CN1150043A - 一种治疗脂溢性脱发的高效低副作用外用药物 - Google Patents

一种治疗脂溢性脱发的高效低副作用外用药物 Download PDF

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CN1150043A
CN1150043A CN96109964A CN96109964A CN1150043A CN 1150043 A CN1150043 A CN 1150043A CN 96109964 A CN96109964 A CN 96109964A CN 96109964 A CN96109964 A CN 96109964A CN 1150043 A CN1150043 A CN 1150043A
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梅晓春
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Abstract

本发明涉及一种治疗脂溢性脱发的高效低副作用外用药配方，它由何首乌，女贞子，桑椹子，生地，旱莲草，丹参，红花，蛇床子，苦参，白藓皮，地肤子与13-顺-维甲酸(或维胺脂，三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem，Ro-13-6298中任一种)加上适当的抗氧化剂和70％乙醇组成，对脂溢性脱发有很好的疗效，可大范围普及推广应用。

Description

一种治疗脂溢性脱发的高效低副作用外用药物
本发明涉及一种治疗脂溢性脱发的高效低副作用药物，具体地说是一种以中草药和维生素A酸类药物配合制成的外用药。
脱发是一种常见多发的皮肤病，主要分为两种类型，即非脂溢性脱发(如斑秃)和脂溢性脱发。非脂溢性脱发的治疗比较容易些，已有许多有效成药。如由何首乌、桑椹子等中药制成的药物对斑秃等非脂溢性脱发就有较好的疗效。然面对于脂溢性脱发，这些药物可以说疗效甚微。脂溢性脱发的治疗可以说是皮肤医学界的一个难题，虽然人们做了许多努力，至今仍无真正有效的药物与治疗方法问世。
脂溢性脱发的本质病因目前尚不很清楚，目前中医认为人体肾血亏虚西医认为雄性激素分泌过旺引起脂溢性脱发，但中医用养血补肾药物西医用抗雄性激素治疗脂溢性脱发都疗效不佳。本发明认为脂溢性脱发的直接原因是由于人体内分泌失调引起皮脂分泌过旺，而过多的皮脂中所含的某些物质如油酸、亚油酸、角鲨烯等对毛囊有毒性作用，导致毛发中毒、枯萎、脱落，即皮脂分泌过旺可能是脂溢性脱发的直接原因。
因此，对脂溢性脱发真正有效的药物首先应当要能有效地抑制或降低头皮脂肪的过量分泌。
另从40年代起，就有人用维生素A来治疗痤疮，痤疮也是由于皮脂分泌过旺而引起的皮肤病，但维生素A抑制皮分泌的能力并不太强，且长期使用有较大的毒副作用，如头痛、骨痛、脱发等。近几十年来人们在维生素A的基础上先后合成了几百种维生素A类物质，寻找更安全有效的治疗痤疮药物。这些物质都有明显的抑制皮脂分泌的作用。然而，仅用维生素A类物质治疗脂溢性脱发也是不完整的，它不能使脱发再生。另外脂溢性脱发患者大多头皮毛囊受损严重，头皮毛细血管萎缩，导致毛发营养不良。本发明人在临床应用中观察到的事实是如果仅用维生素A类物质物质来治疗，许多患者的头发仍会持续出现不正常脱落，若与对毛发生长有促进作用的中药联合组方来治疗脂溢性脱发，效果会大大增强。
本发明人曾在95年申请了一种治疗脂溢性脱发的外用药配方(申请号95103743.9)。本发明在于提出一种新的更为高效的配方，具有更好的去皮脂防脱发与生发作用，且更少副作用，有利于患者接受，同时再一步扩大有效药物的范围。
本发明药物的配方组成为：何首乌20-40克  女贞子10-20克  桑椹子10-20克  生地10-20克旱莲草10-20克  丹参5-15克     红花5-15克     蛇床子10-30克苦参5-15克     白藓皮5-15克   地肤子5-15克2，6-二叔丁基对甲酚0.05-5克   13-顺-维甲酸0.05-5克70％乙醇1000-1500毫升
