CN115052887B - 基于lilrb1的嵌合抗原受体 - Google Patents

基于lilrb1的嵌合抗原受体

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Publication number
CN115052887B
CN115052887B CN202080095978.4A CN202080095978A CN115052887B CN 115052887 B CN115052887 B CN 115052887B CN 202080095978 A CN202080095978 A CN 202080095978A CN 115052887 B CN115052887 B CN 115052887B
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CN115052887A (zh
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C·A·坎布
A·E·汉布格尔
B·迪安德斯
M·E·达里斯
K·德舒马克
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A2 Biotherapy
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/0602—Vertebrate cells
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
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    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/21—Transmembrane domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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CN202080095978.4A 2019-12-11 2020-12-11 基于lilrb1的嵌合抗原受体 Active CN115052887B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962946888P 2019-12-11 2019-12-11
US62/946,888 2019-12-11
US202063085969P 2020-09-30 2020-09-30
US63/085,969 2020-09-30
PCT/US2020/064607 WO2021119489A1 (en) 2019-12-11 2020-12-11 Lilrb1-based chimeric antigen receptor

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CN115052887A CN115052887A (zh) 2022-09-13
CN115052887B true CN115052887B (zh) 2026-03-31

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US (5) US20230029341A1 (https=)
EP (1) EP4073103A1 (https=)
JP (1) JP7832892B2 (https=)
KR (1) KR20220124173A (https=)
CN (1) CN115052887B (https=)
AU (2) AU2020401315B2 (https=)
BR (1) BR112022011399A2 (https=)
CA (1) CA3161112A1 (https=)
IL (1) IL293716A (https=)
MX (1) MX2022006962A (https=)
NZ (1) NZ789779A (https=)
WO (1) WO2021119489A1 (https=)

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