CN115025663B

CN115025663B - Equipment and process for preparing levocarnitine injection

Info

Publication number: CN115025663B
Application number: CN202210810219.2A
Authority: CN
Inventors: 李强; 刘雅辉; 李述智; 张柳香
Original assignee: Hainan Zhuoke Pharmaceutical Co ltd
Current assignee: Hainan Zhuoke Pharmaceutical Co ltd
Priority date: 2022-07-11
Filing date: 2022-07-11
Publication date: 2023-07-07
Anticipated expiration: 2042-07-11
Also published as: CN115025663A

Abstract

The application discloses a levocarnitine injection configuration device, which relates to the technical field of dispensing devices and comprises a medicine mixing bin and a stirring and mixing assembly, wherein the stirring and mixing assembly comprises a central rotating rod and a stirring rod; the central rotating rod is rotationally connected to the upper cover and communicated with the conveying assembly, and comprises a hollow rod body and a rod body rotation driving assembly; the hollow rod body is tubular; the stirring rods are in a sleeve structure and positioned on the central rotating rod, and comprise an outer layer pipe and an inner layer pipe; the end part of the outer layer pipe far away from the central rotating rod is closed and fixed on the inner layer pipe, and a hollow cylindrical space exists between the outer layer pipe and the inner layer pipe; the water permeable holes are densely distributed on the outer layer pipe; the inner layer pipe is tubular, and the space in the inner layer pipe and the hollow cylindrical space are communicated with the inner space of the central rotating rod; the technical effects that the mixing efficiency of the levocarnitine injection preparation equipment is high and the efficient mixing can be carried out on the liquid medicine under the central position of the stirring assembly are achieved.

Description

Equipment and process for preparing levocarnitine injection

Technical Field

The invention relates to the technical field of dispensing equipment, in particular to equipment and a process for preparing levocarnitine injection.

Background

The levocarnitine is an amino acid which promotes fat to be converted into energy, has no toxic or side effect on human bodies, is necessary for fat metabolism, can be used for treating chronic renal failure, cardiomyopathy, coronary heart disease, organic acidemia and the like, and can also be used as an auxiliary treatment drug for chronic liver diseases.

Common formulations of the levocarnitine comprise levocarnitine tablets, levocarnitine oral solution, levocarnitine for injection and levocarnitine injection; in the preparation process of the levocarnitine injection, the levocarnitine is required to be added into water for injection and then stirred until the mixture is uniform, and a PH value regulator is required to be added and then stirred and mixed uniformly; in order to achieve the purpose of mixing, generally, a long stirring time is required (more than 20 minutes are generally required for mixing for multiple times of stirring), which is an important factor affecting the preparation efficiency of the levocarnitine injection; and stirring subassembly among the configuration equipment in the prior art generally only rotates the purpose that realizes the mixing through the axis of control puddler around the back shaft (axis of rotation) of puddler, because of being limited by the influence of the linear velocity of puddler part rotation that is close to the axis of rotation, is relatively poor to the mixing effect of the liquid medicine that is located the region under the stirring subassembly central point position (the position that is close to the medicine mixing bin bottom), and then influences whole mixing effect.

Therefore, there is a need for a levocarnitine injection preparation apparatus that has high mixing efficiency and can efficiently mix a drug solution directly below the center of the stirring assembly.

Disclosure of Invention

According to the configuration equipment for the left carnitine injection, the technical problems that the configuration equipment in the prior art is limited by the linear speed of rotation of the stirring rod part close to the rotation shaft, the mixing effect of liquid medicine in the area right below the central position of the stirring assembly is poor, and the mixing efficiency of the configuration equipment for the liquid medicine is low are solved, and the technical effects that the mixing efficiency of the configuration equipment for the left carnitine injection is high and the liquid medicine right below the central position of the stirring assembly can be mixed efficiently are achieved.

The embodiment of the application provides a levocarnitine injection configuration device, which comprises a medicine mixing bin and a stirring and mixing assembly, wherein the medicine mixing bin comprises an outer shell, an upper cover, a conveying assembly, a medicine adding assembly and a pumping assembly; the stirring and mixing assembly comprises a central rotating rod and a stirring rod;

the central rotating rod is rotationally connected to the upper cover and communicated with the conveying assembly, and comprises a hollow rod body and a rod body rotation driving assembly;

the hollow rod body is tubular; the stirring rods are in a sleeve structure and are positioned on the central rotating rod, and an included angle between the axis and the axis of the central rotating rod is 30-90 degrees and comprises an outer layer pipe and an inner layer pipe;

the end part of the outer layer pipe far away from the central rotating rod is closed and fixed on the inner layer pipe, and a hollow cylindrical space exists between the outer layer pipe and the inner layer pipe;

the water permeable holes are densely distributed on the outer layer pipe;

the inner layer pipe is tubular, and the space in the inner layer pipe and the hollow cylindrical space are communicated with the inner space of the central rotating rod;

when stirring, the pumping assembly cooperates with the conveying assembly to pump the liquid in the medicine mixing bin to the inner space of the central rotating rod, and the liquid is output from the bottom of the hollow rod body, the end part of the inner layer pipe and the water permeable hole respectively.

