CN114921131A - Low-temperature steam formaldehyde sterilization indicating ink composition, preparation method thereof and indicator - Google Patents
Low-temperature steam formaldehyde sterilization indicating ink composition, preparation method thereof and indicator Download PDFInfo
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- CN114921131A CN114921131A CN202210739959.1A CN202210739959A CN114921131A CN 114921131 A CN114921131 A CN 114921131A CN 202210739959 A CN202210739959 A CN 202210739959A CN 114921131 A CN114921131 A CN 114921131A
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- temperature steam
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- steam formaldehyde
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- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 title claims abstract description 246
- 230000001954 sterilising effect Effects 0.000 title claims abstract description 111
- 238000004659 sterilization and disinfection Methods 0.000 title claims abstract description 106
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- 238000002360 preparation method Methods 0.000 title abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920005989 resin Polymers 0.000 claims abstract description 16
- 239000011347 resin Substances 0.000 claims abstract description 16
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 12
- 239000000975 dye Substances 0.000 claims description 26
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 238000002156 mixing Methods 0.000 claims description 8
- 239000000758 substrate Substances 0.000 claims description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000004814 polyurethane Substances 0.000 claims description 6
- 229920005749 polyurethane resin Polymers 0.000 claims description 6
- 239000002562 thickening agent Substances 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 5
- IQFVPQOLBLOTPF-HKXUKFGYSA-L congo red Chemical compound [Na+].[Na+].C1=CC=CC2=C(N)C(/N=N/C3=CC=C(C=C3)C3=CC=C(C=C3)/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)N)=CC(S([O-])(=O)=O)=C21 IQFVPQOLBLOTPF-HKXUKFGYSA-L 0.000 claims description 5
- 239000011975 tartaric acid Substances 0.000 claims description 5
- 235000002906 tartaric acid Nutrition 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 4
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 4
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 claims description 4
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims description 4
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- 239000001045 blue dye Substances 0.000 claims description 3
- -1 direct Red Chemical compound 0.000 claims description 3
- YTLYLLTVENPWFT-UPHRSURJSA-N (Z)-3-aminoacrylic acid Chemical compound N\C=C/C(O)=O YTLYLLTVENPWFT-UPHRSURJSA-N 0.000 claims description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 claims description 2
- FHNINJWBTRXEBC-UHFFFAOYSA-N Sudan III Chemical compound OC1=CC=C2C=CC=CC2=C1N=NC(C=C1)=CC=C1N=NC1=CC=CC=C1 FHNINJWBTRXEBC-UHFFFAOYSA-N 0.000 claims description 2
- 239000001361 adipic acid Substances 0.000 claims description 2
- 235000011037 adipic acid Nutrition 0.000 claims description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 2
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 2
- 239000004327 boric acid Substances 0.000 claims description 2
- 235000015165 citric acid Nutrition 0.000 claims description 2
- TUXJTJITXCHUEL-UHFFFAOYSA-N disperse red 11 Chemical compound C1=CC=C2C(=O)C3=C(N)C(OC)=CC(N)=C3C(=O)C2=C1 TUXJTJITXCHUEL-UHFFFAOYSA-N 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 235000019253 formic acid Nutrition 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- KCTAWXVAICEBSD-UHFFFAOYSA-N prop-2-enoyloxy prop-2-eneperoxoate Chemical compound C=CC(=O)OOOC(=O)C=C KCTAWXVAICEBSD-UHFFFAOYSA-N 0.000 claims description 2
- ALLOLPOYFRLCCX-UHFFFAOYSA-N chembl1986529 Chemical compound COC1=CC=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 ALLOLPOYFRLCCX-UHFFFAOYSA-N 0.000 claims 1
- NHXXLZBKTKNTEF-UHFFFAOYSA-N chembl1997306 Chemical compound CC1=CC=CC(N=NC=2C(=CC(=CC=2)N=NC=2C3=CC=CC=C3C=CC=2O)C)=C1 NHXXLZBKTKNTEF-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000003848 UV Light-Curing Methods 0.000 abstract description 4
- 238000010669 acid-base reaction Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 description 15
- 239000002390 adhesive tape Substances 0.000 description 9
- 238000007639 printing Methods 0.000 description 8
- JBTHDAVBDKKSRW-UHFFFAOYSA-N chembl1552233 Chemical compound CC1=CC(C)=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 JBTHDAVBDKKSRW-UHFFFAOYSA-N 0.000 description 6
