CN212207054U - Slide analyzer - Google Patents

Abstract

The utility model discloses a slide analysis machine includes: the glass slide clamping seat is arranged on the base and used for placing a glass slide; the scanning device is arranged on the base and used for scanning pathological tissues on the slide; the clamping device is movably arranged on the base and is used for clamping and placing the slide; the clamping device is provided with a first working position and a second working position when moving, when the clamping device is positioned at the first working position, the slide corresponds to the slide clamping seat, and when the clamping device is positioned at the second working position, the slide corresponds to the scanning device. The scanning device scans pathological sections, transmits information obtained by scanning to the control system and the high-speed image processing system, automatically and intelligently diagnoses the pathological sections through subsequent pathological analysis, and adopts equipment to replace manual analysis so as to improve the working efficiency of the pathological analysis.

Description

Slide analyzer

Technical Field

The utility model relates to a pathological analysis equipment technical field especially relates to a slide analysis machine.

Background

At present, the most direct disease diagnosis standard of clinical pathology is that pathologists carry out amplification observation on pathological tissues through a microscope, and the pathologists output results after carrying out manual analysis on amplified pathological images based on experience and professional knowledge.

There are many problems with current pathological diagnosis: the manual pathological analysis is long in time and low in efficiency, and a patient needs to wait for a long time to obtain a result, so that the disease is not treated in time; the accuracy of the artificial pathological analysis is influenced by various factors including knowledge level, experience, mental state and the like of a pathologist, the diagnosis of the pathologist is often used as a first diagnosis standard, and once misjudgment occurs, adverse influence is caused on disease treatment. Finally, primary hospitals are largely unable to carry out pathological diagnosis examinations due to the lack of pathologists and pathologists. Obviously, when the pathological analysis is performed manually, the analysis is inefficient.

SUMMERY OF THE UTILITY MODEL

The embodiment of the utility model provides an aim at: the artificial intelligence pathological diagnosis automation equipment adopts a mode that equipment replaces manual analysis so as to improve the working efficiency of pathological analysis.

The embodiment of the utility model provides a another aim at: the accuracy of pathological analysis is improved.

In order to achieve the purpose, the utility model adopts the following technical proposal:

there is provided a slide analyzer comprising:

the glass slide clamping seat is arranged on the base and used for placing a glass slide;

the scanning device is arranged on the base and used for scanning pathological tissues on the slide;

the clamping device is movably arranged on the base and is used for clamping and placing the slide;

the clamping device is provided with a first working position and a second working position when moving, when the clamping device is positioned at the first working position, the slide corresponds to the slide clamping seat, and when the clamping device is positioned at the second working position, the slide corresponds to the scanning device.

Optionally, the scanning device includes:

the scanning platform is arranged on the base;

the scanning lens is arranged above the scanning platform, and the mirror surface of the scanning lens faces the scanning platform.

Optionally, the scanning platform is movably disposed on the base along a horizontal direction and a vertical direction.

Optionally, the scanning platform includes a driving mechanism and a placing groove disposed on the upper surface of the driving mechanism, the driving mechanism is disposed on the body of the base, and the driving mechanism drives the placing groove to move in the front-back direction, the left-right direction, and the up-down direction.

Optionally, the scanning device is further connected with a display screen through a signal transmission device, the display screen is arranged on the base and is provided with a display surface facing the outside, and the display surface is used for displaying the digital image and the pathological analysis result.

Optionally, the slide analyzer further includes a carrying device disposed on the base, the gripping device is in transmission connection with the carrying device, and the carrying device drives the gripping device to move in the horizontal direction and the vertical direction.

Optionally, the conveying device includes:

the X-axis module is arranged on the base, and the slide clamping seat and the scanning device are positioned on one side of the X-axis module and are sequentially arranged along the length direction of the X-axis module;

the Z-axis module can move along with the X-axis module and is arranged on the X-axis module;

the clamping device can move along with the Z-axis module and is arranged on the Z-axis module.

Optionally, the carrying device further includes a Y-axis module, the Y-axis module is disposed on the Z-axis module along with the movement of the Z-axis module, and the gripping device is disposed on the Y-axis module along with the movement of the Y-axis module.

Optionally, a plurality of slide placing positions are arranged on the slide holder, and an induction device is arranged at each slide placing position.

Optionally, the sensing device is further configured to sense the presence or absence of the slide and to locate the position of the slide.

