CN115232513A - Water-soluble indicating ink for peroxide sterilization and preparation method and application thereof - Google Patents

Abstract

The invention discloses water-soluble indicating ink for peroxide sterilization, which is prepared from the following raw materials in percentage by weight: 18-30% of resin binder; 2-3% of a color-changing agent; 3-9% of yellow pigment; 3-6% of an accelerant; 1-2% of an auxiliary agent; 50-70% of solvent. Firstly, adding a resin binder into a mixture of distilled water and ethanol, and stirring and dissolving by using an electric stirrer; then adding the color-changing agent into the resin binder solution, and uniformly stirring; adding the yellow pigment and then continuously stirring uniformly; finally, the accelerant and the auxiliary agent are sequentially added and stirred for 1 hour. The peroxide sterilization water-soluble indicating ink is applied to a peroxide low-temperature plasma sterilization indicating article, in the peroxide sterilization process, the accelerator and the color-changing agent act together, the indicating color is changed from red to yellow in a sudden change mode, and the indicating effect is visual and accurate.

Description

Water-soluble indicating ink for peroxide sterilization and preparation method and application thereof

Technical Field

The invention relates to the field of chemical ink for medical sterilization, in particular to water-soluble indicating ink for hydrogen peroxide and peracetic acid sterilization, and a preparation method and application thereof.

Background

With the rapid development of medical technology, many precise medical instruments such as thoracoscopes, laparoscopes and the like cannot be sterilized by using a conventional pressure steam sterilization mode. The peroxide low-temperature plasma sterilization technology taking hydrogen peroxide and peracetic acid as sterilizing agents is used as a sterilizing means of sterilization departments in hospital disinfection supply centers, and is increasingly widely applied. The sterilization technology is mainly used for medical instruments which are not high in temperature resistance, particularly precise medical instruments. Such low-temperature sterilization techniques using peroxide sterilants have a short sterilization cycle, and the final products of the sterilants are water and oxygen, which is highly favored in the field of disinfection.

For such low temperature sterilization techniques, it is often necessary to monitor the sterilization of instruments by the introduction of chemical indicators. Most of chemical indicator printing ink used for low-temperature sterilization in the market at present is organic printing ink, a large amount of organic chemical reagents are required to be used for blending, certain harm is generated to the environment, and the treatment cost of the waste printing ink is relatively high.

Disclosure of Invention

Aiming at the defects of the existing sterilization indicating ink technology, the invention aims to provide the peroxide sterilization water-soluble indicating ink which can be simultaneously used for sterilization monitoring of two main-stream peroxide sterilizing agents, namely hydrogen peroxide and peracetic acid, and has the advantages of visual and accurate result, no toxicity and harmlessness and capability of effectively avoiding the harm of an organic solvent to the environment.

In order to achieve the purpose, the water-soluble indicating ink for peroxide sterilization is prepared from the following raw materials in percentage by weight:

wherein:

the resin binder is one or a mixture of more of waterborne acrylic resin, polyvinyl alcohol, water-soluble phenolic resin or water-soluble rosin resin.

The color-changing agent is one of basic fuchsin, bromopyrogallol red and reduction red 6B. The color-changing agent presents carmine color, and is compounded with yellow pigment to display red color which is convenient to identify.

The yellow pigment is one of sun-proof yellow G, benzidine yellow or lemon yellow.

The accelerant is one or a mixture of more of ammonium nitrate, ammonium sulfate, ammonium molybdate, ammonium bicarbonate or ammonium chromate. During the peroxide sterilization process, the accelerator and the color-changing agent act together to indicate that the color is suddenly changed from red to yellow.

The auxiliary agent is one of polyethylene glycol 200, polyethylene glycol 400 or polyethylene glycol 600.

The solvent is a mixture of distilled water and absolute ethyl alcohol.

The preparation method of the peroxide sterilization water-soluble indicating ink comprises the following steps:

(1) Adding the resin binder into a mixture of distilled water and ethanol, and stirring and dissolving by using an electric stirrer;

(2) Adding a color-changing agent into the resin binder solution obtained in the step (1), and uniformly stirring;

(3) Adding the yellow pigment and then continuously stirring uniformly;

(4) The accelerator and the auxiliary agent are added in turn and stirred for 1 hour.

The total stirring time is about 6 hours, and the stirring time is required to be prolonged or reduced according to the preparation amount. At the beginning of the study, all the materials were mixed together, and it was difficult to obtain a uniform mixed solution even with continuous stirring. Through constantly testing discovery earlier dissolve the resin binder, then add other raw materialss step by step, can effectively be with the material misce bene of different solubilities, avoid adding in step and appear being difficult to the problem of dissolving.

The water-soluble indication ink for peroxide sterilization is specifically applied to flexography or silk-screen printing to prepare a peroxide low-temperature plasma sterilization chemical monitoring product in the form of an indication card, an indication label or a Tyvek paper-plastic packaging bag.

Compared with the prior art, the invention has the following positive and beneficial results:

(1) The preparation method of the ink is simple and convenient to operate, large-scale grinding equipment is not needed, and the practical application method is simple and feasible.

(2) The peroxide sterilization chemical water-soluble indicating ink prepared by the invention is non-toxic and harmless, does not harm the environment, belongs to environment-friendly ink, is cheap and easily available in raw materials, and is suitable for mass production.

(3) The chemical monitoring product printed by the ink has obvious color change of the indicating ink before and after hydrogen peroxide or peracetic acid sterilization, and the result is visual and accurate.

(4) The peroxide Sterilization Chemical water-soluble indicating ink prepared by the invention can be used for manufacturing Sterilization Chemical indicators in different monitoring categories according to national standard GB18282.1 general rule of medical health product Sterilization Chemical indicator Part 1 and international standard ISO11140-1 2014 of Sterilization of health care products-Chemical indicators-Part 1.