Preferably, the stirring rod rotating assembly is further included;

the stirring rod rotating assembly comprises a bearing block, a rotating block and a driving system;

the bearing blocks are fixed on the outer wall of the central rotating rod, correspond to the stirring rods one by one and are used for bearing the rotating blocks;

the rotating block is rotationally connected to the bearing block, and the axial direction of the rotating shaft is perpendicular to the axial direction of the central rotating rod;

the end part of the stirring rod, which is close to the central rotating rod, is fixed on the central rotating rod, and the angle between the stirring rod and the central rotating rod is 30-60 degrees;

the stirring rod inner space is communicated with the central rotating rod inner space through the bearing block and the rotating block;

the driving system is used for driving the rotating block to rotate around the axis of the rotating block.

Preferably, the device further comprises a closing plate assembly;

the main body of the sealing plate assembly is a plate and is used for controlling the water yield of the stirring rod and further controlling the water yield at the bottom of the central rotating rod in a mode of shielding the water inlet under the control of the control unit;

the sealing plate assembly comprises a sealing plate, a positioning frame and a plate body lifting assembly;

the sealing plates are in one-to-one correspondence with the water inlets of the rotating blocks, are fixed on the positioning frame, and the positioning frame is of a frame structure, is positioned in the central rotating rod and is positioned on the upper cover;

the plate body lifting assembly is of a telescopic rod structure and is controlled by the control unit, and the plate body lifting assembly is used for driving the positioning frame to move up and down so as to control the water yield of the stirring rod.

Preferably, the device further comprises a warehouse cleaning component;

the warehouse cleaning assembly comprises an extrusion water outlet plate assembly and a water curtain generating assembly; the hollow rod body is provided with a special-shaped pipe part at the position close to the bottom, and the inner diameter of the special-shaped pipe part is larger than the inner diameters of other positions of the hollow rod body;

the extrusion water outlet plate assembly is used for controlling water outlet at the bottom of the central rotating rod and comprises a positioning frame, a plugging plate, a force-applying pressure spring, a limiting ring, a lifting extrusion rod and a supporting body; the positioning frame is of a frame structure and is fixed on the inner wall of the hollow rod body and positioned above the special-shaped pipe part and used for positioning the force application pressure spring;

the limiting ring is annular and is fixed on the inner wall of the hollow rod body, is arranged close to the end part of the central rotating rod and is positioned below the special-shaped pipe part and used for bearing the plugging plate;

the blocking plate is abutted against the limiting ring and used for blocking water flow;

the force application pressure spring is positioned between the positioning frame and the plugging plate and used for extruding the plugging plate;

the lifting extrusion rod is fixed on the inner wall of the medicine mixing bin through a support body, is a telescopic rod and is controlled by the control unit, and the top of the lifting extrusion rod is abutted against the bottom of the plugging plate;

after the lifting extrusion rod pushes the plugging plate to move upwards, the plugging plate enters the special-shaped pipe part, and the liquid in the central rotating rod flows out from the bottom;

the water curtain generating assembly is positioned under the central rotating rod and used for forming an annular water curtain to clean the inner wall of the medicine mixing bin and the stirring and mixing assembly, and comprises a water guide disc, a water guide blade and a blade rotating assembly;

the water guide disc is fixed on the medicine mixing bin, is positioned right below the central rotating rod and is disc-shaped, a water passing hole is positioned at the central position of the water guide disc, the water passing hole is used for passing through the lifting extrusion rod and part of medicine liquid output from the bottom of the central rotating rod, and the diameter of the water passing hole is 2-5 cm greater than that of the lifting extrusion rod;

the water guide blades are arc-shaped sheet bodies, the number of the water guide blades is 8 or more, the water guide blades are all rotationally connected to the water guide disc and are uniformly distributed on the periphery of the water guide disc, and the water guide discs and the water guide blades are combined to form a bowl;

the blade rotating assembly is used for controlling all the water guide blades to rotate so as to change the size of a bowl mouth of the combination of the bowl-shaped water guide disc and the water guide blades, and further change the direction of the water curtain.