The utility model has the advantages that: the utility model provides a slide analysis machine, it includes the frame and locates slide cassette, scanning device and the clamp of frame and get the device, when getting the device and removing to slide cassette position, take out the slide clamp on the slide cassette to remove to scanning device, place the slide in scanning device, scanning device scans pathological section, will scan gained information transmission to control system and high-speed image processing system, and through follow-up pathological analysis in order to realize the automatic intelligent diagnosis to pathological section, and, adopt the mode that equipment replaced manual analysis, with the work efficiency who promotes pathological analysis.

Drawings

The present invention will be described in further detail with reference to the accompanying drawings and examples.

FIG. 1 is a schematic perspective view of a slide analyzer according to an embodiment of the present invention;

fig. 2 is a schematic perspective view of a scanning device according to an embodiment of the present invention;

FIG. 3 is an enlarged view of a portion A of FIG. 2;

FIG. 4 is a schematic structural view of a conveying device and a slide holder according to an embodiment of the present invention;

FIG. 5 is a schematic view of the front structure of the slide holder according to the embodiment of the present invention;

fig. 6 is a schematic view of a back structure of a slide holder according to an embodiment of the present invention.

Fig. 7 is a schematic view of a surface structure of a scanning platform according to an embodiment of the present invention.

In the figure:

10. a base plate;

1000. a slide holder; 1100. a card seat main body; 1200. a cassette for glass sheets; 1300. a cassette sensor; 1400. An indicator light; 1500. a positioning sensor; 1600. a yielding groove;

2000. a scanning device; 2100. a body; 2200. a scanning lens; 2300. a scanning platform; 2310. placing a groove; 2320. an XY moving stage; 2321. an X-axis moving mechanism; 2322. a first motor primary; 2323. A first motor secondary; 2324. a slide rail; 2325. a Y-axis moving mechanism; 2326. a load-bearing platform; 2327. a dovetail groove; 2328. a vertical track; 2329. a manipulator abdicating groove; 2330. a slide clamping device; 2331. a light through hole;

3000. a gripping device;

4000. a conveying device; 4100. an X-axis module; 4110. an X-axis base; 4200. a Z-axis module; 4210. a Z-axis fixing plate; 4220. a Z-axis base; 4300. a Y-axis module; 4310. a Y-axis fixing plate; 4320. a Y-axis base;

5000. a display.

Detailed Description

In order to make the technical problems, technical solutions and technical effects achieved by the present invention more clear, the embodiments of the present invention will be described in further detail with reference to the accompanying drawings, and obviously, the described embodiments are only some embodiments, not all embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by those skilled in the art without creative efforts belong to the protection scope of the present invention.

In the description of the present invention, unless otherwise explicitly specified or limited, the terms "connected" and "fixed" are to be understood broadly, e.g. as a fixed connection, a detachable connection or an integral part; can be mechanically or electrically connected; either directly or indirectly through intervening media, either internally or in any other relationship. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

In the present disclosure, unless expressly stated or limited otherwise, the first feature "on" or "under" the second feature may comprise direct contact between the first and second features, or may comprise contact between the first and second features not directly. Also, the first feature being "on," "above" and "over" the second feature includes the first feature being directly on and obliquely above the second feature, or merely indicating that the first feature is at a higher level than the second feature. A first feature being "under," "below," and "beneath" a second feature includes the first feature being directly under and obliquely below the second feature, or simply meaning that the first feature is at a lesser elevation than the second feature.

As shown in fig. 1-7, the present invention provides a slide analyzer, which includes, in an embodiment of the slide analyzer:

the glass slide clamping seat 1000 is arranged on the base, and the glass slide clamping seat 1000 is used for placing a glass slide;

the scanning device 2000 is arranged on the base and used for scanning pathological tissue sections on the slide;

the clamping device 3000 is movably arranged on the base and used for clamping and placing the slide;

the gripping device 3000 has a first working position and a second working position when moved, and when the gripping device 3000 is located at the first working position, the slide corresponds to the slide holder 1000, and when the gripping device 3000 is located at the second working position, the slide corresponds to the scanning device 2000.

In this embodiment, the slide analyzer further includes a housing, the housing cover is disposed above the base and surrounds the slide holder 1000, the scanning device 2000 and the clamping device 3000, the housing is provided with an avoiding opening, and the display screen is mounted at the avoiding opening.

