CN110946804B - 一种预防龋齿和口腔溃疡的漱口水及其制备方法 - Google Patents
一种预防龋齿和口腔溃疡的漱口水及其制备方法 Download PDFInfo
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- CN110946804B CN110946804B CN202010010804.5A CN202010010804A CN110946804B CN 110946804 B CN110946804 B CN 110946804B CN 202010010804 A CN202010010804 A CN 202010010804A CN 110946804 B CN110946804 B CN 110946804B
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Abstract
本发明公开了一种预防龋齿和口腔溃疡的漱口水及其制备方法，属于生物医药技术领域。该漱口水的原料质量份数组成为：海洋寡糖2～4份、芳香植物提取液3～5份、中草药提取液20～30份、山梨醇3～5份、苯甲酸钠1～2份、木糖醇2～4份、维生素C 1～2份、去离子水40～60份。该漱口水具有良好的防治龋齿和口腔溃疡效果，并具有良好的口腔清洁效果，能够清新口气，还具有很好的抗菌抗病毒、消炎、修复口腔黏膜的作用，产品适口性好，并充分利用天然药食同源成分，长期使用无任何副作用产生，具有良好的市场应用前景。
Description
技术领域
本发明涉及一种预防龋齿和口腔溃疡的漱口水及其制备方法，尤其涉及一种以天然活性成分为主的生物抑菌漱口水，属于生物医药技术领域。
背景技术
口腔健康是世界卫生组织确定的人体健康十大标准之一，是反映人体健康和生命质量的一面镜子，口腔健康与全身健康是一个密不可分的整体，口腔健康是全身健康的前提，离开了口腔健康就不会有健康的身体。口腔疾病不仅会引起牙痛、咀嚼能力下降发音不清，影响面部美观，对人的社会交往和心理行为产生影响，更严重的是口腔疾病的病菌还会引发多种全身性疾病，成为许多全身系统性疾病的重要危险因素。目前，随着国人生活水平日益提高，口腔健康问题成为关乎身体健康的头等大事。第四次全国口腔健康流行病学调查显示，中国人的牙齿状况非常令人担忧，全国有一半以上人患有龋齿，其中5岁儿童的乳牙龋齿率达到70.9%，平均每个孩子有将近5个坏牙。“唇齿相依，乳牙为基”，儿童乳牙不但对咀嚼、发音及颌面外形的发育至关重要，而且对恒牙的萌出起着导向作用；龋齿的发生影响儿童的咀嚼和营养摄取的同时，还会伤及恒牙胚，导致恒牙发育障碍，进而演变为错位或扭转生长，导致儿童牙列不齐，甚至损害牙床。对家长和儿童而言，将乳牙龋齿消灭在萌芽状态势在必行。调节饮食结构保护口腔内环境，增加预防性护齿措施是防止儿童龋齿的治本之方。
口腔溃疡是一种常见的发生于口腔黏膜的溃疡性损伤病症，多见于唇内侧、舌体、舌腹、颊黏膜、前庭沟、软腭等部位，其发病的原因是多种因素综合作用的结果，其中血链球菌及幽门螺杆菌等细菌与口腔溃疡的发病关系密切。
消灭细菌、保持口腔卫生是预防龋齿和口腔溃疡的最有效方法，市面上出现了许多不同成分的漱口水，现有技术中公开了诸多漱口水，如：专利201711396145.8公开了一种可预防龋齿和口腔溃疡的漱口水，包括以下重量份的原料：儿茶素5-10份、葡萄多酚5-10份、姜酚15-20份、洋甘菊纯露8-15份、维生素C3-8份、叶酸4-10份、甜味剂1-3份、中药提取物15-20份、茶叶提取物10-20份；专利201810352674.6公开了一种预防龋齿漱口水，包括以下质量百分比的成分：匙羹藤酸0.2-6％，瘤果黑种草子提取物0.2-4％，食用级乙醇5-15％，吐温-80 1-3％，山梨醇10-20％，糖精钠0.1-0.3％，香精0.1-0.5％，苯甲酸钠0.02-0.2％，去离子水余量；专利201811504001.4公开了一种预防龋齿的漱口水，含有如下组分：蒸馏水85-90份、山梨醇2-4份、安赛蜜3-5份、木糖醇3-4份、食用香精2-4份、花椒1-2份、三七1-2份、板蓝根0.5-0.8份。分析现有技术中的漱口水，多以中草药等活性成分为主要组分，尽管药食同源类中草药漱口水可以作为日常口腔护理用品长期使用，但仍存在抑菌消炎效果仍需提升、中草药提取液适口性欠佳等技术问题，因此亟需开发一种抑菌消炎效果显著、对预防龋齿和口腔溃疡功效强、适口性好的漱口水。
