CN114967091A - Mycobacterium tuberculosis micro-scanner - Google Patents

Abstract

The invention relates to a mycobacterium tuberculosis microscopic scanner, which comprises a pretreatment device and an automatic scanning device, wherein the pretreatment device comprises a slide box and a slide transfer device, a plurality of slide racks are arranged in the slide box up and down, slides are arranged on the slide racks, the slide transfer device is used for pushing the slide racks into the automatic scanning device and recovering the slide racks in the automatic scanning device into the slide box, the automatic scanning device is arranged on one side of the pretreatment device and comprises a microscope module and a slide automatic positioning module, the microscope module is arranged above the slide automatic positioning module, the slide automatic positioning module is used for receiving a slide frame transmitted from the pretreatment mechanism and outputting the slide frame for completing scanning by the pretreatment mechanism, and the microscope module is used for scanning slides on the slide frame of which the positions are well adjusted by the slide automatic positioning module. The automatic slide feeding and recovering device can realize automatic slide feeding, automatic scanning and automatic recovery, and improves the scanning efficiency.

Description

Mycobacterium tuberculosis micro-scanner

Technical Field

The invention relates to the technical field of slide scanning detection, in particular to a mycobacterium tuberculosis micro-scanner.

Background

Mycobacterium tuberculosis is a pathogen of human tuberculosis, Mycobacterium tuberculosis smear microscopy is an effective means for detecting Mycobacterium tuberculosis, in Mycobacterium tuberculosis microscopy, after a sample is subjected to slide production and dyeing, workers carry out scanning detection on a scanning microscope, the automation degree of slide sample scanning is higher and higher at present, automatic equipment is arranged in slide production, dyeing and scanning links, the slide scanning efficiency is improved, and the personnel infection risk is reduced.

Disclosure of Invention

The invention aims to provide a mycobacterium tuberculosis micro-scanner to solve the problems of complex slide scanning operation and low slide scanning efficiency in the conventional mycobacterium tuberculosis detection.

In order to achieve the purpose, the invention adopts the following technical scheme:

the mycobacterium tuberculosis micro-scanner comprises a pretreatment device and an automatic scanning device, wherein the pretreatment device comprises a slide box and a slide transfer device, a plurality of slide racks are arranged in the slide box in an up-down arrangement mode, slides are arranged on the slide racks, and the slide transfer device is used for pushing the slide racks into the automatic scanning device and recovering the slide racks in the automatic scanning device into the slide box; the automatic scanning device is established pretreatment device one side, the automatic scanning device includes microscope module and slide automatic positioning module, the microscope module is established slide automatic positioning module top, slide automatic positioning module is used for receiving the follow the slide frame of pretreatment mechanism transmission with to the slide frame of scanning is accomplished in pretreatment mechanism output, the microscope module is used for the scanning warp slide on the slide frame of slide automatic positioning module adjusted the position.

Further preferably, the slide transfer device comprises an elevation mechanism for driving the slide cassette to elevate and a translation mechanism for withdrawing or retracting the slide racks in the slide cassette; the lifting mechanism comprises a first supporting plate, a lifting screw nut mechanism and a storage box placing part, the first supporting plate is arranged up and down, the lifting screw nut mechanism is arranged on the first supporting plate, the storage box placing part is connected with the lifting screw nut mechanism, and the lifting screw nut mechanism is connected with a first servo motor; the storage box placing part comprises a side plate and a bottom plate, the side plate is connected with the lifting screw nut mechanism, the bottom plate is connected with the side plate, and the bottom plate is used for placing the slide box; the translation mechanism comprises a second support plate, a translation screw and nut mechanism and a drawing part, the translation screw and nut mechanism is arranged on the second support plate, and the drawing part is connected with the translation screw and nut mechanism; the translation screw rod nut mechanism is connected with a second servo motor; the drawing part comprises a telescopic plate and a drawing plate, one end of the telescopic plate is connected with the translation screw nut mechanism, the other end of the telescopic plate is connected with the drawing plate, and the end part of the drawing plate is provided with a push-pull head used for driving the slide rack to move.