The base comprises a bottom plate and adjusting feet, the slide clamping seat 1000, the scanning device 2000 and the clamping device 3000 are arranged on the upper surface of the bottom plate, the adjusting feet are arranged on the lower surface of the bottom plate and can adjust the vertical position to adjust the vertical position of the bottom plate.

In the operation of the slide analyzer, the gripping device 3000 is moved to the first working position and the second working position to move the slide, and it should be noted that when the gripping device 3000 is located at the first working position or the second working position, the gripping device 3000 can grip and place the slide.

Specifically, the clamping device 3000 is moved to the first working position, the clamping device 3000 clamps the slide of the slide cassette 1000 from the slide cassette 1000, then the clamping device 3000 is moved to the second working position, the clamping device 3000 places the clamped slide on the scanning device 2000 to scan the slide, and then after the scanning is finished, the clamping device 3000 clamps the slide from the scanning device 2000, and then the clamping device 3000 is moved to the first working position to place the slide back to the slide cassette 1000 to scan another slide.

The utility model provides a slide analysis machine, it includes the frame and locates slide cassette 1000, scanning device 2000 and the clamp of frame and get device 3000 to the realization carries out automatic intelligent diagnosis to the pathology, adopts the mode that equipment replaced artifical analysis, with the work efficiency who promotes pathological analysis.

As shown in fig. 1 to 7, in an embodiment of the slide analyzer of the present invention, the scanner 2000 is mounted to the frame, and includes:

a body 2100, the body 2100 being provided with a scanning lens 2200;

the scanning platform 2300 is disposed below the scanning lens 2200, and includes a driving mechanism and a placing groove 2310 disposed on the driving mechanism, the driving mechanism is disposed on the body 2100, and the driving mechanism drives the placing groove 2310 to move in the front-back direction, the left-right direction, and the up-down direction.

In this embodiment, the body 2100 is vertically disposed and is in a column shape, and has two mounting portions extending in a horizontal direction and being in a rectangular shape, the two mounting portions are sequentially disposed in a vertical direction and are opposite to each other, the mounting portion located below is mounted with a light source, a light emitting direction of the light source is disposed upward, and the light source is used for providing a light source, so as to improve a scanned image brightness and observe a slide more clearly, the mounting portion located above is mounted with the scanning lens 2200, and a mirror surface of the scanning lens 2200 faces downward.

Wherein, scanning lens 2200 includes main shaft camera, condensing lens, sign camera and objective, main shaft camera, condensing lens and objective communicate the setting in proper order from top to bottom, the sign camera is located the place ahead of installing part.

Specifically, the condenser lens passes through the adapter and installs on the installation part that is located the top, objective install under the installation part that is located the top, can understand, be located the top the installation part separately is equipped with the passageway, so that the condenser lens with objective is linked together.

The scanning platform 2300 is installed below the objective lens and above the light source device, it should be noted that the scanning platform 2300 is provided with a light hole 2331, the light hole 2331 is located between the light source device and the objective lens for the light source device to pass through to the slide, the light hole 2331 is located below the placing groove 2310,

further, the scanning platform 2300 is mounted to the body 2100 through the driving mechanism mounted to a vertically disposed portion of the body 2100.

Specifically, the driving mechanism drives the scanning platform 2300 to move in the front-back, left-right, and up-down directions, and it can be understood that the driving mechanism has three driving portions which drive the scanning platform 2300 to move in the front-back, left-right, and up-down directions, respectively.

The utility model discloses an in some embodiments, actuating mechanism can be including three linear electric motor, and three linear electric motor's the direction that sets up is around, about and from top to bottom respectively, actuating mechanism also can be including three step motor or three piezoceramics motor, and the setting mode that the setting mode referred to linear electric motor, actuating mechanism can also be foretell setting mode's mutual alternate use, that is, three drive division can be linear electric motor, step motor or piezoceramics motor respectively, and transmission structure can be screw drive, belt drive etc..

The utility model provides a slide analysis machine, it includes organism 2100 and locates scanning lens 2200, scanning platform 2300 of organism 2100, scanning platform 2300 is located scanning lens 2200's below to the transmission connect in actuating mechanism.

