CN115006282A

CN115006282A - Freeze-dried eye mask and preparation method thereof

Info

Publication number: CN115006282A
Application number: CN202210804356.5A
Authority: CN
Inventors: 陆伟; 蒋正; 杜建平
Original assignee: Guangdong Hongyi Pharmaceutical Technology Co ltd
Current assignee: Guangdong Hongyi Pharmaceutical Technology Co ltd
Priority date: 2022-07-07
Filing date: 2022-07-07
Publication date: 2022-09-06

Abstract

The invention discloses a freeze-dried eye mask and a preparation method thereof, and the freeze-dried eye mask and the preparation method thereof comprise 2-5% of mannitol, 0.2-1% of sodium alginate, 0.7-1.2% of sodium hyaluronate, 0.3-1.5% of hydrolyzed collagen, 0.8-1.5% of pullulanase polysaccharide, 1.5-2% of soluble protein polysaccharide, 0.5-1% of soluble collagen and 80-95% of water. This application just plays certain repairing action to skin through making freeze-drying eye pad pasting have the melanine of desalination and whitening skin, again through carrying out vacuum drying with solution in the mixing container, make the active repairing substance in the material effectively preserve, can squeeze the inside partition department of wrapping bag after applying certain pressure to the wrapping bag, make the powder and the solution on left and right sides mix, thereby make the interior factor activity of solution activatable freeze-drying powder of wrapping bag, repair each layer cell of skin, amazing cell generates nutritive material, improve the lax scheduling problem of skin, make skin elasticity tender full.

Description

Freeze-dried eye mask and preparation method thereof

Technical Field

The invention belongs to the technical field of eye masks, and particularly relates to a freeze-dried eye mask and a preparation method thereof.

Background

The existing membrane-shaped facial mask is usually prepared by directly injecting essence into an eye membrane bag with an eye membrane carrier and then packaging, and along with the increasing requirements of the public, the activity requirements of active substances and small molecular polypeptides in the skin care product are stricter, and the skin care product is required to exert the maximum effect so as to comprehensively improve the skin condition.

Most eye masks in the prior art are prepared by directly injecting essences into eye mask bags with mask cloth, the preparation method causes that some active ingredients which are easy to degrade and oxidize are difficult to store, and the using effect is influenced.

Disclosure of Invention

Aiming at the defects of the prior art, the invention provides a freeze-dried eye mask and a preparation method thereof, and the freeze-dried eye mask has the advantage of being beneficial to the preservation of the activity of small molecular polypeptides.

In order to achieve the purpose, the invention provides the following technical scheme: a freeze-dried eye mask is prepared from mannitol 2-5%, sodium alginate 0.2-1%, sodium hyaluronate 0.7-1.2%, hydrolyzed collagen 0.3-1.5%, pullulanase polysaccharide 0.8-1.5%, soluble proteoglycan 1.5-2%, soluble collagen 0.5-1%, and water 80-95%.

Preferably, the gel comprises 3% -4% of mannitol, 0.4% -0.8% of sodium alginate, 0.8% -1.1% of sodium hyaluronate, 0.5% -1.2% of hydrolyzed collagen, 0.9% -1.2% of pullulanase polysaccharide, 1.7% -1.9% of soluble proteoglycan, 0.6% -1.9% of soluble collagen and 85% -92% of water.

Preferably, the gel comprises 4% of mannitol, 0.8% of sodium alginate, 0.9% of sodium hyaluronate, 1.2% of hydrolyzed collagen, 1.3% of pullulanase polysaccharide, 1.8% of soluble proteoglycan, 0.8% of soluble collagen and 89.2% of water.

Preferably, the method comprises the following steps:

the first step is as follows: weighing 4% of mannitol, 0.8% of sodium alginate, 0.9% of sodium hyaluronate, 1.2% of hydrolyzed collagen, 1.3% of pullulanase polysaccharide, 1.8% of soluble proteoglycan, 0.8% of soluble collagen and 89.2% of water;

the second step: taking the mixing container, and injecting a certain amount of water into the first mixing container;

the third step: pouring the weighed hydrolyzed collagen, soluble proteoglycan and soluble collagen into a mixing container in sequence, and then starting the container to stir;

the fourth step: putting the solution uniformly stirred in the first mixing container and the first mixing container into a vacuum freeze dryer for freeze drying treatment;

the fifth step: putting the weighed mannitol, sodium alginate, sodium hyaluronate, pullulan and water into a second stirring container and uniformly stirring;

and a sixth step: and taking a packaging bag with two independent openings, filling the freeze-dried powder into the left side of the packaging bag, filling the solution in the stirring container II into the right side of the packaging bag, and then sealing the packaging bag.