Preferably, the push-pull head is L-shaped, a push-pull claw is arranged on the push-pull head, the push-pull claw and the pull plate are arranged at an interval from top to bottom, and a claw head is arranged at the end of the push-pull claw.

Further preferably, the slide automatic positioning module comprises an X-axis positioning assembly, a Y-axis positioning assembly and a Z-axis positioning assembly; the Y-axis positioning assembly is connected to the X-axis positioning assembly, the X-axis positioning assembly is connected to the Y-axis positioning assembly, the X-axis positioning assembly is used for driving the Y-axis positioning assembly to move along an X axis, the Z-axis positioning assembly is used for driving the X-axis positioning assembly to move along a Z axis, the Y-axis positioning assembly comprises a slide support frame, and the slide frame is slidably mounted on the slide support frame; the X-axis positioning assembly comprises an X-axis bottom plate, an X-axis guide rail, an X-axis sliding block, an X-axis connecting plate and an X-axis screw nut mechanism, the X-axis guide rail is arranged on the upper side of the X-axis bottom plate, the X-axis sliding block is slidably mounted on the X-axis guide rail, the X-axis screw nut mechanism is arranged below the X-axis bottom plate, the lower end of the X-axis connecting plate is connected with the X-axis screw nut mechanism, the upper end of the X-axis connecting plate is connected with the X-axis sliding block, the Y-axis positioning assembly is connected onto the X-axis connecting plate, and the X-axis screw nut mechanism is connected with an X-axis motor; the Y-axis positioning assembly further comprises a Y-axis guide rail, a Y-axis sliding block and a Y-axis lead screw nut mechanism, the Y-axis lead screw nut mechanism is arranged on the X-axis connecting plate, the Y-axis guide rail is arranged on the X-axis connecting plate, the Y-axis sliding block is slidably mounted on the Y-axis guide rail, the lower end of the slide glass support frame is connected to the Y-axis sliding block, the upper end of the slide glass support frame is connected with the Y-axis lead screw nut mechanism, and the Y-axis lead screw nut mechanism is connected with a Y-axis motor; z axle locating component includes Z axle fixed plate, Z axle guide rail, Z axle slider, Z axle connecting plate and Z axle screw nut mechanism, Z axle screw nut mechanism with the Z axle guide rail is established on the Z axle fixed plate, Z axle slider slidable mounting be in on the Z axle guide rail, X axle bottom plate passes through Z axle connecting plate with Z axle slider connects, Z axle connecting plate with Z axle screw nut mechanism connects, Z axle screw nut mechanism is connected with Z axle motor.

Further preferably, slide support frame both sides are equipped with the confession slide frame the spout of pegging graft, slide support frame's centre is equipped with fretwork portion for the printing opacity, slide support frame's tip is equipped with the guide part, is used for to inserting slide frame leads, slide frame's tip is equipped with the slope of downward sloping, the slope forms the guide part.

It is further preferred, the microscope module includes microscope body, lens dish and camera lens conversion subassembly, the lens dish rotates to set up microscope body lower extreme, the lens dish is equipped with a plurality of camera lenses, lens dish circumference is equipped with the tooth's socket, camera lens conversion subassembly includes rotating electrical machines, rotating electrical machines fixed plate and gear, the rotating electrical machines fixed plate is connected on the microscope body, gear connection is in on the rotating electrical machines, the gear with the tooth's socket meshing, the rotating electrical machines be used for through gear drive the lens dish rotates.

Further preferably, slide automatic positioning module one side is equipped with immersion lens oil dropwise add module, immersion lens oil dropwise add module includes oil drip syringe needle, oil bottle fixed plate and peristaltic pump, the peristaltic pump is established oil bottle fixed plate upper end, peristaltic pump one end with the oil bottle passes through the tube coupling, the other end with the oil drip syringe needle passes through the tube coupling, the vertical downward setting of lower extreme of oil drip syringe needle is used for to slide dropwise add immersion lens oil on the slide frame.