In use, a slide is placed in the placement groove 2310 and the drive mechanism is driven to move the scanning platform 2300 in the front-to-back, left-to-right, and up-and-down directions. In this way, the scanning platform 2300 is driven by the driving mechanism to move in the up-down direction to adjust the vertical position of the scanning platform 2300, i.e., the distance between the slide and the scanning lens 2200, i.e., to facilitate adjustment of the focal length of the scanning lens 2200; the driving mechanism drives the scanning platform 2300 to move left and right and back and forth to adjust the horizontal position of the scanning platform 2300, i.e., the part of the slide opposite to the scanning lens 2200, so that each part of the slide can be scanned conveniently, and the scanning is relatively comprehensive.

The size of the pathological tissue section in the slide may be 15mm by 15mm, and the area of each scanning and photographing of the scanning lens 2200 may be 0.5mm by 0.5mm, so that the driving mechanism may be controlled by the control system to drive the scanning platform 2300 to move up and down, left and right, or front and back, in this scheme, the left and right movement is movement along the X direction, the front and back movement is movement along the Y direction, and the up and down movement is movement along the Z direction, so that the scanning starting point of the pathological tissue section to be scanned is located right below the lens.

Generally, the scan start point is defined as 0.5mm x 0.5mm on the upper surface and left side of the pathological tissue section of 15mm x 15mm, and the scan lens 2200 takes a first image, i.e., a first 0.5mm x 0.5mm area, when the scan start point of the pathological tissue section to be scanned is located right under the lens.

Then, the control system controls the driving mechanism to drive the scanning platform 2300 to horizontally move 0.5mm to the left along the X direction, and at this time, the scanning lens 2200 is controlled to shoot a second 0.5mm by 0.5mm area of image, so that the control system controls the scanning platform 2300 to horizontally move 0.5mm to the left each time and to synchronously shoot by the camera, and the scanning of the first 0.5mm by 15mm image is completed sequentially from left to right;

then, the control system controls the driving mechanism to drive the scanning platform 2300 to move 15mm to the right, and then move 0.5mm to the back, and the position is taken as the starting point of the second line scanning to expand the second line of image scanning; the control system controls the scanning platform 2300 and the scanning lens 2200 to work in cooperation in the same manner as the first line scan until the image scan of all the pathological tissue sections 15mm by 15mm is completed.

In addition, while scanning, the control system sends each 0.5mm by 0.5mm image received from the scanning lens 2200 to the high-speed image processing system through the portal for image processing.

The high-speed image processing system builds a deep learning algorithm model of a multilayer convolutional neural network by using a convolutional neural network technology, trains an optimal pathological image classification mathematical model, realizes high-efficiency analysis and identification of pathological images and obtains a pathological analysis and identification result; the high-speed image processing system sends the pathological analysis result of each slide to the control system, the control system can display the pathological analysis results of all slides and the digital pathological images corresponding to each slide on the display screen, the control system can also be connected with the Internet to upload the pathological analysis results of the slides and the corresponding digital pathological images to the server, and a user can remotely check the pathological analysis results of the slides and the corresponding digital pathological images only by logging in the address of the server. The high-speed image processing system is arranged in a high-performance computer which can be fixedly arranged in the slide analyzer or arranged outside the device and is connected with the slide analyzer through a data line to transmit image data and pathological analysis results.

The driving mechanism drives the scanning platform 2300 to move along the front-back direction, the left-right direction and the up-down direction, the driving mechanism is used for replacing the traditional manual adjustment, the problems of complex procedures, easy error, high time cost and the like caused by manual adjustment of the slide position are solved, and the work efficiency of slide scanning is improved.

In this embodiment, the driving mechanism may be a mechanism powered by a linear motor, a stepping motor, or a piezoelectric ceramic motor, and the linear motor is used as an example in this embodiment.

Specifically, the driving mechanism includes an XY moving platform 2320 capable of moving horizontally and a Z-axis moving mechanism for driving the XY moving platform 2320 to move vertically, and the Z-axis moving mechanism is disposed on the body 2100.

In the working process, the Z-axis moving mechanism drives the XY moving platform 2320 to perform lifting motion, and the scanning platform 2300 realizes the omnibearing movement in the whole three-dimensional space coordinate system through the planar movement of the XY moving platform 2320 on a horizontal plane.

