CN105496822A - Tartaric acid skin lotion and preparation method thereof - Google Patents
Tartaric acid skin lotion and preparation method thereof Download PDFInfo
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- CN105496822A CN105496822A CN201511007852.4A CN201511007852A CN105496822A CN 105496822 A CN105496822 A CN 105496822A CN 201511007852 A CN201511007852 A CN 201511007852A CN 105496822 A CN105496822 A CN 105496822A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
Abstract
The invention discloses a tartaric acid skin lotion and a preparation method thereof. The tartaric acid skin lotion is technically characterized in that the tartaric acid skin lotion is prepared from the following components in parts by weight: 90 to 120 parts of DL-mandelic acid, 55 to 70 parts of melaleuca alternifolia oil, 10 to 16 parts of grease-enrich agent, 8 to 10 parts of nutrient substances, 3 to 5 parts of moisturizer, 50 to 55 parts of lecithin, and 300 to 400 parts of deionized water. The tartaric acid skin lotion has the advantages that by adopting high-concentration tartaric acid, the skin corneum can be effectively removed; by utilizing the melaleuca alternifolia oil, the grease-enrich agent, the moisturizer and the nutrient substances which are coated in lipidosome, the high-concentration tartaric acid can be neutralized after the tartaric acid is active, the damage to the skin by the high-concentration tartaric acid is avoided, and the skin can be moisturized and nourished.
Description
Technical field
The present invention relates to a kind of skin care item and preparation method thereof, more particularly, it relates to a kind of fruit acid skin care liquid and preparation method thereof.
Background technology
Skin is the main barrier of human body.It prevents organ to be subject to the impact of temperature and humidity change and the infringement of external environment condition (as ultraviolet radiation or pollutant).It also plays an important role in maintenance homeostasis, such as: regulate body temperature.But too much chemistry and physical stimulation, pressure, malnutrition etc. are disadvantageous to the normal function of skin, and can accelerate the catabiosis of skin, such as: to follow the string, keratinization and generation wrinkle.Being used for preventing these phenomenons from usually there is various problem with keeping skin health and elastic cosmetics, mainly there is curative effect not enough or cause the various problems of skin side-effects.Fruit acid is a kind of plant extract of pure natural, is the various organic acid extracted from fruit, is be present in the active ingredient in multiple natural fruit or Yoghourt.Comprise DL-mandelic acid, malic acid, citric acid and lactic acid etc., because great majority refine by fruit, therefore title fruit acid, fruit acid is as a kind of natural extract, any toxic and side effects is caused hardly to the skin of user, fruit acid can be divided into according to the difference of molecular structure: glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, mandelic acid etc. 37 kinds, but in medical cosmetology circle, the composition be the most often applied to is glycolic acid and lactic acid.Glycolic acid, is also called Caulis Sacchari sinensis acid, glycol acid, and being obtained by extraction in Caulis Sacchari sinensis the earliest, is a member most widely used in fruit acid product.Glycolic acid has molecular weight (76) minimum in fruit acid, the therefore top layer of the easiest skin permeation, and the effect of absorption is also the most obvious, is the most often be used in the fruit acid changing skin and use.Lactic acid, has the molecular weight (90) that in fruit acid second is little, because moisturizing degree is strong, natural components can not stimulate human body skin, improves scaly dry skin and keratinization phenomenon so be extensively used in.During high concentration, making dermatolysis peel the fastest is then tartaric acid, is secondly glycolic acid and lactic acid.As for promotion cell turnover, then best with lactic acid effect, be secondly glycolic acid.When fruit acid uses according to it, concentration is different, is divided into low concentration fruit acid, middle concentration fruit acid and high concentration fruit acid.In low concentration fruit acid, fruit acid concentration is less than 10%, and low concentration fruit acid can reduce the coagulability between epidermal keratinocyte, can remove aging cutin, improves coarse, obscure, conditioning skin quality, in middle concentration fruit acid, the concentration of fruit acid is 10% ~ 30%, and middle concentration fruit acid can reach dermal tissue, all has good effect for desalination comedo, smooth out wrinkles, in high concentration fruit acid, fruit acid concentration is greater than 30%, the penetrating power of high concentration fruit acid is quite strong, aging cutin once can be peeled off, thus play the effect accelerating speckle dispelling reduce wrinkle, but the skin protection of high concentration fruit acid belongs to changes skin character, need to treat under the operation of medical practitioner, in the cosmetics that market today is sold, the fruit acid concentration added is mostly below 5%, make the overall pH value of cosmetics more than 3, effect of the fruit acid addition of this low concentration focuses on exfoliation and moisture-keeping function, for the DeGrain of reduce wrinkle and whitening, if but add the higher fruit acid of concentration, stronger zest can be caused to skin, likely skin is damaged, therefore the fruit acid of high concentration directly can not be used in individualized cosmetic.