The invention has the beneficial effects that:

according to the mycobacterium tuberculosis micro-scanner, each slide rack is provided with a plurality of slides, the slide box is provided with a plurality of slide racks arranged up and down, the slide racks are sequentially pushed into the slide scanning device through the slide transfer device, the slides are conveyed by the slide automatic positioning module in the slide scanning device and accurately reach the scanning visual field of the microscope module to complete the scanning of the slides, and the slide automatic positioning module sends the slides which are completely scanned back to the initial position to be matched with the slide transfer device and then recovers the slide racks into the slide box, so that the automatic scanning and automatic recovery of the slides are completed, the detection efficiency is obviously improved, and the working strength of operators is reduced.

Drawings

FIG. 1 is a schematic view of the structure of a Mycobacterium tuberculosis microscan of the present invention;

FIG. 2 is a schematic structural diagram of a pre-processing module in the Mycobacterium tuberculosis micro-scanner of the present invention;

FIG. 3 is a schematic view of the structure of FIG. 2 from another angle;

fig. 4 is a schematic view of a configuration of a cassette;

FIG. 5 is a schematic view of the construction of the lifting mechanism;

FIG. 6 is a schematic view of the translation mechanism;

FIG. 7 is a schematic view of the configuration of the slide rack;

FIG. 8 is a schematic structural diagram of an automatic scanning device;

FIG. 9 is a schematic view of the structure of FIG. 8 from another angle;

FIG. 10 is a schematic structural view of a limiting mirror module;

FIG. 11 is a schematic structural diagram of a immersion lens oil dripping module and an image acquisition module;

FIG. 12 is a schematic view of the structure of the slide auto-positioning module;

FIG. 13 is a schematic view of the structure of FIG. 12 from another angle;

FIG. 14 is a schematic view of a slide support frame.

Names corresponding to the marks in the figure:

1. a pretreatment device 11, a slide box 111, a support groove 12, a lifting mechanism 121, a first support plate 122, a lifting screw nut mechanism 123, a first servo motor 124, a side plate 125, a bottom plate 13, a translation mechanism 131, a second support plate 132, a translation screw nut mechanism 133, a second servo motor 134, a telescopic plate 135, a drawing plate 136, a drawing claw 1361, a drawing claw body 1362, a claw head 14, a first housing 15, a feed door 2, an automatic scanning device 21, a microscope module 2111, a microscope body 2112, a lens disk 2114, a rotation motor 2115, a rotation motor fixing plate 2116, a gear 22, a slide automatic positioning module 2211, a slide support frame 2212, a Y-axis guide rail, a Y-axis slide block 2214, a Y-axis screw nut mechanism 2215, a Y-axis motor 2216, a sliding groove 2217, a hollowed-out part, 2218. the device comprises a guide part, 2221, an X-axis bottom plate, 2222, an X-axis guide rail, 2223, an X-axis sliding block, 2224, an X-axis connecting plate, 2225, an X-axis lead screw nut mechanism, 2226, an X-axis motor, 2231, a Z-axis fixing plate, 2232, a Z-axis guide rail, 2233, a Z-axis sliding block, 2234, a Z-axis connecting plate, 2235, a Z-axis lead screw nut mechanism, 2236, a Z-axis motor, 23, an image acquisition module, 231, a camera mounting plate, 232, a camera, 233, a first camera fixing plate, 234, a second camera fixing plate, 235, a photographing background plate, 24, a mirror immersion oil dripping module, 241, an oil dripping needle head, 242, an oil bottle, 243, an oil bottle fixing plate, 244, a peristaltic pump, 25, a second shell, 3, a rack, 31, a clamping hole, 32, an avoiding part, 4 and a slide glass.

Detailed Description

The technical solution in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

Example 1 of the invention:

the mycobacterium tuberculosis micro-scanner in the embodiment realizes automatic scanning and recovery of the slide by matching the pretreatment device and the automatic scanning device, and improves the slide scanning efficiency.

