is prepared from the following raw materials in percentage by weight:
90-98% of color-changing ink and 2-10% of common ink;
wherein:
the color-changing printing ink is prepared from the following raw materials in percentage by weight:
0.008% -0.1% of crystal violet, 30% -50% of n-propanol, 0.5% -3% of water, 2% -10% of ethyl cellulose adhesive, 13% -35% of n-propyl acetate and 10% -35% of auxiliary agent;
the common ink is prepared from the following raw materials in percentage by weight:
20.01 to 4 percent of oil-soluble yellow and 96 to 99.99 percent of normal propyl alcohol.
2. The indicating ink of claim 1, wherein the assistant is prepared from the following raw materials in percentage by weight:
30-45% of plasticizer, 2-9% of defoaming agent, 14-25% of light stabilizer, 7-20% of ultraviolet absorbent, 1-10% of antioxidant and 15-23% of flatting agent.
3. The indicating ink of claim 2 wherein the plasticizer is one or a combination of propylene glycol adipate polyester, dioctyl phthalate or dioctyl adipate; the defoaming agent is one or the combination of two of defoaming agent B-461, defoaming agent B-462 or defoaming agent B-456; the light stabilizer is one or the combination of two of light stabilizer 622, light stabilizer 770 and light stabilizer 783; the ultraviolet absorbent is one or the combination of two of UV-326, UV-9 or UV-531; the antioxidant is one or a combination of two of antioxidant 300, antioxidant 1010 and antioxidant 1076; the leveling agent is one or a combination of two of propylene glycol, butanediol, sorbitol, glycerol or polyethylene glycol.
4. A method for preparing the hydrogen peroxide low-temperature plasma sterilization indicating ink as defined in any one of claims 1 to 3, comprising the steps of:
step 1: preparation of color-changing inks
Weighing the raw materials according to the proportion of the color-changing ink, uniformly mixing n-propanol and water, adding a crystal violet pigment, stirring with a glass rod to completely dissolve the crystal violet pigment, adding n-propyl acetate, stirring and mixing with the glass rod to obtain a dark blue solution, adding ethyl cellulose and an auxiliary agent into the dark blue solution, and stirring on a stirrer to obtain the color-changing ink with uniform brightness and good leveling property, wherein the viscosity of the color-changing ink is 70-100 mPa.s;
step 2: preparation of ordinary ink
Mixing the oil-soluble yellow 2 with n-propanol, and stirring with a glass rod to dissolve completely to obtain common ink of a yellow solution;
and step 3: preparation of hydrogen peroxide low-temperature plasma sterilization indicating ink
And adding the common ink into the color-changing ink, placing the color-changing ink on a stirrer, stirring to obtain a blue adhesive, and filtering the blue adhesive to obtain the hydrogen peroxide low-temperature plasma sterilization indicating ink with uniform purity and brightness when the viscosity value reaches 70-120 mPa.s.
5. The method according to claim 4, wherein in the step 1, the mixer is operated at a rotation speed of 450 to 600r/min for 10 to 25 min.
6. The method of claim 4, wherein the glass rod stirring time is 2min to 10 min.
7. The method according to claim 4, wherein in the step 3, the mixer is operated at a rotation speed of 500 to 650r/min for 15 to 30 min.
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| CN109125773A (en) * | 2018-08-30 | 2019-01-04 | 广州梵康材料科技有限公司 | A kind of plasma sterilization indicator |
| CN109324040A (en) * | 2018-08-30 | 2019-02-12 | 广州梵康材料科技有限公司 | A kind of hydrogen peroxide plasma sterilizing indicating means |
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2019
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105295553A (en) * | 2015-11-05 | 2016-02-03 | 广州市卫信麦迪医疗用品有限公司 | Hydrogen peroxide plasma sterilization discoloration ink and preparation method thereof |
| CN107286752A (en) * | 2017-07-04 | 2017-10-24 | 厦门麓山新材料科技有限公司 | A kind of vapor sensitive color shifting ink and wet sensitive antifalsification label |
| CN107652780A (en) * | 2017-09-01 | 2018-02-02 | 深圳洁康医疗器材有限公司 | A kind of environment-friendly type color shifting ink of hydrogen peroxide low-temperature plasma sterilizing |
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Application publication date: 20200331 |