CN115025030A - 一种用于牙龈炎症的中草药牙膏及其制备方法 - Google Patents
一种用于牙龈炎症的中草药牙膏及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种用于牙龈炎症的中草药牙膏，包括下述重量份的原料，中草药提取物0.3‑0.8份，牙膏膏体基质99.2‑99.7份；所述中草药提取物由下述重量份的原料制成：丹参15‑20份、三七3‑8份、虎杖5‑12份、苦丁茶1‑3份、南非叶5‑10份、天冬4‑8份。本发明的有益效果为：本发明所述用于牙龈炎症的中草药牙膏具有清热去火的功效，可解决牙龈肿痛、口腔溃疡等多重口腔问题，具有治疗口腔牙龈炎症、牙龈出血的功效，能实现对口腔的全面养护，舒解牙齿牙龈疼痛困扰，令口腔环境更健康。本发明所述用于牙龈炎症的中草药牙膏安全无毒副作用，长期使用不会破坏口腔微环境，且不会产生抗药性。
Description
技术领域
本发明属于日常生活用品技术领域，具体涉及一种用于牙龈炎症的中草药牙膏及其制备方法。
背景技术
据流调报告显示，中年人口腔健康中牙龈炎症检出率为87.4％。牙龈炎症的主要临床表现为牙龈肿痛、出血、口臭，引发牙龈萎缩，最终导致牙齿脱落。严重时还会影响和带动全身一系列的健康问题。
改善牙龈炎症最直接有效的方式就是改正不良的口腔护理习惯，使用可以有效抗炎、抑菌的口腔护理产品，来控制口腔环境中致病菌的生长。其中，牙膏作为我们每天必备的口腔护理产品，其功效将对预防口腔疾病具有重要作用。
普通牙膏的主要成份包括磨擦剂、洁净剂、润湿剂、防腐剂、芳香剂，具有一般牙膏共有的作用，药物牙膏则是在普通牙膏的基础上加一定药物，刷牙时牙膏到达牙齿表面或牙齿周围环境中，通过药物的作用，减少牙菌斑，从而起到防龋病和牙周病的作用。药物牙膏极受人们的青睐，而且利用牙膏来推广具有预防功效或治疗功效的药物是一种较理想的方式。但是药物的添加有时会产生副作用，比如长期使用带有抗生素的牙膏可能会导致菌群失调，产生耐药性等不良后果。
发明内容
本发明的目的为提供一种无副作用，具有改善口腔微生态环境，促进牙周细胞活力、缓解和减轻牙龈红肿、出血、镇痛等功效的用于牙龈炎症的中草药牙膏及其制备方法。
为实现本发明的上述目的，本发明采用以下技术方案：
一种用于牙龈炎症的中草药牙膏，包括下述重量份的原料，中草药提取物0.3-0.8份，牙膏膏体基质99.2-99.7份；
所述中草药提取物由下述重量份的原料制成：丹参15-20份、三七3-8份、虎杖5-12份、苦丁茶1-3份、南非叶5-10份、天冬4-8份。
丹参为唇形科植物，味苦、微寒，能促进组织的修复，抑制过度增生的纤维母细胞；具有抗菌和降血脂的作用，对大肠杆菌，变性杆菌有抑制作用。
三七为伞形目五加科植物，味甘、微苦、性温，具有散瘀止血、消肿定痛的功效。此外三七具有抗炎，保肝的作用，三七中的三七皂苷具有抗肿瘤的作用。
虎杖属蓼科、蓼属，味苦、微寒，具有清热解毒、利胆退黄、散瘀定痛的功效，常用来治疗关节痹痛、经闭、跌打损伤、痈肿疮毒等。
苦丁茶是冬青科冬青属苦丁茶种常绿乔木。苦丁茶中含有苦丁皂甙、氨基酸、维生素C、多酚类、黄酮类、咖啡碱、蛋白质等200多种成分。具有很好的抑菌活性和抗氧化活性。
南非叶为菊科植物扁桃斑鸠菊的叶，散热、凉血和清血的功效。适用于降血压、降胆固醇和糖尿病。南非叶中含有多种天然药用成分，它提取以后可以制成消毒药物，可以用于人体消毒，也可以用于环境消毒，能有效预防疟疾和性传播疾病出现。另外，从南非叶中提取出的药物，有时还能代替碘酒或双氧水，用于外伤伤口的消毒，它能有效预防伤处感染。
天冬性寒，味甘，微苦。具有养阴清热，润肺滋肾的功效。天门冬有升高血细胞、增强网状内皮系统吞噬功能和延长抗体存在时间的作用。