Preferably, the weighed materials in the first step are placed in a water-free and oil-free drying container for sealed storage, the volume of water injected into the container in the second step is twice of that of the materials in the third step, hydrolyzed collagen, soluble proteoglycan and soluble collagen are poured into the mixing container in sequence in the third step and are stirred for three minutes, the mannitol, sodium alginate, sodium hyaluronate, pullulanase and water are placed into the stirring container in sequence in the fifth step and are stirred for five minutes, and when the mixing container in the third step and the fifth step is used, the temperature of the internal solution is required to be kept at 10-20 ℃, and the inside of the mixing container is in a sealed state in the stirring process.

Preferably, in the fourth step, before the first mixing container is placed inside the vacuum drying machine, the solution in the first mixing container needs to be pre-frozen, then the solution in the first mixing container is quickly frozen, and finally the solution in the first mixing container is dried in vacuum.

Compared with the prior art, the invention has the following beneficial effects:

the freeze-dried eye mask contains hydrolyzed collagen, soluble proteoglycan, soluble collagen, mannitol, sodium alginate, sodium hyaluronate and pullulanase, so that the freeze-dried eye mask has good effects of locking water and moisturizing, promoting pore contraction, preventing computer radiation and excessive skin grease secretion, can lighten melanin and whiten skin to repair skin to a certain extent, can effectively preserve active repair substances in the material by vacuum drying of solution in a mixing container, can squeeze a partition part in the packaging bag after applying a certain pressure to the packaging bag, can mix powder and solution on the left side and the right side, can activate factor activity in each layer of freeze-dried powder of the solution in the packaging bag, repair skin cells, stimulate the cells to generate nutrient substances, and improve the problems of skin looseness and the like, so that the skin is tender and plump.

Detailed Description

All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The invention provides a technical scheme that: a freeze-dried eye mask and its preparation method, dew sugar alcohol 2% -5%, sodium alginate 0.2% -1%, sodium hyaluronate 0.7% -1.2%, hydrolyzed collagen 0.3% -1.5%, pullulanase 0.8% -1.5%, soluble proteoglycan 1.5% -2%, soluble collagen 0.5% -1%, water 80% -95%, can play the effects of locking water and moisturizing to the skin through dew sugar alcohol, can enhance the water retention, tightness and elasticity of the skin through sodium alginate, can also increase the immunity and the protective action of the skin, thus increase the moisturizing effect of the skin, can also promote the shrinkage of pores, prevent computer radiation and excessive secretion of skin oil, and can also play a certain role in repairing the problems of black spots and the like caused by sunburn and insufficient sleep of the skin.

Wherein, the gel comprises 3 to 4 percent of mannitol, 0.4 to 0.8 percent of sodium alginate, 0.8 to 1.1 percent of sodium hyaluronate, 0.5 to 1.2 percent of hydrolyzed collagen, 0.9 to 1.2 percent of pullulanase polysaccharide, 1.7 to 1.9 percent of soluble proteoglycan, 0.6 to 1.9 percent of soluble collagen and 85 to 92 percent of water, the sodium hyaluronate is a natural moisture-preserving component for the skin, so that the water in tissue cells can be kept and can not be lost due to the surrounding water, the hydrolyzed collagen can play the roles of resisting free radicals and whitening the skin, thereby increasing the elasticity of the skin, enabling the skin to become compact, also playing the role of fading pigmentation in the skin, and the pox-preventing property and the gel-preventing effect are realized through the pullulanase polysaccharide, the solution is sticky and stable, and has excellent salt resistance, enzyme resistance and enzyme resistance, The pullulanase has the thickening effects of heat resistance and pH value change resistance, has good compatibility with other water-soluble high molecular substances, is easy to form a water-soluble edible film, and can be used as a film forming agent and a thickening agent.

