CN110186846B - Pathological slide replacing device - Google Patents
Pathological slide replacing device Download PDFInfo
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- CN110186846B CN110186846B CN201910452902.1A CN201910452902A CN110186846B CN 110186846 B CN110186846 B CN 110186846B CN 201910452902 A CN201910452902 A CN 201910452902A CN 110186846 B CN110186846 B CN 110186846B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The invention discloses a pathological slide replacing device, which comprises a feeding driving mechanism, a double-clamping type slide clamp and a slide fixer, wherein the feeding driving mechanism is used for driving a slide to move along a slide track; the feeding driving mechanism is used for driving the double-clamping type glass sheet clamp to move relative to the glass sheet fixer in a feeding way; the double-clamping type glass sheet clamp is used for clamping a carrier glass sheet and forms an upper clamping groove and a lower clamping groove which can be started asynchronously; the slide holder is used for carrying a slide in an imaging process, and the end of the slide holder is provided with two steps. Starting an upper clamping groove, clamping and carrying a slide to be imaged to a slide groove by the upper clamping groove, and pressing a fixed slide by a first-stage step; starting the lower clamping groove, and clamping the imaged slide back groove by the lower clamping groove; then the first step releases the slide to be imaged, and the slide to be imaged falls into the bottom of the slide groove; and finally, the second-stage step compresses the fixed slide to wait for imaging. The slide taking process and the slide feeding process are completed in the same action, and the serial four-step action process is changed into one-placing-one-taking two-step operation, so that the efficiency of continuous slide scanning is greatly improved.
Description
Technical Field
The invention relates to the field of biomedical instrument design, in particular to the field of an automatic slide changing device in a pathological slide scanner.
Background
At present, in the clinical traditional pathological examination, an optical microscope is adopted for human eye microscopic examination, the examination is seriously dependent on the experience and the service level of a single doctor, certain false detection probability exists, the detection efficiency is low, the preservation and carrying of a tissue sample are extremely unchanged, and great obstacles are created for pathological teaching and remote consultation. Meanwhile, due to the needs of repeated diagnosis, teaching and the like, hospitals need to store pathological slides for years and even decades. With the increase of the number of pathological slides, the preservation and management cost of the pathological slides is higher and higher. Furthermore, some dyes or markers change with time, making long-term storage difficult.
In recent years, the advent of pathology scanners has addressed these problems to some extent. Pathological slide is stored to a local memory and a cloud memory in a digital mode by the pathological scanner, and medical workers can directly read and diagnose the pathological slide through digital images. The digitized image can be further transmitted and shared through the Internet, and is displayed by utilizing a mobile display terminal such as projection, so that remote pathology consultation and pathology teaching can be efficiently and conveniently carried out. The digitalized pathological data not only reduces the storage cost of pathological slides and improves the data sharing efficiency, but also provides a data basis for further realizing computer intelligent diagnosis.
However, the conventional pathology scanner requires manual intervention to place the pathology slides one by one into the scanner for digital imaging. In the batch pathological slide scanning process, the efficiency of the scanner is greatly reduced by manually loading pathological slides, and the labor cost is increased. In order to improve the working efficiency and realize batch automatic scanning, a part of instruments in the existing pathological scanner is designed with a device for automatically loading pathological slides, so that continuous pathological slide scanning is realized without manual intervention.
However, the existing automatic slide-changing device simulates the manual slide-changing process, the scanned pathological slide is taken down, and the unscanned pathological slide is put on an instrument, so that the whole process can be completed by four separated serial actions, and the slide-changing time is long. For batch type pathological slide scanner, long-time slide changing action can lead to low efficiency of slide scanning, and complicated action can increase mechanical damage and reduce the stability of the system, so that a device which has simple action and can quickly change pathological slide samples is needed to improve the operating efficiency of the full-automatic slide scanner.
Disclosure of Invention
In order to solve the problems, the invention aims to provide an automatic pathological slide replacing device which is simple to operate and high in switching speed.