Further, the blade rotating assembly comprises a force application ring and a force application ring lifting assembly;

the force application ring is sleeved on the ring formed by the water guide blades, and the force application ring lifting assembly is used for controlling the lifting of the force application ring so as to control the rotation of the water guide blades.

Preferably, the lifting extrusion rod is also fixed with a hole blocking block for blocking the water passing hole after the lifting extrusion rod rises to a certain degree;

the warehouse cleaning assembly further comprises a second water curtain generating assembly, the structure of the second water curtain generating assembly is identical to that of the water curtain generating assembly, the second water curtain generating assembly and the water curtain generating assembly are symmetrically arranged and controlled by the control unit.

Further, the conveying component is positioned on the upper cover and is a combination of a pump and a pipeline, is communicated with the raw material bin for injection and the pumping component, and plays a role in conveying liquid, gas and energy into the stirring and mixing component;

the medicine adding component is positioned on the upper cover and communicated with the solid raw material bin, and comprises a quantitative discharging component for timely throwing quantitative solid medicines into the medicine mixing bin through an input port on the upper cover;

the pumping assembly is a combination of a pump body, a valve body and a pipeline, is positioned at the bottom of the outer shell, and plays a role in pumping out liquid in the medicine mixing bin and conveying the liquid to the filtering bin or the conveying assembly.

Preferably, a flow limiting plate is fixed on the inner wall of the hollow rod body, which is close to the bottom, and the flow limiting plate is an annular plate and is used for reducing the liquid output from the bottom of the hollow rod body in unit time.

Further, the driving system is positioned inside the central rotating rod and comprises a central driving rod, a first gear ring and a second gear ring;

the central driving rod is a combination of a motor and a rod body, is positioned on the upper cover and rotates around the axis of the central driving rod under the control of the control unit;

the number of the first gear rings and the second gear rings is the same as that of the stirring rods;

the first gear ring is fixed on the central driving rod, and the axial direction of the first gear ring is the same as that of the central driving rod;

the second gear ring is fixed on the rotating block, the axis of the second gear ring coincides with the axis of the rotating block, and the second gear ring is meshed with the first gear ring.

One or more technical solutions provided in the embodiments of the present application at least have the following technical effects or advantages:

through improving a stirring assembly of configuration equipment in the prior art, optimizing a supporting shaft of the stirring assembly into a tubular structure, arranging a stirring rod into a complete pipe structure, stirring a water column with an axis coincident with the axis of the stirring rod by an inner pipe body of the stirring rod, densely distributing through holes for water permeation on an outer pipe body, fixing one end of the outer pipe body far away from the supporting shaft on the inner pipe body, and forming a hollow cylindrical space between the outer pipe body and the inner pipe body, wherein the space in the inner pipe body and the hollow cylindrical space are communicated with the inner space of the supporting shaft; during stirring, the pumping assembly pumps the liquid in the medicine mixing bin to the inner space of the supporting shaft, and outputs the liquid from the bottom of the supporting shaft, the end part of the inner layer pipe body and the through holes on the outer layer pipe body respectively, so that the liquid medicine is stirred and mixed in an accelerating way; the technical problems that the configuration equipment in the prior art is limited by the linear speed influence of the rotation of the stirring rod part close to the rotation shaft, the mixing effect of the liquid medicine in the area right below the central position of the stirring assembly is poor, and the mixing efficiency of the configuration equipment on the liquid medicine is low are effectively solved, and the technical effects that the mixing efficiency of the left carnitine injection configuration equipment is high and the liquid medicine right below the central position of the stirring assembly can be mixed efficiently are further achieved.

Drawings

FIG. 1 is a schematic structural view of a stirring and mixing assembly of a levocarnitine injection preparation device of the present invention;

fig. 2 is a schematic view of the appearance structure of the equipment for preparing the levocarnitine injection;

FIG. 3 is a schematic structural view of a stirring rod of the levocarnitine injection preparation device of the present invention;

FIG. 4 is a schematic diagram showing the positional relationship between a stirring rod and a stirring rod rotating assembly of the levocarnitine injection preparation device of the present invention;

FIG. 5 is a schematic diagram showing the positional relationship between the hollow rod body and the flow limiting plate of the levocarnitine injection preparation device of the present invention;

FIG. 6 is a schematic diagram of the central rotating rod and the rotary drive assembly of the levocarnitine injection preparation apparatus of the present invention;

FIG. 7 is a schematic diagram of a stirring rod and stirring rod rotating assembly of the levocarnitine injection preparation device of the present invention;

FIG. 8 is a cross-sectional view of a stirring rod and stirring rod rotating assembly of the levocarnitine injection preparation apparatus of the present invention;

