CN115023613B - 用于检测生物分析物的传感器及其检测方法 - Google Patents

用于检测生物分析物的传感器及其检测方法

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Publication number
CN115023613B
CN115023613B CN202080094064.6A CN202080094064A CN115023613B CN 115023613 B CN115023613 B CN 115023613B CN 202080094064 A CN202080094064 A CN 202080094064A CN 115023613 B CN115023613 B CN 115023613B
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China
Prior art keywords
sensor
oxygen
metal oxide
bioanalyte
binding
Prior art date
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Application number
CN202080094064.6A
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English (en)
Chinese (zh)
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CN115023613A (zh
Inventor
T·艾哈迈德
M·德林
G·佩雷勒
S·瓦利亚
M·巴斯卡兰
S·斯里拉姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Royal Melbourne Institute of Technology
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Royal Melbourne Institute of Technology
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Priority claimed from AU2019904865A external-priority patent/AU2019904865A0/en
Application filed by Royal Melbourne Institute of Technology filed Critical Royal Melbourne Institute of Technology
Publication of CN115023613A publication Critical patent/CN115023613A/zh
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3278—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction involving nanosized elements, e.g. nanogaps or nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/552—Glass or silica
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
CN202080094064.6A 2019-12-20 2020-12-18 用于检测生物分析物的传感器及其检测方法 Active CN115023613B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2019904865A AU2019904865A0 (en) 2019-12-20 Sensor for detecting a bioanalyte and a method for the detection thereof
AU2019904865 2019-12-20
PCT/AU2020/051396 WO2021119755A1 (en) 2019-12-20 2020-12-18 Sensor for detecting a bioanalyte and a method for the detection thereof

Publications (2)

Publication Number Publication Date
CN115023613A CN115023613A (zh) 2022-09-06
CN115023613B true CN115023613B (zh) 2026-04-03

Family

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CN202080094064.6A Active CN115023613B (zh) 2019-12-20 2020-12-18 用于检测生物分析物的传感器及其检测方法

Country Status (8)

Country Link
US (1) US20230045427A1 (https=)
EP (1) EP4078182A4 (https=)
JP (1) JP7644992B2 (https=)
KR (1) KR20220117326A (https=)
CN (1) CN115023613B (https=)
AU (1) AU2020408371A1 (https=)
CA (1) CA3162465A1 (https=)
WO (1) WO2021119755A1 (https=)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105922A (zh) * 2018-01-04 2020-12-18 利腾股份有限公司 谐振气体传感器

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JP2002031598A (ja) * 2000-05-11 2002-01-31 Toto Ltd センサ素子の製造方法
US6737286B2 (en) * 2001-11-30 2004-05-18 Arizona Board Of Regents Apparatus and method for fabricating arrays of atomic-scale contacts and gaps between electrodes and applications thereof
GB2420180A (en) * 2004-11-11 2006-05-17 Sensor Tech Ltd Method of electrochemical analysis of an analyte
US20100143887A1 (en) * 2008-12-05 2010-06-10 Electronics And Telecommunications Research Institute Biosensor and method for detecting biomolecules by using the biosensor
KR101191386B1 (ko) * 2008-12-19 2012-10-15 한국전자통신연구원 센서용 산화물 반도체 나노섬유 제조 방법 및 그를 이용한 가스 센서
US20100216256A1 (en) * 2009-02-17 2010-08-26 Florida State University Research Foundation Nanobelt-based sensors and detection methods
AU2010256333B2 (en) * 2009-06-01 2013-04-04 Rmit University Electrodeposited gold nanostructures
JP5331952B2 (ja) * 2009-06-08 2013-10-30 哲彌 逢坂 固定化方法及びセンシング方法
US9318614B2 (en) * 2012-08-02 2016-04-19 Cbrite Inc. Self-aligned metal oxide TFT with reduced number of masks and with reduced power consumption
US9064965B2 (en) * 2012-02-24 2015-06-23 Rutgers, The State University Of New Jersey Zinc oxide-based thin film transistor biosensors with high sensitivity and selectivity
GB201207585D0 (en) * 2012-05-01 2012-06-13 Isis Innovation An electrode and use thereof
EP2833129B1 (en) * 2013-07-30 2019-10-09 Sensirion AG Method and apparatus for analyzing a gas by a conductance-type particulate metal-oxide gas sensor
US9702847B2 (en) * 2014-12-30 2017-07-11 Avails Medical, Inc. Systems and methods for detecting a substance in bodily fluid
WO2017088016A1 (en) * 2015-11-24 2017-06-01 Rmit University A memristor device and a method of fabrication thereof
GB2548888A (en) * 2016-03-31 2017-10-04 Cambridge Display Tech Ltd Sensor, method of forming a sensor and use thereof
US9976952B2 (en) * 2016-06-03 2018-05-22 Rmit University Flexible or stretchable sensor for use in detecting a substance and/or electromagnetic radiation, and a method for detecting thereof
JP6782968B2 (ja) * 2016-08-26 2020-11-11 国立大学法人東京海洋大学 電極およびバイオセンサ

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105922A (zh) * 2018-01-04 2020-12-18 利腾股份有限公司 谐振气体传感器

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Rapid and Selective Biomarker Detection with Conductometric Sensors;Ganganath S. Perera 等;Small;20210218;第17卷;1-12 *

Also Published As

Publication number Publication date
AU2020408371A1 (en) 2022-07-21
JP2023507206A (ja) 2023-02-21
EP4078182A1 (en) 2022-10-26
CN115023613A (zh) 2022-09-06
CA3162465A1 (en) 2021-06-24
EP4078182A4 (en) 2023-12-27
US20230045427A1 (en) 2023-02-09
WO2021119755A1 (en) 2021-06-24
KR20220117326A (ko) 2022-08-23
JP7644992B2 (ja) 2025-03-13

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