Specifically, the XY moving platform 2320 includes an X-axis moving mechanism 2321, a Y-axis moving mechanism 2325 disposed on an upper surface of the X-axis moving mechanism 2321, and a bearing platform 2326 disposed on a lower surface of the X-axis moving mechanism 2321, the bearing platform 2326 is connected to the Z-axis moving mechanism in a transmission manner, and the Z-axis moving mechanism can drive the bearing platform 2326 to perform vertical lifting motion.

The movement of the Y-axis moving mechanism 2325 relative to the X-axis moving mechanism 2321 is driven by a first linear motor assembly, the first linear motor assembly includes a first motor primary 2322 and a first motor secondary 2323, the first motor primary 2322 is disposed on one side of the upper surface of the X-axis moving mechanism 2321, and the first motor secondary 2323 is disposed on the Y-axis moving mechanism 2325, and the disposed position of the first motor primary 2322 corresponds to the disposed position of the first motor secondary 2323.

The movement of the X-axis moving mechanism 2321 relative to the loading platform 2326 is driven by a second linear motor assembly. The second linear motor assembly includes a second motor primary and a second motor secondary, the second motor primary is disposed on the bearing platform 2326, the second motor secondary is disposed on the lower surface of the X-axis moving mechanism 2321, and the disposed direction of the second motor secondary is perpendicular to the first motor primary 2322.

A dovetail groove 2327 is disposed behind the bearing platform 2326, a vertical rail 2328 is disposed on the machine body 2100 corresponding to the dovetail groove 2327, and the bearing platform 2326 can move up and down along the vertical rail 2328. The dovetail groove 2327 is used for transmission and limiting, so that the effects of high load intensity, stable transmission and the like are achieved, the motion stability of the bearing platform 2326 along with the axial motion of the Z-axis moving mechanism is improved, the slide is not easy to shift in the moving process of the scanning platform 2300, and the accuracy of the slide scanning of the scanning lens 2200 is further guaranteed.

As a more preferable technical solution, in this embodiment, a sliding rail 2324 is further disposed on an upper surface of the X-axis moving mechanism 2321, a sliding groove is disposed on the Y-axis moving mechanism 2325 corresponding to the sliding rail 2324, and the Y-axis moving mechanism moves along the sliding rail 2324. The sliding rails 2324 may be provided in one or more pieces as required.

The placing groove 2310 comprises a plurality of clamping tables, and the plurality of clamping tables are used for clamping a plurality of corners of the slide respectively.

Preferably, a robot abdicating groove 2329 is further disposed at a side of the placing groove 2310, and when the robot places a slide into the placing groove 2310 or takes a slide out of the placing groove 2310, the robot abdicating groove 329 provides an operation space for the robot.

Further, there are two robot abdicating grooves 2329, and a slide clamping device 2330 is further disposed between the two robot abdicating grooves 2329, and the slide clamping device 2330 is used for clamping a slide when the slide is placed in the placing groove 2310.

The slide clamp 2330 is a spring-loaded clamp that is biased toward the placement recess 2329.

By providing the elastic clamping member, the slide is clamped when it is placed in the placing groove 2310, and the stability of the slide in the scanning process can be ensured. The elastic clamping piece can also drive the slide to move in the direction of overcoming the pretightening force through the mechanical arm in the process of taking out the slide, so that the slide can be taken out from the placing groove 2310.

Specifically, the inner surface of the clamping table is provided with an arc chamfer to avoid interference with the corner of the slide, so that the clamping table is prevented from wearing the corner of the slide when the scanning platform 2300 moves, and the scanning precision of the scanning lens 2200 is influenced.

In this embodiment, the number of the chucking stations is four, but in other embodiments, the number of the chucking stations may be 3, 5, 6 or more, depending on the actual formation arrangement of the slide, and is not limited thereto.

As shown in fig. 1-7, in an embodiment of the slide analyzer of the present invention, the scanning device 2000 further includes a display screen, the display screen is disposed on the base and has a display surface facing outward, and the display surface is used for displaying the digital image and the pathological analysis result. In this embodiment, the display screen is specifically a touch display 5000, which is installed on the avoiding opening of the housing, and the display surface of the display screen faces the opening of the avoiding opening.

It can be understood that, when the touch display 5000 is used, a user can control the operation of the slide analyzer by touching the touch display screen with a human hand, select a slide scanning sequence, and view a slide analysis result and a corresponding digital pathological image through the touch display screen.

