CN115024494A - Preparation method of compound lucid ganoderma composition - Google Patents

Preparation method of compound lucid ganoderma composition Download PDF

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Publication number
CN115024494A
CN115024494A CN202210886794.0A CN202210886794A CN115024494A CN 115024494 A CN115024494 A CN 115024494A CN 202210886794 A CN202210886794 A CN 202210886794A CN 115024494 A CN115024494 A CN 115024494A
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ganoderma
liquorice
parts
stirring
water
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韩光婉
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Huoshan County Tianshoubao Biotechnology Co ltd
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/062Ascomycota
    • A61K36/066Clavicipitaceae
    • A61K36/068Cordyceps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06Fungi, e.g. yeasts
    • A61K36/07Basidiomycota, e.g. Cryptococcus
    • A61K36/074Ganoderma
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10Preparation or pretreatment of starting material
    • A61K2236/19Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/55Liquid-liquid separation; Phase separation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A preparation method of a compound ganoderma lucidum composition comprises the following steps: oven drying Ganoderma and Glycyrrhrizae radix, and pulverizing; placing the pulverized Ganoderma in a sealed container, steaming and decocting over water, and parching; putting the processed Ganoderma, Glycyrrhrizae radix, cured raisin, fructus Lycii and Cordyceps flower into a fermenter, adding water, stirring, adding sugar water, sealing, fermenting for 36 days, and stirring every day; drying the solid at the bottom of the fermentation tank, pulverizing, and tabletting to obtain compound Ganoderma chewable tablet; boiling Glycyrrhrizae radix and semen Tritici Aestivi respectively, adding ethanol, stirring, and filtering to obtain Glycyrrhrizae radix clear solution and semen Tritici Aestivi clear solution; mixing, concentrating under reduced pressure, recovering ethanol to relative density of 1.08, adding the rest liquid phase in fermentation tank, adding sucralose to obtain mixed solution, boiling, cooling, diluting to desired volume, filtering, and bottling to obtain compound Ganoderma oral liquid. The two drugs are taken together to improve the immunity of the human body and the sleep, and the preparation method is simple and efficient and has good market value.