FIG. 9 is a schematic view showing a partial structure of a stirring rod of the levocarnitine injection preparation device of the present invention;

FIG. 10 is a schematic diagram of the drive system and closing plate assembly of the levocarnitine injection preparation apparatus of the present invention;

FIG. 11 is a schematic view of the external appearance structure of a warehouse cleaning component of the levocarnitine injection preparation device of the present invention;

FIG. 12 is a schematic view showing the internal structure of an extruded water plate assembly of the levocarnitine injection preparation apparatus of the present invention;

FIG. 13 is a cross-sectional view of an extruded water plate assembly of the levocarnitine injection dispensing apparatus of the present invention;

FIG. 14 is a schematic view of the water curtain generating assembly of the levocarnitine injection preparation apparatus of the present invention;

fig. 15 is a schematic diagram showing the positional relationship between a water curtain generating assembly and a second water curtain generating assembly of the levocarnitine injection preparation apparatus of the present invention.

In the figure:

drug mixing cartridge 100, outer housing 110, upper cap 120, input port 121, support frame 130, delivery assembly 140, drug addition assembly 150, pumping assembly 160;

stirring and mixing assembly 200, central rotating rod 210, hollow rod body 211, current limiting plate 212, rod body rotation driving assembly 213, stirring rod 220, outer layer tube 221, inner layer tube 222, water permeable hole 224, stirring rod rotation assembly 230, bearing block 231, rotating block 232, driving system 233, central driving rod 234, first gear ring 235, second gear ring 236, closing plate assembly 240, closing plate 241, positioning frame 242, plate body lifting assembly 243, and profiled tube portion 250;

the water curtain generation device comprises a cleaning bin assembly 300, an extrusion water plate assembly 310, a positioning frame 311, a plugging plate 312, a force application pressure spring 313, a limiting ring 314, a lifting extrusion rod 315, a plugging block 316, a supporting body 317, a water curtain generation assembly 320, a water guide disc 321, water holes 322, water guide blades 323, a blade rotation assembly 324, a force application ring 325, a force application ring lifting assembly 326 and a second water curtain generation assembly 330.

Detailed Description

In order that the invention may be readily understood, a more complete description of the invention will be rendered by reference to the appended drawings; the preferred embodiments of the present invention are illustrated in the drawings, however, the present invention may be embodied in many different forms and is not limited to the embodiments described herein; rather, these embodiments are provided so that this disclosure will be thorough and complete.

It should be noted that the terms "vertical", "horizontal", "upper", "lower", "left", "right", and the like are used herein for illustrative purposes only and do not represent the only embodiment.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs; the terminology used herein in the description of the invention is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention; the term "and/or" as used herein includes any and all combinations of one or more of the associated listed items.

Please refer to fig. 1, which is a schematic structural diagram of a stirring and mixing assembly of the levocarnitine injection preparing apparatus of the present invention; according to the levocarnitine injection configuration equipment, through improvement of a stirring component of the configuration equipment in the prior art, a supporting shaft of the stirring component is optimized to be of a tubular structure, a complete pipe structure is arranged on a stirring rod, an inner pipe 222 of the stirring rod is used for forming and outputting a water column with an axis coincident with the axis of the stirring rod for stirring, through holes for water permeation are densely distributed on an outer pipe 221, one end of the outer pipe 221, which is far away from the supporting shaft, is fixed on the inner pipe 222, a hollow cylindrical space exists between the outer pipe 221 and the inner pipe 222, and the space in the inner pipe 222 and the hollow cylindrical space are communicated with the inner space of the supporting shaft; during stirring, the pumping assembly pumps the liquid in the medicine mixing bin 100 to the inner space of the supporting shaft, and outputs the liquid from the bottom of the supporting shaft, the end part of the inner layer pipe 222 and the through holes on the outer layer pipe 221 respectively, so as to accelerate stirring and mixing of the liquid medicine; the technical effects that the mixing efficiency of the levocarnitine injection preparation equipment is high and the efficient mixing can be carried out on the liquid medicine under the central position of the stirring assembly are achieved.

Example 1

As shown in fig. 1, the levocarnitine injection preparation device of the present application comprises a medicine mixing bin 100, a stirring and mixing assembly 200, a power assembly and a control unit.