上述一种用于牙龈炎症的中草药牙膏，作为一种优选的实施方案，包括下述重量份的原料，中草药提取物0.4-0.6份，牙膏膏体基质99.4-99.6份；所述中草药提取物由下述重量份的原料制成：丹参15-20份、三七3-8份、虎杖5-12份、苦丁茶1-3份、南非叶5-10份、天冬4-8份。
上述一种用于牙龈炎症的中草药牙膏，作为一种优选的实施方案，包括下述重量份的原料，中草药提取物0.5份，牙膏膏体基质99.5份；所述中草药提取物由下述重量份的原料制成：丹参15-20份、三七3-8份、虎杖5-12份、苦丁茶1-3份、南非叶5-10份、天冬4-8份。
上述一种用于牙龈炎症的中草药牙膏，作为一种优选的实施方案，所述牙膏膏体基质包括下述重量份的原料：增稠剂0.8-1.2份、摩擦剂18-20份、保湿剂55-60份、表面活性剂1-3份、甜味剂0.5-1.5份、水15-25份。
优选地，所述增稠剂为黄原胶或卡拉胶。
优选地，所述摩擦剂为碳酸钙或磷酸三钙；所述保湿剂为聚乙二醇或丙二醇；所述表面活性剂为十二烷基硫酸钠，所述甜味剂为阿斯巴甜。
本申请的第二方面，提供一种用于牙龈炎症的中草药牙膏的制备方法，包括以下步骤：
(1)制备中草药提取物，将丹参、三七、虎杖、苦丁茶、南非叶和天冬用乙醇进行回流提取，浓缩提取液，冷冻干燥浓缩物得中草药提取物；
(2)将步骤(1)所得中草药提取物和牙膏膏体基质混合搅拌均匀投入共沸锅中，在加热搅拌的条件下，使物料混合均匀，然后移至碾压机上碾压，得所述用于牙龈炎症的中草药牙膏。
上述一种用于牙龈炎症的中草药牙膏的制备方法，作为一种优选的实施方案，步骤(1)中，乙醇与待提取物料的重量比为10-15：1，回流提取的温度为70-75℃。
上述一种用于牙龈炎症的中草药牙膏的制备方法，作为一种优选的实施方案，步骤(1)中，所述冷冻干燥的温度为-20至-30℃，在此温度下干燥的时间为24-32h。
上述一种用于牙龈炎症的中草药牙膏的制备方法，作为一种优选的实施方案，步骤(2)中，所述加热的温度为60-70℃，混合搅拌的转速为200-280r/min，混合搅拌的时间为60-120min。
本发明的有益效果为：本发明所述用于牙龈炎症的中草药牙膏具有清热去火的功效，可解决牙龈肿痛、口腔溃疡等多重口腔问题，具有治疗口腔牙龈炎症、牙龈出血的功效，能实现对口腔的全面养护，舒解牙齿牙龈疼痛困扰，令口腔环境更健康。
本发明所述用于牙龈炎症的中草药牙膏安全无毒副作用，长期使用不会破坏口腔微环境，且不会产生抗药性。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚，下面将对本发明的技术方案进行详细的描述。显然，所描述的实施例仅仅是本发明的一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式，都属于本发明所保护的范围。
实施例1
实施例1所述一种用于牙龈炎症的中草药牙膏，包括下述重量份的原料，中草药提取物0.3重量份，牙膏膏体基质99.7重量份；所述中草药提取物由下述重量份的原料制成：丹参15重量份、三七8重量份、虎杖5重量份、苦丁茶3重量份、南非叶6重量份、天冬4重量份；
所述牙膏膏体基质包括下述重量份的原料：黄原胶0.8重量份、碳酸钙18重量份、聚乙二醇60重量份、十二烷基硫酸钠1重量份、阿斯巴甜0.5重量份、水19.7重量份；
实施例1所述一种用于牙龈炎症的中草药牙膏的制备方法，包括以下步骤：
(1)制备中草药提取物，将丹参、三七、虎杖、苦丁茶、南非叶和天冬用乙醇进行回流提取，乙醇与待提取物料的重量比为10：1，回流提取的温度为70℃，浓缩提取液，在温度为-20℃的条件下冷冻干燥32h浓缩物得中草药提取物；