Description

Preparation method of compound lucid ganoderma composition
Technical Field
The invention relates to a preparation method of a compound ganoderma lucidum composition
Background
Immunity refers to the ability of the body to resist external attack and maintain the stability of the environment in the body. The air is filled with various microorganisms, bacteria, viruses, mycoplasma, chlamydia, fungi, etc. In the case of inadequate immunity, they can be pathogens of the morning shift. Modern medical science finds that immunity is a factor closely related to aging, and hypoimmunity is one of the most important causes of aging. The special cells of the body's immune system can engulf and eliminate bacteria, viruses, aged dead cells, mutated cells and allergic substances, and maintain the health of body. But the immune function begins to decline in the age of about 30 years, and the change is silently, slowly and continuously carried out.
Ganoderma lucidum has been used in China for over 2000 years, and is regarded as a miraculous treasure by medical doctors of all ages for nourishing and strengthening body, strengthening body resistance and consolidating constitution. Through a large number of clinical researches, the ganoderma lucidum has different degrees of curative effects on neurasthenia, hyperlipidemia, coronary heart disease, angina pectoris, arrhythmia, keshan disease, altitude sickness, hepatitis, hemorrhagic fever, dyspepsia, tracheitis and the like. The licorice has the functions of strengthening body's immunity, protecting liver, promoting urination, resisting senility, resisting stress, lowering blood pressure and resisting bacteria. The fructus Lycii is rich in fructus Lycii polysaccharide, and has effects of enhancing nonspecific immunity, improving disease resistance, and inhibiting tumor growth and cell mutation. The raisin is rich in iron and calcium, can supplement blood and qi, warm kidney, help to improve anemia and reduce blood platelets, contains a large amount of glucose, has a nutritional effect on heart muscle, and is beneficial to the recovery of patients with coronary heart disease. The cordycepic acid and cordycepin contained in the cordyceps flower can comprehensively condition the internal environment of human bodies, enhance the function of macrophages in the human bodies, and have certain effects of enhancing and adjusting the immunologic function of the human bodies and improving the disease resistance of the human bodies.
With the aging of the population of China becoming more and more severe and various diseases occurring, people have higher and higher requirements on products for improving immunity. However, because the ganoderma lucidum is difficult to directly take, various ganoderma lucidum products are available on the market, wherein ganoderma lucidum powder, ganoderma lucidum spore powder or ganoderma lucidum extract is mainly used as a main component, and although the ganoderma lucidum products in the forms are rich in the nutrient components of the ganoderma lucidum, the ganoderma lucidum products cannot have remarkable effects because the ganoderma lucidum products cannot be effectively absorbed by human bodies.
Disclosure of Invention
The invention aims to solve the technical problem of providing a preparation method of a compound lucid ganoderma composition, wherein a compound lucid ganoderma solid beverage capable of being drunk as a brewing beverage and a compound lucid ganoderma oral liquid capable of being drunk directly are prepared by a fermentation process, and the two types of solid beverage and the compound lucid ganoderma oral liquid can be taken in a matching manner to improve the immunity of a human body and the sleep, and the preparation method is simple and efficient and has good market value.
In order to solve the technical problems, the invention provides a preparation method of a compound ganoderma lucidum composition, which comprises the following steps:
(1) preparing raw materials, namely taking 16 parts of lucid ganoderma, 16 parts of medlar, 16 parts of raisin, 8 parts of cordyceps flower, 1 part of liquorice and 40 parts of white granulated sugar according to parts by weight;
(2) putting the lucid ganoderma and the liquorice into a hot air circulation oven, and drying;
(3) respectively crushing the dried ganoderma lucidum and the dried liquorice to 10 meshes;
(4) placing the crushed ganoderma lucidum into a sealed container, and steaming and boiling the ganoderma lucidum over water for 30 to 36 hours;
(5) frying the steamed ganoderma lucidum at 320 ℃ for 10-15 minutes;
(6) putting the processed ganoderma lucidum, liquorice, raisin, medlar and cordyceps flower into a fermentation tank, adding water to 2.9 times of the volume of the raw materials, stirring for 1 hour, adding sugar water, wherein the sugar water is obtained by boiling the white granulated sugar and the water for 30 minutes according to the mass ratio of 1:1, then continuously stirring for 1 hour, sealing, soaking, uncovering the cover and stirring for 30 minutes to 1 hour every day, and continuously fermenting for 36 days;
(7) collecting solid precipitated at the bottom of fermentation tank, oven drying at 70 deg.C, pulverizing to 80-120 mesh, and directly tabletting to obtain compound Ganoderma chewable tablet;