Summary of the invention
For the deficiency that prior art exists, the object of the present invention is to provide a kind of fruit acid concentration higher and do not injure the skin care liquid of skin.
For achieving the above object, the invention provides following technical scheme: a kind of fruit acid skin care liquid, in this formula, each component is designated as by weight
DL-mandelic acid 90 ~ 120 parts
Titrol 55 ~ 70 parts
Compose fat agent 10 ~ 16 parts
Nutrient substance 8 ~ 10 parts
Wetting agent 3 ~ 5 parts
50 ~ 55 parts, lecithin
Deionized water 300 ~ 400 parts.
In this fruit acid skin care liquid, the concentration of fruit acid is about 30%, belong to high concentration fruit acid, the penetrating power of high concentration fruit acid is quite strong, aging cutin once can be peeled off, thus play the effect accelerating speckle dispelling reduce wrinkle, here fruit acid adopts DL-mandelic acid, the exfoliation function that DL-mandelic acid not only has general fruit acid to have, also there is very strong sterilization and bacteria resistance function, the tender and lovely skin after removing cutin can be protected not to be subject to the invasion of antibacterial and microorganism, but the fruit acid that concentration is higher, stronger zest can be caused to skin, likely skin is damaged, therefore need to add in fruit acid skin care liquid in and the basic component of fruit acid, here basic component selects titrol, titrol is also known as tea tree oil, that one has weakly alkaline skin protection material, therefore, it is possible in and the zest brought of the acidity of high concentration fruit acid, thoroughly can also remove excess oil secretion simultaneously, regulate water oil balance, help and dispel acne, prevention small pox and acceleration recovery from illness, for skin provides moisture content to strengthen fine and smooth repair ability simultaneously, promote skin smooth, make pore more healthy careful, tea tree oil has very strong facilitation effect for the healing of skin injury simultaneously, the reparation of skin histology can be promoted while using this fruit acid skin care liquid, thus effectively protect skin when using high concentration fruit acid goods, but for this fruit acid skin care liquid, fruit acid is before use needed not to be neutralized, to retell after the onset of fruit acid part in fruit acid and, therefore lecithin is added here, liposome is made to wrap up titrol with lecithin, in making it not occur with fruit acid in skin care liquid and, add in this fruit acid skin care liquid and compose fat agent, wetting agent and nutrient substance are then in order to maintaining skin better, protected by liposome simultaneously and compose fat agent, wetting agent and nutrient substance, the agent of tax fat can be made, wetting agent keeps being separated before contact skin with nutrient substance each other, thus contribute to keeping best character.
Preferably, the agent of described weak tax fat is one or more in the macrogol ester of isopropyl myristate and glyceryl Oleum Cocois.
Isopropyl myristate is non-fat emollient, is very easily absorbed by the skin.Be one of component of semisolid matrix, also can be used as the solvent of many materials in local administration preparation.It is applied to various topical formulations and cosmetics, comprises bath oil, cosmetics, hair care armor product, facial cream, lotion, lip-stick, shaving cream, emollient, deodorizer, ear's suspensoid, vaginal cream.Such as, isopropyl myristate is a kind of self emulsifying composition in a certain cold cream prescription, and this cold cream prescription can be used as the substrate of many medicines and dermatologic thing; In cosmetics, it also has application in the stable mixed liquor of water and glycerol.Isopropyl myristate can be used as the penetration enhancers in transdermal absorption formulation, can combine use with treatment ultrasound wave and iontophoresis.Isopropyl myristate can be used as the main component of oil phase in water-oleogel slow release breast (water-oilgelprolonged-releaseemulsion); therefore can as a kind of tax fat agent of function admirable; coconut oil glyceride polarity is very weak; in skin ductility and absorbability good; fully can extend at skin surface; form the protecting film of skin, one deck oil phase thin film can be formed at skin surface well as the agent of tax fat, thus good protected effect is played to skin.
Preferably, described wetting agent is ketopyrrolidine hydroxy acid sodium.
