CN115087436A - 盐酸米托蒽醌脂质体治疗乳腺癌的用途 - Google Patents
盐酸米托蒽醌脂质体治疗乳腺癌的用途 Download PDFInfo
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- CN115087436A CN115087436A CN202180013477.1A CN202180013477A CN115087436A CN 115087436 A CN115087436 A CN 115087436A CN 202180013477 A CN202180013477 A CN 202180013477A CN 115087436 A CN115087436 A CN 115087436A
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- mitoxantrone
- breast cancer
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- mitoxantrone hydrochloride
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Abstract
盐酸米托蒽醌脂质体作为唯一活性成分在制备用于治疗乳腺癌的药物中的用途，所述乳腺癌优选为晚期乳腺癌。同时，还提供一种治疗乳腺癌的方法，所述方法为给予乳腺癌患者治疗有效量的盐酸米托蒽醌脂质体，所述治疗有效量是指8‑30mg/m2，以米托蒽醌计。临床试验结果表明，与普通盐酸米托蒽醌注射剂比较，盐酸米托蒽醌脂质体疗效更好，不良反应更少，尤其是心脏毒性显著降低。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020100837454 | 2020-02-10 | ||
| CN202010083745 | 2020-02-10 | ||
| PCT/CN2021/076210 WO2021160115A1 (zh) | 2020-02-10 | 2021-02-09 | 盐酸米托蒽醌脂质体治疗乳腺癌的用途 |
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| Publication Number | Publication Date |
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| CN115087436A true CN115087436A (zh) | 2022-09-20 |
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| CN202180013477.1A Pending CN115087436A (zh) | 2020-02-10 | 2021-02-09 | 盐酸米托蒽醌脂质体治疗乳腺癌的用途 |
Country Status (8)
| Country | Link |
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| US (1) | US20230078702A1 (zh) |
| EP (1) | EP4098251A4 (zh) |
| JP (1) | JP7561198B2 (zh) |
| KR (1) | KR20220140805A (zh) |
| CN (1) | CN115087436A (zh) |
| AU (1) | AU2021218871B2 (zh) |
| CA (1) | CA3167470A1 (zh) |
| WO (1) | WO2021160115A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115212168A (zh) * | 2021-04-16 | 2022-10-21 | 石药集团中奇制药技术（石家庄）有限公司 | 盐酸米托蒽醌脂质体的用途 |
| WO2023242097A1 (en) | 2022-06-13 | 2023-12-21 | KHR Biotec GmbH | Mitoxanthrone derivatives as ras inhibitors |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209243A (zh) * | 2006-12-29 | 2008-07-02 | 石药集团中奇制药技术（石家庄）有限公司 | 一种脂质体药物及其制备方法 |
| CN103622909A (zh) * | 2012-08-28 | 2014-03-12 | 吉林大学 | 一种含心磷脂的脂质体新制剂及其在抗肿瘤药物中的应用 |
| CN104971044A (zh) * | 2015-02-14 | 2015-10-14 | 吉林大学 | 一种米托蒽醌雌激素靶向peg修饰脂质体及其应用 |
| WO2018048752A1 (en) * | 2016-09-09 | 2018-03-15 | Irisys, Inc. | Lipsomal anticancer compositions |
| CN110711178A (zh) * | 2018-07-11 | 2020-01-21 | 石药集团中奇制药技术（石家庄）有限公司 | 盐酸米托蒽醌脂质体治疗非霍奇金淋巴瘤的用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105287383A (zh) * | 2015-11-19 | 2016-02-03 | 吉林大学 | 新型米托蒽醌脂质体联合化疗药物在抗肿瘤治疗中的应用 |
-
2021
- 2021-02-09 CA CA3167470A patent/CA3167470A1/en active Pending
- 2021-02-09 EP EP21753821.4A patent/EP4098251A4/en active Pending
- 2021-02-09 CN CN202180013477.1A patent/CN115087436A/zh active Pending
- 2021-02-09 WO PCT/CN2021/076210 patent/WO2021160115A1/zh active Application Filing
- 2021-02-09 JP JP2022548491A patent/JP7561198B2/ja active Active
- 2021-02-09 AU AU2021218871A patent/AU2021218871B2/en active Active
- 2021-02-09 KR KR1020227031536A patent/KR20220140805A/ko unknown
- 2021-02-09 US US17/760,240 patent/US20230078702A1/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101209243A (zh) * | 2006-12-29 | 2008-07-02 | 石药集团中奇制药技术（石家庄）有限公司 | 一种脂质体药物及其制备方法 |
| CN103622909A (zh) * | 2012-08-28 | 2014-03-12 | 吉林大学 | 一种含心磷脂的脂质体新制剂及其在抗肿瘤药物中的应用 |
| CN104971044A (zh) * | 2015-02-14 | 2015-10-14 | 吉林大学 | 一种米托蒽醌雌激素靶向peg修饰脂质体及其应用 |
| WO2018048752A1 (en) * | 2016-09-09 | 2018-03-15 | Irisys, Inc. | Lipsomal anticancer compositions |
| CN110711178A (zh) * | 2018-07-11 | 2020-01-21 | 石药集团中奇制药技术（石家庄）有限公司 | 盐酸米托蒽醌脂质体治疗非霍奇金淋巴瘤的用途 |
Non-Patent Citations (1)
| Title |
|---|
| POUJOL SYLVAIN等: "Effect of Mitoxantrone Liposomes on Multidruy-Resistant Breast Cancer Cells" * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021160115A1 (zh) | 2021-08-19 |
| KR20220140805A (ko) | 2022-10-18 |
| JP2023513269A (ja) | 2023-03-30 |
| US20230078702A1 (en) | 2023-03-16 |
| EP4098251A4 (en) | 2024-02-14 |
| EP4098251A1 (en) | 2022-12-07 |
| CA3167470A1 (en) | 2021-08-19 |
| AU2021218871A1 (en) | 2022-09-22 |
| AU2021218871B2 (en) | 2024-04-11 |
| JP7561198B2 (ja) | 2024-10-03 |
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