若用其他维生素A酸类物质，如维胺酯，三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etrenate，Tasmadem，RO-13-6298中的任一种代替13-顺-维甲酸，也可以制成具有相同作用的药物，其配方成为：何首乌20-40克  女贞子10-20克  桑椹子10-20克  生地10-20克旱莲草10-20克  丹参5-15克     红花5-15克     蛇床子10-30克苦参5-15克     白藓皮5-15克   地肤子5-15克2，6-二叔丁基对甲酚0.05-5克，维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem中任一种)0.05-5克，70％乙醇1000-1500毫升。
制备方法是：
将上述配方中的何首乌，女贞子，桑椹子、生地，旱莲草、丹参，红花、蛇床子、苦参、白藓皮、地肤子粉碎后加70％乙醇浸泡一个星期，过滤去渣，在滤液中如入配方量的维生素A甲酸类物质和抗氯化剂(2，6-二叔丁基对甲酚)，混合均匀即可制得本发明的外用药。
制备本发明的优选配方为：何首乌30克    女贞子15克    桑椹子15克    生地15克旱莲草15克    丹参10克      红花10克      蛇床子20克苦参10克      白藓皮10克    地肤子10克2，6-二叔丁基对甲酚1克      13-顺-维甲酸1克70％乙醇1200毫升，制成药液1000毫升。
本发明的另一优选配方为：何首乌30克    女贞子15克    桑椹子15克    生地15克旱莲草15克    丹参10克      红花10克      蛇床子20克苦参10克      白藓皮10克    地肤子10克2，6-二叔丁基对甲酚1克，维胺脂(或三甲基甲氧苯维甲酸(或维胺脂，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem中任一种)2克，70％乙醇1200毫升，制成药液1000毫升。
大量临床应用表明，本发明的外用药用于脂溢性脱发的治疗有很明确的效果，由于13-顺-维甲酸等维生素A酸类物质对皮脂有很强的抑制作用，患者使用几天即可感到头皮油脂明显减少，头发脱落程度大大降低，使用十几-二十天左右就可基本制止不正常脱发。同时中药何首乌，女贞子、桑椹子、生地、旱莲草中所合成份有很好的促进头发生长的作用。丹参，红花能起到活血，促进头皮血液循环，改善头皮营养输送作用。另维生素A酸类物质在外涂液中的浓度对控制脱发的效果有较大的影响，浓度越高去皮肤防脱发效果越强。但另一方面浓度较大时会使皮肤产生骚痒，皮疹与刺激作用，从而限制了浓度的提高。本发明者发现蛇床子、苦参、白藓皮、地肤子等中药对维生素A酸类物质引起的皮肤骚痒，皮疹，刺激等症状有较好的抑制作用，故在外用药中加入这几种中药成份能有效地减少维生素A酸类物质对头皮的不良副作用，从而可以大大提高外用药中维生素A酸类物的浓度，从而大大提高疗效。大量临床应用表明，本发明配方的疗效比本发明人95年申请的同类药物的疗效有一个较大的提高。95年申请的专利配方在夏天高温季节(气温越高患者皮脂分泌越多)疗效明显降低，而本发明的配方在高温季节仍能保持很好的疗效。因此可以说本发明的药物是一种治疗脂溢性脱发的理想药物，值得大规模推广应用。
以下给出一些实施例，进一步详细描述本发明：
实施例1
取何首乌30克，女贞子15克，桑椹子15克，生地15克，旱莲草15克，丹参10克，红花10克，蛇床子20克，苦参10克，白藓皮10克，地肤子10克，将它们粉碎混合，加入70％乙醇1200毫升，浸泡一个星期，过滤去渣，精确量取1000毫升滤液，加入2，6-二叔丁基对甲酚1克，13-顺-维甲酸1克，溶解后混合均匀，制得本发明药液1000毫升。
实施例2
取何首乌30克，女贞子15克，桑椹子15克，生地15克，旱莲草15克，丹参10克，红花10克，蛇床子20克，苦参10克，白藓皮10克，地肤子10克，将它们粉碎混合，加入70％乙醇1200毫升，浸泡一个星期，过滤去渣，精确量取1000毫升滤夜，加2，6-二叔丁基对甲酚1克，维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate Tasmadem中任一种)2克混合均匀，制成本发明药剂1000毫升。

Claims (8)

1、一种治疗脂溢性脱发的外用药，其特征在于它由以下组分制成的外用药剂：何首乌20-40克   女贞子10-20克    桑椹子10-20克    生地10-20克旱莲草10-20克   丹参5-15克       红花5-15克       蛇床子10-30克苦参5-15克      白藓皮5-15克     地肤子5-15克2，6-二叔丁基对甲酚0.05-5克      13-顺-维甲酸0.05-5克70％乙醇1000-1500毫升
2、根据权利要求1所述的药物，其特征在于它是由以下组分制成的药剂：何首乌30克    女贞子15克    桑椹子15克    生地15克旱莲草15克    丹参10克      红花10克      蛇床子20克苦参10克      白藓皮10克    地肤子10克2，6-二叔丁基对甲酚1克      13-顺-维甲酸1克70％乙醇1200毫升
3、一种治疗脂溢性脱发药物的制备方法，其特征在于原料配方为：何首乌20-40克   女贞子10-20克    桑椹子10-20克   生地10-20克旱莲草10-20克   丹参5-15克       红花5-15克      蛇床子10-30克苦参5-15克      白藓皮5-15克     地肤子5-15克2，6-二叔丁基对甲酚0.05-5克      13-顺-维甲酸0.05-5克70％乙醇1000-1500毫升
加工工艺如下：
将中药何首乌、女贞子、桑椹子、生地、旱莲草、丹参、红花、蛇床子、苦参、白藓皮、地肤子粉碎，加70％乙醇浸泡一个星期，过滤，取滤液，加入配方量的13-顺-维甲酸，2，6-二叔丁基对甲酚，充分混合均匀，制成本发明的外用药。
4、根据权利要求3所述药物的制备方法，其特征在于原料配方为：何首乌30克    女贞子15克    桑椹子15克    生地15克旱莲草15克    丹参10克      红花10克      蛇床子20克苦参10克      白藓皮10克    地肤子10克2，6-二叔丁基对甲酚1克      13-顺-维甲酸1克70％乙醇1200毫升，制成药液1000毫升。
5、一种治疗脂溢性脱发的外用药物，其特征在于它也可由以下组分制成：何首乌20-40克  女贞子10-20克  桑椹子10-20克  生地10-20克旱莲草10-20克  丹参5-15克     红花5-15克     蛇床子10-30克苦参5-15克     白藓皮5-15克   地肤子5-15克2，6-二叔丁基对甲酚0.05-5克   维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem中任一种)0.05-5克70％乙醇1000-1500毫升。
6、根据权利要求5所述的药物，其特征在于它由以下组份制成的外用药剂：何首乌30克    女贞子15克    桑椹子15克    生地15克旱莲草15克    丹参10克      红花10克      蛇床子20克苦参10克      白藓皮10克    地肤子10克2，6-二叔丁基对甲酚1克      维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem中任一种)2克，70％乙醇1200毫升，制成药液1000毫升。
7、一种治疗脂溢性脱发药物的制备方法，其特征在于原料配方为：何首乌20-40克  女贞子10-20克  桑椹子10-20克   生地10-20克旱莲草10-20克  丹参5-15克     红花5-15克      蛇床子10-30克苦参5-15克     白藓皮5-15克   地肤子5-15克2，6-二叔丁基对甲酚0.05-5克   维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem中任一种)0.05-5克，70％乙醇1000-1500毫升，制成药液1000毫升。
加工工艺如下：
将中药何首乌，女贞子，桑椹子，生地，旱莲草，丹参，蛇床子，苦参，白藓皮，地肤子粉碎混合后加70％乙醇浸泡一个星期，过滤，在中药滤液中加入配方量的2，6-二叔丁基对甲酚，维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretenate，Tasmadem中任一种)，充分混合均匀，制成本发明的外用药。
8、根据权利7要求的药物制备方法，其特征在于原料配方为：何首乌30克    女贞子15克    桑椹子15克    生地15克旱莲草15克    丹参10克      红花10克      蛇床子20克苦参10克      白藓皮10克    地肤子10克2，6-二叔丁基对甲酚1克      维胺脂(或三甲基甲氧苯维甲酸，三氯甲基甲氧苯维甲酸，Etretinate，Tasmadem中任一种)2克，70％乙醇1200毫升，制成1000毫升药液。
CN96109964A 1996-08-09 1996-08-09 一种治疗脂溢性脱发的高效低副作用的改进型外用药物 Expired - Fee Related CN1065435C (zh)

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US6261566B1 (en) * 1999-10-22 2001-07-17 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Cosmetic compositions containing mulberry extract and retinoids
KR20030070686A (ko) * 2002-02-26 2003-09-02 정성인 발모 촉진 및 탈모 예방용 외용제의 제조 방법
KR100953278B1 (ko) * 2008-02-25 2010-04-19 보령메디앙스 주식회사 항염 및 피부자극완화용 화장료 조성물
DE102022100053A1 (de) 2022-01-03 2023-07-06 Snejan Dimitrov Ivantchev Topisches Mittel zur Behandlung von Alopecia areata (SNEZHALIN))

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CN1097140A (zh) * 1994-01-19 1995-01-11 柴瑞霞 主治白发及脱发的荣发丸
CN1051464C (zh) * 1994-04-14 2000-04-19 梅晓春 一种治疗脂溢性脱发的内服药物
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CN111084726A (zh) * 2020-01-08 2020-05-01 北京幸福益生再生医学科技有限公司 一种防脱生发组合物及其制备方法

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