CN115025167A - 一种绞股蓝降粘液处方及其制作工艺 - Google Patents
一种绞股蓝降粘液处方及其制作工艺 Download PDFInfo
- Publication number
- CN115025167A CN115025167A CN202210878409.8A CN202210878409A CN115025167A CN 115025167 A CN115025167 A CN 115025167A CN 202210878409 A CN202210878409 A CN 202210878409A CN 115025167 A CN115025167 A CN 115025167A
- Authority
- CN
- China
- Prior art keywords
- gynostemma pentaphylla
- preparation process
- solution
- viscosity reducing
- reducing liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 title claims abstract description 26
- 239000007788 liquid Substances 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 241001065361 Gynostemma Species 0.000 title claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 8
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 8
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 8
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 8
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 8
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 8
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 8
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 8
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 8
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 8
- 235000021419 vinegar Nutrition 0.000 claims abstract description 8
- 239000000052 vinegar Substances 0.000 claims abstract description 8
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 6
- 235000003365 Ilex pubescens Nutrition 0.000 claims abstract description 6
- 241001100932 Ilex pubescens Species 0.000 claims abstract description 6
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 6
- 241000131458 Elsholtzia Species 0.000 claims abstract description 5
- 241001289529 Fallopia multiflora Species 0.000 claims abstract description 5
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 5
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 3
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 3
- 239000000243 solution Substances 0.000 claims description 19
- 239000002994 raw material Substances 0.000 claims description 16
- 238000004806 packaging method and process Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000011550 stock solution Substances 0.000 claims description 6
- 238000001514 detection method Methods 0.000 claims description 3
- 238000010790 dilution Methods 0.000 claims description 3
- 239000012895 dilution Substances 0.000 claims description 3
- 239000000428 dust Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 210000004907 gland Anatomy 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000005070 sampling Methods 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 240000007890 Leonurus cardiaca Species 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 21
