CN115087662A - 双特异性融合多肽化合物 - Google Patents
双特异性融合多肽化合物 Download PDFInfo
- Publication number
- CN115087662A CN115087662A CN202180014524.4A CN202180014524A CN115087662A CN 115087662 A CN115087662 A CN 115087662A CN 202180014524 A CN202180014524 A CN 202180014524A CN 115087662 A CN115087662 A CN 115087662A
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- Prior art keywords
- xaa
- gly
- seq
- cysteine
- homocysteine
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Abstract
提供了一种多肽化合物，其为X‑ID‑Y或Y‑ID‑X；其中：X是钙敏感受体激动剂；ID是分子内的二硫键或连接臂，将X和Y连接；Y是骨生长肽受体激动剂或骨髓间充质干细胞刺激剂，还提供了包含上述多肽化合物的药物组合物，以及所述化合物和药物组合物的用途。
Description
PCT国内申请，说明书已公开。
Claims (11)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
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| CN202010946404 | 2020-09-10 | ||
| CN2020109464045 | 2020-09-10 | ||
| PCT/CN2021/088266 WO2022052471A1 (zh) | 2020-09-10 | 2021-04-20 | 双特异性融合多肽化合物 |
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| CN115087662A true CN115087662A (zh) | 2022-09-20 |
| CN115087662B CN115087662B (zh) | 2023-09-26 |
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| CN202180014524.4A Active CN115087662B (zh) | 2020-09-10 | 2021-04-20 | 双特异性融合多肽化合物 |
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| US (1) | US20230331779A1 (zh) |
| EP (1) | EP4212542A1 (zh) |
| JP (1) | JP7440132B2 (zh) |
| KR (1) | KR20230066044A (zh) |
| CN (1) | CN115087662B (zh) |
| AU (1) | AU2021338639B2 (zh) |
| CA (1) | CA3194729A1 (zh) |
| WO (1) | WO2022052471A1 (zh) |
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| WO2022257940A1 (zh) * | 2021-06-08 | 2022-12-15 | 北京拓界生物医药科技有限公司 | 钙敏感受体激动剂化合物的盐酸盐及药物组合物和其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005100571A1 (en) * | 2004-04-19 | 2005-10-27 | Novo Nordisk A/S | Osteogenic growth peptide fusion proteins |
| CN102711789A (zh) * | 2009-07-29 | 2012-10-03 | 凯伊药品公司 | 用于降低甲状旁腺激素水平的治疗剂 |
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| US20040091503A1 (en) * | 2002-08-20 | 2004-05-13 | Genitrix, Llc | Lectin compositions and methods for modulating an immune response to an antigen |
| KR101805201B1 (ko) * | 2009-03-30 | 2017-12-05 | 악셀레론 파마 인코포레이티드 | Ｂｍｐ-ａｌｋ3 길항제 및 골 성장을 촉진시키는 사용되는 이의 용도 |
| CA2773353C (en) * | 2009-09-29 | 2018-02-27 | Nektar Therapeutics | Oligomer-calcimimetic conjugates and related compounds |
| US20140315809A1 (en) * | 2011-11-10 | 2014-10-23 | Kai Pharmaceuticals, Inc. | Calcimimetics and methods for their use |
| US11615864B2 (en) * | 2017-02-17 | 2023-03-28 | The Board Of Trustees Of The Leland Stanford Junior University | Accurate and sensitive unveiling of chimeric biomolecule sequences and applications thereof |
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| CN109734778A (zh) * | 2019-03-07 | 2019-05-10 | 苏州科技大学 | 一种维拉卡肽的制备方法 |
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2021
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- 2021-04-20 CN CN202180014524.4A patent/CN115087662B/zh active Active
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- 2021-04-20 AU AU2021338639A patent/AU2021338639B2/en active Active
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| WO2005100571A1 (en) * | 2004-04-19 | 2005-10-27 | Novo Nordisk A/S | Osteogenic growth peptide fusion proteins |
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| CA3194729A1 (en) | 2022-03-17 |
| JP7440132B2 (ja) | 2024-02-28 |
| KR20230066044A (ko) | 2023-05-12 |
| AU2021338639A1 (en) | 2023-05-04 |
| CN115087662B (zh) | 2023-09-26 |
| AU2021338639B2 (en) | 2024-05-23 |
| WO2022052471A1 (zh) | 2022-03-17 |
| EP4212542A1 (en) | 2023-07-19 |
| US20230331779A1 (en) | 2023-10-19 |
| JP2023520687A (ja) | 2023-05-18 |
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