Wherein, the gel sugar alcohol is 4 percent, the sodium alginate is 0.8 percent, the sodium hyaluronate is 0.9 percent, the hydrolyzed collagen is 1.2 percent, the pullulanase is 1.3 percent, the soluble proteoglycan is 1.8 percent, the soluble collagen is 0.8 percent, the water is 89.2 percent, the soluble proteoglycan can be used as a skin conditioner and a humectant without causing acne and generally has no influence on pregnant women, so that the eye mask is safer and more reliable, the soluble collagen is a non-hydrolyzed protain, is derived from the association tissue of young animals, can be diffused to the deep layer of the skin when acting as an active substance in cosmetics, the contained leucine competes with the leucine in the skin and is combined with the catalytic center of the neuraminidase, thereby inhibiting the generation of melanin, enhancing the collagen activity in the skin, keeping the integrity of stratum corneum moisture and a fiber structure and promoting the metabolism of skin tissues, has good effects of moistening skin, removing wrinkles and beautifying.

The method comprises the following steps:

the second step is that: taking the mixing container, and injecting a certain amount of water into the first mixing container;

Wherein, the material weighed in the first step is placed in a dry container without water or oil for sealed storage, the water capacity injected in the container in the second step is twice of that of the material in the third step, hydrolyzed collagen, soluble proteoglycan and soluble collagen are poured into a mixing container in sequence for stirring for three minutes, the maltitol, sodium alginate, sodium hyaluronate, pullulanase polysaccharide and water are placed into a stirring container in sequence for stirring for five minutes, the temperature of the internal solution is required to be kept at 10-20 ℃ when the mixing container is used in the third step and the fifth step, and the inside of the mixing container is in a sealed state in the stirring process, the material weighed in the first step is placed in the dry container without water for sealed storage, the material weighed is prevented from being polluted by impurities in the air and is prevented from being placed and oxidized, and the hydrolyzed collagen and the soluble proteoglycan polysaccharide are placed in the third step, And the soluble collagen is poured into the mixing container I in sequence and stirred for three minutes, the mannitol, the sodium alginate, the sodium hyaluronate, the pullulanase polysaccharide and the water are placed into the mixing container II in sequence and stirred for five minutes in the fifth step, so that all the materials are uniformly mixed, when the mixing container in the third step and the fifth step is used, the temperature of the internal solution needs to be kept at 10-20 ℃, the inside of the mixing container is in a sealed state in the stirring process, and the materials are prevented from losing activity after being stirred and are prevented from being oxidized when being placed and stirred.

Wherein, in the fourth step, the solution in the first mixing container needs to be pre-frozen before the first mixing container is placed in the vacuum dryer, then the solution in the first mixing container is quickly frozen, and finally the solution in the first mixing container is vacuum dried, in the sixth step, the two independent openings of the packaging bag are not connected, but the separation part in the packaging bag can be squeezed open after a certain pressure is applied to the packaging bag, so that the powder and the solution on the left side and the right side are mixed, the solution in the first mixing container needs to be pre-frozen before the first mixing container is placed in the vacuum dryer in the fourth step, so that the gas dissolved in water is prevented from escaping due to the reduction of the external pressure, the solution in the first mixing container is quickly frozen, the freezing time is shortened, the crystallization in the material is small, the mechanical damage of the material cells is reduced, and the solution in the first mixing container is vacuum dried, the active repairing substances in the material are effectively stored, and the separation part inside the packaging bag can be squeezed open by applying a certain pressure to the packaging bag, so that the powder and the solution on the left side and the right side are mixed, and the freeze-dried eye mask is easy to use.

Specific examples will be listed below in detail:

example 1:

the first step is as follows: weighing 4% of mannitol, 0.8% of sodium alginate, 0.9% of sodium hyaluronate, 1.2% of hydrolyzed collagen, 1.3% of pullulanase polysaccharide, 1.8% of soluble proteoglycan, 0.8% of soluble collagen and 89.2% of water.

The second step is that: : taking the mixing container, and injecting a certain amount of water into the first mixing container;

the fifth step: putting the weighed mannitol, sodium alginate, sodium hyaluronate, pullulanase and water into a stirring container II and uniformly stirring;

The method comprises the following steps of weighing materials in the first step, placing the materials in a water-free and oil-free drying container, sealing and storing, wherein the volume of water injected into the container in the second step is twice of that of the materials in the third step, pouring hydrolyzed collagen, soluble proteoglycan and soluble collagen into a mixing container in sequence, stirring for three minutes, placing dew sugar alcohol, sodium alginate, sodium hyaluronate, pullulanase polysaccharide and water into a stirring container in sequence, stirring for five minutes, and keeping the temperature of an internal solution at 10-20 ℃ when the mixing container is used in the third step and the fifth step, and keeping the inside of the mixing container in a sealed state in the stirring process.