- 229940073450 sudan red Drugs 0.000 description 6
- 239000004952 Polyamide Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 229920002647 polyamide Polymers 0.000 description 5
- 239000012855 volatile organic compound Substances 0.000 description 5
- 239000004925 Acrylic resin Substances 0.000 description 4
- 229920000178 Acrylic resin Polymers 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- JAOZKJMVYIWLKU-UHFFFAOYSA-N sodium 7-hydroxy-8-[(4-sulfonaphthalen-1-yl)diazenyl]naphthalene-1,3-disulfonic acid Chemical compound C1=CC=C2C(=C1)C(=CC=C2S(=O)(=O)O)N=NC3=C(C=CC4=CC(=CC(=C43)S(=O)(=O)O)S(=O)(=O)O)O.[Na+] JAOZKJMVYIWLKU-UHFFFAOYSA-N 0.000 description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 3
- SJEYSFABYSGQBG-UHFFFAOYSA-M Patent blue Chemical compound [Na+].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=CC=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 SJEYSFABYSGQBG-UHFFFAOYSA-M 0.000 description 3
- YVNQAIFQFWTPLQ-UHFFFAOYSA-O [4-[[4-(4-ethoxyanilino)phenyl]-[4-[ethyl-[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylidene]-3-methylcyclohexa-2,5-dien-1-ylidene]-ethyl-[(3-sulfophenyl)methyl]azanium Chemical compound C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C(=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S(O)(=O)=O)C)C=2C(=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S(O)(=O)=O)C)C=C1 YVNQAIFQFWTPLQ-UHFFFAOYSA-O 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 238000001723 curing Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 239000000987 azo dye Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 241001474374 Blennius Species 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- NKLPQNGYXWVELD-UHFFFAOYSA-M coomassie brilliant blue Chemical compound [Na+].C1=CC(OCC)=CC=C1NC1=CC=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C=CC(=CC=2)N(CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=C1 NKLPQNGYXWVELD-UHFFFAOYSA-M 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- NYGZLYXAPMMJTE-UHFFFAOYSA-M metanil yellow Chemical group [Na+].[O-]S(=O)(=O)C1=CC=CC(N=NC=2C=CC(NC=3C=CC=CC=3)=CC=2)=C1 NYGZLYXAPMMJTE-UHFFFAOYSA-M 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/50—Sympathetic, colour changing or similar inks
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/03—Printing inks characterised by features other than the chemical nature of the binder
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/10—Printing inks based on artificial resins
- C09D11/101—Inks specially adapted for printing processes involving curing by wave energy or particle radiation, e.g. with UV-curing following the printing
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D11/00—Inks
- C09D11/02—Printing inks
- C09D11/10—Printing inks based on artificial resins
- C09D11/102—Printing inks based on artificial resins containing macromolecular compounds obtained by reactions other than those only involving unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Inks, Pencil-Leads, Or Crayons (AREA)
Abstract
The application provides a low-temperature steam formaldehyde sterilization indicating ink composition, a preparation method thereof and an indicator, wherein the low-temperature steam formaldehyde sterilization indicating ink composition comprises the following components in percentage by mass: 60% -95% of water-based UV resin; 1 to 3 percent of color-changing dye; 0.1 to 2 percent of toning dye; 1 to 20 percent of control agent; 1 to 20 percent of consistency regulator. The low-temperature steam formaldehyde sterilization indicating ink disclosed by the invention is water-based UV curing ink, and can meet the requirements of various sterilization parameters by adopting a non-acid-base reaction color-changing principle, so that the sterilization standard of hospitals is met.
Description
Technical Field
The invention belongs to the field of medical sterilization, and particularly relates to a low-temperature steam formaldehyde sterilization indicating ink composition, a preparation method thereof and an indicator.
Background
With the development of modern medical science and technology, more and more medical instruments cannot resist high temperature or have short service life under the high-temperature condition, and only a low-temperature sterilization method can be selected. The low-temperature sterilization technology comprises ethylene oxide sterilization, hydrogen peroxide plasma sterilization and low-temperature steam formaldehyde sterilization.