(8) adding 13 parts of liquorice into water of which the weight is 5-6 times that of the liquorice, boiling for 2 hours, adding equivalent ethanol, stirring for 1 hour, standing for 24 hours, and filtering to obtain liquorice supernatant for later use;
adding water of 3-4 times of the weight of the wheat 44 parts into the wheat, boiling the mixture, soaking the mixture for 2 hours at the temperature of 70-80 ℃, adding ethanol of the same amount into the mixture, stirring the mixture for 1 hour, standing the mixture for 24 hours, and filtering the mixture to obtain a wheat supernatant for later use;
and (3) mixing the liquorice supernatant and the wheat supernatant, concentrating under reduced pressure to recover ethanol until the relative density is 1.08, then adding the residual liquid phase in the step (8), finally adding sucralose to obtain a mixed solution, wherein the mass fraction of the sucralose in the mixed solution is 0.25%, mixing and boiling for 1 hour, cooling to 60 ℃, fixing the volume, filtering by a 200-mesh sieve, and encapsulating to prepare the compound lucid ganoderma oral liquid.
For the sake of simplicity, the compound ganoderma lucidum composition and the preparation method thereof are simply referred to as the method below.
The method comprises the following steps: wheat is sweet in taste and slightly cold in nature, and as early as in Ling Shu & Wu Wei, it is recorded that "wheat is suitable for heart disease patients to eat", which indicates that it is the main drug for treating heart disease, and later thought that it has the functions of nourishing heart, relieving restlessness and tranquilizing mind. The liquorice is sweet in taste and neutral in nature, mainly enters spleen, lung and heart channels, can tonify heart and spleen, tonify qi and nourish blood, relieve urgency and calm nerves, can assist in treating symptoms of heart qi and heart blood deficiency and heart-mind malnutrition, has the effects of tonifying middle-jiao and qi, moistening dryness and relieving urgency, nourishing blood and calm nerves and relieving drug properties, and can supplement qi and engender blood, nourish blood and calm nerves with wheat and liquorice.
The method has the advantages that: the method adopts a special fermentation process, extracts the effective components of the ganoderma lucidum efficiently, can better exert the effect of the product, prepares the compound ganoderma lucidum chewable tablet which can be directly eaten, and has good curative effect on patients with low immunity, early recovery from a large disease and weak health. The two products prepared by the method have the advantages of good taste, convenient carrying and taking, no side effect, safety, effectiveness and good market value. In addition, the preparation method is simple and efficient, all components can be utilized, no waste is discharged, and the method is green and pollution-free.
Detailed Description
A preparation method of a compound ganoderma composition comprises the following steps:
(1) preparing raw materials, namely taking 16 parts of lucid ganoderma, 16 parts of medlar, 16 parts of raisin, 8 parts of cordyceps flower, 1 part of liquorice and 40 parts of white granulated sugar according to parts by weight;
(2) putting the lucid ganoderma and the liquorice into a hot air circulation oven, and drying;
(3) respectively pulverizing the baked Ganoderma and Glycyrrhrizae radix to 10 mesh;
(4) placing the crushed lucid ganoderma in a sealed container, and steaming and boiling the lucid ganoderma for 30 to 36 hours in a water-proof way;
(5) frying the steamed ganoderma lucidum at 320 ℃ for 10-15 minutes;
(6) putting the processed ganoderma lucidum, liquorice, raisin, medlar and cordyceps flower into a fermentation tank, adding water to 2.9 times of the volume of the raw materials, stirring for 1 hour, adding sugar water, wherein the sugar water is obtained by boiling the white granulated sugar and the water for 30 minutes according to the mass ratio of 1:1, then continuously stirring for 1 hour, sealing, soaking, uncovering the cover and stirring for 30 minutes to 1 hour every day, and continuously fermenting for 36 days;
(7) collecting solid precipitated at the bottom of fermentation tank, oven drying at 70 deg.C, pulverizing to 80-120 mesh, and directly tabletting to obtain compound Ganoderma chewable tablet;
(8) adding water of 5-6 times of the weight of 13 parts of liquorice into the liquorice, boiling the mixture for 2 hours, adding equivalent ethanol into the mixture, stirring the mixture for 1 hour, standing the mixture for 24 hours, and filtering the mixture to obtain liquorice supernatant for later use;
adding water of 3-4 times of the weight of the wheat 44 parts into the wheat, boiling the mixture, soaking the mixture for 2 hours at the temperature of 70-80 ℃, adding ethanol of the same amount into the mixture, stirring the mixture for 1 hour, standing the mixture for 24 hours, and filtering the mixture to obtain a wheat supernatant for later use;
and (3) mixing the liquorice supernatant and the wheat supernatant, concentrating under reduced pressure to recover ethanol until the relative density is 1.08, then adding the residual liquid phase in the step (8), finally adding sucralose to obtain a mixed solution, wherein the mass fraction of the sucralose in the mixed solution is 0.25%, mixing and boiling for 1 hour, cooling to 60 ℃, fixing the volume, filtering by a 200-mesh sieve, and encapsulating to prepare the compound lucid ganoderma oral liquid.