(2)将步骤(1)所得中草药提取物和牙膏膏体基质混合搅拌均匀投入共沸锅中，在加热温度为60℃，搅拌转速为280r/min的条件下，混合搅拌120min，然后移至碾压机上碾压，得所述用于牙龈炎症的中草药牙膏。
实施例2
实施例2所述一种用于牙龈炎症的中草药牙膏，包括下述重量份的原料，中草药提取物0.5重量份，牙膏膏体基质99.5重量份；所述中草药提取物由下述重量份的原料制成：丹参15重量份、三七3重量份、虎杖10重量份、苦丁茶2重量份、南非叶8重量份、天冬6重量份；
所述牙膏膏体基质包括下述重量份的原料：卡拉胶1重量份、碳酸钙18重量份、丙二醇58重量份、十二烷基硫酸钠2重量份、阿斯巴甜1重量份、水20重量份；
实施例2所述一种用于牙龈炎症的中草药牙膏的制备方法，包括以下步骤：
(1)制备中草药提取物，将丹参、三七、虎杖、苦丁茶、南非叶和天冬用乙醇进行回流提取，乙醇与待提取物料的重量比为12：1，回流提取的温度为72℃，浓缩提取液，在温度为-25℃的条件下冷冻干燥28h浓缩物得中草药提取物；
(2)将步骤(1)所得中草药提取物和牙膏膏体基质混合搅拌均匀投入共沸锅中，在加热温度为65℃，搅拌转速为250r/min的条件下，混合搅拌80min，然后移至碾压机上碾压，得所述用于牙龈炎症的中草药牙膏。
实施例3
实施例3所述一种用于牙龈炎症的中草药牙膏，包括下述重量份的原料，中草药提取物0.8重量份，牙膏膏体基质99.2重量份；所述中草药提取物由下述重量份的原料制成：丹参20重量份、三七3重量份、虎杖5重量份、苦丁茶3重量份、南非叶6重量份、天冬6重量份；
所述牙膏膏体基质包括下述重量份的原料：黄原胶1.2重量份、磷酸三钙20重量份、丙二醇60重量份、十二烷基硫酸钠2重量份、阿斯巴甜1.5重量份、水15.3重量份；
实施例3所述一种用于牙龈炎症的中草药牙膏的制备方法，包括以下步骤：
(1)制备中草药提取物，将丹参、三七、虎杖、苦丁茶、南非叶和天冬用乙醇进行回流提取，乙醇与待提取物料的重量比为15：1，回流提取的温度为75℃，浓缩提取液，在温度为-30℃的条件下冷冻干燥24h浓缩物得中草药提取物；
(2)将步骤(1)所得中草药提取物和牙膏膏体基质混合搅拌均匀投入共沸锅中，在加热温度为70℃，搅拌转速为200r/min的条件下，混合搅拌120min，然后移至碾压机上碾压，得所述用于牙龈炎症的中草药牙膏。
对比例1
对比例1所述一种用于牙龈炎症的中草药牙膏与实施例1所述一种用于牙龈炎症的中草药牙膏不同之处在于：对比例1所述一种用于牙龈炎症的中草药牙膏所含中草药提取物不含原料三七和苦丁茶。
对比例2
对比例2所述一种用于牙龈炎症的中草药牙膏与实施例2所述一种用于牙龈炎症的中草药牙膏不同之处在于：对比例2所述一种用于牙龈炎症的中草药牙膏所含中草药提取物不含原料虎杖和天冬。
对比例3
对比例3所述一种用于牙龈炎症的中草药牙膏与实施例3所述一种用于牙龈炎症的中草药牙膏不同之处在于：对比例3所述一种用于牙龈炎症的中草药牙膏所含中草药提取物不含原料南非叶。
本申请所述一种用于牙龈炎症的中草药牙膏的功效研究：
1、体外抑菌实验
选取口腔常见病菌白色念珠菌、牙龈卟啉单胞菌。在无菌操作条件下，取各菌株的斜面培养物，挑取一环至已灭菌的100mL特定液体培养基中活化培养24h。取活化后的菌悬液1mL至已灭菌的培养皿中，倾注平板法倒平板，摇匀。待培养基凝固后用镊子将已灭菌的牛津杯均匀的放在培养皿中，每个培养皿放6个。
分别采用本发明实施例1-3所述一种用于牙龈炎症的中草药牙膏与纯净水配制成浓度为100mg/ml的稀释牙膏作为试验组1、试验组2和试验组3.