The utility model discloses an in other embodiments, the display screen can be fixed in dodge in the mouth, also detachably joint, screw connection, adhesive bonding or be the mode of lock install in dodge in the mouth, do not do the restriction here.

As shown in fig. 1-7, in an embodiment of the slide analyzer of the present invention, the slide analyzer further includes a carrying device 4000 disposed on the base, the clamping device 3000 is connected to the carrying device 4000 in a transmission manner, and the carrying device 4000 drives the clamping device 3000 to move in a horizontal direction and a vertical direction.

In the present embodiment, the carrying device 4000 is mounted on the upper surface of the frame, and specifically, the carrying device 4000 drives the gripper 3000 to move in the front-back, left-right, and up-down directions, it can be understood that the carrying device 4000 has three carrying sections which drive the gripper 3000 to move in the front-back, left-right, and up-down directions, respectively.

In some embodiments of the present invention, the carrying device 4000 may include three linear motors, the setting directions of the three linear motors are respectively the front and back, left and right, and up and down directions, the carrying device 4000 may further include three step motors or piezoelectric ceramic motors, the setting mode of the setting device refers to the setting mode of the linear motors, the carrying device 4000 may further be the mutual alternate use of the setting modes, that is, the three carrying parts may be the linear motors, the step motors, and the piezoelectric ceramic motors, the transmission structure may be screw transmission, belt transmission, etc., and the limitation is not made here.

The carrying device 4000 is connected with a clamping device 3000 in a transmission manner, and is used for clamping a slide and placing the slide through the clamping device 3000, specifically, the clamping device 3000 is a manipulator clamp which is provided with two clamping parts for clamping two opposite side edges of the slide, and the two clamping parts can move close to and away from each other to clamp and place the slide.

As shown in fig. 1 to 7, in an embodiment of the slide analyzer of the present invention, the carrying device 4000 includes:

the X-axis module 4100 is arranged on the machine base, and the slide clamping seat 1000 and the scanning device 2000 are both positioned on one side of the X-axis module 4100 and are sequentially arranged along the length direction of the X-axis module 4100;

a Z-axis module 4200, wherein the Z-axis module 4200 is movably disposed on the X-axis module 4100 along with the X-axis module 4100;

a Y-axis module 4300, the Y-axis module 4300 being movably disposed on the Z-axis module 4200 along with the Z-axis module 4200, and the gripping device 3000 being movably disposed on the Y-axis module 4300 along with the Y-axis module 4300.

Preferably, the X-axis module 4100 includes an X-axis base 4110, and an X-axis motor disposed on the X-axis base 4110, and the X-axis motor is configured to drive the Z-axis module 4200 to move in the X-axis direction.

Specifically, X axle base 4110 can set up on bottom plate 10, be provided with the first chamber that holds in the X axle base 4110, set up first lead screw in the first chamber that holds, first lead screw with the output of X axle motor is connected.

The Z-axis module 4200 includes a Z-axis fixing plate 4210, a Z-axis base 4220 fixedly mounted on the Z-axis fixing plate 4210, and a Z-axis motor disposed on the Z-axis base 4220, wherein the Z-axis fixing plate 4210 is disposed on the X-axis base 4110, the X-axis motor is configured to drive the Z-axis fixing plate 4210 to move, and the X-axis motor drives the Z-axis fixing plate 4210 to move while the Z-axis base 4220 fixedly mounted on the Z-axis fixing plate 4210 follows to move.

A second accommodating cavity is formed in the Z-axis base 4220, a second lead screw can be arranged in the second accommodating cavity, and the second lead screw is connected to the output end of the Z-axis motor.

The Y-axis module 4300 includes a Y-axis fixing plate 4310, a Y-axis base 4320 fixedly mounted on the Y-axis fixing plate 4310, and a Y-axis motor disposed on the Y-axis base 4320, wherein the Y-axis base 4320 is disposed on the Y-axis fixing plate 4310, and the Z-axis motor is configured to drive the Y-axis fixing plate 4310 and the Y-axis base 4320 to move.

A third accommodating cavity is formed in the Y-axis base 4320, a third lead screw can be arranged in the third accommodating cavity, and the third lead screw is connected to the output end of the Y-axis motor.

The manipulator is arranged on one side of the Y-axis base 4320, and the Y-axis motor is used for driving the manipulator to move in the Y-axis direction.

