CN114958580B - A hot lid structure for full-automatic nucleic acid analytic system - Google Patents
A hot lid structure for full-automatic nucleic acid analytic system Download PDFInfo
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- CN114958580B CN114958580B CN202210611682.4A CN202210611682A CN114958580B CN 114958580 B CN114958580 B CN 114958580B CN 202210611682 A CN202210611682 A CN 202210611682A CN 114958580 B CN114958580 B CN 114958580B
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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Abstract
The invention discloses a hot cover structure for a full-automatic nucleic acid analysis system, and relates to the technical field of full-automatic nucleic acid detection systems. A hot lid structure for full-automatic nucleic acid analytic system includes slide, hot lid mechanism, detection mechanism and set up in actuating mechanism on the slide, hot lid mechanism include with slide sliding connection's hot lid fixed plate, set up in hot lid fixed plate lower extreme hot lid with hot lid elastic connection's hot platen, actuating mechanism is used for the drive hot lid mechanism is relative slide vertical motion, detection mechanism include with hot platen upper end fixed connection's first separation blade, be provided with on the hot lid fixed plate with the corresponding first photoelectric switch of first separation blade. The hot cover structure for the full-automatic nucleic acid analysis system can detect whether the reagent plate is correctly placed below the hot cover, and avoids false detection.
Description
Technical Field
The invention relates to the technical field of full-automatic nucleic acid detection and analysis systems, in particular to a thermal cover structure for a full-automatic nucleic acid analysis system.
Background
In the existing full-automatic nucleic acid detection and analysis system, because the instrument is large in size and the reagent plate is placed at an unobtrusive position in the instrument, an operator cannot visually observe whether the reagent plate is correctly placed below the hot cover before reagent detection. Although the apparatus can perform the operation of reagent test analysis even when the reagent plate is not properly placed under the thermal cover, the result of the analysis is invalid because the reagent plate is not properly placed, and it takes several hours for each reagent analysis, and it takes time, labor and cost to perform the false detection.
Disclosure of Invention
The invention provides a hot cover structure for a full-automatic nucleic acid analysis system, which can detect whether a reagent plate is correctly placed below the hot cover and avoid false detection.
In order to solve the technical problems, the invention provides the following technical scheme:
the invention provides a hot cover structure for a full-automatic nucleic acid analysis system, which comprises a sliding plate, a hot cover mechanism, a detection mechanism and a driving mechanism arranged on the sliding plate, wherein the hot cover mechanism comprises a hot cover fixing plate connected with the sliding plate in a sliding manner, a hot cover arranged at the lower end of the hot cover fixing plate and a hot pressing plate elastically connected with the hot cover, the driving mechanism is used for driving the hot cover mechanism to vertically move relative to the sliding plate, the detection mechanism comprises a first blocking piece fixedly connected with the upper end of the hot pressing plate, and a first photoelectric switch corresponding to the first blocking piece is arranged on the hot cover fixing plate.
Furthermore, an elastic piece and a first guide rod are arranged between the hot cover and the hot pressing plate.
Furthermore, the first guide rod is a stepped shaft, and a stepped through hole matched with the stepped shaft is formed in the upper end of the hot cover.
Furthermore, the lower end of the hot cover is positioned in the hot cover, a baffle is arranged in the hot cover, and the hot pressing plate can be placed on the baffle.
Furthermore, the elastic part is a compression spring, and the compression spring is sleeved on the outer edge of the first guide rod.
Furthermore, the driving mechanism comprises a fixing frame arranged on the sliding plate and a motor arranged on the fixing frame, a gear is arranged at the output end of the motor, a rack meshed with the gear is arranged on the hot cover fixing plate, the bottom of the rack is fixedly connected with the hot cover fixing plate, and the rack is connected with the sliding plate in a sliding manner.
Furthermore, a rack guide groove is formed in the sliding plate, and the rack is arranged in the rack guide groove in a sliding mode.
Further, a second guide rod is arranged between the hot cover fixing plate and the sliding plate.
Furthermore, a linear bearing is arranged on the hot cover fixing plate, the upper end of the second guide rod is fixedly connected with the sliding plate, and the second guide rod is sleeved in the linear bearing.