分别采用本发明对比例1-3所述一种用于牙龈炎症的中草药牙膏与纯净水配制成浓度为100mg/ml的稀释牙膏作为对照组1、对照组2和对照组3。
分别取0.25ml试验组1-3所述一种用于牙龈炎症的中草药牙膏溶液，0.25ml对照组1-3所述一种用于牙龈炎症的中草药牙膏溶液，分别注入6个牛津杯中(因是两种菌株即共12个牛津杯，需重复抽取6中牙膏溶液注入另外6个牛津杯中)，然后小心地将培养皿放入37℃培养箱中培养24h后，用游标卡尺测量抑菌圈直径。
实验结果如表1所示：
表1
从表1可以看出，本发明所述用于牙龈炎症的中草药牙膏对口腔常见病菌白色念珠菌、牙龈卟啉单胞菌均具有明显的抑制作用。其抑菌效果优于对比例1-3所述牙膏。本申请所述牙膏对白色念珠菌的抑菌直径达到21.6mm优于对照组的16.5mm，本申请所述牙膏对牙龈卟啉单胞菌的抑菌直径达到16.8mm优于对照组的12.7。
以上所述仅为本申请的优选实施例而已，并不用于限制本申请，对于本领域的技术人员来说，本申请可以有各种更改和变化。凡在本申请的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本申请的保护范围之内。
Claims (10)
1.一种用于牙龈炎症的中草药牙膏，其特征在于，包括下述重量份的原料，中草药提取物0.3-0.8份，牙膏膏体基质99.2-99.7份；
所述中草药提取物由下述重量份的原料制成：丹参15-20份、三七3-8份、虎杖5-12份、苦丁茶1-3份、南非叶5-10份、天冬4-8份。
2.根据权利要求1所述用于牙龈炎症的中草药牙膏，其特征在于，包括下述重量份的原料，中草药提取物0.4-0.6份，牙膏膏体基质99.4-99.6份；
所述中草药提取物由下述重量份的原料制成：丹参15-20份、三七3-8份、虎杖5-12份、苦丁茶1-3份、南非叶5-10份、天冬4-8份。
3.根据权利要求1所述用于牙龈炎症的中草药牙膏，其特征在于，包括下述重量份的原料，中草药提取物0.5份，牙膏膏体基质99.5份；
所述中草药提取物由下述重量份的原料制成：丹参15-20份、三七3-8份、虎杖5-12份、苦丁茶1-3份、南非叶5-10份、天冬4-8份。
4.根据权利要求1所述用于牙龈炎症的中草药牙膏，其特征在于，所述牙膏膏体基质包括下述重量份的原料：增稠剂0.8-1.2份、摩擦剂18-20份、保湿剂55-60份、表面活性剂1-3份、甜味剂0.5-1.5份、水15-25份。
5.根据权利要求4所述用于牙龈炎症的中草药牙膏，其特征在于，所述增稠剂为黄原胶或卡拉胶。
6.根据权利要求4所述用于牙龈炎症的中草药牙膏，其特征在于，所述摩擦剂为碳酸钙或磷酸三钙；所述保湿剂为聚乙二醇或丙二醇；所述表面活性剂为十二烷基硫酸钠，所述甜味剂为阿斯巴甜。
7.权利要求1-6任一项所述用于牙龈炎症的中草药牙膏的制备方法，其特征在于，包括以下步骤：
(1)制备中草药提取物，将丹参、三七、虎杖、苦丁茶、南非叶和天冬用乙醇进行回流提取，浓缩提取液，冷冻干燥浓缩物得中草药提取物；
(2)将步骤(1)所得中草药提取物和牙膏膏体基质混合搅拌均匀投入共沸锅中，在加热搅拌的条件下，使物料混合均匀，然后移至碾压机上碾压，得所述用于牙龈炎症的中草药牙膏。
8.根据权利要求7所述用于牙龈炎症的中草药牙膏的制备方法，其特征在于，步骤(1)中，乙醇与待提取物料的重量比为10-15：1，回流提取的温度为70-75℃。
9.根据权利要求7所述用于牙龈炎症的中草药牙膏的制备方法，其特征在于，步骤(1)中，所述冷冻干燥的温度为-20至-30℃，在此温度下干燥的时间为24-32h。
10.根据权利要求7所述用于牙龈炎症的中草药牙膏的制备方法，其特征在于，步骤(2)中，所述加热的温度为60-70℃，混合搅拌的转速为200-280r/min，混合搅拌的时间为60-120min。
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| CN105106081A (zh) * | 2015-10-12 | 2015-12-02 | 浙江康德药业集团股份有限公司 | 一种用于口腔炎症的中草药牙膏及其制备方法 |
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| CN112315856A (zh) * | 2019-11-11 | 2021-02-05 | 冼国茂 | 一种多功效的中药牙膏及其制备方法 |
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| CN107982410A (zh) * | 2017-12-15 | 2018-05-04 | 保髓特（天津）生物科技有限公司 | 一种早期牙髓炎、保髓口腔抑菌液及其制备方法 |
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