发明内容
针对现有技术中存在的问题，本发明提供了一种预防龋齿及口腔溃疡的漱口水及其制备方法，该漱口水具有良好的防治龋齿和口腔溃疡效果，并具有良好的口腔清洁效果，能够清新口气，还具有很好的抗菌抗病毒、消炎、修复口腔黏膜的作用，产品适口性好。
为了达到上述目的，本发明通过以下技术方案来实现的：
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖2～4份、芳香植物提取液3～5份、中草药提取液20～30份、山梨醇3～5份、苯甲酸钠1～2份、木糖醇2～4份、维生素C 1～2份、去离子水40～60份。
优选的，一种预防龋齿和口腔溃疡的漱口水，其原料质量分数组成为：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份。
优选的，上述海洋寡糖选用褐藻寡糖、浒苔寡糖糖和新琼寡糖的一种或两种的混合物。
优选的，上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
最优的，上述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1。
优选的，上述芳香植物提取液的原料包括薄荷、肉桂、玫瑰中的一种或几种的混合物。
最优的，上述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3。
进一步的，上述芳香植物提取液通过如下工艺制备：将芳香植物原料分别粉碎成粉，按比例混合制得芳香植物粉，向芳香植物粉加入其质量5倍体积的纯化水，置于超声波提取装置中，控制超声波提取功率为350W～500W，连续提取15～25min后将提取液转移至蒸馏锅中，加热控制蒸馏锅内温度为55～69℃，蒸馏锅内压力为2～3Kpa，连续蒸馏1～1.5h，将温度升高至150～160℃，馏出芳香植物油水混合液，将芳香植物油水混合液通过冷凝管冷凝，冷凝管的入口温度为150℃，出口温度为70℃，然后将其通过油水分离器进行分离，得到包含精油的芳香植物提取液。
优选的，上述中草药提取液的原料质量分数组成为：绿茶10～16份、胖大海5～10份、甘草4～6份、鱼腥草6～10份、黄芩3～6份、马齿苋4～7份、辣木籽2～3份。
更优的，上述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份。
优选的，上述中草药提取液通过如下工艺制备：将中草药去除蛀虫及腐烂者，然后剪切破碎过40目筛；按照上述比例配伍原料，加入3倍纯净水，在超声波辅助作用下破碎20min；用葡萄糖调整发酵液初始总糖含量6%，加入3%纤维素酶、2%木聚糖酶、0.15%硫酸铵、0.10%磷酸二氢钾，接种酿酒酵母和枯草芽孢杆菌，接种比例分别为3%、2%，好氧条件下发酵24h；发酵结束后在超声波辅助作用下二次浸提10min，过滤；滤渣加入1～2倍纯净水，在微波辅助作用下提取10～20min，重复提取两次，合并滤液即得中草药提取液。
本发明提供的一种预防龋齿和口腔溃疡的漱口水的制备方法，具体包括如下步骤：将海洋寡糖、山梨醇、苯甲酸钠、木糖醇、维生素C加入去离子水中搅拌均匀，升温至40～50℃，搅拌1h；然后依次加入芳香植物提取液和中草药提取液，搅拌均匀，降温至室温，即得预防龋齿和口腔溃疡的漱口水。
本发明相对于现有技术具有如下技术优势：
（1）本发明在漱口水中添加海洋寡糖，具体包括褐藻寡糖、浒苔寡糖和新琼寡糖，其中酶解褐藻寡糖对细胞因子的释放具有诱导作用，且在一定程度上能够暂时性改变粘蛋白网络结构，可能具有治疗口腔系统粘膜病变及增加药物透膜渗透吸收的作用，从而具有提高药物生物利用度的潜在作用，对提高漱口水的预防龋齿、抑菌消炎具有显著的促进功效；浒苔寡糖能与病毒表面直接作用，对多种含有囊膜的病毒具有直接杀伤作用,使其失去感染能力，且具有一定的抑菌功效；新琼寡糖具有显著的协同增效作用，实验结果表明褐藻寡糖、浒苔寡糖和新琼寡糖间的协同作用可以显著提升漱口水的抑菌消炎作用效果；
（2）本发明在漱口水中添加芳香植物提取液，不仅充分利用芳香植物的抑菌功效，而且可以显著提升漱口水产品的适口性；