Specifically, as shown in fig. 1, the mycobacterium tuberculosis micro-scanner includes a pre-processing device 1 and an automatic scanning device 2, the pre-processing device 1 is used for filling a slide, and sending the slide to the automatic scanning device 2 for scanning, and then recovering the scanned slide, and the automatic scanning device 2 is used for receiving the slide transferred by the pre-processing device 1, automatically scanning the slide, and then sending the slide back.

As shown in fig. 1-3, the preprocessing mechanism includes a first housing 14, a slide cassette 11, and a slide transfer device, the slide cassette 11 and the slide transfer device being disposed in the first housing 14, the slide cassette 11 being provided with a plurality of slide racks 3 arranged in an up-down arrangement, the slide racks 3 having slides 4 mounted thereon, the slide transfer device being configured to transfer the slides 4 from the slide cassette 11 to the automatic scanning device 2.

In this embodiment, as shown in fig. 4, the slide cassette 11 is a cassette structure, the inner wall of the slide cassette 11 is provided with a support groove 111, the support groove 111 is arranged vertically, the slide rack 3 is slidably mounted in the support groove 111, so that the slide rack 3 is also arranged vertically, one side of the slide cassette 11 is open and arranged for the slide rack 3 to come in and go out, the slide rack 3 is conveniently filled in the slide cassette 11, and the slide rack 3 is convenient to be extracted by the slide rack 3 transfer mechanism.

To facilitate the operation of the slide rack 3 transfer mechanism, in this embodiment, the length of the slide cassette 11 is shorter than that of the slide rack 3, and after the slide rack 3 is mounted in place, the end of the slide rack 3 protrudes out of the slide cassette 11, so that the slide rack 3 transfer mechanism facilitates the drawing operation of the slide rack 3.

As shown in fig. 5 and 6, the slide transfer device includes an elevating mechanism 12 and a translation mechanism 13, the elevating mechanism 12 includes a first support plate 121, a screw nut mechanism 122, and a cassette placing section, in this embodiment, the screw nut mechanism is referred to as an elevating screw nut mechanism 122, the first support plate 121 is vertically disposed in the first housing 14, the elevating screw nut mechanism 122 is disposed on the first support plate 121, the cassette placing section is connected to the elevating screw nut mechanism 122, and the elevating screw nut mechanism 122 can drive the cassette placing section to vertically move, thereby vertically moving the cassette 11.

In this embodiment, the first servo motor 123 is connected to the elevation screw nut mechanism 122, the first servo motor 123 is configured to drive the storage cassette accommodating portion to move up and down, the storage cassette accommodating portion includes a side plate 124 and a bottom plate 125, the side plate 124 is connected to the elevation screw nut mechanism 122, the bottom plate 125 is connected to the side plate 124, and the bottom plate 125 is configured to accommodate the slide cassette 11.

With the above arrangement, after the cassette 11 is placed on the base plate 125, the first servo motor 123 can drive the base plate 125 up and down, thereby moving the cassette 11 placed on the base plate 125 up and down.

As shown in fig. 1, a feed gate 15 is provided at a corresponding position on the first housing 14 to facilitate the placement of the cassette 11 into the housing and also to facilitate the replacement of the cassette 11.

As shown in fig. 6, translation mechanism 13 includes second backup pad 131, lead screw nut mechanism and pull-out portion, lead screw nut mechanism is marked as translation lead screw nut mechanism 132, second backup pad 131 is established in first casing 14, translation lead screw nut mechanism 132 is established in second backup pad 131, pull-out portion is connected with translation lead screw nut mechanism 132, translation lead screw nut mechanism 132 is connected with servo motor, mark as second servo motor 133, pull-out portion includes expansion plate 134 and pull-out board 135, expansion plate 134 one end is connected on translation lead screw nut mechanism 132, the other end is connected with pull-out board 135, be equipped with the pull-out claw that is used for driving slide rack 3 to remove on pull-out board 135.