Drawings

Fig. 1 is a color change chart of the chemical indicating label according to example 1 before and after sterilization.

Fig. 2 is a color change chart of the chemical indicating label according to example 2 before and after sterilization.

Fig. 3 is a graph showing a color change of the chemical indicator label according to example 3 before and after sterilization.

Fig. 4 is a graph showing the color change of the chemical indicating label related to comparative example 1 before and after sterilization.

Fig. 5 is a graph showing the color change of the chemical indicating label related to comparative example 2 before and after sterilization.

Detailed Description

The present invention is further described in detail by the following examples, but the technical content of the examples is illustrative and not restrictive, and the scope of the present invention should not be limited thereby. The reagents and materials are commercially available, unless otherwise specified.

Example 1

The peroxide sterilization chemical water-soluble indicating ink is prepared from the following raw materials in percentage by weight:

and (3) printing indication ink on the PVC paper by adopting a water-based silk screen printing mode to produce the chemical indication card. After the indicator card is applied to a hydrogen peroxide sterilization program, under the sterilization conditions that the concentration of hydrogen peroxide is 2.3mg/L and the sterilization temperature is 50 ℃, the color of the chemical indicating ink on the indicator card is changed from red to yellow, so that the color change effect can be accurately and visually indicated, the misjudgment caused by subjective factors of medical workers is reduced, and the specific color change comparison is shown in figure 1.

Example 2

The peroxide sterilization chemical water-soluble indicating ink is prepared from the following raw materials in percentage by weight:

and printing indicating ink on the PVC label paper by adopting a water-based silk screen printing mode to produce the chemical indicating label. After the sterilization label is applied to a peroxyacetic acid sterilization program, the color of the chemical indicating ink on the indicating label is changed from red to yellow under the sterilization conditions that the concentration of peroxyacetic acid is 2.3mg/L and the sterilization temperature is 50 ℃, the color change effect can be accurately and visually indicated, medical workers can be helped to quickly judge whether the instrument bag is sterilized, and the specific color change comparison is shown in figure 2.

Example 3

The peroxide sterilization chemical water-soluble indicating ink is prepared from the following raw materials in percentage by weight:

and printing indication ink on the Tyvek paper by adopting a flexography mode, and using the indication ink for producing paper-plastic packaging bags. After the chemical indication ink is applied to a hydrogen peroxide sterilization program, the color of the chemical indication ink on the paper-plastic packaging bag is changed from red to yellow under the sterilization conditions that the concentration of hydrogen peroxide is 2.3mg/L and the sterilization temperature is 50 ℃, the color change effect can be accurately and visually indicated, the misjudgment caused by subjective factors of medical staff is reduced, and the specific color change comparison is shown in a graph 3.

Comparative example 1 (comparison with example 1):

the peroxide sterilization chemical water-soluble indicating ink is prepared from the following raw materials in percentage by weight:

and printing indication ink on the PVC paper by adopting a water-based silk screen printing mode to produce the chemical indication card. After the indicator card is applied to a hydrogen peroxide sterilization procedure, the color of the chemical indicating ink on the indicator card is changed from carmine to colorless under the sterilization condition that the hydrogen peroxide concentration is 2.3mg/L and the sterilization temperature is 50 ℃, and the specific color change contrast is shown in figure 4. The indicating ink after sterilization becomes colorless after removing the yellow pigment, and is slightly inferior in practicality compared with the color change visible to the naked eye during the actual use, so that it is necessary to add the yellow pigment as the end point indicating color.

Comparative example 2 (comparison with example 1):

the peroxide sterilization chemical water-soluble indicating ink is prepared from the following raw materials in percentage by weight:

and (3) printing indication ink on the PVC paper by adopting a water-based silk screen printing mode to produce the chemical indication card. After the indicator card is applied to a hydrogen peroxide sterilization program, the color of the chemical indicating ink on the indicator card is basically not obviously changed but slightly lightened under the sterilization condition that the hydrogen peroxide concentration is 2.3mg/L and the sterilization temperature is 50 ℃, and the specific color change comparison is shown in a graph 5. Indicating that the indicator ink lost its color change properties after removal of the accelerator.

Claims (3)

1. The water-soluble indicating ink for peroxide sterilization is characterized by being prepared from the following raw materials in percentage by weight:

wherein:

the resin binder is one or a mixture of more of waterborne acrylic resin, polyvinyl alcohol, water-soluble phenolic resin or water-soluble rosin resin;

the color-changing agent is one of basic fuchsin, bromopyrogallol red and vat red 6B;

the yellow pigment is one of sun-proof yellow G, benzidine yellow or lemon yellow;

the accelerant is one or a mixture of more of ammonium nitrate, ammonium sulfate, ammonium molybdate, ammonium bicarbonate or ammonium chromate;

the auxiliary agent is one of polyethylene glycol 200, polyethylene glycol 400 or polyethylene glycol 600;

the solvent is a mixture of distilled water and absolute ethyl alcohol.

2. A method for preparing the peroxide sterilization water-soluble indicating ink as defined in claim 1, which comprises the following steps:

(1) Adding the resin binder into a mixture of distilled water and ethanol, and stirring and dissolving by using an electric stirrer;

(2) Adding a color-changing agent into the resin binder solution obtained in the step (1), and uniformly stirring;

(3) Adding the yellow pigment and then continuously stirring uniformly;

(4) The accelerator and the auxiliary agent are added in turn and stirred for 1 hour.

3. Use of the peroxide sterilization water-soluble indicator ink of claim 1 in a peroxide low temperature plasma sterilization indicator article.

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