（3）本发明在漱口水中添加中草药提取液，选用具有抗菌消炎功能的中药，能有效杀灭口腔细菌，可起到预防龋齿和口腔溃疡的作用，而且所选的中药成分还可以起到防腐的作用；实验结果表明中草药提取液中中草药原料的组成对产品的抑菌消炎效果影响显著；
（4）本发明原料配比科学，组方合理、口感舒适，能针对口腔细菌、炎症，达到协同预防龋齿和口腔溃疡、清洁和调节口腔环境的作用，并充分利用天然药食同源成分，长期使用无任何副作用产生，具有良好的市场应用前景。
具体实施方式
以下结合具体实施例对本发明的技术方案及优点作进一步详细的说明。具体实施例中共同的技术方案包括：
1、芳香植物提取液制备工艺：将芳香植物原料分别粉碎成粉，按比例混合制得芳香植物粉，向芳香植物粉加入其质量5倍体积的纯化水，置于超声波提取装置中，控制超声波提取功率为350W～500W，连续提取15～25min后将提取液转移至蒸馏锅中，加热控制蒸馏锅内温度为55～69℃，蒸馏锅内压力为2～3Kpa，连续蒸馏1～1.5h，将温度升高至150～160℃，馏出芳香植物油水混合液，将芳香植物油水混合液通过冷凝管冷凝，冷凝管的入口温度为150℃，出口温度为70℃，然后将其通过油水分离器进行分离，得到包含精油的芳香植物提取液；
2、中草药提取液制备工艺：将中草药去除蛀虫及腐烂者，然后剪切破碎过40目筛；按照上述比例配伍原料，加入3倍纯净水，在超声波辅助作用下破碎20min；用葡萄糖调整发酵液初始总糖含量6%，加入3%纤维素酶、2%木聚糖酶、0.15%硫酸铵、0.10%磷酸二氢钾，接种酿酒酵母和枯草芽孢杆菌，接种比例分别为3%、2%，好氧条件下发酵24h；发酵结束后在超声波辅助作用下二次浸提10min，过滤；滤渣加入1～2倍纯净水，在微波辅助作用下提取10～20min，重复提取两次，合并滤液即得中草药提取液。
3、漱口水的制备方法：将海洋寡糖、山梨醇、苯甲酸钠、木糖醇、维生素C加入去离子水中搅拌均匀，升温至40～50℃，搅拌1h；然后依次加入芳香植物提取液和中草药提取液，搅拌均匀，降温至室温，即得预防龋齿和口腔溃疡的漱口水。
实施例1
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例2
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例3
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为浒苔寡糖；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例4
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为新琼寡糖；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例5
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:2:1；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例6
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述芳香植物提取液的原料是薄荷；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例7
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述芳香植物提取液的原料是玫瑰；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例8
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶16份、胖大海5份、甘草6份、鱼腥草6份、黄芩6份、马齿苋4份、辣木籽3份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例9
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶10份、胖大海10份、甘草4份、鱼腥草10份、黄芩3份、马齿苋7份、辣木籽2份；
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
