CN115066268B - 药剂输送装置 - Google Patents

药剂输送装置 Download PDF

Info

Publication number
CN115066268B
CN115066268B CN202080095362.7A CN202080095362A CN115066268B CN 115066268 B CN115066268 B CN 115066268B CN 202080095362 A CN202080095362 A CN 202080095362A CN 115066268 B CN115066268 B CN 115066268B
Authority
CN
China
Prior art keywords
chamber
medicament
piston
tube
sheath
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080095362.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN115066268A (zh
Inventor
约翰·托马斯·法夫罗
斯坦·罗伯特·吉尔伯特
珍妮佛·马格
安德鲁·皮克
马修·勒普拉卡
詹妮弗·戈尔登
珍妮佛·维勒汉
特拉维斯·亨奇
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Scimed Life Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scimed Life Systems Inc filed Critical Scimed Life Systems Inc
Priority to CN202411431188.5A priority Critical patent/CN119158141A/zh
Publication of CN115066268A publication Critical patent/CN115066268A/zh
Application granted granted Critical
Publication of CN115066268B publication Critical patent/CN115066268B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/00491Surgical glue applicators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B1/00Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M25/0029Multi-lumen catheters with stationary elements characterized by features relating to least one lumen located at the middle part of the catheter, e.g. slots, flaps, valves, cuffs, apertures, notches, grooves or rapid exchange ports
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/0105Steering means as part of the catheter or advancing means; Markers for positioning
    • A61M25/0133Tip steering devices
    • A61M25/0136Handles therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/145Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/19Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3294Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles comprising means for injection of two or more media, e.g. by mixing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods
    • A61B17/00491Surgical glue applicators
    • A61B2017/00495Surgical glue applicators for two-component glue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M2025/0037Multi-lumen catheters with stationary elements characterized by lumina being arranged side-by-side
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0021Catheters; Hollow probes characterised by the form of the tubing
    • A61M25/0023Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
    • A61M25/0026Multi-lumen catheters with stationary elements
    • A61M2025/0039Multi-lumen catheters with stationary elements characterized by lumina being arranged coaxially
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/091Guide wires having a lumen for drug delivery or suction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/01Introducing, guiding, advancing, emplacing or holding catheters
    • A61M25/09Guide wires
    • A61M2025/09116Design of handles or shafts or gripping surfaces thereof for manipulating guide wires
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/07General characteristics of the apparatus having air pumping means
    • A61M2205/071General characteristics of the apparatus having air pumping means hand operated
    • A61M2205/073Syringe, piston type

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
CN202080095362.7A 2019-12-03 2020-12-02 药剂输送装置 Active CN115066268B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411431188.5A CN119158141A (zh) 2019-12-03 2020-12-02 药剂输送装置

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962942887P 2019-12-03 2019-12-03
US62/942,887 2019-12-03
PCT/US2020/062811 WO2021113303A1 (en) 2019-12-03 2020-12-02 Agent delivery devices

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202411431188.5A Division CN119158141A (zh) 2019-12-03 2020-12-02 药剂输送装置

Publications (2)

Publication Number Publication Date
CN115066268A CN115066268A (zh) 2022-09-16
CN115066268B true CN115066268B (zh) 2024-10-29

Family

ID=74003909

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080095362.7A Active CN115066268B (zh) 2019-12-03 2020-12-02 药剂输送装置
CN202411431188.5A Pending CN119158141A (zh) 2019-12-03 2020-12-02 药剂输送装置

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202411431188.5A Pending CN119158141A (zh) 2019-12-03 2020-12-02 药剂输送装置

Country Status (8)

Country Link
US (1) US12109372B2 (https=)
EP (1) EP4048361B1 (https=)
JP (2) JP2023504627A (https=)
KR (1) KR20220110526A (https=)
CN (2) CN115066268B (https=)
AU (1) AU2020395124B2 (https=)
CA (1) CA3163519A1 (https=)
WO (1) WO2021113303A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119033431A (zh) 2019-04-30 2024-11-29 波士顿科学国际有限公司 内窥镜贴片施用器
CN121419722A (zh) * 2023-04-26 2026-01-27 波士顿科学国际有限公司 流体输送系统、装置以及相关的方法
US20240366875A1 (en) * 2023-05-04 2024-11-07 Boston Scientific Scimed, Inc. Fluid mixing devices and methods
US20250352763A1 (en) * 2024-05-15 2025-11-20 Boston Scientific Scimed, Inc. Medical devices for delivering fluid