Furthermore, a second photoelectric switch and a third photoelectric switch are further arranged on the fixing frame, a second blocking piece is arranged on the hot cover fixing plate, and when the hot cover fixing plate moves to the upper limit and the lower limit, the second blocking piece respectively triggers the second photoelectric switch and the third photoelectric switch.
Compared with the prior art, the invention has the following beneficial effects:
according to the heat cover structure for the full-automatic nucleic acid analysis system, the driving mechanism arranged on the sliding plate drives the heat cover mechanism to vertically move relative to the sliding plate, the heat cover is elastically connected with the hot pressing plate, so that the first blocking piece fixedly connected with the upper end of the hot pressing plate and the first photoelectric switch arranged at the upper end of the hot cover fixing plate can vertically and relatively move, when the reagent plate is correctly placed below the heat cover, the first blocking piece can trigger the first photoelectric switch in the vertical movement process, and the full-automatic nucleic acid analysis system starts to perform the next reagent detection and analysis process. By the structure, whether the reagent plate is correctly placed below the hot cover or not can be detected before a reagent detection and analysis process, so that loss caused by false detection is avoided, and the fault-tolerant rate is improved.
Drawings
FIG. 1 is a schematic view showing the overall structure of a thermal cap structure for a fully automatic nucleic acid analysis system according to the present invention;
FIG. 2 is an upper partial exploded view of a thermal cover structure for a fully automated nucleic acid analysis system according to the present invention;
FIG. 3 is an exploded view of the lower part of a thermal cover structure for a fully automated nucleic acid analysis system according to the present invention;
FIG. 4 is a side view of a thermal cap structure for a fully automated nucleic acid analysis system according to the present invention;
in the figure: the device comprises a sliding plate 1, a fixing frame 2, a second photoelectric switch 3, a third photoelectric switch 4, a second blocking piece 5, a motor 6, a gear 7, a rack guide groove 8, a rack 9, a linear bearing 10, a second guide rod 11, a hot cover fixing plate 12, a hot cover 13, a first guide rod 14, a compression spring 15, a hot pressing plate 16, a first blocking piece 17 and a first photoelectric switch 18.
Detailed Description
In order to make the technical problems, technical solutions and advantages of the present invention more apparent, the following detailed description is given with reference to the accompanying drawings and specific embodiments.
The invention provides a hot cover structure for a full-automatic nucleic acid analysis system, which comprises a sliding plate 1, a hot cover mechanism, a detection mechanism and a driving mechanism arranged on the sliding plate 1, wherein the hot cover mechanism comprises a hot cover fixing plate 12 connected with the sliding plate 1 in a sliding way, a hot cover 13 arranged at the lower end of the hot cover fixing plate 12 and a hot pressing plate 16 elastically connected with the hot cover 13, the driving mechanism is used for driving the hot cover mechanism to move vertically relative to the sliding plate 1, the detection mechanism comprises a first blocking piece 17 fixedly connected with the upper end of the hot pressing plate 16, and a first photoelectric switch 18 corresponding to the first blocking piece 17 is arranged on the hot cover fixing plate 12. Drive the relative slide 1 of hot lid mechanism through the actuating mechanism that sets up on the slide 1 and carry out vertical motion, because hot lid 13 and hot pressboard 16 elastic connection, so hot pressboard 16 upper end fixed connection's first separation blade 17 and the first photoelectric switch 18 that hot lid fixed plate 12 upper end set up can be in the relative motion in the vertical direction, when the reagent board has just been placed to hot lid 13 below, first separation blade 17 can trigger first photoelectric switch 18 at a certain moment in the vertical motion process, full-automatic nucleic acid analysis system begins to carry out reagent detection analysis processes on next step. By adopting the structure, whether the reagent plate is correctly placed below the hot cover 13 can be detected before a reagent detection and analysis process, the loss caused by false detection is avoided, and the fault-tolerant rate is improved.
In an embodiment of the present invention, an elastic member and a first guide bar 14 are disposed between the thermal cover 13 and the thermal platen 16. Specifically, the elastic member is engaged with the first guide bar 14, and when the reagent plate is properly placed under the thermal cover 13, the guide bar can move vertically upward relative to the thermal cover 13 under the elastic force of the elastic member.