The method comprises the following steps of putting a first mixing container into a vacuum dryer, pre-freezing solution in the first mixing container, quickly freezing the solution in the first mixing container, and finally vacuum-drying the solution in the first mixing container, wherein in the fourth step, the two independent openings of a packaging bag are not connected, but the separation part in the packaging bag can be squeezed open after certain pressure is applied to the packaging bag, so that powder and solution on the left side and the right side are mixed.

Example 2:

the first step is as follows: weighing 3% of mannitol, 0.8% of sodium alginate, 0.9% of sodium hyaluronate, 1.2% of hydrolyzed collagen, 1.3% of pullulanase polysaccharide, 1.8% of soluble proteoglycan, 0.8% of soluble collagen and 90.2% of water.

Wherein, in the fourth step, the solution in the first mixing container needs to be prefrozen before the first mixing container is placed in the vacuum drying machine, the solution in the first mixing container is then subjected to quick freezing, and finally the solution in the first mixing container is subjected to vacuum drying, and in the sixth step, the two independent openings of the packaging bag are not connected with each other, but the separation part in the packaging bag can be squeezed open after a certain pressure is applied to the packaging bag, so that the powder and the solution on the left side and the right side are mixed.

Example 3:

the first step is as follows: weighing 4% of mannitol, 0.8% of sodium alginate, 0.9% of sodium hyaluronate, 1.2% of hydrolyzed collagen, 1.3% of pullulanase polysaccharide, 2% of soluble proteoglycan, 1% of soluble collagen and 89.6% of water;

The results of the performance tests of a lyophilized eye patch of inventive examples 1-3 are as follows:

the activity of the freeze-dried eye mask small-molecule polypeptide in example 1 is 98.2%:

the activity of the freeze-dried eye mask small-molecule polypeptide in example 2 is 98.5%;

the activity of the freeze-dried eye mask small-molecule polypeptide in example 3 is 98.8%.

It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A freeze-dried eye mask is characterized in that: 2 to 5 percent of mannitol, 0.2 to 1 percent of sodium alginate, 0.7 to 1.2 percent of sodium hyaluronate, 0.3 to 1.5 percent of hydrolyzed collagen, 0.8 to 1.5 percent of pullulanase polysaccharide, 1.5 to 2 percent of soluble proteoglycan, 0.5 to 1 percent of soluble collagen and 80 to 95 percent of water.

2. The lyophilized eye patch according to claim 1, wherein: 3 to 4 percent of mannitol, 0.4 to 0.8 percent of sodium alginate, 0.8 to 1.1 percent of sodium hyaluronate, 0.5 to 1.2 percent of hydrolyzed collagen, 0.9 to 1.2 percent of pullulanase polysaccharide, 1.7 to 1.9 percent of soluble proteoglycan, 0.6 to 1.9 percent of soluble collagen and 85 to 92 percent of water.

3. The freeze-dried eye mask and the preparation method thereof according to claim 1, wherein the freeze-dried eye mask comprises the following components: mannitol 4%, sodium alginate 0.8%, sodium hyaluronate 0.9%, hydrolyzed collagen 1.2%, pullulanase polysaccharide 1.3%, soluble proteoglycan 1.8%, soluble collagen 0.8%, and water 89.2%.

4. The method for preparing a lyophilized eye patch according to claim 1, comprising the steps of:

5. The freeze-dried eye mask and the preparation method thereof according to claim 3, wherein the freeze-dried eye mask comprises the following components: the material weighed in the first step is placed in a water-free and oil-free drying container for sealed storage, the volume of water injected into the container in the second step is twice that of the material in the third step, hydrolyzed collagen, soluble proteoglycan and soluble collagen are poured into a mixing container in sequence and stirred for three minutes, the mannitol, sodium alginate, sodium hyaluronate, pullulanase and water are placed into a stirring container in sequence and stirred for five minutes, and when the mixing container in the third step and the fifth step is used, the temperature of the internal solution is required to be kept at 10-20 ℃, and the inside of the mixing container is in a sealed state in the stirring process.

6. The freeze-dried eye mask and the preparation method thereof according to claim 3, wherein the freeze-dried eye mask comprises the following components: in the fourth step, the solution in the first mixing container needs to be pre-frozen before the first mixing container is placed inside the vacuum drying machine, then the solution in the first mixing container is quickly frozen, finally the solution in the first mixing container is vacuum dried, and in the sixth step, the two independent openings of the packaging bag are not connected, but the separation part inside the packaging bag can be squeezed open after certain pressure is applied to the packaging bag, so that the powder and the solution on the left side and the right side are mixed.