As shown in fig. 1 to 7, in an embodiment of the slide analyzer of the present invention, a plurality of slide placing positions are provided on the slide holder 1000, each slide placing position is provided with a sensing device for sensing information of the slide cassette, and the carrying device 4000 is configured to receive the information of the slide cassette.

The slide cassette 1000 includes a cassette main body 1100, the cassette main body 1100 is provided with a plurality of slide cassette mounting grooves, the slide cassette 1200 is mounted on the cassette main body 1100 through the slide cassette mounting grooves, slides may be selectively provided in the slide cassette 1200, and a sensing sensor for sensing information of the slide cassette 1200 is provided corresponding to each of the slide cassette mounting grooves.

In the using process of the slide holder 1000 of this embodiment, a series of preparation steps are first performed on the tissue of the human body to prepare a slide that can be used for observing cells with a microscope, and labeling the information of the patient including the name, age, human tissue part, etc. of the patient to the slide, then the marked slide is fixed in the box main body through the clamping groove, the slide box 1200 is matched with the limiting groove on the slide box mounting groove through the limiting bulge to realize the fixation of the slide box 1200, and each of the cassette mounting grooves is provided with an induction sensor for inducing information of the cassette 1200, which can accurately acquire information of the cassette 1200, this slide cassette 1000 can be applied to automatic slide access arrangement, reduces artifical working strength, reduces the bad consequence that artificial misoperation caused, improves work efficiency.

In this embodiment, the cassette body 1100 has a rectangular structure and has a first surface and a second surface that are opposite to each other, and the cassette mounting slots are uniformly distributed on the first surface in 4 rows and 5 columns.

Specifically, the cassette body 1100 is provided with 20 rectangular cassette mounting slots, each cassette mounting slot being capable of holding one cassette 1200, each cassette 1200 being capable of holding 20 slides.

The induction sensor includes a slide cassette 1200 sensor, a positioning sensor 1500, the slide cassette 1200 sensor is used for sensing whether a slide cassette 1200 is provided in a slide cassette mounting groove, the positioning sensor 1500 is used for positioning the position of a corresponding slide.

When the slide holder 1000 is applied to an automated slide analysis system, the sensor can be in communication connection with a main control system in the automated slide analysis system, so that the slide taking analysis operation can be performed smoothly.

As a preferred technical solution of the present application, the slide cassette 1000 further comprises an indicator lamp 1400, wherein the indicator lamp 1400 is used for indicating whether the slide cassette mounting groove has the slide cassette 1200 and whether the slide cassette 1200 is mounted in place.

Specifically, the positioning sensor 1500 is disposed on the right side of the cassette main body 1100, the positioning sensor 1500 is configured to position the Z-axis coordinate of the slide at the bottom of the slide cassette 1200, the slide cassette 1200 sensor is disposed on the back side of the cassette main body 1100, one slide cassette 1200 sensor is correspondingly mounted in each slide cassette mounting groove, when a slide cassette 1200 is detected, the corresponding indicator 1400 is on, otherwise, the corresponding indicator 1400 is off.

In the present scheme, the sensor is mounted in a manner that a sensor mounting hole is formed in the card holder body 1100, and the inductive sensor is disposed in the sensor mounting hole.

At least a set of relative surface is provided with the spacing groove in the glass sheet box mounting groove, on the glass sheet box 1200 with what the spacing groove corresponds is provided with spacing arch glass sheet box 1200 installs when in the glass sheet box mounting groove, spacing arch with spacing groove cooperatees and makes the stable setting of glass sheet box 1200 is in the glass sheet box mounting groove.

It should be noted that the limiting groove can be symmetrically arranged on the upper and lower side surfaces of the mounting groove of the glass box, and also can be symmetrically arranged on the left and right side surfaces of the mounting groove of the glass box, similarly, the glass box 1200 is correspondingly provided with a limiting bulge, and the limiting bulge is matched with the limiting groove to fix the glass box 1200 in the mounting groove of the glass box.

Preferably, the two sides of the slide box mounting groove are provided with a yielding groove 1600.

Specifically, the abdicating groove 1600 can reserve operation space for loading and unloading the glass sheet box 1200, the abdicating groove 1600 is arranged at the left and right sides of the glass sheet box installation groove, the abdicating groove 1600 is an inward concave groove.

Slide cassette 1200 includes a cassette body and a plurality of card slots provided on the cassette body through which slides are installed in the cassette body.