The connection between the thermal cover 13 and the thermal platen 16 may be made by the following two methods:
example 1:
the first guide bar 14 is a stepped shaft, and a stepped through hole matched with the stepped shaft is formed at the upper end of the hot cover 13. The first guide rod 14 drives the hot pressing plate 16 to move up and down relative to the hot cover 13 in the stepped hole, and the arrangement of the stepped hole can limit the moving distance between the hot pressing plate 16 and the hot cover 13, so that the hot pressing plate 16 is prevented from falling.
In this embodiment, the first blocking piece 17 may be disposed at the upper end of the stepped shaft, and move along with the stepped shaft, and can contact with the first photoelectric switch 18, so as to further limit the moving distance of the hot-pressing plate 16.
Example 2:
a baffle plate (not shown) is provided in the heat cover 13 at the lower end of the heat cover 13, and the heat press plate 16 may be placed on the baffle plate (not shown). By providing a baffle plate (not shown), the hot press board 16 can be prevented from falling down by the influence of gravity.
In an embodiment of the present invention, the elastic member is a compression spring 15, and the compression spring 15 is sleeved on an outer edge of the first guiding rod 14. If the reagent plate is correctly arranged below the hot cover 13, when the hot pressing plate 16 moves vertically relative to the hot cover 13, the hot pressing plate 16 contacts and presses the reagent plate, and the first guide rail is driven to move vertically upward relative to the hot cover 13 under the action of the elastic force of the compression spring 15.
In one embodiment of the invention, the driving mechanism comprises a fixed frame 2 arranged on the sliding plate 1 and a motor 6 arranged on the fixed frame 2, a gear 7 is arranged at the output end of the motor 6, a rack 9 meshed with the gear 7 is arranged on a hot cover fixing plate 12, the bottom of the rack 9 is fixedly connected with the hot cover fixing plate 12, and the rack 9 is connected with the sliding plate 1 in a sliding manner. The motor 6 drives the gear 7 to rotate, the gear 7 drives the rack 9 to vertically move, and then the rack 9 drives the hot cover fixing plate 12 to vertically move, so that the driving mechanism drives the hot cover mechanism to vertically move relative to the sliding plate 1; the rack 9 is slidable through the slide 1 according to the distance of relative vertical movement between the thermal cap fixing plate 12 and the slide 1.
In an embodiment of the present invention, the sliding plate 1 is provided with a rack guide groove 8, and the rack 9 is slidably disposed in the rack guide groove 8. The rack 9 slides in the rack guide groove 8, which plays a guiding role.
In an embodiment of the present invention, a second guide rod 11 is disposed between the thermal cover fixing plate 12 and the sliding plate 1. The second guide bar 11 can serve to guide the vertical movement of the cap fixing plate 12, and prevent the cap fixing mechanism from tilting during movement.
In an embodiment of the present invention, a linear bearing 10 is disposed on the thermal cover fixing plate 12, an upper end of the second guide rod 11 is fixedly connected to the sliding plate 1, and the second guide rod 11 is sleeved in the linear bearing 10. Specifically, the sliding plate 1 and the second guide rod 11 can move downwards relative to the hot cover fixing plate 12, and the linear bearing 10 is arranged, so that the second guide rod 11 can move more smoothly in the vertical movement.
In an embodiment of the present invention, the fixing frame 2 is further provided with a second photoelectric switch 3 and a third photoelectric switch 4, the thermal cover fixing plate 12 is provided with a second blocking plate 5, and when the thermal cover fixing plate 12 moves to the upper limit and the lower limit, the second blocking plate 5 triggers the second photoelectric switch 3 and the third photoelectric switch 4, respectively. When the second blocking piece 5 triggers the second photoelectric switch 3, the driving mechanism stops driving the hot cover mechanism to continue to move vertically upwards; when the second blocking piece 5 triggers the third photoelectric switch 4, the thermal cover 13 completely covers the reagent plate, at this time, the driving mechanism stops driving the thermal cover mechanism to continue to move vertically downwards, and at this time, the first blocking piece 17 triggers the first photoelectric switch 18, and the full-automatic nucleic acid analysis system starts to perform the next reagent detection and analysis process.