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1960705A (zh) * 2003-11-17 2007-05-09 英国技术集团国际有限公司 治疗性泡沫

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360410A (en) 1991-01-16 1994-11-01 Senetek Plc Safety syringe for mixing two-component medicaments
US5312333A (en) 1992-04-03 1994-05-17 United States Surgical Corporation Endoscopic material delivery device
US5437291A (en) 1993-08-26 1995-08-01 Univ Johns Hopkins Method for treating gastrointestinal muscle disorders and other smooth muscle dysfunction
US6659996B1 (en) * 1995-11-09 2003-12-09 Intermed, Inc. Device for delivering biological agents
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
CA2241615A1 (en) 1997-06-26 1998-12-26 An-Go-Gen Inc. Catheters
US6764461B2 (en) * 1997-12-01 2004-07-20 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume bolus
US6050986A (en) * 1997-12-01 2000-04-18 Scimed Life Systems, Inc. Catheter system for the delivery of a low volume liquid bolus
US6224566B1 (en) * 1999-05-04 2001-05-01 Cardiodyne, Inc. Method and devices for creating a trap for confining therapeutic drugs and/or genes in the myocardium
US8251946B2 (en) * 2000-08-24 2012-08-28 Cardiac Science, Inc. Method for constructing an instrument with a two-part plunger for subcutaneous implantation
US6969373B2 (en) 2001-04-13 2005-11-29 Tricardia, Llc Syringe system
US7455657B2 (en) * 2001-06-19 2008-11-25 Boston Scientific Scimed, Inc Method and apparatus to modify a fluid using a selectively permeable membrane
US6663596B2 (en) * 2001-08-13 2003-12-16 Scimed Life Systems, Inc. Delivering material to a patient
AU2003295963B2 (en) * 2002-11-25 2009-09-03 Boston Scientific Limited Injection device for treating mammalian body
US8357147B2 (en) 2005-08-17 2013-01-22 Spinal Restoration, Inc. Method for repairing intervertebral discs
US7686788B2 (en) * 2005-03-03 2010-03-30 Boston Scientific Scimed, Inc. Catheter having a distal drug delivery unit and method of using same
EP1983917B1 (en) * 2006-01-27 2014-06-25 Spinal Ventures, LLC Low pressure delivery system for delivering a solid and liquid mixture into a target site for medical treatment
US20080021486A1 (en) * 2006-07-19 2008-01-24 Boston Scientific Scimed, Inc. Method and apparatus for tissue resection
US9039761B2 (en) * 2006-08-04 2015-05-26 Allergan, Inc. Ocular implant delivery assemblies with distal caps
US8137320B2 (en) * 2007-05-01 2012-03-20 Suros Surgical Systems, Inc. Securement for a surgical site marker and deployment device for same
US8894608B2 (en) * 2009-05-22 2014-11-25 Michael P. Connair Steroid delivery system
US20110146692A1 (en) * 2009-12-23 2011-06-23 Hologic, Inc. Implant Delivery Device
CN102933243A (zh) * 2010-04-05 2013-02-13 尼奥文股份有限公司 用于创口密封剂施加的方法和设备
US9629979B2 (en) * 2010-04-28 2017-04-25 Sanovas, Inc. Pressure/Vacuum actuated catheter drug delivery probe
EP2407194A1 (en) * 2010-07-12 2012-01-18 SOFIC (Sté Française d'Instruments de Chirurgie) Injection system for mixing two injectable compositions prior to injection
US8550087B2 (en) * 2010-11-05 2013-10-08 Hologic, Inc. Implant delivery device with expanding tip
WO2012094549A1 (en) 2011-01-06 2012-07-12 Synthes Usa, Llc Hydraulic injection system for bone cement
BE1020761A3 (nl) * 2012-06-20 2014-04-01 Jan Gustaaf M Vermeylen Houder gevuld met een lokaal anestheticum en werkwijze om een mengsel van een lokaal anestheticum met een tweede vloeistof aan te maken.
WO2014061014A2 (en) * 2012-10-15 2014-04-24 Elcam Medical Agricultural Cooperative Association Ltd. Multi-chamber syringe
EP3003428A4 (en) * 2013-06-05 2017-05-31 The Regents of the University of California Hydrogel pressure sealant system
KR20160088852A (ko) * 2013-07-16 2016-07-26 유니트랙트 시린지 피티와이 엘티디 주사 가능 물질의 반복적 혼합 및 주입용 주사기
US9919111B2 (en) * 2014-06-30 2018-03-20 Elwha Llc Active lubrication of penetrating devices
KR20170092650A (ko) * 2014-12-08 2017-08-11 제넨테크, 인크. 다용도 주사기 플랫폼
US9700680B2 (en) * 2015-03-31 2017-07-11 Medtrick Inc. Medical devices and methods for creating bubbles
WO2017011668A1 (en) * 2015-07-14 2017-01-19 Boston Scientific Scimed, Inc. Gel delivery catheters, systems, and methods
EP3355978A1 (en) * 2015-10-01 2018-08-08 Boston Scientific Scimed, Inc. Systems, devices and kits for delivering therapeutic agents
US20170189649A1 (en) * 2016-01-05 2017-07-06 Common Sense Insemination Products Co., Llc. Post cervical artificial insemination catheter
US11020160B2 (en) * 2016-03-21 2021-06-01 Warsaw Orthopedic, Inc. Surgical injection system and method
US20180085555A1 (en) * 2016-09-26 2018-03-29 Boston Scientific Scimed, Inc. Injection catheter
KR101759272B1 (ko) * 2016-11-08 2017-07-19 진세훈 진피 재생용 주사기
CN114668931B (zh) * 2017-04-19 2024-07-30 巴克斯特国际公司 无堵塞分配装置
US11672956B2 (en) * 2019-03-12 2023-06-13 Wisconsin Alumni Research Foundation Multi-purpose catheter for brachytherapy and intratumoral injection