As shown in fig. 7, the drawing claw 136 includes a drawing claw body 1361 and a claw head 1362, the claw head 1362 is disposed at an end of the drawing claw body 1361, the claw head 1362 extends along an edge of the drawing claw body 1361 to both sides, and an end of the slide rack 3 is disposed with a corresponding engaging hole 31, in this embodiment, the engaging hole 31 is disposed with an avoiding portion 32 for the drawing claw body 1361 to go in and out, in actual work, when the slide rack 3 moves down to a proper position, the claw head 1362 is just located in the engaging hole 31, and then the second servo motor 133 can drive the drawing claw 136 to move horizontally, so as to draw out the slide rack 3 from the slide box 11.

After the slide rack 3 is drawn out, it is sent to the automatic scanning device 2 to be scanned.

As shown in fig. 8 and 9, the automatic scanning device 2 includes a second housing 25, a microscope module 21, and a slide automatic positioning module 22, the microscope module 21 being used for scanning the slide 4, and the slide automatic positioning module 22 being used for sequentially feeding the slide 4 to the field of view of the microscope module 21 for scanning.

Slide automatic positioning mechanism includes X axle locating component, Y axle locating component and Z axle locating component, Y axle locating component connects on X axle locating component, X axle locating component connects on Y axle locating component, X axle locating component is used for driving Y axle locating component and removes along the X axle, Z axle locating component is used for driving X axle locating component and removes along the Z axle, Y axle locating component includes slide holder 2211, slide holder 3 slidable mounting is on slide holder 2211.

As shown in fig. 14, the slide holder 2211 has two sliding grooves 2216 on two sides for inserting the slide holder 3, a hollow portion 2217 is disposed in the middle of the slide holder 2211 for transmitting light, and a guiding portion 2218 is disposed at the end of the slide holder 2211 for guiding the inserted slide holder 3 to facilitate the slide holder 3 to slide in smoothly, in this embodiment, the end of the slide holder 3 has a downward slope, and the slope forms the guiding portion 2218.

In this embodiment, as shown in fig. 12 and 13, the X-axis positioning component includes an X-axis base plate 2221, an X-axis guide rail 2222, an X-axis slider 2223, an X-axis connection plate 2224, and an X-axis screw nut mechanism 2225, the X-axis guide rail 2222 is disposed on the upper side of the X-axis base plate 2221, the X-axis slider 2223 is slidably mounted on the X-axis guide rail 2222, the X-axis screw nut mechanism 2225 is disposed below the X-axis base plate 2221, the lower end of the X-axis connection plate 2224 is connected to the X-axis screw nut mechanism 2225, the upper end of the X-axis connection plate 2223 is connected to the X-axis connection plate 2224, the X-axis screw nut mechanism 2225 is connected to an X-axis motor 2226, and the X-axis connection plate 2224 can be driven to move by the X-axis motor 2226, so as to drive the Y-axis positioning component to move.

The Y-axis positioning assembly further comprises a Y-axis guide rail 2212, a Y-axis slider 2213 and a Y-axis lead screw nut mechanism 2214, the Y-axis lead screw nut mechanism 2214 is arranged on the X-axis connecting plate 2224, the Y-axis guide rail 2212 is arranged on the X-axis connecting plate 2224, the Y-axis slider 2213 is slidably arranged on the Y-axis guide rail 2212, the lower end of the slide support 2211 is connected to the Y-axis slider 2213, the upper end of the slide support 2211 is connected to the Y-axis lead screw nut mechanism 2214, the Y-axis lead screw nut mechanism 2214 is connected to a Y-axis motor 2215, and the slide support 2211 can be driven to move along the Y-axis guide rail 2212 through the Y-axis motor 2215.

The Z-axis positioning assembly comprises a Z-axis fixing plate 2231, a Z-axis guide rail 2232, a Z-axis sliding block 2233, a Z-axis connecting plate 2234 and a Z-axis screw nut mechanism 2235, wherein the Z-axis screw nut mechanism 2235 and the Z-axis guide rail 2232 are arranged on the Z-axis fixing plate 2231, the Z-axis sliding block 2233 is slidably mounted on the Z-axis guide rail 2232, an X-axis bottom plate 2221 is connected with the Z-axis sliding block 2233 through the Z-axis connecting plate 2234, the Z-axis connecting plate 2234 is connected with the Z-axis screw nut mechanism 2235, the Z-axis screw nut mechanism 2235 is connected with a Z-axis motor 2236, and the X-axis bottom plate 2221 can be driven to move along the Z-axis guide rail 2232 through the Z-axis motor 2236.