- 210000004369 blood Anatomy 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 18
- 230000001737 promoting effect Effects 0.000 abstract description 16
- 239000003814 drug Substances 0.000 abstract description 12
- 208000031226 Hyperlipidaemia Diseases 0.000 abstract description 10
- 208000004880 Polyuria Diseases 0.000 abstract description 8
- 230000035619 diuresis Effects 0.000 abstract description 8
- 230000017531 blood circulation Effects 0.000 abstract description 7
- 210000003734 kidney Anatomy 0.000 abstract description 7
- 229940079593 drug Drugs 0.000 abstract description 6
- 210000004185 liver Anatomy 0.000 abstract description 6
- 208000024172 Cardiovascular disease Diseases 0.000 abstract description 5
- 208000026106 cerebrovascular disease Diseases 0.000 abstract description 5
- 230000002526 effect on cardiovascular system Effects 0.000 abstract description 5
- 241000207925 Leonurus Species 0.000 abstract description 4
- 230000003213 activating effect Effects 0.000 abstract description 3
- 208000011580 syndromic disease Diseases 0.000 abstract description 3
- 241000721047 Danaus plexippus Species 0.000 abstract description 2
- 239000002671 adjuvant Substances 0.000 abstract description 2
- 238000002386 leaching Methods 0.000 abstract description 2
- 240000006509 Gynostemma pentaphyllum Species 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 7
- 241001092040 Crataegus Species 0.000 description 5
- 201000010099 disease Diseases 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 208000005577 Gastroenteritis Diseases 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 3
- 206010062717 Increased upper airway secretion Diseases 0.000 description 3
- 206010030113 Oedema Diseases 0.000 description 3
- 230000036772 blood pressure Effects 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 208000026435 phlegm Diseases 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 235000019640 taste Nutrition 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 208000005171 Dysmenorrhea Diseases 0.000 description 2
- 206010013935 Dysmenorrhoea Diseases 0.000 description 2
- 208000019255 Menstrual disease Diseases 0.000 description 2
- 206010030302 Oliguria Diseases 0.000 description 2
- 206010044302 Tracheitis Diseases 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 235000019606 astringent taste Nutrition 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 201000009240 nasopharyngitis Diseases 0.000 description 2
- 244000132619 red sage Species 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 240000000031 Achyranthes bidentata Species 0.000 description 1
- DJQOOSBJCLSSEY-UHFFFAOYSA-N Acipimox Chemical compound CC1=CN=C(C(O)=O)C=[N+]1[O-] DJQOOSBJCLSSEY-UHFFFAOYSA-N 0.000 description 1