As shown in fig. 1 and 2, the drug mixing cartridge 100 is a mixing container configured with a drug, and functions as a carrier for the stirring and mixing assembly 200, and includes an outer housing 110, an upper cover 120, a support frame 130, a delivery assembly 140, a drug adding assembly 150, and a pumping assembly 160; the outer housing 110 is a container with an open top, preferably a horn shape with a big top and a small bottom; the upper cover 120 is positioned on the outer housing 110 to close the space formed by the outer housing 110 and to carry the delivery assembly 140 and the drug addition assembly 150; the supporting frame 130 is a frame structure or a rod body, and is used for fixing the outer shell 110 on a horizontal ground or other devices, so as to play a role in supporting and fixing; the delivery assembly 140 is positioned on the upper cover 120, is a combination of a pump, a pipeline and the like, is communicated with an injection raw material bin (for storing injection water for pharmaceutical use) and the pumping assembly 160, and plays a role in delivering liquid, gas and energy (electricity) into the stirring and mixing assembly 200; the medicine adding assembly 150 is positioned on the upper cover 120, is communicated with a solid raw material bin (for storing solid raw materials for medicines), and comprises a quantitative discharging assembly (a material dividing and blocking mechanism) for timely feeding quantitative solid medicines into the medicine mixing bin 100 through an input port 121 on the upper cover 120; the pumping assembly 160 is a combination of a pump body, a valve body and a pipe, and is positioned at the bottom of the outer housing 110 to pump out the liquid in the drug mixing cartridge 100 and deliver the liquid to the filtration cartridge or delivery assembly 140.

As shown in fig. 3 and 4, the stirring and mixing assembly 200 is rotatably connected to the upper cover 120, and is used for uniformly mixing the liquid medicine in the medicine mixing chamber 100 by rotating itself, and comprises a central rotating rod 210 and a stirring rod 220; the central rotating rod 210 is rotatably connected to the upper cover 120 around its own axis and is in communication with the conveying assembly 140, and comprises a hollow rod body 211 and a rod body rotation driving assembly 213; the hollow rod body 211 is tubular; the rod rotation driving assembly 213 is preferably a combination of a motor, a gear and a gear ring, because it drives the hollow rod 211 to rotate around its own axis; the stirring rods 220 are in a sleeve structure and are fixed on the central rotating rod 210, and an included angle between the axis of each stirring rod and the axis of the central rotating rod 210 is 30-90 degrees, and each stirring rod comprises an outer layer pipe 221 and an inner layer pipe 222; the end of the outer tube 221 far away from the central rotating rod 210 is closed and fixed on the inner tube 222, a hollow cylindrical space exists between the outer tube 221 and the inner tube 222, and the gap between the outer tube 221 and the inner tube 222 is larger than 5 mm; the outer layer pipe 221 is densely provided with water permeable holes 224 which are through holes; the inner tube 222 is tubular, and is used for forming and outputting a water column with an axis coincident with the axis of the stirring rod so as to assist stirring, and the space in the inner tube 222 and the hollow cylindrical space are communicated with the inner space of the central rotating rod 210; during stirring, the pumping assembly 160 cooperates with the conveying assembly 140 to pump the liquid in the drug mixing bin 100 to the inner space of the central rotating rod 210, and the liquid is output from the bottom of the hollow rod body 211, the end of the inner layer tube 222 far away from the hollow rod body 211 and the water permeable hole 224 on the outer layer tube 221 respectively, so that the liquid is stirred and mixed in an accelerating way.

Preferably, the inner space of the hollow rod body 211 is large and small, so as to reduce the amount of liquid output from the bottom of the hollow rod body 211 per unit time, thereby forcing a part of the liquid to flow toward the stirring rod 220.

Preferably, as shown in fig. 5, a flow-limiting plate 212 is fixed on the inner wall of the hollow rod body 211 near the bottom, and the flow-limiting plate 212 is an annular plate, so as to reduce the amount of liquid output from the bottom of the hollow rod body 211 in unit time, thereby increasing the water pressure in the inner space of the hollow rod body 211 and forcing part of the liquid to flow toward the stirring rod 220.

Preferably, the end of the inner tube 222 remote from the central rotating rod 210 is also positioned with an annular restrictor plate 212.

The power component is used for providing power for the operation of each component of the left carnitine injection preparation device, and the control unit plays a role in controlling the coordinated operation of each component of the left carnitine injection preparation device, which are all in the prior art and are not described in detail herein.

Preferably, the control unit is a combination of a programmable logic controller and a control key.

The preparation process of the levocarnitine injection comprises the following steps:

s1, weighing water for injection and levocarnitine (the step can be realized by matching a conveying component 140 and a medicine adding component 150);

s2, seventy-five percent of water for injection is injected into the drug mixing cartridge 100 (the step can be realized by the delivery assembly 140);

s3, adding the prescription amount of levocarnitine, and uniformly stirring and mixing (the stirring rotation speed is preferably 60rpm and the time is preferably 5min when the drug adding component 150 is matched with the stirring and mixing component 200);

s4, adding quantitative hydrochloric acid, and regulating the pH value of the liquid medicine to meet the intermediate control standard (the stirring rotation speed is preferably 60rpm and the time is preferably 5min when the drug adding component 150 is matched with the stirring and mixing component 200);

s5, adding water for injection to fix the volume (which can be performed in the drug mixing bin 100 or the filtering bin);

s6, filtering by using a 0.45 μm and 0.22 μm filter membrane (intermediate product detection is needed after filtering);

and S7, filling, sealing (leak detection is needed), sterilizing, lamp inspection, packaging and finally performing full inspection.