Peeling will be produced during xerosis cutis, the various skin problems such as be full of cracks and a skin ulcer, therefore as skin care item, moisturizing is an important performance, in this fruit acid skin care liquid, fruit acid concentration is higher simultaneously, acidity is too high to be damaged skin to keep skin wet also to help avoid, the wetting agent that the performance of ketopyrrolidine hydroxy acid sodium is more traditional is more superior, one of important component of PCA-Na system human body natural Moisture factor, hygroscopicity is high, and it is nontoxic, non-stimulated, good stability, the desirable natural cosmetic health product of skin or hair care in modern age, skin can be made, hair has wettability, flexibility, elasticity and glossiness, antistatic behaviour, PCA-Na or a kind of superior keratolytic of performance simultaneously, can before high concentration fruit acid Stratum Corneum be removed, in advance horny layer is softened, contribute to improving the effect that cutin removed by fruit acid.
Preferably, described nutrient substance is one or more in aminosal and lanolin derivative.
Hydrolyzed protein with milk casein or fibrin obtained by the acidolysis or enzymolysis; essential amino acid can be provided for body anabolism; therefore, it is possible to provide required nutrient substance for skin; lanolin derivative comprises lanonol; lanoceric acid, pure lanocerin, acetylated lanolin wax; acetylated lanolin, polyethylene glycol hydrogenated lanoline etc.Lanonol is faint yellow to light brown waxy solid, slightly abnormal smells from the patient, water insoluble, and Performance Ratio lanoline is good, is widely used in all kinds of cosmetics, as steamer, and dry skin skin care item, cream frost, emulsion etc.Lanoceric acid has good moist effect to skin, and adding above-mentioned nutrient substance is exactly to supplement the nutrients to the skin acid-treated through fruit, promoting the generation of neoplastic skin.
The method of the fruit acid skin care liquid as described in preparation is as any in claim 1 ~ 4:
Step one: add titrol in deionized water, adopts ultrasonic wave concussion to stir 100 ~ 120s;
Step 2: add in the turbid liquid obtained in step one and compose fat agent, wetting agent and nutrient substance, stirs 130 ~ 150s to the mixture of gained subsequently;
Step 3: add lecithin in the turbid liquid obtained in step 2 and stir 60 ~ 80s;
Step 4: add DL-mandelic acid in the mixture obtained in step 3, stirs until tartaric acid fully dissolves.
Stirring titrol with ultrasonic wave concussion is to enable titrol be fully dispersed as fine droplet and be well dispersed in aqueous phase; and then can fully be wrapped up in the liposome of lecithin formation; add before adding lecithin compose fat agent, wetting agent and nutrient substance be also in order to make these three components also can wrap up by liposome protection, finally in mixed liquor, add DL-mandelic acid again.
Preferably, in step 2, be 800 ~ 1000rpm to the stir speed (S.S.) of mixture.
Compose fat agent, wetting agent and nutrient substance also to need fully to be broken up, therefore mixing speed can not be too slow, therefore mixing speed is fixed on 800 ~ 1000rpm.
Preferably, in step 3, adding the stir speed (S.S.) after lecithin is 400 ~ 600rpm.
After adding lecithin, needing lecithin to break up, and be dispersed into liposome, therefore need certain mixing speed, but mixing speed is too fast, can be that liposome structure is broken up, therefore mixing speed be decided to be 400 ~ 600rpm here.
Preferably, in step 4, the speed of stirring is 250 ~ 300rpm.
In step 4, the package structure molding of liposome, if therefore liposome structure is broken up in the too fast meeting of mixing speed, therefore mixing speed fixes on 250 ~ 300rpm.