- 201000004384 Alopecia Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 208000008035 Back Pain Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- 206010006326 Breath odour Diseases 0.000 description 1
- 206010008479 Chest Pain Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 241000219104 Cucurbitaceae Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010016807 Fluid retention Diseases 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 208000032139 Halitosis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010019345 Heat stroke Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000007330 LDL Lipoproteins Human genes 0.000 description 1
- 108010007622 LDL Lipoproteins Proteins 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- 208000037093 Menstruation Disturbances Diseases 0.000 description 1
- 206010027339 Menstruation irregular Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 240000007164 Salvia officinalis Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041349 Somnolence Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000007180 Sunstroke Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 229960003526 acipimox Drugs 0.000 description 1
- 208000012873 acute gastroenteritis Diseases 0.000 description 1
- 231100000360 alopecia Toxicity 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000009194 climbing Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 230000037356 lipid metabolism Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000004792 malaria Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 235000005412 red sage Nutrition 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 229940126673 western medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/424—Gynostemma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/884—Alismataceae (Water-plantain family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种绞股蓝降粘液处方及其制作工艺，通过将绞股蓝50g，益母草20g，丹参30g，泽泻10g，毛冬青10g，何首乌10g，怀牛膝10g，香薷10g，山楂醋50ml原料进行两次加水煎煮后，合并煎液，静置、过滤并加水调整总量至1000ml制成，活血化瘀，补肾利湿，绞股蓝、益母草、丹参、山楂醋活血化瘀为君药；辅以何首乌、怀牛膝、毛冬青滋补肝肾为臣药；佐以泽泻、香薷以利湿；瘀散湿利而降粘，共奏活血化瘀、补肾利湿降粘之功，临床用于治疗心脑血管病中的高血脂、高粘血症之属于湿蕴血瘀证等，疗效确切，且药性平和、质量稳定，通过两次煎煮增强了对药力的浸出，方便患者饮用。
Description
技术领域
本发明涉及口服液制备技术领域，具体为一种绞股蓝降粘液处方及其制作工艺。
背景技术
高血脂是一种常见的疾病，系人体脂代谢失常所致，主要指血清总胆固醇、甘油三酯和低密度脂蛋白水平过高或高密度脂蛋白水平过低。高血脂症早期没有明显的临床症状，它对身体的损害时隐匿性、渐行性的，并且是全身性的。因为高血脂可加速动脉粥样硬化，一旦动脉堵塞，就会引起很多疾病，如心脑血管疾病、肾脏病、肝脏疾病等。心脑血管疾病是中老年人致死的主要原因，是威胁人类健康的头号杀手。据世界卫生组织统计，每年大约有1700万人死于这种慢性疾病，占全球总死亡人数的30％左右。
绞股蓝是一种葫芦科、绞股蓝属草质攀援植物，在中医中性寒、味苦，具有清热解毒、止咳清肺祛痰、养心安神、补气生精之功效，可用于降血压、降血脂、护肝、促进睡眠以及肠胃炎、气管炎、咽喉炎的治疗，并用于多种癌症的抗癌临床治疗。
在现行高血脂与高粘血症的治疗中，患者常服用西药进行治疗，鲜有通过绞股蓝进行中药治疗，而绞股蓝对降血压、降血脂有着独特的效果，对临床用于治疗心脑血管病中的高血脂、高粘血症之属于湿蕴血瘀证等，疗效确切，且药性平和、质量稳定