The sterilization of the blind end lumen instrument is mainly completed by ethylene oxide sterilization, but the ethylene oxide sterilization instrument has low turnover rate and has strict requirements on the sterilization temperature of the instrument. The low-temperature steam formaldehyde has strong sterilizing penetrating power, and can thoroughly sterilize the blind end tube cavity with a complex structure; the formaldehyde gas with low concentration is easy to be analyzed and can not remain on the inner surface of the instrument, thereby being safe and reliable; and thirdly, the sterilization time stage improves the turnover rate of the apparatus. Based on the advantages, the low-temperature steam formaldehyde sterilization technology is concerned and advocated by more and more medical workers.
According to the national standard for sterilization of medical instruments, hospital medical care personnel are required to place corresponding chemical indicator cards for sterilization at the same time when the instruments are sterilized every time, observe the color change of the indicator cards, and conveniently judge whether set sterilization parameters are reached or not by the medical care personnel, and package, record or pack the corresponding labels, tapes, paper plastic bags and other products.
The prior art adopts a solvent type printing ink system, is very environment-friendly, has huge discharge amount of VOCs (volatile organic compounds), and is not green and environment-friendly; the common water-based UV ink has the problems that ink is dissolved to pollute instruments and the like, is mostly indication ink of a formaldehyde fumigation sterilization mode, and cannot meet the application of a low-temperature steam formaldehyde sterilizer.
With the increasing importance of the country on environmental protection, the development of solvent type ink is more and more limited, the discharge and treatment of VOCs are limited, and however, the common water-based UV ink has the problems that ink dissolves and pollutes instruments and the like.
Disclosure of Invention
In view of the above, the present invention aims to provide a low-temperature steam formaldehyde sterilization indicating ink composition, a preparation method thereof, and an indicator, which are beneficial to improving the stability of the ink.
In order to achieve the purpose, the technical scheme of the invention is that the low-temperature steam formaldehyde sterilization indicating ink composition comprises the following components in percentage by mass:
60% -95% of water-based UV resin;
1% -3% of color-changing dye;
0.1-2% of toning dye;
1 to 20 percent of control agent;
1 to 20 percent of consistency regulator.
The low-temperature steam formaldehyde sterilization indicating ink composition comprises 60-95% of water-based UV resin, wherein the solid content of the water-based UV resin is 40-70%. The aqueous UV resin comprises one or more of an aqueous UV polyurethane resin, an aqueous UV polyurethane acrylic, a polyester acrylate, an amino acrylate, and an epoxy acrylate, the aqueous UV resin comprises aqueous UV resins of different functionalities, in one embodiment, the low temperature steam formaldehyde sterilization indicator ink comprises 80% aqueous 2 functional UV polyurethane acrylic resin; in another embodiment, the low temperature steam formaldehyde sterilization indicator ink comprises a 70% aqueous 6 functional UV polyurethane resin. The aqueous UV resin is used for improving the stability of the low-temperature steam formaldehyde sterilization indicating ink composition, improving the unsaturated functionality of the aqueous UV resin, improving the crosslinking density of a cured product of the aqueous UV resin, and improving the curing performance and the mechanical property.
The low-temperature steam formaldehyde sterilization indicating ink composition comprises 1% -3% of color-changing dye, wherein the color-changing dye is azo dye, and can be monoazo dye or polyazo dye. The azo dye comprises one or more of Congo red, direct red, Sudan red III, Sudan red B, Sudan red G, Sudan I, Sudan IV, Sudan red 197 and disperse red. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink comprises 3% congo red. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink includes 2% sudan red 197.
The low-temperature steam formaldehyde sterilization indicating ink composition comprises 0.1-2% of toning dye, wherein the toning dye is water-based blue dye, and the water-based blue dye comprises one or more of acid blue, acid blue and Coomassie brilliant blue. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink comprises 0.2% acid blue 1. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink includes 0.1% coomassie brilliant blue G250. The color matching dye is used for matching with a color changing dye to adjust the color of the low-temperature steam formaldehyde sterilization indicating ink.