A pathological slide replacing device comprises a feeding driving mechanism, a double-clamping type slide clamp and a slide fixer;
the feeding driving mechanism is used for fixing the double-clamping type slide clamp and driving the double-clamping type slide clamp to move relative to the slide fixer in a feeding way;
the double-clamping type glass slide clamp is provided with an upper clamping groove and a lower clamping groove which can be started asynchronously, and the glass slide fixer is provided with a glass slide groove and an upper fixing structure and a lower fixing structure which can be used asynchronously; when the upper clamping groove is started, the feeding driving mechanism drives the upper clamping groove to clamp and carry the slide to be imaged to the slide groove, and the first-stage step is started to press and fix the slide to be imaged; when the lower clamping groove is started, the lower clamping groove is driven by the feeding driving mechanism to clamp the imaged slide and move back, at the moment, the slide to be imaged released by the first-stage step falls into the bottom of the slide groove, and the second-stage step is started to press the fixed slide to wait for imaging.
Further, the double-clamping type glass sheet clamp comprises a longitudinal displacement mechanism, a clamp base and a movable clamping sheet; an upper clamping plate and a lower clamping plate are arranged on one side of the clamp base; the longitudinal movement mechanism is fixed on the clamp base, one end of the longitudinal movement mechanism is provided with a movable clamping piece, the movable clamping piece is positioned between the upper clamp plate and the lower clamp plate, and the longitudinal movement of the longitudinal movement mechanism adjusts the longitudinal position of the movable clamping piece, so that the movable clamping piece and the upper clamp plate are alternately combined to form an upper glass clamping groove or a lower glass clamping groove.
Further, the slide holder comprises a holder platform, a push driving mechanism and a double-step type push device; the middle part of the fixer base is provided with a slide groove for placing pathological slides; the pushing driving mechanism is arranged on the fixer base, and one end of the pushing driving mechanism is connected with the double-step pusher; two steps are arranged at the end part of the double-step pusher facing the slide groove, and the position of the two steps relative to the slide groove is adjusted through the plane motion of the pushing driving mechanism, so that the two steps alternately form an upper fixing structure and a lower fixing structure for fixing slides in the slide groove.
Furthermore, the glass sheet clamping device also comprises a lifting mechanism which is used for driving the feeding driving mechanism and the double-clamping type glass sheet clamp to move longitudinally.
Furthermore, the glass sheet clamping device also comprises a rotating mechanism which is used for driving the feeding driving mechanism and the double-clamping type glass sheet clamp to rotate in a plane.
Further, a pathological slide storage box for storing slides is also included.
Furthermore, the feed driving mechanism adopts any one of a stepping motor matched lead screw structure, a direct current motor matched synchronous wheel synchronous belt structure, a servo motor matched lead screw structure, a direct current motor matched synchronous wheel synchronous belt structure and a multi-shaft mechanical arm structure.
Furthermore, the longitudinal displacement mechanism adopts any one of a bidirectional electromagnet structure, a direct current motor matched lead screw sliding table structure and a stepping motor matched lead screw sliding table structure.
Furthermore, the pushing and pressing driving mechanism adopts any one of a direct current motor matched screw rod sliding table or a gear rack structure, a servo motor matched screw rod sliding table or a gear rack structure, and a stepping motor matched screw rod sliding table or a gear rack structure.
The beneficial technical effects of the invention are as follows:
the invention realizes the synchronization of the operation of taking out the imaged slide and placing a new pathological slide by utilizing the double-clamping pathological slide clamp to match with the stepped slide fixing base. In the traditional pathological slide switching process, the process of taking out an old slide sample and the process of placing a new pathological slide are completed in the same action, and the serial four-step action process is changed into a two-step operation of placing one slide and taking one slide. The slide replacing scheme is simple in action, and can shorten the slide replacing time of a minute level to less than six seconds at a very high speed, so that the efficiency of continuous slide scanning is greatly improved.
Drawings
FIG. 1 is a schematic view of the overall structure of embodiment 1 of the present invention;
FIG. 2 is a schematic diagram of a dual-clamping type pathological glass clamp in embodiment 1 of the present invention;
FIG. 3 is a schematic view showing the structure of a slide holder according to embodiment 1 of the present invention;
FIG. 4 is a schematic structural view of example 2 of the present invention;
FIG. 5 is a schematic structural view of example 3 of the present invention;
FIG. 6 is a schematic structural view of example 4 of the present invention;
FIG. 7 is a schematic view showing the operation of the structure of the holder of example 1 of the present invention in cooperation with a slide holder;
the numbers in the figures identify the description:
a rotating mechanism 10, an elevating mechanism 50, a feeding driving mechanism 60, a double-clamping type slide clamp 70, a slide holder 20, a longitudinal displacement mechanism 701, a clamp base 702, an upper clamping plate 703, a lower clamping plate 704, a movable clamping sheet 705, a holder platform 203, a pushing driving mechanism 201, a double-step pusher 202, a slide groove 204, a pathological slide storage box 40, and a three-axis rotating slide table 30.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. In addition, the technical features involved in the embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1:
referring to fig. 1, the present embodiment includes a feed drive mechanism 60, a dual-grip slide gripper 70, and a slide holder 20.