The application provides a levocarnitine injection preparation equipment when in actual use: the stirring rod 220 is stirred by rotating around the central rotating rod 210, and the pumping assembly 160 is matched with the conveying assembly 140 to pump the liquid to the inner space of the central rotating rod 210, so that the mixing effect and speed of the liquid medicine are improved, namely, the bottom of the hollow rod body 211 (improving the mixing efficiency of the liquid medicine at the bottom of the medicine mixing bin 100), the end part of the inner layer pipe 222 far away from the hollow rod body 211 (increasing the flow amount of the liquid medicine) and the water permeable holes 224 on the outer layer pipe 221 are respectively output (increasing the flow amount of the liquid medicine).

The mixing can be accelerated by the bubbles by introducing gas into the center turn bar 210.

The technical scheme in the embodiment of the application at least has the following technical effects or advantages:

the technical problems that the configuration equipment in the prior art is limited by the linear speed influence of the rotation of the stirring rod part close to the rotation shaft, the mixing effect of the liquid medicine in the area right below the central position of the stirring assembly is poor, and the mixing efficiency of the configuration equipment on the liquid medicine is low are solved, and the technical effects that the mixing efficiency of the left carnitine injection configuration equipment is high and the liquid medicine right below the central position of the stirring assembly can be mixed efficiently are achieved.

Example two

In order to further increase the mixing efficiency of the levocarnitine injection preparation device, shorten the preparation time and further reduce the production cost, the embodiment of the present application adds the stirring rod rotating assembly 230 on the basis of the above embodiment, specifically:

as shown in fig. 4 to 10, the stirring rod rotating assembly 230 is used for driving the inclined stirring rod 220 to rotate around the direction perpendicular to the axial direction of the central rotating rod 210 so as to accelerate mixing, and comprises a bearing block 231, a rotating block 232 and a driving system 233; the bearing blocks 231 are fixed on the outer wall of the central rotating rod 210, are in one-to-one correspondence with the stirring rods 220, and are used for bearing the rotating blocks 232; the rotating block 232 is preferably tubular and is rotatably connected to the bearing block 231, and the axial direction of the rotating shaft is perpendicular to the axial direction of the central rotating rod 210; the end of the stirring rod 220, which is close to the central rotating rod 210, is fixed on the central rotating rod 210, and the angle between the stirring rod 220 and the central rotating rod 210 is 30-60 degrees; the inner space of the stirring rod 220 (i.e. the space in the inner pipe 222 and the hollow cylindrical space) is communicated with the inner space of the central rotating rod 210 through the bearing block 231 and the rotating block 232; the driving system 233 is used for driving the rotating block 232 to rotate around the axis thereof.

Further, as shown in fig. 7 and 10, the driving system 233 is positioned inside the center rotating rod 210, and includes a center driving rod 234, a first gear ring 235, and a second gear ring 236; the central driving rod 234 is a combination of a motor and a rod body, is positioned on the upper cover 120, and rotates around the axis thereof under the control of the control unit; the number of the first gear rings 235 and the second gear rings 236 is the same as that of the stirring bars 220; the first gear ring 235 is fixed on the central driving rod 234, and the axial direction is the same as that of the central driving rod 234; the second gear ring 236 is fixed on the rotating block 232, and the axis of the second gear ring 236 coincides with the axis of the rotating block 232 and is meshed with the first gear ring 235; in practice, the rotation of the central driving rod 234 drives the stirring rod 220 to rotate around the axis of the rotating block 232.