The low-temperature steam formaldehyde sterilization indicating ink composition comprises 1-20% of a control agent, wherein the control agent is an acid substance and comprises one or more of organic acid and inorganic acid. The organic acid is one or more of acrylic acid, adipic acid, formic acid, citric acid and tartaric acid, and the inorganic acid is one or more of hydrochloric acid, sulfuric acid, phosphoric acid and boric acid. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink includes 2% citric acid. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink comprises 7% tartaric acid.
The low-temperature steam formaldehyde sterilization indicating ink composition comprises 1% -20% of consistency regulator, wherein the consistency regulator is one or more of distilled water, methanol, ethanol, n-propanol, isopropanol, n-butanol and thickener. The thickener is a thickener commonly used in ink, and includes but is not limited to pectin, gelatin, polyamide wax, polyvinylpyrrolidone, seaweed gel, dextrin, cellulose derivatives and the like. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink includes 7.5% water, 1.3% thickener, and 6% isopropyl alcohol. In one embodiment, the low temperature steam formaldehyde sterilization indicator ink includes 10.6% water, 1.3% thickener, and 10% isopropyl alcohol.
The present invention does not require any particular source of the components, and if not specified, commercially available products known to those skilled in the art may be used.
The low-temperature steam formaldehyde sterilization indicating ink composition is an aqueous UV curing ink composition, can be dispersed to form stable and uniform components by adjusting the addition amount of the control agent, can meet the requirements of various sterilization parameters and reach the sterilization application standard of hospitals, and experimental results show that the low-temperature steam formaldehyde sterilization indicating ink composition has the advantages of good stability, long storage time, no ink dissolution, no instrument pollution, low VOC (volatile organic compound) gas emission and environmental protection after sterilization.
The invention also provides a preparation method of the low-temperature steam formaldehyde sterilization indicating ink composition, which comprises the following steps: and mixing the color-changing dye, the toning dye and the consistency regulator, and then sequentially mixing the mixture with the water-based UV resin and the control agent to obtain the sterilization indicating ink composition.
The sterilization indicating ink composition is prepared by mixing a color-changing dye, a toning dye and a consistency regulator, regulating the color of the dye, then sequentially mixing the dye with a water-based UV resin and a control agent, and stirring for 3 hours at normal temperature.
The preparation method of the low-temperature steam formaldehyde sterilization indicating ink composition is simple, the components interact with each other, and the color of the ink composition changes after low-temperature steam formaldehyde sterilization, so that the indicating effect is achieved.
The invention also provides a low-temperature steam formaldehyde sterilization indicator, which comprises a substrate and a sterilization indicating ink layer compounded on the substrate, wherein the sterilization indicating ink layer is obtained by curing the low-temperature steam formaldehyde sterilization indicating ink composition in the technical scheme.
The low-temperature steam formaldehyde sterilization indicator is obtained by printing a low-temperature steam formaldehyde sterilization indicating ink composition on a substrate and curing the low-temperature steam formaldehyde sterilization indicating ink composition, wherein the substrate can be a label, an adhesive tape or a card, and the substrate is not limited herein. The low-temperature steam formaldehyde sterilization indicator can be a low-temperature steam formaldehyde sterilization chemical indicator label, a low-temperature steam formaldehyde sterilization chemical indicator tape or a low-temperature steam formaldehyde sterilization chemical indicator card. The low-temperature steam formaldehyde sterilization indicating ink composition is suitable for various printing scenes, can be printed and UV cured on the surfaces of a flexible plate, a gravure plate and a silk screen, realizes printing on various substrates, can be visually interpreted by an indicator obtained by printing, and reduces artificial subjective factors of medical workers.
The invention provides a low-temperature steam formaldehyde sterilization indicating ink composition which comprises the following components in percentage by mass: 60% -95% of water-based UV resin; 1% -3% of color-changing dye; 0.1 to 2 percent of toning dye; 1 to 20 percent of control agent; 1 to 20 percent of consistency regulator. The low-temperature steam formaldehyde sterilization indicating ink composition is an aqueous UV curing ink composition, and can meet the requirements of various sterilization parameters by adopting a color change principle of non-acid-base reaction, so that the standard of sterilization application in hospitals is met.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
the low-temperature steam formaldehyde sterilization indicating ink comprises the following components in percentage by mass:
80% of aqueous 2-functional UV polyurethane acrylic resin with a solid content of 60%;
3% Congo red;
0.2% acid blue 1;
2% citric acid;
7.5% water, 1.3% polyamide wax and 6% isopropanol.