Compared with prior art the present invention has following advantage: in this fruit acid skin care liquid, the concentration of fruit acid is about 30%, belong to high concentration fruit acid, the penetrating power of high concentration fruit acid is quite strong, aging cutin once can be peeled off, thus play the effect accelerating speckle dispelling reduce wrinkle, here fruit acid adopts DL-mandelic acid, the exfoliation function that DL-mandelic acid not only has general fruit acid to have, also there is very strong sterilization and bacteria resistance function, the tender and lovely skin after removing cutin can be protected not to be subject to the invasion of antibacterial and microorganism, but the fruit acid that concentration is higher, stronger zest can be caused to skin, likely skin is damaged, therefore need to add in fruit acid skin care liquid in and the basic component of fruit acid, here basic component selects titrol, titrol is also known as tea tree oil, that one has weakly alkaline skin protection material, therefore, it is possible in and the zest brought of the acidity of high concentration fruit acid, thoroughly can also remove excess oil secretion simultaneously, regulate water oil balance, help and dispel acne, prevention small pox and acceleration recovery from illness, for skin provides moisture content to strengthen fine and smooth repair ability simultaneously, promote skin smooth, make pore more healthy careful, tea tree oil has very strong facilitation effect for the healing of skin injury simultaneously, the reparation of skin histology can be promoted while using this fruit acid skin care liquid, thus effectively protect skin when using high concentration fruit acid goods, but for this fruit acid skin care liquid, fruit acid is before use needed not to be neutralized, to retell after the onset of fruit acid part in fruit acid and, therefore lecithin is added here, liposome is made to wrap up titrol with lecithin, in making it not occur with fruit acid in skin care liquid and, add in this fruit acid skin care liquid and compose fat agent, wetting agent and nutrient substance are then in order to maintaining skin better, protected by liposome simultaneously and compose fat agent, wetting agent and nutrient substance, the agent of tax fat can be made, wetting agent keeps being separated before contact skin with nutrient substance each other, thus contribute to keeping best character.
Detailed description of the invention
Embodiment 1
DL-mandelic acid 120 parts
Titrol 70 parts
The macrogol ester of glyceryl Oleum Cocois 16 parts
Lanolin derivative 10 parts
5 parts, ketopyrrolidine hydroxy acid sodium
55 parts, lecithin
Deionized water 400 parts
Preparation method
Step one: add titrol in deionized water, adopts ultrasonic wave concussion to stir 120s;
Step 2: add in the turbid liquid obtained in step one and compose fat agent, wetting agent and nutrient substance, stirs 130s to the mixture of gained with the rotating speed of 1000rpm subsequently;
Step 3: add lecithin in the turbid liquid obtained in step 2 and the rotating speed of 600rpm stirring 60s;
Step 4: add DL-mandelic acid in the mixture obtained in step 3, stirs until tartaric acid fully dissolves with the rotating speed of 300rpm.
Embodiment 2
DL-mandelic acid 90 parts
Titrol 55 parts
Isopropyl myristate 10 parts
Aminosal 8 parts
3 parts, ketopyrrolidine hydroxy acid sodium
50 parts, lecithin
Deionized water 300 parts
Preparation method
Step one: add titrol in deionized water, adopts ultrasonic wave concussion to stir 100s;
Step 2: add in the turbid liquid obtained in step one and compose fat agent, wetting agent and nutrient substance, stirs 150s to the mixture of gained with the rotating speed of 800rpm subsequently;
Step 3: add lecithin in the turbid liquid obtained in step 2 and the rotating speed of 400rpm stirring 80s;
Step 4: add DL-mandelic acid in the mixture obtained in step 3, stirs until tartaric acid fully dissolves with the rotating speed of 250rpm.
Embodiment 3
DL-mandelic acid 107 parts
Titrol 62 parts
Isopropyl myristate 7 parts
The macrogol ester of glyceryl Oleum Cocois 7 parts
Aminosal 5 parts
Lanolin derivative 4 parts
4 parts, ketopyrrolidine hydroxy acid sodium
53 parts, lecithin
Deionized water 352 parts
Preparation method
Step one: add titrol in deionized water, adopts ultrasonic wave concussion to stir 109s;
Step 2: add in the turbid liquid obtained in step one and compose fat agent, wetting agent and nutrient substance, stirs 138s to the mixture of gained with the rotating speed of 910rpm subsequently;
Step 3: add lecithin in the turbid liquid obtained in step 2 and the rotating speed of 500rpm stirring 73s;
Step 4: add DL-mandelic acid in the mixture obtained in step 3, stirs until tartaric acid fully dissolves with the rotating speed of 277rpm.
The above is only the preferred embodiment of the present invention, protection scope of the present invention be not only confined to above-described embodiment, and all technical schemes belonged under thinking of the present invention all belong to protection scope of the present invention.It should be pointed out that for those skilled in the art, some improvements and modifications without departing from the principles of the present invention, these improvements and modifications also should be considered as protection scope of the present invention.
properties of product are tested
For this fruit acid skin care liquid, mainly to consider its osmotic effect in skin and after using alkaline matter to the neutralization of fruit acid, here the silica gel simulation skin that 2cm is thick is taken, respectively apply the product 1g prepared according to three groups of embodiments thereon, respectively test 1 minute time skin depth be 1cm place pH value and 3 minutes time 1cm place, skin depths pH value.