Through the arrangement, the movement of the slide frame 3 in the three-axis direction is realized, and the slide frame is matched with the image acquisition module 23, so that the accurate scanning of the biological sample on the slide can be realized, and the scanning efficiency is ensured.

In this embodiment, as shown in fig. 10, the microscope module 21 includes a microscope body 2111, a lens tray 2112 and a lens conversion assembly, the lens tray 2112 is rotatably disposed at the lower end of the microscope body 2111, the lens tray 2112 is provided with a plurality of lenses (not shown in the figure), each lens is circumferentially disposed at the lower end of the lens tray 2112, and in actual use, different lenses can be selected according to different types of biological samples, so that the use range of the device is expanded.

In this embodiment, the lens tray 2112 is circumferentially provided with a tooth space, the lens conversion assembly includes a rotating motor 2114, a rotating motor fixing plate 2115 and a gear 2116, the rotating motor fixing plate 2115 is connected to the microscope body 2111, the gear 2116 is connected to the rotating motor 2114, the gear 2116 is engaged with the tooth space, and the rotating motor 2114 is used for driving the lens tray 2112 to rotate through the gear 2116.

In this embodiment, an image acquisition module 23 is disposed at one side of the microscope module 21 for acquiring an image of a biological sample on a slide, the image collecting module 23 comprises a camera mounting plate 231, a camera fixing plate and a camera 232, the camera mounting plate 231 is arranged above the slide support 2211, the camera fixing plate is connected to the camera mounting plate 231, the camera fixing plate comprises a first camera fixing plate 233 and a second camera fixing plate 234, the first camera fixing plate 233 is connected to one end of the camera mounting plate 231, the second camera fixing plate 234 is arranged on the first camera fixing plate 233, the first camera fixing plate 233 and the second camera fixing plate 234 are arranged perpendicularly to each other, a camera mounting groove is arranged on the second camera fixing plate 234, the camera is mounted in the camera mounting groove, the camera 232 is connected with a control module, and a photographing background plate 235 is arranged below the camera 232.

In this embodiment, as shown in fig. 11, an immersion lens oil dripping module 24 is further disposed on one side of the microscope module 21, which is used for dripping immersion lens oil onto a slide, so as to ensure a scanning effect, the immersion lens oil dripping module 24 includes an oil dripping needle 241, an oil bottle 242, an oil bottle fixing plate 243 and a peristaltic pump 244, the lower end of the oil bottle fixing plate 243 is connected to the camera mounting plate 231, the oil bottle 242 is fixed to the oil bottle fixing plate 243, the peristaltic pump 244 is disposed at the upper end of the oil bottle fixing plate 243, one end of the peristaltic pump 244 is connected to the oil bottle through a pipeline, the other end of the peristaltic pump 244 is connected to the oil dripping needle 241 through a pipeline, a compressing block is disposed on the second camera fixing plate 234, the oil dripping needle 241 is fixed to the second camera fixing plate 234 through a compressing block, the lower end of the oil dripping needle 241 is disposed vertically downward, and is used for dripping immersion lens oil onto a slide on the slide rack 3.

The working principle is as follows:

a plurality of slide glass mounting positions are arranged on a slide glass rack 3, after the slide glass 4 is mounted, the slide glass rack 3 is arranged layer by layer and is arranged in a slide glass box 11, an operator opens a feeding door 15 to place the slide glass box 11 on a bottom plate, after the slide glass box 4 is placed in place, a first servo motor 123 works to enable the slide glass box 11 to move downwards, after the slide glass box 11 moves for a preset distance, a clamping hole 31 which is arranged at one end of a containing box of the slide glass rack 3 and protrudes out of the containing box of the slide glass rack 3 is just clamped and connected with a drawing claw 136 which is arranged on a drawing plate 135, then a second servo motor 133 is started to drive the drawing plate 135 to move horizontally, the drawing claw 136 draws the slide glass rack 3 out of the containing box of the slide glass rack 3 and sends the slide glass rack 3 to a slide glass support 2211, after the slide glass rack 3 is sent to the slide glass support 2211, an X-axis motor 2226 drives the slide glass support 1 to move, and a camera 232 sequentially collects images of the slides 2211 on the slide glass rack 3 in the moving process, the acquired images are uploaded to a control module, the control module judges the position of a biological sample on a slide according to image information, then an X-axis motor 2226, a Y-axis motor 2215 and a Z-axis motor 2236 are controlled to act, the slide 4 is accurately moved to the position below a lens to be scanned, and the peristaltic pump 244 extracts immersion oil in an oil bottle and drips the immersion oil onto the slide through an oil dripping needle 241 while the images are acquired. After the scanning is finished, the control module controls the X-axis motor 2226, the Y-axis motor 2215 and the Z-axis motor 2236 again to move, the slide rack 3 is sent back to the initial position, at this time, the second servo motor 133 is started again to drive the drawing plate 135 to move horizontally, the drawing claw 136 is positioned above the slide rack 3, then the Z-axis motor 2236 is started to drive the slide support 2211 to move upwards, the drawing claw is clamped with the slide rack 3, then the second servo motor 133 drives the drawing plate 135 to send the slide rack 3 back to the slide box 11, the scanning of the slide 4 on the slide rack 3 is finished, then the slide box 11 moves downwards, the scanning of the next slide rack 3 is carried out, and the above actions are repeated, so that all slide scanning work can be finished.

The automatic microscopic scanner has compact structure and high scanning efficiency, and realizes automatic scanning and recovery of slides.

Claims (7)

1. A mycobacterium tuberculosis micro-scanner is characterized in that: the automatic slide frame processing device comprises a pretreatment device and an automatic scanning device, wherein the pretreatment device comprises a slide box and a slide transfer device, a plurality of slide frames are arranged in the slide box in an up-down arrangement mode, slides are arranged on the slide frames, and the slide transfer device is used for pushing the slide frames into the automatic scanning device and recovering the slide frames in the automatic scanning device into the slide box; the automatic scanning device is arranged on one side of the pretreatment device and comprises a microscope module and a slide automatic positioning module, the microscope module is arranged above the slide automatic positioning module, the slide automatic positioning module is used for receiving the slide frame transmitted by the pretreatment mechanism and outputting the slide frame for completing scanning to the pretreatment mechanism, and the microscope module is used for scanning the slide on the slide frame with the position adjusted by the slide automatic positioning module.

2. The mycobacterium tuberculosis microscanner of claim 1, wherein: the slide transfer device comprises a lifting mechanism and a translation mechanism, wherein the lifting mechanism is used for driving the slide box to lift, and the translation mechanism is used for drawing out or drawing back a slide frame in the slide box; the lifting mechanism comprises a first supporting plate, a lifting screw nut mechanism and a storage box placing part, the first supporting plate is arranged up and down, the lifting screw nut mechanism is arranged on the first supporting plate, the storage box placing part is connected with the lifting screw nut mechanism, and the lifting screw nut mechanism is connected with a first servo motor; the storage box placing part comprises a side plate and a bottom plate, the side plate is connected with the lifting screw nut mechanism, the bottom plate is connected with the side plate, and the bottom plate is used for placing the slide box; the translation mechanism comprises a second support plate, a translation screw and nut mechanism and a drawing part, the translation screw and nut mechanism is arranged on the second support plate, and the drawing part is connected with the translation screw and nut mechanism; the translation screw rod nut mechanism is connected with a second servo motor; the drawing part comprises a telescopic plate and a drawing plate, one end of the telescopic plate is connected with the translation screw nut mechanism, the other end of the telescopic plate is connected with the drawing plate, and the end part of the drawing plate is provided with a push-pull head used for driving the slide rack to move.

3. A mycobacterium tuberculosis microscanner according to claim 2, wherein: the push-pull head is L-shaped, a push-pull claw is arranged on the push-pull head, the push-pull claw and the pull plate are arranged at an interval from top to bottom, and a claw head is arranged at the end of the push-pull claw.