发明内容
本发明的目的在于针对现有技术的不足之处，提供一种绞股蓝降粘液处方及其制作工艺，以解决背景技术中所提出的问题。
为实现上述目的，本发明提供如下技术方案：所述溶液有以下重量的原料组成：绞股蓝50g，益母草20g，丹参30g，泽泻10g，毛冬青10g，何首乌10g，怀牛膝10g，香薷10g，山楂醋50ml。
作为本发明的优选技术方案，包括如下步骤：
步骤一：对上述原料进行称重备用；
步骤二：对上述原料进行冲洗，使其表面灰尘与污垢清洗干净后备用；
步骤三：将上述原料放入锅中加水煎煮1小时后倒出第一次溶液；
步骤四：在锅中再次加入水煎煮40分钟后倒出第二次溶液，并将第二次溶液与第一次溶液混合；
步骤五：对混合后的原液进行静置后过滤，去除固体残留；
步骤六：在过滤的原液中加入水稀释后，调整总量至1000ml；
步骤七：对稀释后的溶液进行封装并抽样检测，检测合格后进行压盖封装。
作为本发明的优选技术方案，步骤三中，加入水的重量为1000g，煎煮温度为98℃-103℃。
作为本发明的优选技术方案，步骤四中，加入水的重量为800g，煎煮温度为98℃-103℃。
作为本发明的优选技术方案，步骤七中，封装规格为每瓶500ml。
与现有技术相比，本发明提供了一种绞股蓝降粘液处方及其制作工艺，具备以下有益效果：
1、一种绞股蓝降粘液处方及其制作工艺，通过由绞股蓝50g，益母草20g，丹参30g，泽泻10g，毛冬青10g，何首乌10g，怀牛膝10g，香薷10g，山楂醋50ml混合的原料进行两次加水煎煮后，静置、过滤并加水调整总量至1000ml制成，其主要功能为活血化瘀，补肾利湿，方中绞股蓝、益母草、丹参、山楂醋活血化瘀为君药；辅以何首乌、怀牛膝、毛冬青滋补肝肾为臣药；佐以泽泻、香薷以利湿；瘀散湿利而降粘，共奏活血化瘀、补肾利湿降粘之功，临床用于治疗心脑血管病中的高血脂、高粘血症之属于湿蕴血瘀证等，疗效确切，且药性平和、质量稳定；
2、该一种绞股蓝降粘液处方及其制作工艺，采用更加方便进行的制备工艺，使得其制备效率得以稳定提升的同时，亦能够确保其制得溶液的品质，通过两次煎煮增强了对药力的浸出，方便患者饮用。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1，具体的使用方法：一种绞股蓝降粘液处方及其制作工艺，所述溶液由以下重量的原料组成：绞股蓝50g，益母草20g，丹参30g，泽泻10g，毛冬青10g，何首乌10g，怀牛膝10g，香薷10g，山楂醋50ml。
进一步的，包括如下步骤：
步骤一：对上述原料进行称重备用；
步骤二：对上述原料进行冲洗，使其表面灰尘与污垢清洗干净后备用；
步骤三：将上述原料放入锅中加水煎煮1小时后倒出第一次溶液；
步骤四：在锅中再次加入水煎煮40分钟后倒出第二次溶液，并将第二次溶液与第一次溶液混合；
步骤五：对混合后的原液进行静置后过滤，去除固体残留；
步骤六：在过滤的原液中加入水稀释后，调整总量至1000ml；
步骤七：对稀释后的溶液进行封装并抽样检测，检测合格后进行压盖封装。
具体地，步骤三中，加入水的重量为1000g，煎煮温度为98℃-103℃，步骤四中，加入水的重量为800g，煎煮温度为98℃-103℃，步骤七中，封装规格为每瓶500ml；
具体的，用法用量为口服；一次10ml，一日3次；饭后服用。
在上述配方的各味中药中：
绞股蓝：性寒、味苦，具有清热解毒、止咳清肺祛痰、养心安神、补气生精之功效，可用于降血压、降血脂、护肝、促进睡眠以及肠胃炎、气管炎、咽喉炎的治疗。
益母草：具有活血调经，利尿消肿，清热解毒之功效。用于月经不调，痛经经闭，恶露不尽，水肿尿少，疮疡肿毒。
丹参：味苦，微寒，具有活血祛瘀，通经止痛，清心除烦，凉血消痈之功效。用于胸痹心痛，脘腹胁痛，症瘕积聚，热痹疼痛，心烦不眠，月经不调，痛经经闭，疮疡肿痛。
泽泻：味甘、淡，性寒，利水渗湿，泄热，化浊降脂，用于小便不利，水肿胀满，泄泻尿少，痰饮眩晕，热淋涩痛，高脂血症。
毛冬青：味道苦涩、性寒，人肺、肝、大肠经，能够清热解毒、活血通络。
何首乌：具有安神、养血、活络，解毒(截疟)、消痈的效果。
怀牛膝：可补肝益肾、强壮筋骨、通经络、散恶血。临床常用于治疗寒湿，腰膝骨疼、腰膝酸软，四肢拘挛、经血不调、产后瘀血腹疼、血淋、跌打损伤及屈膝碍等症。
香薷：可发汗解暑，行水散湿，温胃调中，可治急性肠胃炎、腹痛吐泻、夏秋阳暑、头痛发热、恶寒无汗、霍乱、水肿、鼻衄、口臭等症。
山楂醋：具有清除疲劳、增进食欲、帮助消化、抗菌消炎、防治感冒、消暑降温等作用，并能防治动脉硬化、高血脂、降血压、降血脂、高血压、冠心病、骨质增生、风湿性腰腿疼、感冒、皮肤病、脱发、头皮痒等症状。
实施例2，具体案例：
案例一：刘某，男，58岁，河南许昌人。既往高血脂3年，于当地医院就诊，经治疗后效果一般，仍不时出现胸闷、心悸等；后给予本降粘液服用，每日三次，每次十毫升，一月后症状明显改善。
案例二：王某，女，53岁，河南禹州人。2021年10月检查中发现高粘血症，自诉头晕、困倦、记忆力减退，给予阿西莫司治疗效果一般，后经朋友介绍，开始服用本降粘液，2月后症状减轻。
最后应说明的是：以上所述仅为本发明的优选实施例而已，并不用于限制本发明，尽管参照前述实施例对本发明进行了详细的说明，对于本领域的技术人员来说，其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换。凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。
Claims (5)
1.一种绞股蓝降粘液处方，其特征在于：所述溶液由以下重量的原料组成：绞股蓝50g，益母草20g，丹参30g，泽泻10g，毛冬青10g，何首乌10g，怀牛膝10g，香薷10g，山楂醋50ml。
2.根据权利要求1所述的一种绞股蓝降粘液处方的制作工艺，其特征在于：包括如下步骤：
步骤一：对上述原料进行称重备用；
步骤二：对上述原料进行冲洗，使其表面灰尘与污垢清洗干净后备用；
步骤三：将上述原料放入锅中加水煎煮1小时后倒出第一次溶液；
步骤四：在锅中再次加入水煎煮40分钟后倒出第二次溶液，并将第二次溶液与第一次溶液混合；
步骤五：对混合后的原液进行静置后过滤，去除固体残留；
步骤六：在过滤的原液中加入水稀释后，调整总量至1000ml；
步骤七：对稀释后的溶液进行封装并抽样检测，检测合格后进行压盖封装。