The operation principle of the hot cover structure for the full-automatic nucleic acid analysis system is as follows:
when the reagent plate is properly placed under the hot lid 13:
the first stage is as follows: the motor 6 drives the gear 7 to rotate, so as to drive the rack 9 to vertically move downwards in the rack guide groove 8, and the rack 9 drives the hot cover mechanism to integrally vertically move downwards under the guide of the second guide rod as the bottom of the rack 9 is fixedly connected with the hot cover fixing plate 12; and a second stage: the hot pressing plate 16 contacts the reagent plate, and the hot cover 13 can cover the reagent plate, so the hot cover 13 and the hot cover fixing plate 12 can continue to move vertically downwards, the hot pressing plate 16 is still, that is, the first photoelectric switch 18 continues to move vertically downwards, the first blocking piece 17 is still until the hot cover 13 completely covers the reagent plate, that is, the hot cover 13 reaches the lower limit, at this time, the first blocking piece 17 triggers the first photoelectric switch 18, the second blocking piece 5 triggers the third photoelectric switch 4, the full-automatic nucleic acid analysis system starts to perform the next reagent detection and analysis process, and meanwhile, the hot cover 13 stops continuing to move vertically downwards. And a third stage: after the detection and analysis process of each reagent plate is finished, the driving mechanism drives the thermal cover 13 and the thermal cover fixing plate 12 to vertically move upwards, the thermal pressing plate 16 firstly keeps still until the thermal pressing plate 16 contacts with the baffle, the thermal cover mechanism starts to integrally and vertically move upwards, when the thermal cover mechanism integrally moves to the upper limit, the second baffle 5 on the thermal cover fixing plate 12 triggers the second photoelectric switch 3, and at the moment, the driving mechanism stops driving the thermal cover mechanism to continuously and vertically move upwards.
When the reagent plate is not properly placed under the hot lid 13:
the first stage is the same as the first stage when the reagent plate is properly placed under the hot lid 13, and is not described herein; and a second stage: the driving mechanism drives the hot cover mechanism to vertically move downwards until the hot cover 13 reaches a lower limit position, the second blocking piece 5 triggers the third photoelectric switch 4, at this time, the hot cover mechanism does not continuously vertically move downwards, but at this stage, the hot pressing plate 16 is not contacted with the reagent plate, so that the hot pressing plate 16, the hot cover 13 and the hot cover fixing plate 12 are always kept in a relatively static state, and therefore, the first blocking piece 17 cannot trigger the first photoelectric switch 18, namely, the next reagent detection and analysis process of the full-automatic nucleic acid analysis system cannot be started; and a third stage: the driving mechanism drives the whole hot cover mechanism to integrally start to move vertically upwards, when the whole hot cover mechanism moves to the upper limit position, the second baffle 5 on the hot cover fixing plate 12 triggers the second photoelectric switch 3, and at the moment, the driving mechanism stops driving the hot cover mechanism to continuously move vertically upwards.
While the foregoing is directed to the preferred embodiment of the present invention, it will be understood by those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (8)
1. The utility model provides a hot lid structure for full-automatic nucleic acid analytic system, its characterized in that, including slide, hot lid mechanism, detection mechanism and set up in actuating mechanism on the slide, hot lid mechanism include with slide sliding connection's hot lid fixed plate, set up in hot lid of hot lid fixed plate lower extreme and with hot lid elastic connection's hot pressing plate, actuating mechanism including set up in mount on the slide with set up in motor on the mount, the output of motor is provided with the gear, be provided with on the hot lid fixed plate with gear engagement's rack, the bottom of rack with hot lid fixed plate fixed connection, the rack with slide sliding connection, actuating mechanism is used for the drive hot lid mechanism is relative slide vertical motion, detection mechanism include with hot pressing plate upper end fixed connection's first separation blade, be provided with on the hot lid fixed plate with the corresponding first photoelectric switch of first separation blade, still be provided with second photoelectric switch and third photoelectric switch on the mount, be provided with the second separation blade on the hot lid fixed plate, the hot lid fixed plate is in motion limit position and lower limit position, the second photoelectric switch is the second separation blade trigger respectively with third photoelectric switch.
