CN115052603A - Bi853520与化疗药物的联用 - Google Patents

Bi853520与化疗药物的联用 Download PDF

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Publication number
CN115052603A
CN115052603A CN202180012434.1A CN202180012434A CN115052603A CN 115052603 A CN115052603 A CN 115052603A CN 202180012434 A CN202180012434 A CN 202180012434A CN 115052603 A CN115052603 A CN 115052603A
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cancer
tumor
group
chemotherapeutic agent
pld
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CN115052603B (zh
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王在琪
张江伟
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Yingshi Biotechnology Nanjing Co ltd
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Yingshi Biotechnology Nanjing Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/243Platinum; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

本发明涉及BI853520或其药学上可接受的盐在制备用于与化疗药物联用治疗肿瘤的药物中的用途。

Description

PCT国内申请,说明书已公开。

Claims (32)

  1. PCT国内申请,权利要求书已公开。
CN202180012434.1A 2020-02-05 2021-01-29 Bi853520与化疗药物的联用 Active CN115052603B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202311560963.2A CN117599060A (zh) 2020-02-05 2021-01-29 Bi853520与化疗药物的联用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN202010080757 2020-02-05
CN2020100807571 2020-02-05
PCT/CN2021/074371 WO2021155764A1 (zh) 2020-02-05 2021-01-29 Bi853520与化疗药物的联用

Related Child Applications (1)

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CN202311560963.2A Division CN117599060A (zh) 2020-02-05 2021-01-29 Bi853520与化疗药物的联用

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CN115052603A true CN115052603A (zh) 2022-09-13
CN115052603B CN115052603B (zh) 2023-12-19

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CN202180012434.1A Active CN115052603B (zh) 2020-02-05 2021-01-29 Bi853520与化疗药物的联用
CN202311560963.2A Pending CN117599060A (zh) 2020-02-05 2021-01-29 Bi853520与化疗药物的联用

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US (2) US20230079055A1 (zh)
EP (1) EP4101453A4 (zh)
JP (1) JP2023515765A (zh)
KR (1) KR20220137666A (zh)
CN (2) CN115052603B (zh)
AU (1) AU2021215747A1 (zh)
BR (1) BR112022015150A2 (zh)
CA (1) CA3165980A1 (zh)
MX (1) MX2022009612A (zh)
WO (1) WO2021155764A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023503897A (ja) * 2019-11-18 2023-02-01 ▲應▼世生物科技(南京)有限公司 Nras変異を有する腫瘍を治療するための医薬品の調製におけるfak阻害剤の使用
JP2023515765A (ja) * 2020-02-05 2023-04-14 ▲應▼世生物科技(南京)有限公司 Bi853520と化学療法薬の併用
MX2023001418A (es) * 2020-08-03 2023-04-10 Inxmed Nanjing Co Ltd Forma sólida de compuesto.
WO2023020291A1 (zh) * 2021-08-16 2023-02-23 应世生物科技(南京)有限公司 In10018与pld的联用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102292322A (zh) * 2008-11-24 2011-12-21 贝林格尔.英格海姆国际有限公司 用于治疗例如癌症的疾病的取代的嘧啶
CN108289892A (zh) * 2015-06-29 2018-07-17 维瑞斯特姆股份有限公司 治疗组合物、组合和使用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023503897A (ja) * 2019-11-18 2023-02-01 ▲應▼世生物科技(南京)有限公司 Nras変異を有する腫瘍を治療するための医薬品の調製におけるfak阻害剤の使用
JP2023515765A (ja) * 2020-02-05 2023-04-14 ▲應▼世生物科技(南京)有限公司 Bi853520と化学療法薬の併用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102292322A (zh) * 2008-11-24 2011-12-21 贝林格尔.英格海姆国际有限公司 用于治疗例如癌症的疾病的取代的嘧啶
CN108289892A (zh) * 2015-06-29 2018-07-17 维瑞斯特姆股份有限公司 治疗组合物、组合和使用方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
医药观澜: "应世生物与默沙东达成全球临床合作,评估FAK抑制剂与帕博利珠单抗联合用药", pages 2 - 3, Retrieved from the Internet <URL:https://xueqiu.com/9766314542/138813166> *
美通社: "应世生物FAK抑制剂IN10018中国一期临床试验获批", pages 4, Retrieved from the Internet <URL:https://www.prnasia.com/story/268783-1.shtm> *

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EP4101453A4 (en) 2024-05-15
BR112022015150A2 (pt) 2022-10-11
JP2023515765A (ja) 2023-04-14
MX2022009612A (es) 2022-09-19
EP4101453A1 (en) 2022-12-14
CN117599060A (zh) 2024-02-27
CA3165980A1 (en) 2021-08-12
US20240024319A1 (en) 2024-01-25
KR20220137666A (ko) 2022-10-12
CN115052603B (zh) 2023-12-19
WO2021155764A1 (zh) 2021-08-12
US20230079055A1 (en) 2023-03-16
AU2021215747A1 (en) 2022-08-18

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