Dissolving Congo red, acid blue 1, water, polyamide wax and isopropanol, sequentially adding aqueous 2-functional UV polyurethane acrylic resin and citric acid, mixing, and stirring at normal temperature for 3 hours to obtain the low-temperature steam formaldehyde sterilization indicating ink.
And (3) screen-printing the obtained low-temperature steam formaldehyde sterilization indicating ink on laminating base paper, and then carrying out UV curing to obtain the low-temperature steam formaldehyde sterilization chemical indicating card.
And placing the obtained chemical indicator card for low-temperature steam formaldehyde sterilization into a low-temperature steam formaldehyde sterilizer, and sterilizing at the temperature of 60 ℃, the formaldehyde solubility of 2% and the sterilization time of 15min, wherein the color of the indicator card is changed from purple red to green, and the ink in the indicator card is not dissolved. The unused low-temperature steam formaldehyde sterilization chemical indicator card is placed in a constant-temperature and constant-humidity box with the temperature of 60 ℃ and the humidity of 80%, the printing ink is not separated, and the sterilization effect can be normally monitored.
Comparative example 1:
a low temperature steam formaldehyde sterilization chemical indicator card was prepared according to the method of example 1, wherein 80% of the aqueous 2 functional UV polyurethane acrylic resin was replaced with an equal amount of a polyvinyl alcohol solution of the same consistency.
And (2) placing the obtained low-temperature steam formaldehyde sterilization chemical indicator card into a formaldehyde sterilizer, sterilizing at the temperature of 60 ℃, the formaldehyde solubility of 2% and the sterilization time of 15min, wherein the color of the indicator card is changed from purple red to green, but part of ink of the indicator card is dissolved to pollute the surface of an instrument, and in a constant-temperature and constant-humidity box with the temperature of 60 ℃ and the humidity of 80%, the ink is partially separated, so that the sterilization effect cannot be normally monitored.
Example 2:
the low-temperature steam formaldehyde sterilization indicating ink comprises the following components in percentage by weight:
70% of a waterborne 6 functional UV polyurethane resin with a solid content of 60%;
2% sudan red 197;
0.1% coomassie brilliant blue G250;
7% tartaric acid;
10.6% water, 1.3% polyamide wax and 10% isopropanol.
Dissolving Sudan red 197, Coomassie brilliant blue G250, water, polyamide wax and isopropanol, sequentially adding aqueous 6-functional UV polyurethane resin and tartaric acid, mixing, and stirring at normal temperature for 3 hours to obtain the low-temperature steam formaldehyde sterilization indicating ink.
And printing the obtained low-temperature steam formaldehyde sterilization indicating ink to obtain the low-temperature steam formaldehyde sterilization chemical indicating label and the adhesive tape.
Placing the prepared chemical indication label and adhesive tape for low-temperature steam formaldehyde sterilization into a low-temperature steam formaldehyde sterilizer, sterilizing at the temperature of 60 ℃, the formaldehyde solubility of 2% and the sterilization time of 15min, wherein the color of the indication label and the adhesive tape is changed from purple red to green, and the indication label and the adhesive tape are dissolved without printing ink. The unused chemical indication label and the adhesive tape are placed in a constant temperature and humidity box with the temperature of 60 ℃ and the humidity of 80 percent, the ink is not separated, and the sterilization effect can be normally monitored.
Comparative example 2:
a low temperature steam formaldehyde sterilization chemical indicating label and tape were prepared according to the method of example 2, wherein 70% aqueous 6 functional UV polyurethane resin was replaced with an equal amount of polyvinyl alcohol solution of the same consistency.
And (3) placing the obtained low-temperature steam formaldehyde sterilization chemical indication label and the adhesive tape into a formaldehyde sterilizer, sterilizing under the conditions that the temperature is 60 ℃, the formaldehyde solubility is 2% and the sterilization time is 15min, wherein the colors of the indication label and the adhesive tape are changed from purple red to green, but part of ink is dissolved in the indication label and the adhesive tape, so that the surfaces of instruments are polluted, and in a constant-temperature and constant-humidity box with the temperature of 60 ℃ and the humidity of 80%, the ink is partially separated, so that the sterilization effect cannot be normally monitored.