3.根据权利要求2所述的一种绞股蓝降粘液处方的制作工艺，其特征在于：步骤三中，加入水的重量为1000g，煎煮温度为98℃-103℃。
4.根据权利要求2所述的一种绞股蓝降粘液处方的制作工艺，其特征在于：步骤四中，加入水的重量为800g，煎煮温度为98℃-103℃。
5.根据权利要求2所述的一种绞股蓝降粘液处方的制作工艺，其特征在于：步骤七中，封装规格为每瓶500ml。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210878409.8A CN115025167A (zh) | 2022-07-25 | 2022-07-25 | 一种绞股蓝降粘液处方及其制作工艺 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210878409.8A CN115025167A (zh) | 2022-07-25 | 2022-07-25 | 一种绞股蓝降粘液处方及其制作工艺 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115025167A true CN115025167A (zh) | 2022-09-09 |
Family
ID=83130626
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210878409.8A Pending CN115025167A (zh) | 2022-07-25 | 2022-07-25 | 一种绞股蓝降粘液处方及其制作工艺 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN115025167A (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839702A (zh) * | 2005-04-03 | 2006-10-04 | 钟锦习 | 复方绞股兰活心健脑辅疗茶及其制备方法 |
| CN103251043A (zh) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | 辅助降血脂保健食品 |
| CN107551089A (zh) * | 2017-10-18 | 2018-01-09 | 新疆阿勒泰地区哈萨克医医院 | 一种治疗高脂血症的药物及其制备方法与检测方法 |
-
2022
- 2022-07-25 CN CN202210878409.8A patent/CN115025167A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839702A (zh) * | 2005-04-03 | 2006-10-04 | 钟锦习 | 复方绞股兰活心健脑辅疗茶及其制备方法 |
| CN103251043A (zh) * | 2012-03-23 | 2013-08-21 | 山东德圣医药科技有限公司 | 辅助降血脂保健食品 |
| CN107551089A (zh) * | 2017-10-18 | 2018-01-09 | 新疆阿勒泰地区哈萨克医医院 | 一种治疗高脂血症的药物及其制备方法与检测方法 |
Non-Patent Citations (1)
| Title |
|---|
| 晋玉梅;: "通络调脂汤治疗血脂异常", 中国民间疗法, vol. 19, no. 12, pages 28 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103623280B (zh) | 一种治疗心脑血管疾病的中药制剂 | |
| CN105999058B (zh) | 鬼针草降脂片 | |
| CN104857210A (zh) | 一种治疗脂肪肝的中药组合制剂及其制备方法 | |
| CN103977164A (zh) | 一种治疗心绞痛的中药制剂及制备方法 | |
| CN115025167A (zh) | 一种绞股蓝降粘液处方及其制作工艺 | |
| CN111419924A (zh) | 一种治疗多种肌肉、骨骼疾病的外用中药组合物及其制备装置 | |
| CN111011852A (zh) | 一种具有保肝功能的人参方便食品的制备方法 | |
| CN104623330A (zh) | 一种治疗高血脂的中药组合物 | |
| CN113117017A (zh) | 一种治疗心脑血管疾病的中药组合物及其制备方法 | |
| CN110755501A (zh) | 一种治疗糖尿病周围神经病变的中药组合物 | |
| CN104338052A (zh) | 治疗脑血栓的中药配方 | |
| CN114712466B (zh) | 一种具有减肥养颜功效的药物及其制备方法 | |
| CN114732882B (zh) | 一种中药组合物及其制备方法和应用 | |
| CN102406906A (zh) | 一种治疗急性乙型肝炎的中药组合物 | |
| CN101095753A (zh) | 治疗糖尿病性高脂血症的一种中药制剂 | |
| CN106074918A (zh) | 一种治疗非酒精性脂肪性肝病的疏肝消脂中药组合物 | |
| CN105709176A (zh) | 一种治疗心血瘀阻型心悸的中药组合物及其制备方法 | |
| CN105770354A (zh) | 一种用于治疗慢性肾炎的药物及制备方法 | |
| CN105477171A (zh) | 一种用于治疗高脂血症的胶囊及制备方法 | |
| CN104997881A (zh) | 一种可治疗增生性脊椎炎的汤剂药物及其制备方法 | |
| CN104547635A (zh) | 一种治疗重症肝炎的中药胶囊及制备方法 | |
| CN105012656A (zh) | 一种可治疗颈椎病关节炎骨质增生的中草药水剂及其制备方法 | |
| CN105106783A (zh) | 一种治疗慢性阑尾炎的中药组合物及其应用 | |
| CN114712480A (zh) | 一种温阳通脉中药配方及其制备方法与应用 | |
| CN104873896A (zh) | 一种治疗高血压引发中风的中药组合物 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20220909 |