Example III

Considering that, in the solution of the above embodiment, during the pharmaceutical process, a part of the liquid medicine is remained on the inner wall of the drug mixing bin 100 and the stirring and mixing assembly 200, if the drug mixing bin 100 is not continuously used, the drug mixing bin 100 needs to be cleaned after use and before use, otherwise, the pharmaceutical quality is easily affected by deterioration; for cleaning effect, the medicine mixing bin 100 is generally required to be filled with clean water for rinsing, so that water resources are seriously wasted and the time is long; in view of the above problems, the embodiments of the present application add the closing plate assembly 240 and the cleaning assembly 300 on the basis of the above embodiments; the method comprises the following steps:

as shown in fig. 10, the main body of the sealing plate assembly 240 is a plate, and is used for controlling the water yield of the stirring rod 220 and thus the water yield at the bottom of the central rotating rod 210 by shielding the water inlet under the control of the control unit; the closing plate assembly 240 includes a closing plate 241, a positioning frame 242, and a plate body elevating assembly 243; the sealing plates 241 are in one-to-one correspondence with the water inlets of the rotating blocks 232, and are fixed on the positioning frame 242, and the positioning frame 242 has a frame structure, is positioned inside the central rotating rod 210 and is positioned on the upper cover 120; the plate lifting assembly 243 is preferably a telescopic rod structure, and is controlled by a control unit for driving the positioning frame 242 to move up and down to control the water yield of the stirring rod 220.

As shown in fig. 11 to 14, the cleaning assembly 300 includes a squeeze-out water plate assembly 310 and a water curtain generating assembly 320; the hollow rod body 211 is provided with a special-shaped pipe part 250 at a position close to the bottom, and the inner diameter of the special-shaped pipe part 250 is larger than the inner diameters of other positions of the hollow rod body 211;

the squeeze water outlet plate assembly 310 is used for controlling water outlet at the bottom of the central rotating rod 210, and comprises a positioning frame 311, a plugging plate 312, a force-applying pressure spring 313, a limiting ring 314, a lifting squeeze rod 315 and a supporting body 317; the positioning frame 311 is a frame structure, is fixed on the inner wall of the hollow rod 211, is located above the special-shaped pipe 250, and is used for positioning the force-applying compression spring 313; the limiting ring 314 is annular, is fixed on the inner wall of the hollow rod body 211, is disposed near the end of the central rotating rod 210, is located below the special-shaped pipe 250, and is used for bearing the plugging plate 312; the blocking plate 312 abuts against the limiting ring 314 and is used for blocking water flow; the force-applying compression spring 313 is positioned between the positioning frame 311 and the plugging plate 312 and is used for extruding the plugging plate 312; the lifting extrusion rod 315 is fixed on the inner wall of the drug mixing bin 100 through a support 317, is a telescopic rod, is controlled by a control unit, and the top of the lifting extrusion rod is abutted against the bottom of the plugging plate 312; after the lifting extrusion rod 315 pushes the plugging plate 312 to move upwards, the plugging plate 312 enters the special-shaped pipe portion 250, and the liquid in the central rotating rod 210 flows out from the bottom;

the water curtain generating assembly 320 is positioned under the central rotating rod 210, and is used for forming an annular water curtain to clean the inner wall of the medicine mixing bin 100 and the stirring and mixing assembly 200, and comprises a water guide disc 321, a water guide blade 323 and a blade rotating assembly 324; the water guiding disc 321 is fixed on the medicine mixing bin 100 and is located under the central rotating rod 210, and is disc-shaped, the central position of the water guiding disc 321 is located with a water passing hole 322, the water passing hole 322 is used for passing through the lifting extrusion rod 315 and part of the medicine liquid output from the bottom of the central rotating rod 210, and the diameter of the water passing hole 322 is 2-5 cm greater than that of the lifting extrusion rod 315; the water guide blades 323 are arc-shaped sheet bodies, the number of the water guide blades 323 is 8 or more, the water guide blades are all rotationally connected to the water guide plate 321 and are uniformly distributed on the periphery of the water guide plate 321, and the water guide plates 321 and the water guide blades 323 are combined to form a bowl shape; the blade rotating assembly 324 is used for controlling all the water guiding blades 323 to rotate so as to change the bowl opening size of the combination of the bowl-shaped water guiding disc 321 and the water guiding blades 323, and further change the direction of the water curtain. The water curtain can also play a role in rinsing the container (avoiding the waste of liquid medicine) in the constant volume process. In practice, the blocking plate 312 is first moved upward, and then the blocking plate assembly 240 is operated to reduce the water yield of the stirring rod 220, at this time, part of the liquid output from the bottom of the central rotating rod 210 is output to the lower side of the water guiding plate 321 through the water passing holes 322, and the other part of the liquid impacts the water guiding plate 321 to form a water curtain.

Further, as shown in FIG. 14, the blade rotation assembly 324 includes a force ring 325 and a force ring lift assembly 326; the force application ring 325 is sleeved on a ring formed by the water guide blades 323, and the force application ring lifting assembly 326 is used for controlling the lifting of the force application ring 325 so as to control the rotation of the water guide blades 323, and is preferably a telescopic rod controlled by a control unit.