A feed drive mechanism 60 for securing the dual-grip slide holder 70 and driving the dual-grip slide holder 70 into feed motion relative to the slide holder 20;
in the present embodiment, referring to fig. 2, the double-clamping type slide clamp 70 is used for clamping a slide carrier, and includes a longitudinal displacement mechanism 701, a clamp base 702 and a movable clamping piece 705; an upper clamping plate 703 and a lower clamping plate 704 are arranged on one side of the clamp base 702; the longitudinal moving mechanism 701 is fixed on the clamp base 702, one end of the longitudinal moving mechanism 701 is provided with a movable clamping piece 705, the movable clamping piece 705 is positioned between the upper clamping plate 703 and the lower clamping plate 704, and the longitudinal position of the movable clamping piece 705 is adjusted through the longitudinal up-and-down movement of the longitudinal moving mechanism 701, so that the movable clamping piece 705 and the upper clamping plate 703 are combined to form an upper slide clamping groove or combined with the lower clamping plate 704 to form a lower slide clamping groove, only the upper slide clamping groove or the lower slide clamping groove is started at the same time to form an asynchronous working mode, an alternative working mode is formed in continuous working, and the synchronization of the operation of taking out the imaged slide and placing a new pathological slide is realized.
In this embodiment, the longitudinal displacement mechanism 701 is implemented by a bidirectional stabilizing electromagnet and a connecting rod, the output end of the bidirectional stabilizing electromagnet is connected with the connecting rod, the bidirectional electrically stabilizing electromagnet has two stable states, under the switching of positive and negative voltages, a push rod on the electromagnet generates corresponding telescopic action, and the stable state thrust or pull force of the push rod reaches more than 5N. The movable clamping piece 705 is rigidly connected with the push rod of the electromagnet 701 through a screw, and the pathological slide clamp 70 can respectively generate two pathological slide upper and lower clamping grooves in two telescopic states of the push rod. The double-clamping pathological slide clamp 70 has the beneficial effects that when a slide sample needs to be replaced, a new sample is clamped by the upper clamping groove on the pathological slide clamp and sent into the scanner, when the new sample reaches the appointed placing point, the upper clamping groove is loosened, and meanwhile, the lower clamping groove is closed, so that the scanned slide sample is clamped and fixed, and the scanning instrument is withdrawn along with the feeding shaft.
In order to ensure that the pathological slide holder takes away the old slide sample while the new slide sample does not displace, the present invention designs a special stepped slide holder 20, as shown in fig. 3. The slide holder 20, which is used for carrying slides in the imaging process, comprises a holder platform 203, a pushing drive mechanism 201 and a double-step type pusher 202; the middle part of the holder base 203 is provided with a slide groove 204 for placing pathological slides; the pushing driving mechanism 201 is arranged on the fixer base 203, and one end of the pushing driving mechanism is connected with the double-step type pusher 202; the double step pusher 202 has two steps towards the end of the slide groove 204. the advantage of this step design is that it is not a single step. The position of the two steps relative to the slide groove 204 is adjusted by the planar movement of the push drive mechanism 201 so that the two steps form upper and lower fixing structures for fixing slides that are activated asynchronously.
When the slide upper clamping groove of the double-clamping type slide clamp 70 clamps the carrier slide to the slide groove 204, the pushing driving mechanism 201 drives the double-step pusher 202 to be close to the slide, and the first step compresses and fixes the slide to be imaged; the lower clamping slot is activated, which clamps the last imaged slide at the bottom of the slide slot, and the slot is withdrawn by the drive of the feed drive mechanism 60; the pushing driving mechanism 201 drives the double-step pusher 202 to move backwards, the first step presses and releases the slide, the slide to be imaged falls into the bottom of the slide groove 204, and the second step presses and fixes the slide to wait for imaging; when the slide imaging is finished, the second-stage step presses the released slide, then the upper clamping groove is started to feed a new slide to be imaged again according to the previous mode, and the lower clamping groove clamps the imaged slide to move back from the groove.
