CN115010769B - 固相亚磷酰胺三酯法合成长链rna核酸的方法 - Google Patents
固相亚磷酰胺三酯法合成长链rna核酸的方法 Download PDFInfo
- Publication number
- CN115010769B CN115010769B CN202210929386.9A CN202210929386A CN115010769B CN 115010769 B CN115010769 B CN 115010769B CN 202210929386 A CN202210929386 A CN 202210929386A CN 115010769 B CN115010769 B CN 115010769B
- Authority
- CN
- China
- Prior art keywords
- nucleic acid
- rna nucleic
- time
- synthesis
- seconds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210929386.9A CN115010769B (zh) | 2022-08-04 | 2022-08-04 | 固相亚磷酰胺三酯法合成长链rna核酸的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202210929386.9A CN115010769B (zh) | 2022-08-04 | 2022-08-04 | 固相亚磷酰胺三酯法合成长链rna核酸的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN115010769A CN115010769A (zh) | 2022-09-06 |
CN115010769B true CN115010769B (zh) | 2022-11-15 |
Family
ID=83065399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202210929386.9A Active CN115010769B (zh) | 2022-08-04 | 2022-08-04 | 固相亚磷酰胺三酯法合成长链rna核酸的方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN115010769B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN118047824B (zh) * | 2024-04-01 | 2024-06-28 | 北京瑞博奥医药科技有限公司 | 二烷基膦酸在寡核苷酸合成中的应用 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7205399B1 (en) * | 2001-07-06 | 2007-04-17 | Sirna Therapeutics, Inc. | Methods and reagents for oligonucleotide synthesis |
CN101048423A (zh) * | 2004-08-26 | 2007-10-03 | 日本新药株式会社 | 亚磷酰胺化合物及低聚核糖核酸的制备方法 |
CN103068834A (zh) * | 2010-02-19 | 2013-04-24 | 坎姆根公司 | 用于反向合成rna的亚磷酰胺 |
CN110468171A (zh) * | 2019-09-20 | 2019-11-19 | 凯莱英医药集团(天津)股份有限公司 | 核酸的合成方法 |
CN111235198A (zh) * | 2020-01-20 | 2020-06-05 | 深圳市瑞吉生物科技有限公司 | 规模化合成长链rna的方法及其定点修饰的方法 |
CN113150041A (zh) * | 2021-03-31 | 2021-07-23 | 北京悦康科创医药科技股份有限公司 | 一种硫代寡核苷酸的制备方法 |
-
2022
- 2022-08-04 CN CN202210929386.9A patent/CN115010769B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7205399B1 (en) * | 2001-07-06 | 2007-04-17 | Sirna Therapeutics, Inc. | Methods and reagents for oligonucleotide synthesis |
CN101048423A (zh) * | 2004-08-26 | 2007-10-03 | 日本新药株式会社 | 亚磷酰胺化合物及低聚核糖核酸的制备方法 |
CN103068834A (zh) * | 2010-02-19 | 2013-04-24 | 坎姆根公司 | 用于反向合成rna的亚磷酰胺 |
CN110468171A (zh) * | 2019-09-20 | 2019-11-19 | 凯莱英医药集团(天津)股份有限公司 | 核酸的合成方法 |
CN111235198A (zh) * | 2020-01-20 | 2020-06-05 | 深圳市瑞吉生物科技有限公司 | 规模化合成长链rna的方法及其定点修饰的方法 |
CN113150041A (zh) * | 2021-03-31 | 2021-07-23 | 北京悦康科创医药科技股份有限公司 | 一种硫代寡核苷酸的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN115010769A (zh) | 2022-09-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6111086A (en) | Orthoester protecting groups | |
EP3044228B1 (en) | Highly efficient synthesis of long rna using reverse direction approach | |
CN115010769B (zh) | 固相亚磷酰胺三酯法合成长链rna核酸的方法 | |
CN111235198B (zh) | 规模化合成长链rna的方法及其定点修饰的方法 | |
EP2125854B1 (en) | Oligonucleotides containing high concentrations of guanine monomers | |
EP1287010A1 (en) | Methods for improving the sequence fidelity of synthetic double-stranded oligonucleotides | |
CN110468171B (zh) | 核酸的合成方法 | |
EP3319975B1 (en) | Guanine-rich oligonucleotides | |
CN115010770B (zh) | 使用混合脱保护剂合成rna核酸的方法 | |
CN115414703B (zh) | 染料修饰后的核酸探针纯化方法 | |
Wang et al. | Enzymatic and NMR analysis of oligoribonucleotides synthesized with 2′-tert-butyldimethylsilyl protected cyanoethlphosphoramidite monomers | |
US5352578A (en) | Method of separating oligonucleotides from a mixture | |
CN102070679A (zh) | 1-乙酰氧基-2-脱氧-3,5-二-o-芴甲氧羰酰基-d-呋喃核糖及应用 | |
CN109988127A (zh) | 由7差向-10-去乙酰基紫杉醇合成紫杉醇的方法 | |
CN103242267B (zh) | 卡巴他赛及其中间体的制备方法及卡巴他赛中间体 | |
CN108997460A (zh) | 2`-脱氧-2`-氟-2`-c-甲基尿嘧啶核苷亚磷酰胺单体及其合成方法 | |
CN108997462A (zh) | 2`-脱氧-2`-氟-2`-c-甲基腺嘌呤核苷亚磷酰胺单体及其合成方法 | |
CN113735926A (zh) | 一种尿苷的合成工艺 | |
CN113735930A (zh) | 一种引物纯化方法 | |
CN117603958B (zh) | 一种纯化体外转录mRNA的方法及应用 | |
CN114317521B (zh) | 寡核糖核苷酸的纯化方法及试剂盒 | |
CN118048420B (zh) | 一种加帽mRNA的制备方法 | |
CN109053839A (zh) | 核苷修饰物3’-O-CH2N3-2’-O-Me-胞嘧啶核苷的新型制备方法 | |
CN117510564B (zh) | 一种医药中间体N2-Ac-5'-O-DMT-2'-O-炔丙基鸟苷的合成方法 | |
Auganov et al. | Solid-phase synthesis of oligonucleotides, purification and their application |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP01 | Change in the name or title of a patent holder |
Address after: Building 23, No. 99, Shuhai Road, Songjiang District, Shanghai, 201611 Patentee after: Briggs Biotechnology (Shanghai) Co.,Ltd. Address before: Building 23, No. 99, Shuhai Road, Songjiang District, Shanghai, 201611 Patentee before: SHANGHAI BIOLIGO BIOTECHNOLOGY CO.,LTD. |
|
CP01 | Change in the name or title of a patent holder | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20220906 Assignee: Shanghai Baiji Biotechnology Co.,Ltd. Assignor: Briggs Biotechnology (Shanghai) Co.,Ltd. Contract record no.: X2023980034660 Denomination of invention: Method for Synthesis of Long Chain RNA Nucleic Acid by Solid Phase Phosphosamide Triester Method Granted publication date: 20221115 License type: Common License Record date: 20230412 |
|
EE01 | Entry into force of recordation of patent licensing contract |