Preferably, in order to expand the cleaning range and enhance the cleaning effect, as shown in fig. 13, a hole blocking block 316 is further fixed on the lifting extrusion rod 315, and the size of the hole blocking block 316 is slightly smaller than the size of the water passing hole 322, so as to block the water passing hole 322 after the lifting extrusion rod 315 rises to a certain extent; as shown in fig. 15, the cleaning assembly 300 further includes a second water curtain generating assembly 330, the second water curtain generating assembly 330 has the same structure as the water curtain generating assembly 320, and is fixed on the upper cover 120, and the second water curtain generating assembly 330 and the water curtain generating assembly 320 are symmetrically arranged and are controlled by the control unit. In actual use, the control unit firstly controls the hole blocking block 316 to block the water passing hole 322, and simultaneously controls the bowl mouth of the bowl-shaped water guide disc 321 and the water guide blades 323 to be reduced, so that the water curtain is flushed towards the second water curtain generating assembly 330, and the second water curtain generating assembly 330 forms a new annular water curtain to further clean the medicine mixing bin 100.

The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications and variations can be made to the present invention by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. The levocarnitine injection preparation device comprises a medicine mixing bin and a stirring mixing assembly, wherein the medicine mixing bin comprises an outer shell, an upper cover, a conveying assembly, a medicine adding assembly and a pumping assembly; the method is characterized in that: the stirring and mixing assembly comprises a central rotating rod and a stirring rod;

the water permeable holes are densely distributed on the outer layer pipe;

when stirring, the pumping assembly is matched with the conveying assembly to pump the liquid in the medicine mixing bin to the inner space of the central rotating rod, and the liquid is output from the bottom of the hollow rod body, the end part of the inner layer pipe and the water permeable hole respectively;

also included is a closure plate assembly;

the plate body lifting assembly is of a telescopic rod structure and is controlled by the control unit, and the plate body lifting assembly is used for driving the positioning frame to move up and down so as to control the water yield of the stirring rod;

the device also comprises a warehouse cleaning component;

after the lifting extrusion rod pushes the plugging plate to move upwards, the plugging plate enters the special-shaped pipe part, and the liquid in the central rotating rod flows out from the bottom; the water curtain generating assembly is positioned under the central rotating rod and used for forming an annular water curtain to clean the inner wall of the medicine mixing bin and the stirring and mixing assembly, and comprises a water guide disc, a water guide blade and a blade rotating assembly;

2. The levocarnitine injection configuring apparatus of claim 1 wherein: the stirring rod rotating assembly is also included; the stirring rod rotating assembly comprises a bearing block, a rotating block and a driving system;

the bearing blocks are fixed on the outer wall of the central rotating rod, correspond to the stirring rods one by one and are used for bearing the rotating blocks; the rotating block is rotationally connected to the bearing block, and the axial direction of the rotating shaft is perpendicular to the axial direction of the central rotating rod;

3. The levocarnitine injection configuring apparatus of claim 1 wherein: the blade rotating assembly comprises a force application ring and a force application ring lifting assembly;

4. The levocarnitine injection configuring apparatus of claim 1 wherein: the lifting extrusion rod is also fixedly provided with a hole blocking block for blocking the water passing hole after the lifting extrusion rod rises to a certain degree;

5. The levocarnitine injection configuring apparatus of claim 1 wherein: the conveying component is positioned on the upper cover, is a combination of a pump and a pipeline, is communicated with the raw material bin for injection and the pumping component, and plays a role in conveying liquid, gas and energy into the stirring and mixing component;

6. The levocarnitine injection configuring apparatus of claim 1 wherein: the inner wall of the hollow rod body, which is close to the bottom, is fixedly provided with a flow limiting plate, and the flow limiting plate is an annular plate and is used for reducing the liquid output from the bottom of the hollow rod body in unit time.

7. The levocarnitine injection configuring apparatus of claim 2 wherein: the driving system is positioned inside the central rotating rod and comprises a central driving rod, a first gear ring and a second gear ring;

8. A preparation process of a levocarnitine injection is characterized by comprising the following steps of: the method for preparing the levocarnitine injection according to claim 1 comprises the following steps in sequence:

s1, weighing water for injection and levocarnitine;

s2, seventy-five percent of water for injection is injected into the medicine mixing bin;

s3, adding the prescription amount of levocarnitine, and uniformly stirring and mixing;

s4, adding quantitative hydrochloric acid, and adjusting the PH value of the liquid medicine to meet the intermediate control standard;

s5, adding water for injection to fix the volume;

s6, filtering by using a 0.45 μm filter membrane and a 0.22 μm filter membrane;

and S7, filling, sealing, sterilizing, inspecting by a lamp, packaging and finally performing full inspection.