In this example, the pushing driving mechanism 201 is implemented by a stepping screw motor, and when the screw motor rotates, the screw motor drives the slider to translate, so that the stepped pusher translates.
In this example, a square hollow structure is designed in the middle of the slide groove 204 for projection illumination of microscopic imaging, and four corners of the hollow structure are designed with upright columns, and the height of the upright columns is greater than the thickness of two slides.
The working process is as follows:
after the previous pathological slide is scanned, the double-step pusher 202 on the slide holder 20 is driven by the screw motor 201 to release the slide sample, and the feed driving mechanism 60 is driven to move horizontally to drive the double-clamping type slide clamp 70 to feed the next pathological slide to be imaged into the slide groove 204. At this time, two slides exist in the slide groove, namely the pathological slide to be imaged in the upper clamping groove and the imaged pathological slide in the lower clamping groove.
The bi-directional stabilizing electromagnet is energized in the reverse direction, the upper clamping slot is released and the lower clamping slot is closed (clamping the imaged slide that falls into the bottom of slide slot 204). Meanwhile, the stepped pusher 202 is driven by the pushing driving mechanism 201 to feed, and the pathological slide to be imaged loosened in the upper clamping groove is pushed and fixed by the first step.
The feed drive mechanism 60 translates to drive the dual-grip slide gripper 70 to remove the imaged pathological slide in the lower grip slot from the slide slot 204.
After the sample in the lower clamping groove completely exits the slide groove 204, the step type pusher 202 is driven by the screw motor to loosen the slide sample to be imaged, the sample automatically slides to the bottom of the slide groove 204, then the step type pusher is used for feeding, and the second-stage step is used for pushing and fixing the sample to be imaged.
The double-clamping pathological slide clamp and the step slide fixer change the motion mode of 'two-in and two-out' in the slide changing process into 'one-in and one-out', and further improve the slide changing efficiency by one time.
By applying the invention, the slide replacing process and the action of the pathological slide scanner are designed to run in parallel, so that the waiting process of the slide scanner in the slide replacing process is greatly reduced, and the slide replacing efficiency is obviously improved. Through practical tests, the replacement time of the single pathological slide of the automatic slide replacement scheme is within 6 s.
Example 2:
referring to fig. 4, the present invention further comprises an elevating mechanism 50 on the basis of embodiment 1, a driving mechanism 60 and a dual-holding slide holder 70 are mounted on the elevating mechanism for driving the feeding driving mechanism 60 and the dual-holding slide holder 70 to move longitudinally, so that the height of the dual-holding slide holder 70 can be flexibly adjusted to suit the height of the slide storage box or slide holder 20
The elevating mechanism 50 is composed of a stepping motor screw sliding table in this example, and when the stepping motor is fed, the stepping motor drives the screw to rotate, driving the sliding table to move longitudinally.
Example 3:
referring to fig. 5, a rotating mechanism 10 is further added to example 2, and the rotating mechanism 10 is installed at the bottom of the lifting mechanism for driving the feeding driving mechanism 60 and the dual-holding slide holder 70 to rotate in a plane. In practice, the slide storage cassette and slide holder 20 are likely not in the same orientation, and thus the dual-grip slide holder 70 can be aligned with the slide storage cassette during slide retrieval and the dual-grip slide holder 70 can be rotated an angle to align with the slide holder 20 during slide delivery by the flexible rotation of the rotation mechanism.
In this example, the rotating mechanism 10 is composed of a stepping motor and a worm gear structure, and when the stepping motor is fed, the stepping motor rotates to drive the worm gear structure to rotate.
Example 4:
referring to fig. 6, a pathological slide storage box 40 for storing pathological slides is further added to example 3. The pathological slide storage box 40 is composed of six columns of slide grooves in parallel groups, and each column has twenty slide grooves.
As optimizing, still be equipped with one-dimensional translation platform 30 bottom the storage box, constitute by step motor cooperation lead screw slip table in this embodiment, feed step motor, can drive lead screw slip table horizontal direction and remove, and then drive the slide and remove. The purpose of accurate positioning can be achieved by controlling the number of pulses. In order to prevent the accumulated error, an original point switch is designed in the sliding table.