Claims (1)

1. A preparation method of a compound ganoderma lucidum composition is characterized by comprising the following steps:
(1) preparing raw materials, namely taking 16 parts of lucid ganoderma, 16 parts of medlar, 16 parts of raisin, 8 parts of cordyceps flower, 1 part of liquorice and 40 parts of white granulated sugar according to parts by weight;
(2) putting the lucid ganoderma and the liquorice into a hot air circulation oven, and drying;
(3) respectively crushing the dried ganoderma lucidum and the dried liquorice to 10 meshes;
(4) placing the crushed ganoderma lucidum into a sealed container, and steaming and boiling the ganoderma lucidum over water for 30 to 36 hours;
(5) frying the steamed ganoderma lucidum at 320 ℃ for 10-15 minutes;
(6) putting the processed ganoderma lucidum, liquorice, raisin, medlar and cordyceps flower into a fermentation tank, adding water to 2.9 times of the volume of the raw materials, stirring for 1 hour, adding sugar water, wherein the sugar water is obtained by boiling the white granulated sugar and the water for 30 minutes according to the mass ratio of 1:1, then continuously stirring for 1 hour, sealing, soaking, uncovering the cover and stirring for 30 minutes to 1 hour every day, and continuously fermenting for 36 days;
(7) collecting solid precipitated at the bottom of fermentation tank, oven drying at 70 deg.C, pulverizing to 80-120 mesh, and directly tabletting to obtain compound Ganoderma chewable tablet;
(8) adding 13 parts of liquorice into water of which the weight is 5-6 times that of the liquorice, boiling for 2 hours, adding equivalent ethanol, stirring for 1 hour, standing for 24 hours, and filtering to obtain liquorice supernatant for later use;
adding water in an amount which is 3-4 times the weight of the wheat 44 parts, boiling, soaking at 70-80 ℃ for 2 hours, adding ethanol in the same amount, stirring for 1 hour, standing for 24 hours, and filtering to obtain a wheat supernatant for later use;
and (3) mixing the liquorice supernatant and the wheat supernatant, concentrating under reduced pressure to recover ethanol until the relative density is 1.08, then adding the residual liquid phase in the step (8), finally adding sucralose to obtain a mixed solution, wherein the mass fraction of the sucralose in the mixed solution is 0.25%, mixing and boiling for 1 hour, cooling to 60 ℃, fixing the volume, filtering by a 200-mesh sieve, and encapsulating to prepare the compound lucid ganoderma oral liquid.
CN202210886794.0A 2022-07-26 2022-07-26 Preparation method of compound lucid ganoderma composition Pending CN115024494A (en)

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062330A (en) * 2006-04-26 2007-10-31 成都地奥九泓制药厂 Chinese medicine composition for improving sleeping and preparing method thereof
CN101897454A (en) * 2010-07-07 2010-12-01 魏元龙 Health care beverage
KR20120053564A (en) * 2010-11-18 2012-05-29 한국교통대학교산학협력단 Fermented ginseng with ganoderma lucidum beverage manufacturing method and that beverage
CN105535552A (en) * 2016-03-04 2016-05-04 上海交通大学医学院附属第九人民医院 Traditional Chinese medicine oral liquid for improving immunity of human bodies and preparation method of traditional Chinese medicine oral liquid
CN106620517A (en) * 2016-09-21 2017-05-10 深圳市得道中医馆管理有限责任公司 Traditional Chinese medicine composition, and preparation method and application thereof in treatment of nasopharyngeal carcinoma
CN107753929A (en) * 2017-11-10 2018-03-06 河南工业大学 A kind of health care oral liquid of the globulin containing wheat germ and preparation method thereof
CN109247571A (en) * 2018-10-31 2019-01-22 吉林省恒实传食品科技发展有限公司 A kind of anti-aging health preserving health-care food and preparation method thereof
CN112022931A (en) * 2020-08-15 2020-12-04 盈姿生物科技(上海)有限公司 Oral liquid for enhancing immunity and preparation process thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101062330A (en) * 2006-04-26 2007-10-31 成都地奥九泓制药厂 Chinese medicine composition for improving sleeping and preparing method thereof
CN101897454A (en) * 2010-07-07 2010-12-01 魏元龙 Health care beverage
KR20120053564A (en) * 2010-11-18 2012-05-29 한국교통대학교산학협력단 Fermented ginseng with ganoderma lucidum beverage manufacturing method and that beverage
CN105535552A (en) * 2016-03-04 2016-05-04 上海交通大学医学院附属第九人民医院 Traditional Chinese medicine oral liquid for improving immunity of human bodies and preparation method of traditional Chinese medicine oral liquid
CN106620517A (en) * 2016-09-21 2017-05-10 深圳市得道中医馆管理有限责任公司 Traditional Chinese medicine composition, and preparation method and application thereof in treatment of nasopharyngeal carcinoma
CN107753929A (en) * 2017-11-10 2018-03-06 河南工业大学 A kind of health care oral liquid of the globulin containing wheat germ and preparation method thereof
CN109247571A (en) * 2018-10-31 2019-01-22 吉林省恒实传食品科技发展有限公司 A kind of anti-aging health preserving health-care food and preparation method thereof
CN112022931A (en) * 2020-08-15 2020-12-04 盈姿生物科技(上海)有限公司 Oral liquid for enhancing immunity and preparation process thereof

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