The box main body is of a rectangular structure and is provided with a back plate and side plates arranged on the periphery of the back plate, the back plate and the side plates jointly form an accommodating space for installing a glass slide, an opening is formed in the surface of the accommodating space opposite to the back plate, and the clamping groove extends from the back plate to the opening direction.

It should be noted that the depth of the inward recess of the cassette body should not be less than 1/2 the length of the slide, which further ensures that the center of gravity of the slide falls within the cassette body, further ensuring that the slide is not prone to falling.

And a partition plate is arranged between the adjacent clamping grooves, and a chamfer is arranged at the end part of the partition plate facing the opening.

In the description herein, it is to be understood that the terms "upper", "lower", "left", "right", and the like are used in a descriptive sense and with reference to the illustrated orientation or positional relationship, and are used for convenience in description and simplicity in operation, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first" and "second" are used merely for descriptive purposes and are not intended to have any special meaning.

In the description herein, references to the description of "an embodiment," "an example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be appropriately combined to form other embodiments as will be appreciated by those skilled in the art.

The technical principle of the present invention is described above with reference to specific embodiments. The description is made for the purpose of illustrating the principles of the invention and should not be construed in any way as limiting the scope of the invention. Based on the explanations herein, those skilled in the art will be able to conceive of other embodiments of the present invention without any inventive effort, which would fall within the scope of the present invention.

Claims (10)

1. A slide analyzer, comprising:

the glass slide clamping seat (1000) is arranged on the base, and the glass slide clamping seat (1000) is used for placing a glass slide;

the scanning device (2000), the said scanning device (2000) locates the said frame, is used for scanning the pathological tissue on the said slide;

the clamping device (3000), the said clamping device (3000) is movably mounted to the said base, is used for clamping and placing the said slide;

the gripping device (3000) is movable with a first work position, in which the slide corresponds to the slide holder (1000), and a second work position, in which the gripping device (3000) is located, in which the slide corresponds to the scanning device (2000), in which the gripping device (3000) is located.

2. Slide analyser according to claim 1, wherein the scanning device (2000) comprises:

the scanning platform (2300), the said scanning platform (2300) locates the said bed;

the scanning lens (2200) is arranged above the scanning platform (2300), and the mirror surface of the scanning lens (2200) faces the scanning platform (2300).

3. Slide analyser according to claim 2, wherein the scanning platform (2300) is movably arranged to the frame in a horizontal direction as well as in a vertical direction.

4. The slide analyzer according to claim 3, wherein the scanning platform (2300) comprises a driving mechanism and a placement groove (2310) provided in the driving mechanism, the driving mechanism is provided in a body (2100) provided on the base, and the driving mechanism moves the placement groove (2310) in the front-back, left-right, and up-down directions.

5. The slide analysis machine according to claim 1, characterized in that the scanning device (2000) is further connected to a display screen via a signal transmission device, the display screen is disposed on the base and has a display surface facing outward, and the display surface is used for displaying digital images and pathological analysis results.

6. The slide analyzer according to any one of claims 1 to 5, further comprising a carrying device (4000) provided to the base, wherein the gripping device (3000) is drivingly connected to the carrying device (4000), and the carrying device (4000) drives the gripping device (3000) to move in a horizontal direction and a vertical direction.

7. Slide analyser according to claim 6, wherein the handling device (4000) comprises:

the X-axis module (4100) is arranged on the machine base, and the slide clamping seat (1000) and the scanning device (2000) are positioned on one side of the X-axis module (4100) and are sequentially arranged along the length direction of the X-axis module;

a Z-axis module (4200), wherein the Z-axis module (4200) is movably disposed on the X-axis module (4100) along with the X-axis module (4100);

the clamping device (3000) can move with the Z-axis module (4200) and is arranged on the Z-axis module (4200).

8. The slide analyzer according to claim 7, wherein the carrying device (4000) further includes a Y-axis module (4300), the Y-axis module (4300) being movably provided to the Z-axis module (4200) along with the Z-axis module (4200), and the gripping device (3000) being movably provided to the Y-axis module (4300) along with the Y-axis module (4300).

9. Slide analyser according to claim 6, wherein a plurality of slide placement locations are provided on the slide holder (1000), each slide placement location being provided with a sensing device.

10. The slide analyzer of claim 9, wherein the sensing device is further configured to sense the presence and absence of a slide and to locate the position of the slide.

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