对比实施例1
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水53.5份；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份。
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
对比实施例2
一种预防龋齿和口腔溃疡的漱口水，按照质量百分数，漱口水的组分包括：海洋寡糖3.5份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水54份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份。
上述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖。
实施例10：漱口水抑菌试验
参照专利CN2018103038193测定本发明漱口水抑菌效果，实验结果如下表所示：
表1 漱口水抑菌实验效果
上述实验结果表明本发明实施例对变形链球菌、金黄色葡萄球菌、幽门螺杆菌和大肠杆菌均具有较好的抑制作用，说明本发明漱口水具有较好的抑菌作用，其中实施例1为本发明最佳实施例。此外，实验结果还表明海藻寡糖、芳香植物提取液和中草药提取液的原料组成对本发明漱口水的抑菌作用影响显著。
以上实施例仅用于说明本发明的技术方案，而非对其进行限制；尽管参照前述实施例对被发明进行了详细的说明，但对于本领域的普通技术人员来说，依然可以对前述实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而对这些修改或者替换，并不使相应技术方案的本质脱离本发明所要求保护的技术方案的精神和范围。
Claims (2)
1.一种预防龋齿和口腔溃疡的漱口水，其特征在于按照质量百分数漱口水的组分包括：海洋寡糖3.5份、芳香植物提取液4份、中草药提取液27份、山梨醇4份、苯甲酸钠1份、木糖醇3份、维生素C 2份、去离子水50份；所述海洋寡糖为褐藻寡糖、浒苔寡糖和新琼寡糖的混合物，其质量比为2:1:1；所述芳香植物提取液的原料是薄荷和玫瑰的混合物，其质量比为2:3；所述中草药提取液的原料质量分数组成为：绿茶15份、胖大海6份、甘草5份、鱼腥草9份、黄芩4份、马齿苋6份、辣木籽3份；所述褐藻寡糖选用酶解褐藻寡糖，分子量在1000-2000Da之间；浒苔寡糖选用酶解浒苔寡糖，分子量小于1000Da；新琼寡糖为酶法降解得到的聚合度为2～20的偶数寡糖；排除其作为化妆品；
所述芳香植物提取液通过如下工艺制备：将芳香植物原料分别粉碎成粉，按比例混合制得芳香植物粉，向芳香植物粉加入其质量5倍体积的纯化水，置于超声波提取装置中，控制超声波提取功率为350W～500W，连续提取15～25min后将提取液转移至蒸馏锅中，加热控制蒸馏锅内温度为55～69℃，蒸馏锅内压力为2～3Kpa，连续蒸馏1～1.5h，将温度升高至150～160℃，馏出芳香植物油水混合液，将芳香植物油水混合液通过冷凝管冷凝，冷凝管的入口温度为150℃，出口温度为70℃，然后将其通过油水分离器进行分离，得到包含精油的芳香植物提取液；
所述中草药提取液通过如下工艺制备：将中草药去除蛀虫及腐烂者，然后剪切破碎过40目筛；准确配伍原料，加入3倍纯净水，在超声波辅助作用下破碎20min；用葡萄糖调整发酵液初始总糖含量6%，加入3%纤维素酶、2%木聚糖酶、0.15%硫酸铵、0.10%磷酸二氢钾，接种酿酒酵母和枯草芽孢杆菌，接种比例分别为3%、2%，好氧条件下发酵24h；发酵结束后在超声波辅助作用下二次浸提10min，过滤；滤渣加入1～2倍纯净水，在微波辅助作用下提取10～20min，重复提取两次，合并滤液即得中草药提取液。
2.根据权利要求1所述的一种预防龋齿和口腔溃疡的漱口水，其特征在于所述漱口水的制备方法具体包括如下步骤：将海洋寡糖、山梨醇、苯甲酸钠、木糖醇、维生素C加入去离子水中搅拌均匀，升温至40～50℃，搅拌1h；然后依次加入芳香植物提取液和中草药提取液，搅拌均匀，降温至室温，即得预防龋齿和口腔溃疡的漱口水。
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