2. The structure of claim 1, wherein an elastic member and a first guide bar are disposed between the thermal cover and the thermal platen.
3. The structure of claim 2, wherein the first guide bar is a stepped shaft, and the upper end of the thermal cap is provided with a stepped through hole for engaging with the stepped shaft.
4. The structure of claim 2, wherein the lower end of the thermal cover is positioned in the thermal cover and is provided with a baffle plate, and the thermal pressing plate is placed on the baffle plate.
5. The structure of a thermal cap for a fully automatic nucleic acid analysis system according to any one of claims 2 to 4, wherein the elastic member is a compression spring, and the compression spring is fitted around the outer edge of the first guide rod.
6. The thermal cover structure for the fully automatic nucleic acid analysis system according to claim 1, wherein the slide plate has a rack guide slot, and the rack is slidably disposed in the rack guide slot.
7. The structure of claim 1, wherein a second guide bar is disposed between the thermal cap fixing plate and the slide plate.
8. The structure of claim 7, wherein a linear bearing is disposed on the thermal cap fixing plate, the upper end of the second guide rod is fixedly connected to the sliding plate, and the second guide rod is sleeved in the linear bearing.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210611682.4A CN114958580B (en) | 2022-05-31 | 2022-05-31 | A hot lid structure for full-automatic nucleic acid analytic system |
| PCT/CN2022/128768 WO2023231291A1 (en) | 2022-05-31 | 2022-10-31 | Heat cover structure for full-automatic nucleic acid analysis system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210611682.4A CN114958580B (en) | 2022-05-31 | 2022-05-31 | A hot lid structure for full-automatic nucleic acid analytic system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114958580A CN114958580A (en) | 2022-08-30 |
| CN114958580B true CN114958580B (en) | 2023-01-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210611682.4A Active CN114958580B (en) | 2022-05-31 | 2022-05-31 | A hot lid structure for full-automatic nucleic acid analytic system |
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| Country | Link |
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| CN (1) | CN114958580B (en) |
| WO (1) | WO2023231291A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114958580B (en) * | 2022-05-31 | 2023-01-13 | 山东省高精生物诊断分析产业技术研究院有限公司 | A hot lid structure for full-automatic nucleic acid analytic system |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3899370B2 (en) * | 2003-03-25 | 2007-03-28 | 富士フイルム株式会社 | Automatic analyzer |
| CN103725602B (en) * | 2012-10-16 | 2015-05-27 | 常州福生生物技术有限公司 | Thermal cover plate used in nucleic acid amplification detector |
| CN204474683U (en) * | 2015-03-05 | 2015-07-15 | 东南大学 | A kind of full-automatic heat circulating instrument heat lid |
| CN208829679U (en) * | 2018-03-30 | 2019-05-07 | 北京和利康源医疗科技有限公司 | A kind of automatic instrument for extracting nucleic acid |
| CN110564610B (en) * | 2019-10-15 | 2024-08-23 | 杭州比芯诊断技术有限公司 | Double-temperature-zone PCR amplification device |
| CN114437919A (en) * | 2020-10-30 | 2022-05-06 | 中元汇吉生物技术股份有限公司 | Hot lid device and nucleic acid detection analyzer |
| CN113308355A (en) * | 2021-06-09 | 2021-08-27 | 圣湘生物科技股份有限公司 | Hot lid device and nucleic acid detection equipment |
| CN114958580B (en) * | 2022-05-31 | 2023-01-13 | 山东省高精生物诊断分析产业技术研究院有限公司 | A hot lid structure for full-automatic nucleic acid analytic system |
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2022
- 2022-05-31 CN CN202210611682.4A patent/CN114958580B/en active Active
- 2022-10-31 WO PCT/CN2022/128768 patent/WO2023231291A1/en unknown
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| Publication number | Publication date |
|---|---|
| CN114958580A (en) | 2022-08-30 |
| WO2023231291A1 (en) | 2023-12-07 |
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