The above description of the embodiments is only intended to facilitate the understanding of the method of the invention and its core idea. It should be noted that, for those skilled in the art, it is possible to make various improvements and modifications to the present invention without departing from the principle of the present invention, and those improvements and modifications also fall within the scope of the claims of the present invention.
Claims (10)
1. The low-temperature steam formaldehyde sterilization indicating ink composition is characterized by comprising the following components in percentage by mass:
60% -95% of water-based UV resin;
1 to 3 percent of color-changing dye;
0.1-2% of toning dye;
1 to 20 percent of control agent;
1 to 20 percent of consistency regulator.
2. The low temperature steam formaldehyde sterilization indicating ink composition of claim 1, wherein the aqueous UV resin comprises one or more of an aqueous UV polyurethane resin, an aqueous UV polyurethane acrylic acid, a polyester acrylate, an amino acrylate, and an epoxy acrylate.
3. The low temperature steam formaldehyde sterilization indicator ink composition of claim 1, wherein the color changing dye is an azo-based dye.
4. The low temperature steam formaldehyde sterilization indicating ink composition of claim 3, wherein the azo-based dye comprises one or more of Congo Red, direct Red, Sudan Red III, Sudan Red B, Sudan Red G, Sudan I, Sudan IV, Sudan Red 197, and disperse Red.
5. The low temperature steam formaldehyde sterilization indicating ink composition of claim 1, wherein the hueing dye is an aqueous blue dye.
6. The low temperature steam formaldehyde sterilization indicator ink composition of claim 1, wherein the control agent is one or more of an organic acid and an inorganic acid.
7. The low temperature steam formaldehyde sterilization indicator ink composition of claim 6, wherein the organic acid is one or more of acrylic acid, adipic acid, formic acid, citric acid, and tartaric acid, and the inorganic acid is one or more of hydrochloric acid, sulfuric acid, phosphoric acid, and boric acid.
8. The low temperature steam formaldehyde sterilization indicating ink composition of claim 1, wherein the consistency agent is one or more of distilled water, methanol, ethanol, n-propanol, isopropanol, n-butanol, and a thickener.
9. A method of making a low temperature steam formaldehyde sterilization indicating ink composition, comprising: and mixing the color-changing dye, the toning dye and the consistency regulator, and then sequentially mixing the mixture with the water-based UV resin and the control agent to obtain the sterilization indicating ink composition.
10. A low-temperature steam formaldehyde sterilization indicator, which is characterized by comprising a substrate and a sterilization indicating ink layer compounded on the substrate, wherein the sterilization indicating ink layer is obtained by curing the low-temperature steam formaldehyde sterilization indicating ink composition according to any one of claims 1 to 8.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172412A (en) * | 2011-04-02 | 2011-09-07 | 天津康德莱医疗产品有限公司 | Chemical indicator used for monitoring formaldehyde steam sterilization at low temperature and application |
| CN103232585A (en) * | 2013-04-03 | 2013-08-07 | 广东工业大学 | Preparation method for polyfunctional urethane acrylate aqueous UV resin |
| CN105733353A (en) * | 2016-05-12 | 2016-07-06 | 东莞泰升玻璃有限公司 | High-stability ultraviolet-light cured water-based ink for glass |
| CN107418297A (en) * | 2017-05-26 | 2017-12-01 | 南京巨鲨显示科技有限公司 | A kind of anti-dizzy dye pressuresteam sterilization instruction ink of UV photocurings and preparation method thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102172412A (en) * | 2011-04-02 | 2011-09-07 | 天津康德莱医疗产品有限公司 | Chemical indicator used for monitoring formaldehyde steam sterilization at low temperature and application |
| CN103232585A (en) * | 2013-04-03 | 2013-08-07 | 广东工业大学 | Preparation method for polyfunctional urethane acrylate aqueous UV resin |
| CN105733353A (en) * | 2016-05-12 | 2016-07-06 | 东莞泰升玻璃有限公司 | High-stability ultraviolet-light cured water-based ink for glass |
| CN107418297A (en) * | 2017-05-26 | 2017-12-01 | 南京巨鲨显示科技有限公司 | A kind of anti-dizzy dye pressuresteam sterilization instruction ink of UV photocurings and preparation method thereof |
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Application publication date: 20220819 |