When (1) 1 minute
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| PH value | 2.68 | 2.91 | 2.82 |
From above-mentioned data, product is good and bad and DL-mandelic acid concentration is proportional to the osmotic effect of skin.
When (2) 2 minutes
| Embodiment 1 | Embodiment 2 | Embodiment 3 | |
| PH value | 5.77 | 5.18 | 5.46 |
From above-mentioned data, alkaline matter to the neutralization of fruit acid and the concentration of alkaline matter proportional.
Claims (8)
1. a fruit acid skin care liquid, is characterized in that: in this formula, each component is designated as by weight
DL-mandelic acid 90 ~ 120 parts
Titrol 55 ~ 70 parts
Compose fat agent 10 ~ 16 parts
Nutrient substance 8 ~ 10 parts
Wetting agent 3 ~ 5 parts
50 ~ 55 parts, lecithin
Deionized water 300 ~ 400 parts.
2. fruit acid skin care liquid according to claim 1, is characterized in that: the agent of described weak tax fat is one or more in the macrogol ester of isopropyl myristate and glyceryl Oleum Cocois.
3. fruit acid skin care liquid according to claim 1, is characterized in that: described wetting agent is ketopyrrolidine hydroxy acid sodium.
4. fruit acid skin care liquid according to claim 1, is characterized in that: described nutrient substance is one or more in aminosal and lanolin derivative.
5. preparation as any in claim 1 ~ 4 as described in the method for fruit acid skin care liquid:
Step one: add titrol in deionized water, adopts ultrasonic wave concussion to stir 100 ~ 120s;
Step 2: add in the turbid liquid obtained in step one and compose fat agent, wetting agent and nutrient substance, stirs 130 ~ 150s to the mixture of gained subsequently;
Step 3: add lecithin in the turbid liquid obtained in step 2 and stir 60 ~ 80s;
Step 4: add DL-mandelic acid in the mixture obtained in step 3, stirs until tartaric acid fully dissolves.
6. the method preparing fruit acid skin care oil according to claim 5, is characterized in that: in step 2, is 800 ~ 1000rpm to the stir speed (S.S.) of mixture.
7. the method preparing fruit acid skin care oil according to claim 5, is characterized in that: in step 3, and adding the stir speed (S.S.) after lecithin is 400 ~ 600rpm.
8. the method preparing fruit acid skin care oil according to claim 5, is characterized in that: in step 4, and the speed of stirring is 250 ~ 300rpm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007852.4A CN105496822A (en) | 2015-12-29 | 2015-12-29 | Tartaric acid skin lotion and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201511007852.4A CN105496822A (en) | 2015-12-29 | 2015-12-29 | Tartaric acid skin lotion and preparation method thereof |
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| Publication Number | Publication Date |
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| CN105496822A true CN105496822A (en) | 2016-04-20 |
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| CN201511007852.4A Pending CN105496822A (en) | 2015-12-29 | 2015-12-29 | Tartaric acid skin lotion and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096111A (en) * | 2018-01-10 | 2018-06-01 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of improvement chicken dermal compositions |
| CN112007060A (en) * | 2020-09-15 | 2020-12-01 | 维美康颜(广州)生物技术有限公司 | Wart and freckle removing composition and preparation method thereof |
| CN113546031A (en) * | 2021-08-13 | 2021-10-26 | 上海美浮特生物科技有限公司 | Composition for promoting stratum corneum renewal and preparation method and application thereof |
-
2015
- 2015-12-29 CN CN201511007852.4A patent/CN105496822A/en active Pending
Non-Patent Citations (2)
| Title |
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| 中华人民共和国卫生部: "表3化妆品组分中限用物质", 《化妆品卫生规范》 * |
| 翟文龙主编: "《健康常识全知道》", 30 November 2014 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108096111A (en) * | 2018-01-10 | 2018-06-01 | 广州市聚吉科绿色化学共性技术研究院有限公司 | A kind of improvement chicken dermal compositions |
| CN112007060A (en) * | 2020-09-15 | 2020-12-01 | 维美康颜(广州)生物技术有限公司 | Wart and freckle removing composition and preparation method thereof |
| CN113546031A (en) * | 2021-08-13 | 2021-10-26 | 上海美浮特生物科技有限公司 | Composition for promoting stratum corneum renewal and preparation method and application thereof |
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Application publication date: 20160420 |