It will be understood by those skilled in the art that the foregoing is only a preferred embodiment of the present invention, and is not intended to limit the invention, and that any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (7)
1. A pathological slide exchange device, comprising a feed drive mechanism (60), a dual-grip slide holder (70), and a slide holder (20);
a feed drive mechanism (60) for securing the dual-grip slide holder (70) and for driving the dual-grip slide holder (70) into feed motion relative to the slide holder (20);
the double-clamping type slide fixture (70) is provided with a slide upper clamping groove and a slide lower clamping groove which are started asynchronously, and the slide fixer (20) is provided with a slide groove and an upper fixing structure and a lower fixing structure which are used asynchronously; when the clamping groove on the slide is started, the feeding driving mechanism (60) drives the clamping groove to clamp and carry the slide to be imaged to the slide groove, and the first-stage step pressing is started to fix the slide to be imaged; when the lower glass slide clamping groove is started, the lower glass slide clamping groove is driven by a feeding driving mechanism (60) to clamp the imaged glass slide to move back, at the moment, the glass slide to be imaged released by the first-stage step falls into the bottom of the glass slide groove, and the second-stage step is started to press the fixed glass slide to wait for imaging;
the slide holder (20) comprises a holder platform (203), a push drive mechanism (201) and a two-step pusher (202); the middle part of the fixer platform (203) is provided with a slide groove (204) for placing a pathological slide; the pushing driving mechanism (201) is arranged on the fixer platform (203), and one end of the pushing driving mechanism is connected with the double-step type pusher (202); the end part of the double-step pusher (202) facing the slide groove (204) is provided with two steps, and the position of the two steps relative to the slide groove (204) is adjusted through the planar motion of the pushing driving mechanism (201), so that an upper fixing structure and a lower fixing structure for fixing the slide in the slide groove (204) are alternately formed by the two steps;
the double-clamping type slide clamp (70) comprises a longitudinal displacement mechanism (701), a clamp base (702) and a movable clamping sheet (705); an upper clamping plate (703) and a lower clamping plate (704) are arranged on one side of the clamp base (702); the longitudinal movement mechanism (701) is fixed on the clamp base (702), one end of the longitudinal movement mechanism (701) is provided with a movable clamping piece (705), the movable clamping piece (705) is positioned between the upper clamping plate (703) and the lower clamping plate (704), and the longitudinal position of the movable clamping piece (705) is adjusted through the longitudinal alternate movement of the longitudinal movement mechanism (701), so that the movable clamping piece (705) and the upper clamping plate (703) are alternately combined to form an upper glass slide clamping groove or combined with the lower clamping plate (704) to form a lower glass slide clamping groove.
2. The pathological slide replacement device of claim 1, further comprising an elevator mechanism (50) for moving the feed drive mechanism (60) and the dual-grip slide gripper (70) longitudinally.
3. The pathological slide exchange device according to claim 1, further comprising a rotation mechanism (10) for planar rotation of the feed drive mechanism (60) and the dual-grip slide gripper (70).
4. The pathological slide replacement device of claim 1, further comprising a pathological slide storage case (40) for storing slides.
5. The pathological slide replacing device according to claim 1, wherein the feeding driving mechanism (60) adopts any one of a stepping motor-matched screw structure, a direct current motor-matched synchronous wheel synchronous belt structure, a servo motor-matched screw structure, a direct current motor-matched synchronous wheel synchronous belt structure and a multi-axis mechanical arm structure.
6. The pathological slide replacing device according to claim 1, wherein the longitudinal displacement mechanism (701) adopts any one of a two-way electromagnet structure, a direct current motor matched lead screw sliding table structure and a stepping motor matched lead screw sliding table structure.
7. The pathological slide replacing device according to claim 1, wherein the pushing and pressing driving mechanism (201) adopts any one of a direct current motor matched screw rod sliding table or a gear rack structure, a servo motor matched screw rod sliding table or a gear rack structure, and a stepping motor matched screw rod sliding table or a gear rack structure.
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| CN201910452902.1A CN110186846B (en) | 2019-05-28 | 2019-05-28 | Pathological slide replacing device |
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| CN201910452902.1A CN110186846B (en) | 2019-05-28 | 2019-05-28 | Pathological slide replacing device |
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| CN110186846B true CN110186846B (en) | 2022-02-18 |
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| CN113686857A (en) * | 2021-08-31 | 2021-11-23 | 杭州智微信息科技有限公司 | Glass sheet box rotary lifting structure for bone marrow smear scanner |
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