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1960705A (zh) * 2003-11-17 2007-05-09 英国技术集团国际有限公司 治疗性泡沫

Also Published As

Publication number Publication date
WO2021113303A1 (en) 2021-06-10
US20210162175A1 (en) 2021-06-03
KR20220110526A (ko) 2022-08-08
US12109372B2 (en) 2024-10-08
AU2020395124B2 (en) 2026-03-12
AU2020395124A1 (en) 2022-06-09
EP4048361B1 (en) 2026-02-11
EP4048361A1 (en) 2022-08-31
JP2025161912A (ja) 2025-10-24
JP2023504627A (ja) 2023-02-06
CN115066268A (zh) 2022-09-16
CA3163519A1 (en) 2021-06-10
CN119158141A (zh) 2024-12-20

Similar Documents

Publication Publication Date Title
CN115066268B (zh) 药剂输送装置
US6599293B2 (en) Delivery device for bone cement
AU2002228930B2 (en) Ligating band delivery apparatus
EP1047464B1 (en) Two component dispenser system
CN104718001B (zh) 可转向且可弯曲的空腔形成系统
US5312333A (en) Endoscopic material delivery device
US7918867B2 (en) Suture trimmer
EP1242134B1 (en) Apparatus for delivery of controlled doses of therapeutic drugs in endoluminal procedures
CN114746027B (zh) 用于药物输送的医疗装置及相关使用方法
US20120158004A1 (en) Steerable and curvable vertebroplasty system with clog-resistant exit ports
AU2002228930A1 (en) Ligating band delivery apparatus
CN107801381A (zh) 止血粉末递送装置和方法
KR102716316B1 (ko) 듀얼 체크 밸브 한 손 어플리케이터
US12053341B2 (en) Device, method, and system for automated dispensing of periodontal medication
EP1463450B1 (en) Suture trimmer
HK1205701B (en) Steerable and curvable cavity creation system
HK1151706A1 (en) Steerable vertebroplasty system with cavity creation element

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant