CN114984138A

CN114984138A - Traditional Chinese medicine composition, preparation method and application thereof

Info

Publication number: CN114984138A
Application number: CN202210879820.7A
Authority: CN
Inventors: 曾志安
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-07-25
Filing date: 2022-07-25
Publication date: 2022-09-02

Abstract

The application provides a traditional Chinese medicine composition, a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The application provides a traditional Chinese medicine composition, which comprises the following components: herba Pteridis Semipinnatae and radix Ranunculi Ternati have effects of removing toxic substance, eliminating phlegm and resolving masses; ministerial drugs: leech, garden balsam seed, Chinese honeylocust spine and airpotato yam seed strengthen the effects of detoxifying and reducing swelling of monarch drug, reducing phlegm and resolving masses; adjuvant drugs: the black tiger, the wine-processed rhubarb, the cocklebur fruit and the notopterygium root play roles of assisting monarch drugs and ministerial drugs to strengthen the treatment; a messenger drug: peach kernel, safflower, cinnamon, cornu cervi degelatinatum, rehmannia root, radix asteris, thunberg fritillary bulb and sun euphorbia can be introduced to achieve the disease institute, the monarch, minister, assistant and guide medicines are reasonable in compatibility, and the traditional Chinese medicine is non-toxic and free of side effects, and has a good treatment effect and a quick response in preparation of drugs for treating sarcoidosis. The preparation method of the composition is simple, the liquid medicine is prepared by decoction and concentration, the effective components can be effectively extracted, and the drug effect can be better exerted; the prepared pills are not required to be decocted, are convenient to carry and are suitable for patients without decoction conditions.

Description

Traditional Chinese medicine composition, preparation method and application thereof

Technical Field

The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, a preparation method and application thereof.

Background

Sarcoidosis is a granulomatous inflammatory disease, has unknown etiology, mainly invades lung parenchyma, involves tissues of multiple organs of the whole body, such as lymph nodes, skin, joints, liver, kidney, heart and the like, is relatively unconscious in clinical treatment, and can cause sudden death of patients due to complete atrioventricular conduction block and/or congestive heart failure, even causes sudden death as the first symptom. The good onset age of sarcoidosis is 30-40 years old, the onset of sarcoidosis is slow, and about 40% of patients can be asymptomatic and found only in physical examination. The disease can invade most internal organs in a body, such as skin, eyes, a chest cavity and other systemic organs, wherein the enlargement of the lymph nodes in the chest and the pathological changes of the lung are the most common, and account for about 90 percent, and the disease can be clinically manifested as erythema nodosum skin, blurred vision, cough, chest pain, dyspnea, hypodynamia and weight loss, and a few patients can have short-term low fever and the like.

Most of the sarcoidosis has benign processes and tends to be relieved by self, so that patients with mild disease can be treated without special treatment, but the patients with obvious symptoms need to be treated by adrenocortical hormone, the initial dose is 30 mg per day, the dose is reduced by 5 mg every 2-3 months, and the treatment course is 2 years. Periodic review of chest radiographs and measurement of serum enzymology can determine whether the disease is controlled or relapsed. If not treated completely, the sarcoidosis can progress further, leading to severe complications such as extensive lung fibrosis and respiratory failure. However, patients with sarcoidosis have low immune function, and if they take corticosteroids for a long time, they have low immunity, and are likely to be infected with other diseases.

Therefore, it is very necessary to provide a Chinese medicinal composition for treating sarcoidosis.

Disclosure of Invention

The application aims to provide the traditional Chinese medicine composition which is very effective in treating the sarcoidosis, adopts natural Chinese herbal medicines as raw materials, is easy to obtain, low in cost, easy to accept by the public, reasonable in medicine compatibility, non-toxic, free of side effects and remarkable in treatment effect.

Another objective of the present application is to provide a method for preparing a Chinese medicinal composition, wherein the decoction is prepared by decoction and concentration, and the effective components can be effectively extracted to better exert the drug effect; the prepared pills are not required to be decocted, are convenient to carry and are suitable for patients without decoction conditions.

Another objective of the present application is to provide an application of a traditional Chinese medicine composition in preparing a drug for treating sarcoidosis. The composition is prepared into the medicine, and has good treatment effect and quick response.

The technical problem to be solved by the application is solved by adopting the following technical scheme.

In a first aspect, an embodiment of the present application provides a traditional Chinese medicine composition, which includes the following raw materials in parts by weight: 20-30 parts of flaccid semiaquilegia herb, 20-30 parts of ternate buttercup root, 2-6 parts of black tiger, 2-6 parts of wine-processed rhubarb, 2-6 parts of cocklebur fruit, 2-6 parts of notopterygium root, 2-5 parts of peach kernel, 2-5 parts of safflower, 2-5 parts of cinnamon, 2-5 parts of cornu cervi degelatinatum, 2-5 parts of rehmannia root, 2-8 parts of aster tataricus, 2-8 parts of thunberg fritillary bulb and 5-15 parts of sun euphorbia herb.

In a second aspect, the present application provides a method for preparing a traditional Chinese medicine composition, comprising the following steps: weighing the above raw materials, firstly adding water which is not used for the medicinal materials into herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae, radix Polygoni Ciliinerve, radix Asteris, Bulbus Fritillariae Thunbergii and herba Euphorbiae Helioscopiae, decocting with strong fire until boiling, decocting with slow fire, keeping slightly boiling for 40-45min, adding wine-processed radix et rhizoma Rhei, decocting for 6-8min, filtering, and concentrating to obtain a liquid medicine.

In a third aspect, an embodiment of the present application provides a method for preparing a traditional Chinese medicine composition, which includes the following steps: weighing herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, radix et rhizoma Rhei, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae, rhizoma Dioscoreae Bulbiferae, radix Asteris, Bulbus Fritillariae Thunbergii and herba Euphorbiae Helioscopiae, pulverizing into powder, adding water of the above materials, decocting with strong fire, decocting to boil, decocting with slow fire for 40-50min, filtering, concentrating to obtain concentrated medicinal liquid, adding water and binder, and making into pill.

In a fourth aspect, the present application provides an application of a Chinese medicinal composition in preparing a medicament for treating sarcoidosis.

Compared with the prior art, the embodiment of the application has at least the following advantages or beneficial effects:

firstly, the application aims to provide a traditional Chinese medicine composition which is very effective in treating sarcoidosis, adopts natural Chinese herbal medicines as raw materials, is easy to obtain, has low cost and is easily accepted by the public. Monarch drug: herba Pteridis Semipinnatae and radix Ranunculi Ternati have effects of removing toxic substance, eliminating phlegm and resolving masses; ministerial drugs: leech, garden balsam seed, spina gleditsiae and airpotato yam rhizome strengthen the effects of detoxifying and reducing swelling of monarch drug, reducing phlegm and resolving masses; adjuvant drugs: the black tiger, the wine-processed rhubarb, the cocklebur fruit and the notopterygium root play roles of assisting monarch drugs and ministerial drugs to strengthen the treatment; a messenger drug: peach kernel, safflower, cinnamon, deglued antler powder and rehmannia root can guide all the medicines in the prescription to reach the disease institute, and the monarch, minister, assistant and guide medicines have reasonable compatibility, no toxicity, no side effect and obvious treatment effect.

Secondly, the application aims to provide a preparation method of the traditional Chinese medicine composition, the liquid medicine is prepared by decocting and concentrating, the effective ingredients can be effectively extracted, and the drug effect can be better exerted; the prepared pills are not required to be decocted, are convenient to carry and are suitable for patients without decoction conditions.

Third, the present application aims to provide an application of a traditional Chinese medicine composition in the preparation of drugs for treating sarcoidosis. The composition is prepared into the medicine, not only has good treatment effect, but also has quick response.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions of the embodiments of the present application will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.

It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to specific examples.

Firstly, the embodiment of the application provides a traditional Chinese medicine composition, which comprises the following raw materials in parts by weight: 20-30 parts of flaccid semiaquilegia herb, 20-30 parts of ternate buttercup root, 2-6 parts of black tiger, 2-6 parts of wine-processed rhubarb, 2-6 parts of cocklebur fruit, 2-6 parts of notopterygium root, 2-5 parts of peach kernel, 2-5 parts of safflower, 2-5 parts of cinnamon, 2-5 parts of cornu cervi degelatinatum, 2-5 parts of rehmannia root, 2-8 parts of aster tataricus, 2-8 parts of thunberg fritillary bulb and 5-15 parts of sun euphorbia herb.

In some embodiments of the present application, the composition further comprises the following raw materials in parts by weight: 3-8 parts of leech, 3-8 parts of garden balsam seed, 3-8 parts of spina gleditsiae and 3-8 parts of airpotato yam rhizome.

In some embodiments of the present application, the composition comprises the following raw materials in parts by weight: 20 parts of herba laggerae, 20 parts of radix ranunculi ternati, 2 parts of kadsura coccinea, 2 parts of wine rhubarb, 2 parts of cocklebur fruit, 2 parts of notopterygium root, 2 parts of peach kernel, 2 parts of safflower, 2 parts of cinnamon, 2 parts of cornu cervi degelatinatum, 2 parts of rehmannia root, 3 parts of leech, 3 parts of garden balsam seed, 3 parts of spina gleditsiae, 3 parts of airpotato yam rhizome, 2 parts of aster tataricus, 2 parts of thunberg fritillary bulb and 5 parts of sun euphorbia herb.

In some embodiments of the present application, the composition comprises the following raw materials in parts by weight: 30 parts of herba Pteridis Semipinnatae, 30 parts of radix Ranunculi Ternati, 6 parts of black tiger, 6 parts of wine rhubarb, 6 parts of cocklebur fruit, 6 parts of notopterygium root, 5 parts of peach kernel, 5 parts of safflower, 5 parts of cinnamon, 5 parts of cornu cervi degelatinatum, 5 parts of rehmannia root, 8 parts of leech, 8 parts of garden balsam seed, 8 parts of spina Gleditsiae, 8 parts of airpotato yam, 8 parts of radix Asteris, 8 parts of thunberg fritillary bulb and 15 parts of sun euphorbia herb.

Half flag, name of Chinese medicinal material. The product is whole grass with root of Pteris semipinnata of Pteridaceae. Collected all the year round, washed and dried in the sun. The main functional indications are as follows: stop bleeding, promote granulation, remove toxicity and relieve swelling. It is indicated for hematemesis, traumatic hemorrhage, back-related disease, furuncle, traumatic injury, conjunctival congestion, and swelling and pain. (Ringnan treatise on drug collection): for poisonous snake bites, the leaves can be pounded and tabletted: for sores and furuncles, it is decocted and washed. ② the Zhi Nanning City drugs: stop bleeding, promote granulation, relieve swelling and alleviate pain. It is indicated for traumatic injury, dysentery, back injury, and snake injury. ③ Zhejiang Tianmu Yam Zhi (Yam plant records in Zhejiang Tianmu): decoct the rhizome and root for swelling and pain of eyes.

Ranunculus ternatus (L.) Ching is an annual herb of Ranunculaceae. Most of the fasciculate plants have small fleshy root tubers, hard top ends, the shape of cat claws, scattered stems, the height of the fasciculate plants can reach 20 cm, and the fasciculate plants have more branches, are softer and mostly have no hair. The basal leaves have long stems; the leaf shape is changeable, the shape is from wide oval to round kidney, the cauline leaves have no stem, the leaves are smaller, the splinters are linear, the stem tops and branch tops of the flower buds grow, and the hair is dredged and softened outside the sepals; the petals become yellow or white after the petals become yellow, and the flower receptacle has no hair. The polymerized fruit is nearly spherical, the lean fruit is egg-spherical, the flowering phase is early, the flowering is carried out in 3 months in spring, and the fruits are grown in 4 to 7 months. Sweet, pungent, warm and neutral; it enters liver and lung meridians; has the effects of removing toxic substances, eliminating phlegm and resolving masses. Can be used for treating scrofula, tuberculosis, pharyngitis, furuncle, snake bite, malaria, migraine, and toothache.

Kadsura coccinea is a plant of Schisandra of Magnoliaceae. Vine, whole plant without hair. The leafy leather is in a shape of a long circle to an oval and is coated with a needle, the length of the leafy leather is 7-18 cm, and the width of the leafy leather is 3-8 cm. The flower grows in the axilla of the leaf, is sparse in pairs and is isogenic; male flowers: the floral quilt is red, and 10-16 pieces. The polymerized fruit is nearly spherical, red or dark purple. A seed heart shape or an egg-shaped heart shape. The flowering period is 4-7 months, and the fruit period is 7-11 months. The whole plant of the root to the leaf can be used as a medicine, and has the functions of clearing heat and detoxicating, dispelling wind and activating collaterals, regulating qi and relieving pain, clearing liver and improving vision, tonifying kidney and securing essence, enriching blood and beautifying, and the like. It can be used for treating chronic gastritis, ulcer, gastroenteritis, arthritis, traumatic injury, dysmenorrhea, and puerperal blood stasis.

The rhubarb processed by wine belongs to one of rhubarb processed products, and has different clinical effects because of different processing specifications, including raw rhubarb, cooked rhubarb, rhubarb processed by wine, rhubarb processed by vinegar and rhubarb charcoal. Has effects in purging heat and relaxing bowels, and can be used for treating gastrointestinal sthenia heat stagnation, constipation, abdominal distention, pain, tenderness, high fever, coma and delirium, such as DACHENGQI decoction; or constipation due to cold accumulation due to insufficiency of spleen yang, such as Wen Pi Tang. It has effects in removing toxic substance and resolving carbuncle, and can be used for treating pyocutaneous disease due to heat-toxin, acute conjunctivitis, ophthalmalgia, and gingival swelling and pain, such as DAHUANGDANDAN decoction. Has effects of removing blood stasis and dredging channels, and can be used for treating amenorrhea due to blood stasis, puerperal blood stasis, abdominal mass accumulation, traumatic injury, and swelling and pain due to blood stasis. Clearing heat and eliminating dampness, and can be used for treating jaundice, dysuria, and constipation due to damp-heat stagnation; heat-stranguria and urolithic stranguria are treated as the Ba Zheng san. It also has the actions of cooling blood and stopping bleeding, and is indicated for hematemesis, epistaxis, hematochezia, metrorrhagia and metrostaxis, and leucorrhea with red and white discharge due to heat damaging blood collaterals. The modern clinic can be used for treating epidemic meningitis, lobar pneumonia, acute biliary tract infection, acute parotitis, acute appendicitis, acute infectious icterohepatitis, acute enteritis, bacillary dysentery, digestive tract hemorrhage, pharyngolaryngitis, gingival abscess, dermatitis, eczema, gonorrhea, herpes zoster, etc.

Siberian cocklebur fruit, name of traditional Chinese medicine. Alias: fructus xanthil, folium praecocis, fructus rubi, fructus xanthil, fructus litsea cubeba, rhizoma zingiberis, semen echinocaulis, fructus robi, herba polygoni cuspidati, fructus xanthil, solanum indicum, pig ear, common rue fungus, fructus xanthil, guangdong and also called Japanese mangifera (Japanese manger) in Kangdong. Fruit with involucre of Xanthium strumarium belonging to Compositae and annual herb Compositae, and Xanthium strumarium belonging to common Chinese herbal medicine, and has effects of dispelling pathogenic wind, removing dampness and dredging orifice. Bitter, sweet and pungent in flavor and warm in nature. It enters lung and liver meridians. Has the effects of dispersing wind-cold, relieving stuffy nose, dispelling wind-damp and relieving pain. It can be used for treating wind-cold type common cold, nasosinusitis, rheumatalgia, rubella, pruritus, etc.

Notopterygium root, rhizoma Et radix Notopterygii, the name of Chinese medicine. Rhizoma Et radix Notopterygii, rhizoma Seu radix Phrymatis, rhizoma Seu radix Notopterygii, radix Seu herba Lespedezae Buergeri, radix Polygoni Ciliinerve, Umbelliferae, and rhizoma Et radix Notopterygii, and is prepared from perennial herbs with height of 60-120 cm, thick and strong root and long bamboo joint. The neck of the root has withered leaf sheath. The stem is upright, cylindrical, hollow, has straight and thin stripes and is purple. It has warm nature, and has effects of relieving exterior syndrome, dispelling cold and dampness, and can be used for treating wind cold, headache, anidrosis, arthralgia due to cold-dampness, and upper limb rheumatalgia. Growing in forest edge and bush with elevation of 2000 and 4000 meters; shaanxi, Sichuan, Gansu, Qinghai and Tibet in China. The part of the medicine is: dried root of Notopterygium incisum of Umbelliferae family. Pungent and bitter taste, warm nature; enter bladder and kidney meridians. Has the effects of relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, eliminating dampness, and relieving pain. It can be used for treating wind-cold type common cold, arthralgia due to wind-cold-dampness, neck stiffness, spasm of muscles, soreness of bone joints, edema due to wind-damp, superficial infection, and skin sore.

Peach kernel, name of traditional Chinese medicine. Is dried mature seed of Prunus persica or Prunus davidiana of Rosaceae. Harvesting after the fruits are ripe, removing pulp and nucleocapsid, taking out seeds, and drying in the sun. Is generally cultivated all over the country. Has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, acute appendicitis, traumatic injury, constipation due to intestinal dryness, cough, and asthma. The part of the medicine is: dried mature seeds of the plant. Bitter, sweet and mild in nature. It enters heart, liver and large intestine meridians. Has the effects of promoting blood circulation, removing blood stasis, moistening the intestines, relaxing bowels, relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, constipation due to intestinal dryness, cough, and asthma.

Cinnamon, name of traditional Chinese medicine. Is dried bark of Cinnamomum cassia Presl of Lauraceae. In autumn, the seeds are peeled off and dried in the shade. Removing impurities and coarse skin. It is administered by mashing. The part for medicine application: dried bark of the plant. Pungent and sweet in flavor and strongly hot in nature. It enters kidney, spleen, heart and liver meridians. Has the effects of supplementing fire and supporting yang, guiding fire to the origin, dispelling cold and relieving pain, and warming and dredging channels and collaterals. Can be used for treating sexual impotence, cold womb, lumbago, knee psychroalgia, asthma due to kidney deficiency, floating of deficient yang, giddiness, conjunctival congestion, cold pain of heart and abdomen, vomiting and diarrhea due to deficiency cold, cold hernia, abdominal pain, dysmenorrhea, and amenorrhea.

Cornu cervi degelatinatum, named as traditional Chinese medicine. Is the bone residue obtained by decocting colla Cornus Cervi in cornu Cervi of Cervidae such as Cervus Nippon Temminck or Cervus Elaphus L. Distributed in Jilin, Liaoning, Heilongjiang, Shandong, Beijing, etc. Has the effects of warming kidney, tonifying yang, astringing and stopping bleeding. It is indicated for spleen-kidney yang deficiency, leukorrhagia, enuresis, frequent urination, metrorrhagia, metrostaxis, bleeding, unhealing sores and ulcers. The part of the medicine is: the bone residue left after decocting the antler glue with the antler. Salty and astringent taste, warm in nature. It enters liver and kidney meridians.

Rehmannia is a perennial herb of the rehmannia genus of the Scrophulariaceae family, the height of which can reach 30 cm, the rhizome of which is fleshy, is fresh yellow, and the stem is purple red under cultivation conditions. The diameter can reach 5.5 cm, the leaves are oval to oblong, the veins are sunken on the upper surface, flowers are slightly arranged into a general inflorescence at the top of the stem, the corolla is purplish red, the interior is yellowish purple, the medicine chamber is rectangular and circular, the capsule is oval to oblong, and the flowering period is 4-7 months. The root of underground root tuber is yellow-white, so the root of the root tuber is one of the traditional Chinese medicines, and the earliest classics is recorded in Shen nong Ben Cao Jing. The method comprises the following steps: fresh rehmannia root, dry rehmannia root and prepared rehmannia root have great difference in property and efficacy, and are classified according to the efficacy of the Chinese materia medica: fresh rehmannia root is a heat-clearing and blood-cooling medicine; shu Di Huang is tonifying drug. Rehmannia is cool in nature and sweet and bitter in taste, and has the effects of nourishing yin, tonifying kidney, nourishing blood, enriching blood and cooling blood. It is very beneficial to eat for yin deficiency, blood deficiency and kidney deficiency. In addition, rehmanniae radix has effects of tonifying heart, promoting diuresis, relieving fever, relieving inflammation, promoting blood coagulation and reducing blood sugar.

Leech, name of traditional Chinese medicine. Is dried whole of leech, leech or leech of Hirudinidae. Catching in summer and autumn, scalding with boiling water, and sun drying or drying at low temperature. The distribution range is wide, and the method is available in most areas of China. The part for medicine application: dried whole animal. Property and taste: salty, bitter and neutral. It enters liver meridian. Has effects of removing blood stasis, dredging channels, removing blood stasis, and eliminating abdominal mass. Can be used for treating amenorrhea due to blood stasis, abdominal mass, apoplexy, hemiplegia, traumatic injury.

Garden balsam seed, name of traditional Chinese medicine. Is dried mature seed of impatiens balsamina L of Balsaminaceae. Harvesting fruits in summer and autumn when they are about to mature, drying in the sun, and removing pericarp and impurities. All over the country. The part for medicine application: dried mature seeds of the plant. Nature and taste: slightly bitter and pungent taste, warm nature. It enters lung and liver meridians. Has effects of removing blood stasis, softening hard masses, and resolving food stagnation. Can be used for treating abdominal mass, amenorrhea, and dysphagia.

Spina Gleditsiae, named as Chinese medicine. Is dried spina Gleditsiae of Leguminosae. Is distributed in Hebei, Shandong, Henan, Shanxi, Shaanxi, Gansu, Jiangsu, Anhui, Zhejiang, Jiangxi, Hunan, Hubei, Fujian, Guangdong, Guangxi, Sichuan, Guizhou, Yunnan, etc. The part for medicine application: drying the thorn. Pungent flavor and warm nature. It enters liver and stomach meridians. Has the functions of eliminating swelling, expelling toxin, discharging pus and killing pests. It is commonly indicated for early stage of abscess or abscess without ulceration; it is indicated for external treatment of scabies and leprosy.

Huang Yao Zi, name of Chinese medicine. Is dried tuber of Dioscorea bulbifera of Dioscorea of Dioscoreaceae. Is distributed in Henan, Anhui, Jiangsu, Zhejiang, Jiangxi, Fujian, Taiwan, Hubei, Hunan, Guangdong, Guangxi, Shaanxi, Gansu, Sichuan, Guizhou, Yunnan, Tibet and other places. The part of the medicine is: drying the tubers; bitter and pungent taste and cool in nature; it enters liver, stomach, heart and lung meridians. Has the effects of removing toxic substances, relieving swelling, eliminating phlegm, resolving masses, cooling blood and stopping bleeding. It is commonly used for goiter, tuberculous lymphadenitis, sore throat, hematemesis, hemoptysis, pertussis, and cancer; it is used externally to treat sore and furuncle.

Aster, alternative name: radix asteris, purple wonder, braid and the like; aster genus of Compositae family, perennial herb, with obliquely rising rhizome. Property and taste: bitter and warm; the functional indications are as follows: warm lung, descend qi, resolve phlegm and relieve cough. It is used to treat cough and asthma due to wind-cold evil, cough with pus and blood, throat impediment, and dysuria. The pharmacological action is as follows: according to the traditional Chinese medicine, the aster has the functions of warming lung, descending qi, dissolving phlegm and stopping cough. Experiments show that the water decoction has the effect of eliminating phlegm without the effects of relieving cough and asthma; the benzene and methanol extracts also have expectorant effect. Aster has certain inhibition effect on 7 gram-negative intestinal pathogenic bacteria such as escherichia coli, dysentery bacillus, proteus, typhoid bacillus, paratyphoid bacillus, pseudomonas aeruginosa, vibrio cholerae and the like in vitro; and has an effect against pathogenic fungi.

Zhejiang fritillaria bulb, the name of the traditional Chinese medicine. Is dried bulb of Bulbus Fritillariae Thunbergii of Liliaceae. Collected and cleaned when the plants wither in early summer. The sizes are separated, and the core buds are removed in the big case, which is called as the large shell; the small one will not remove the core bud and is called as "pearl shell". Respectively rubbing, removing outer skin, mixing with calcined shell powder, sucking to remove the juice, and drying; or separating bulb into different sizes, cleaning, removing core bud, cutting into thick slices, cleaning, and drying. Bitter taste and cold nature. It enters lung and heart meridians. Has effects of clearing heat, eliminating phlegm, relieving cough, removing toxic substance, resolving hard mass and resolving carbuncle. Can be used for treating cough due to wind-heat evil, phlegm-fire cough, pulmonary abscess, acute mastitis, scrofula, and sore.

Sun euphorbia herb, name of traditional Chinese medicine. Is the aerial part of Euphorbia helioscopia of Euphorbiaceae family. The whole herbs are used as the medicine. Collect the whole herb in spring and summer, dry in the sun and use as medicine. Pungent and bitter in flavor and slightly cold in nature. It enters lung, small intestine and large intestine meridians. Has the functions of inducing diuresis to alleviate edema, eliminating phlegm and stopping cough, detoxicating and killing parasite. The main treatment is as follows: it can be used for treating edema of water and qi, phlegm retention, cough, asthma, malaria, bacillary dysentery, scrofula, tuberculous fistula, and osteomyelitis.

In some embodiments of the present application, the Chinese medicinal composition can be prepared into pills, capsules, tablets, powders, granules or oral liquids.

Second, the embodiment of the present application provides a method for preparing a traditional Chinese medicine composition, which comprises the following steps:

step A: weighing the above raw materials, firstly adding water of herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae, radix Polygoni Ciliinerve, radix Asteris, Bulbus Fritillariae Thunbergii and herba Euphorbiae Helioscopiae, decocting with strong fire until boiling, decocting with slow fire, keeping slightly boiling for 40-45min, adding wine-processed radix et rhizoma Rhei, decocting for 6-8min, filtering, and concentrating to obtain medicinal liquid.

And B: the liquid medicine is concentrated into 300-450ml of concentrated liquid medicine.

During the decoction process, the wine rhubarb is added finally, and has the effects of purgation, disease elimination and nodule removal, long-time decoction is not suitable, and the efficacy of the wine rhubarb is reduced after long-time decoction.

Third, the embodiment of the present application provides a method for preparing a traditional Chinese medicine composition, which comprises the following steps: weighing herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, radix et rhizoma Rhei, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae, radix Polygoni Ciliinerve, radix Asteris, Bulbus Fritillariae Thunbergii and herba Euphorbiae Helioscopiae, pulverizing into powder, adding water above materials, decocting with strong fire to boil, decocting with slow fire, maintaining slightly boiling for 40-50min, filtering, concentrating to obtain concentrated medicinal liquid, adding water and binder, and making into pill.

In some embodiments of the present disclosure, the powder has a particle size of 100 to 150 mesh. The powder is ground into smaller particle size, and is more convenient to dissolve in the body after being taken, thereby being better absorbed by the human body.

In some embodiments of the present application, the binder is one or more of honey, rice paste, batter, syrup.

Honey: the honey used should accord with the regulation of Chinese pharmacopoeia, and the honey as the adhesive has unique characteristics and certain pharmacological action, and is one of the important compositions of honeyed pills. When used as a binder, the binder is generally refined, and the refining degree depends on the viscosity of the pelleting material and is generally divided into three types: tender honey: is prepared by heating honey to 105-115 deg.C, has water content of 18-20% and relative density of 1.34, and can be used for preparing pill with high viscosity. ② Chinese honey: is a product which is heated to 116-118 ℃ and generates billow uniform light yellow fine bubbles, has the water content of 14-16 percent and the relative density of about 1.37, and is used for preparing pills with moderate viscosity. ③ old honey: is prepared by heating honey to 119-122 deg.C to generate large reddish brown bubbles, has water content below 10% and relative density of 14, and can be used for making pill with poor viscosity.

Rice paste and batter: is prepared from fine powders of semen Panici Miliacei, Oryza Glutinosa, semen Tritici Aestivi and Massa Medicata Fermentata by mixing, decocting and making into paste, wherein the dosage of the paste is about 40% of the fine powder of the raw materials. The prepared pills are generally hard and slow in disintegration in the stomach, and are commonly used for preparing pills containing toxic and violent medicines and irritant medicines.

Syrup: the common sucrose syrup or liquid glucose has both viscosity and reducing effect, and is suitable for making pills of medicines with weak viscosity and easy oxidation.

Fourth, the present application provides an application of a Chinese medicinal composition in preparing a medicament for treating sarcoidosis.

The features and properties of the present application are described in further detail below with reference to examples.

Example 1

The present embodiment aims to provide a traditional Chinese medicine composition, which comprises the following raw materials: 20g of semiaquilegia root, 20g of radix ranunculi ternati, 2g of black tiger, 2g of wine-processed rhubarb, 2g of cocklebur fruit, 2g of notopterygium root, 2g of peach kernel, 2g of safflower, 2g of cinnamon, 2g of cornu cervi degelatinatum, 2g of rehmannia root, 3g of leech, 3g of garden balsam seed, 3g of spina gleditsiae, 3g of airpotato yam rhizome, 2g of aster, 2g of thunberg fritillary bulb and 5g of sun euphorbia herb.

The preparation method of the composition comprises the following steps:

step A: weighing the above raw materials, adding water of herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae and radix Polygoni Ciliinerve, decocting with strong fire until boiling, decocting with slow fire for 45min, adding radix et rhizoma Rhei preparata, decocting for 8min, filtering, and concentrating to obtain medicinal liquid.

Example 2

The present embodiment aims at providing a traditional Chinese medicine composition, which comprises the following raw materials: 30g of herba Pteridis Semipinnatae, 30g of radix Ranunculi Ternati, 6g of black tiger, 6g of wine-processed rhubarb, 6g of cocklebur fruit, 6g of notopterygium root, 5g of peach kernel, 5g of safflower, 5g of cinnamon, 5g of cornu cervi degelatinatum, 5g of rehmannia root, 8g of leech, 8g of garden balsam seed, 8g of spina Gleditsiae, 8g of airpotato yam, 8g of radix Asteris, 8g of thunberg fritillary bulb and 15g of sun euphorbia herb.

The preparation method of the composition comprises the following steps:

step A: weighing the above raw materials, adding water of herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae and radix Polygoni Ciliinerve, decocting with strong fire until boiling, decocting with slow fire for 40min, adding radix et rhizoma Rhei preparata, decocting for 6min, filtering, and concentrating to obtain medicinal liquid.

Example 3

The present embodiment aims to provide a traditional Chinese medicine composition, which comprises the following raw materials: 25g of herba Pteridis Semipinnatae, 25g of radix Ranunculi Ternati, 4g of black tiger, 4g of wine-processed rhubarb, 4g of cocklebur fruit, 4g of notopterygium root, 3g of peach kernel, 3g of safflower, 3g of cinnamon, 3g of cornu cervi degelatinatum, 3g of rehmannia root, 6g of leech, 6g of garden balsam seed, 6g of spina Gleditsiae, 6g of airpotato yam, 5g of radix Asteris, 5g of thunberg fritillary bulb and 10g of sun euphorbia herb.

The preparation method of the composition comprises the following steps:

step A: weighing the above raw materials, firstly adding water which is over the raw materials into herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae and radix Polygoni Ciliinerve, decocting with strong fire until boiling, then decocting with slow fire, keeping slightly boiling for 43min, adding wine-processed radix et rhizoma Rhei, decocting for 7min, filtering, and concentrating to obtain the liquid medicine.

Example 4

The present embodiment aims to provide a traditional Chinese medicine composition, which comprises the following raw materials: 20g of herba Pteridis Semipinnatae, 20g of radix Ranunculi Ternati, 2g of Kadsura coccinea, 2g of wine-processed rhubarb, 2g of fructus Xanthii, 2g of notopterygium root, 2g of peach kernel, 2g of safflower, 2g of cinnamon, 2g of cornu cervi degelatinatum, 2g of rehmannia glutinosa, 3g of leech, 3g of garden balsam seed, 3g of spina Gleditsiae, 3g of airpotato yam rhizome, 2g of radix Asteris, 2g of thunberg fritillary bulb and 5g of sun euphorbia herb.

The preparation method of the composition comprises the following steps:

weighing the above materials according to a certain amount, pulverizing the medicines into powder with particle size of 120 meshes, adding water which has not been decocted, decocting with strong fire until boiling, decocting with slow fire again, keeping slightly boiling for 40min, filtering, concentrating to obtain concentrated liquid medicine, adding 12g of honey, and making into pill with diameter of 1.0 mm.

Example 5

The preparation method of the composition comprises the following steps:

weighing the above raw materials according to a certain amount, pulverizing the medicines into powder with particle size of 100 meshes, adding water which has not been decocted, decocting with strong fire until boiling, decocting with slow fire, keeping slightly boiling for 45min, filtering, concentrating to obtain concentrated liquid medicine, adding 10g syrup, and making into pill with diameter of 1.0 mm.

Example 6

The present embodiment aims at providing a traditional Chinese medicine composition, which comprises the following raw materials: 25g of herba Pteridis Semipinnatae, 25g of radix Ranunculi Ternati, 4g of black tiger, 4g of wine-processed rhubarb, 4g of cocklebur fruit, 4g of notopterygium root, 3g of peach kernel, 3g of safflower, 3g of cinnamon, 3g of cornu cervi degelatinatum, 3g of rehmannia root, 6g of leech, 6g of garden balsam seed, 6g of spina Gleditsiae, 6g of airpotato yam, 5g of radix Asteris, 5g of thunberg fritillary bulb and 10g of sun euphorbia herb.

The preparation method of the composition comprises the following steps:

weighing the above materials according to a certain amount, pulverizing the medicines into powder with particle size of 150 meshes, adding water which has not been decocted, decocting with strong fire until boiling, decocting with slow fire, keeping slightly boiling for 50min, filtering, concentrating to obtain concentrated liquid medicine, adding 12g of rice paste, and making into pill with diameter of 1.0 mm.

Examples of effects

180 patients with nodules were enrolled, aged 25-60 years, with an average age of 35 years. The shortest disease course is 1 month, and the longest disease course is 6.5 years. Specifically, the patients were divided into 6 groups according to symptoms, which were examples 1 to 6 groups, with 30 patients each;

the treatment method comprises the following steps: oral administration: the decoction after soaking, decocting and concentrating is taken for 3 times by one dose per day; the decoction is inconvenient, pills are taken, 15g is taken each time, and the medicine is taken 3 times a day. The therapeutic effect is shown in table 1:

TABLE 1 therapeutic Effect

The traditional Chinese medicine composition has the advantages of definite curative effect on the sarcoidosis, low price and effectiveness, capability of saving limited sanitary resources, honest social and family economic burdens and worthy of clinical popularization and application.

Typical case 1:

tan Shi in China, male, 36 years old, through medical image observation: the anterior basal segment of the inferior lobe of the right lung has a semi-solid nodule shadow with a diameter of about 7mm, the posterior segment of the superior lobe tip of the left lung has a ground glass nodule focus with a diameter of about 5mm, and no obvious abnormal density focus is seen in the rest lung. The trachea, the main bronchi on both sides and the visible segmental bronchi are normal in shape and position. No apparent abnormal density image was seen within the mediastinum. Bilateral symmetry of the thorax, no abnormality of the chest wall. The diagnosis is as follows: the semi-solid nodules of the right inferior lobe of the right lung, and the small ground vitreous nodules of the posterior segment of the tip of the upper lobe of the left lung, were reviewed after the proposed anti-inflammatory treatment. After taking the decoction of example 3 for 14 days, both nodules disappeared at the time of the review.

Typical case 2:

zhao, women, 28 years old. The main complaints are: thyroid nodules were found by physical examination for 10 days. The current medical history: thyroid nodules were detected in the patient on 10 day precursor examination. Patients feel vexation and irritability, distending pain of head, dry mouth and bitter taste, phlegm in pharynx, dysphagia, fatigue and weakness, poor appetite, loose stool and clear and abundant urine. The tongue is pale red with teeth marks and ecchymosis on the edge, a grey and greasy coating, and a deep, wiry and thready pulse. Thyroid ultrasound in local hospitals showed: the hypothyroid nodule in the left lobe is about 2.0cm × 2.5cm in size, has clear boundary and is clearly separated from surrounding tissues, and the echo is not uniform substantially. CDFI: no significant blood flow signal was seen within the nodule. And (4) checking and prompting: the thyroid nodule of the left lobe TI-RADS 3 class. Thyroid function and other laboratory tests were not abnormal. The medicine in the example 2 is taken according to the using method, the medicine is continuously taken for 14 days, one dose is taken every day, and the medicine is decocted for warm taking twice. After 14 days, the patients have a double-diagnosis, the mood of the patients is more smooth, and the discomfort symptoms are obviously relieved. The prescription is continuously taken, and after 3 months, the color ultrasonic examination is carried out: the thyroid gland is not abnormal. No recurrence was observed in half a year of follow-up.

Typical case 3:

in patients of Hu-ji, women, age 52, 2 patients had intermittent cough, no phlegm and no severe cough, and after the pulmonary nodules were detected by physical examination, the patients were easy to be anxious, had poor sleep and had a sense of weakness. CT of chest shows: left inferior lobe nodule, about 7mm, edge blur. The four diagnostic methods are combined, and the syndrome differentiation is that the lung and spleen are qi deficiency and phlegm stasis is internally accumulated, so that the treatment is suitable for tonifying qi and spleen, and activating blood and dissolving stasis; meanwhile, the mind is smooth. The medicine of the embodiment 4 is taken according to the using method, and after the medicine is taken by a patient for 1 week, the patient can take more sleep, improve the fatigue and relieve the anxiety. After taking the medicine for 2 months, the high-resolution CT of the chest shows that the nodules of the lower lobes of the left lung disappear.

Typical case 4:

du Yi, male, age 39, the two lungs have clear texture, the posterior segment and middle lobe of the right upper lung have tiny nodular high-density foci, less uniform density, clear boundary, diameter of about 0.4cm, no obvious abnormal density foci in the remaining lung, and unobstructed trachea and bronchus. The structure of the bilateral lung portal is clear, and no abnormal density shadow and swollen lymph nodes are seen in the bilateral lung portal and mediastinum. No abnormalities were observed in the cardiac image and the large blood vessels. There was no fluid accumulation in the thoracic cavities on both sides. No abnormality was found in the bony thorax. And (3) diagnosis: the right lung, a tiny nodule, has a high probability of inflammatory lesions. After taking the decoction of example 6 for 14 days, both nodules disappeared after the review.

In summary, the present application aims to provide a Chinese medicinal composition, which is very effective in treating sarcoidosis, and the raw materials are all natural Chinese herbal medicines, so that the Chinese medicinal composition is easy to obtain, low in cost and easy to accept by the public. Monarch drug: herba Pteridis Semipinnatae and radix Ranunculi Ternati have effects of removing toxic substance, eliminating phlegm and resolving masses; ministerial drugs: leech, garden balsam seed, spina gleditsiae and airpotato yam rhizome strengthen the effects of detoxifying and reducing swelling of monarch drug, reducing phlegm and resolving masses; adjuvant drugs: the black tiger, the wine-processed rhubarb, the cocklebur fruit and the notopterygium root play roles of assisting monarch drugs and ministerial drugs to strengthen the treatment; a messenger drug: peach kernel, safflower, cinnamon, deglued antler powder and rehmannia root can guide all the medicines in the prescription to reach the disease institute, and the monarch, minister, assistant and guide medicines have reasonable compatibility, no toxicity, no side effect and obvious treatment effect.

Secondly, the application aims to provide a preparation method of the traditional Chinese medicine composition, the liquid medicine is prepared by decoction and concentration, the effective components can be effectively extracted, and the drug effect can be better exerted; the prepared pill is not required to be decocted, is convenient to carry and is suitable for patients without decoction conditions.

Third, the present application is directed to providing an application of a Chinese medicinal composition in preparing a drug for treating sarcoidosis. The composition is prepared into the medicine, and has good treatment effect and quick response.

The embodiments described above are some, but not all embodiments of the present application. The detailed description of the embodiments of the present application is not intended to limit the scope of the claimed application, but is merely representative of selected embodiments of the application. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

Claims

1. The traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight:

20-30 parts of flaccid semiaquilegia herb, 20-30 parts of ternate buttercup root, 2-6 parts of black tiger, 2-6 parts of wine-processed rhubarb, 2-6 parts of cocklebur fruit, 2-6 parts of notopterygium root, 2-5 parts of peach kernel, 2-5 parts of safflower, 2-5 parts of cinnamon, 2-5 parts of cornu cervi degelatinatum, 2-5 parts of rehmannia root, 2-8 parts of aster tataricus, 2-8 parts of thunberg fritillary bulb and 5-15 parts of sun euphorbia herb.

2. The traditional Chinese medicine composition according to claim 1, further comprising the following raw materials in parts by weight: 3-8 parts of leech, 3-8 parts of garden balsam seed, 3-8 parts of spina gleditsiae and 3-8 parts of airpotato yam rhizome.

3. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight:

20 parts of semiaquilegia flabellata, 20 parts of radix ranunculi ternati, 2 parts of black tiger, 2 parts of rhubarb with wine, 2 parts of cocklebur fruit, 2 parts of notopterygium root, 2 parts of peach kernel, 2 parts of safflower, 2 parts of cinnamon, 2 parts of cornu cervi degelatinatum, 2 parts of rehmannia, 3 parts of leech, 3 parts of garden balsam seed, 3 parts of spina gleditsiae, 3 parts of airpotato yam rhizome, 2 parts of aster tataricus, 2 parts of thunberg fritillary bulb and 5 parts of sun euphorbia herb.

4. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight:

30 parts of herba Pteridis Semipinnatae, 30 parts of radix Ranunculi Ternati, 6 parts of black tiger, 6 parts of wine rhubarb, 6 parts of cocklebur fruit, 6 parts of notopterygium root, 5 parts of peach kernel, 5 parts of safflower, 5 parts of cinnamon, 5 parts of cornu cervi degelatinatum, 5 parts of rehmannia root, 8 parts of leech, 8 parts of garden balsam seed, 8 parts of spina Gleditsiae, 8 parts of airpotato yam, 8 parts of radix Asteris, 8 parts of thunberg fritillary bulb and 15 parts of sun euphorbia herb.

5. The composition of claim 1, wherein the composition is in the form of pill, capsule, tablet, powder, granule or oral liquid.

6. A method for preparing a Chinese medicinal composition according to any one of claims 1 to 5, comprising the steps of: weighing the above raw materials, firstly adding water of herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae, radix Polygoni Ciliinerve, radix Asteris, Bulbus Fritillariae Thunbergii and herba Euphorbiae Helioscopiae, decocting with strong fire until boiling, decocting with slow fire, keeping slightly boiling for 40-45min, adding wine-processed radix et rhizoma Rhei, decocting for 6-8min, filtering, and concentrating to obtain medicinal liquid.

7. A method for preparing the Chinese medicinal composition of any one of claims 1 to 5, comprising the steps of: weighing herba Pteridis Semipinnatae, radix Ranunculi Ternati, caulis Kadsurae Coccineae, radix et rhizoma Rhei, fructus Xanthii, Notopterygii rhizoma, semen Persicae, Carthami flos, cortex Cinnamomi, cornu Cervi Degelatinatum, rehmanniae radix, Hirudo, semen Impatientis, spina Gleditsiae, rhizoma Dioscoreae Bulbiferae, radix Asteris, Bulbus Fritillariae Thunbergii and herba Euphorbiae Helioscopiae, pulverizing into powder, adding water of the above materials, decocting with strong fire, decocting to boil, decocting with slow fire for 40-50min, filtering, concentrating to obtain concentrated medicinal liquid, adding water and binder, and making into pill.

8. The method for preparing a Chinese medicinal composition according to claim 7, wherein the powder has a particle size of 100-150 mesh.

9. The method for preparing a Chinese medicinal composition according to claim 7, wherein the binder is one or more of honey, rice paste, batter and syrup.

10. The use of the Chinese medicinal composition according to any one of claims 1 to 9 in the preparation of a medicament for treating sarcoidosis.