4. The mycobacterium tuberculosis microscanner of claim 1, wherein: the automatic slide positioning module comprises an X-axis positioning assembly, a Y-axis positioning assembly and a Z-axis positioning assembly; the Y-axis positioning assembly is connected to the X-axis positioning assembly, the X-axis positioning assembly is connected to the Y-axis positioning assembly, the X-axis positioning assembly is used for driving the Y-axis positioning assembly to move along an X axis, the Z-axis positioning assembly is used for driving the X-axis positioning assembly to move along a Z axis, the Y-axis positioning assembly comprises a slide support frame, and the slide frame is slidably mounted on the slide support frame; the X-axis positioning assembly comprises an X-axis bottom plate, an X-axis guide rail, an X-axis sliding block, an X-axis connecting plate and an X-axis screw nut mechanism, the X-axis guide rail is arranged on the upper side of the X-axis bottom plate, the X-axis sliding block is slidably mounted on the X-axis guide rail, the X-axis screw nut mechanism is arranged below the X-axis bottom plate, the lower end of the X-axis connecting plate is connected with the X-axis screw nut mechanism, the upper end of the X-axis connecting plate is connected with the X-axis sliding block, the Y-axis positioning assembly is connected onto the X-axis connecting plate, and the X-axis screw nut mechanism is connected with an X-axis motor; the Y-axis positioning assembly further comprises a Y-axis guide rail, a Y-axis sliding block and a Y-axis lead screw nut mechanism, the Y-axis lead screw nut mechanism is arranged on the X-axis connecting plate, the Y-axis guide rail is arranged on the X-axis connecting plate, the Y-axis sliding block is slidably mounted on the Y-axis guide rail, the lower end of the slide support frame is connected to the Y-axis sliding block, the upper end of the slide support frame is connected with the Y-axis lead screw nut mechanism, and the Y-axis lead screw nut mechanism is connected with a Y-axis motor; z axle locating component includes Z axle fixed plate, Z axle guide rail, Z axle slider, Z axle connecting plate and Z axle screw nut mechanism, Z axle screw nut mechanism with the Z axle guide rail is established on the Z axle fixed plate, Z axle slider slidable mounting be in on the Z axle guide rail, X axle bottom plate passes through Z axle connecting plate with Z axle slider connects, Z axle connecting plate with Z axle screw nut mechanism connects, Z axle screw nut mechanism is connected with Z axle motor.

5. The mycobacterium tuberculosis microscanner of claim 4, wherein: slide support frame both sides are equipped with the confession the spout that the slide frame was pegged graft, the centre of slide support frame is equipped with fretwork portion for the printing opacity, the tip of slide support frame is equipped with the guide part, is used for inserting the slide frame leads, the tip of slide frame is equipped with the slope of downward sloping, the slope forms the guide part.

6. The mycobacterium tuberculosis microscanner of claim 1, wherein: the microscope module includes microscope body, lens dish and camera lens conversion subassembly, the lens dish rotates to be set up microscope body lower extreme, the lens dish is equipped with a plurality of camera lenses, lens dish circumference is equipped with the tooth's socket, camera lens conversion subassembly includes rotating electrical machines, rotating electrical machines fixed plate and gear, the rotating electrical machines fixed plate is connected on the microscope body, the gear connection be in on the rotating electrical machines, the gear with the tooth's socket meshing, the rotating electrical machines is used for passing through gear drive the lens dish rotates.

7. The mycobacterium tuberculosis microscanner of claim 1, wherein: slide automatic positioning module one side is equipped with immersion lens oil dropwise add module, immersion lens oil dropwise add module includes oil drip syringe needle, oil bottle fixed plate and peristaltic pump, the peristaltic pump is established oil bottle fixed plate upper end, peristaltic pump one end with the oil bottle passes through the tube coupling, the other end with the oil drip syringe needle passes through the tube coupling, the vertical downward setting of lower extreme of oil drip syringe needle is used for to slide dropwise add immersion lens oil on the slide frame.

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